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                  <text>Jurnal Internasional Afrika vol. 12 issue 2 2022</text>
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                <text>Jurnal Internasional vol.12 issue 2 2022&#13;
African Journal of Emergency Medicine&#13;
Utilisation of peripheral vasopressor medications and extravasation events among critically ill patients in Rwanda: A prospective cohort study</text>
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                <text>Rwanda&#13;
Vasoactive agents&#13;
Peripheral vasopressors&#13;
Extravasation&#13;
Resuscitation&#13;
Global health</text>
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                <text>Introduction: In high-income settings, vasopressor administration to treat haemodynamic instability through a&#13;
central venous catheter (CVC) is the preferred standard. However, due to lack of availability and potential for&#13;
complications, CVCs are not widely used in low- and middle-income countries. This prospective cohort study&#13;
evaluated the use of peripheral vasopressors and associated incidence of extravasation events in patients with&#13;
haemodynamic instability at the Centre Hospitalier Universitaire Kigali, Rwanda.&#13;
Methods: Patients ≥18 years of age receiving peripheral vasopressors in the emergency centre (EC) or intensive&#13;
care unit (ICU) for &gt;1 hour were eligible for inclusion. The primary outcome was extravasation events. Patients&#13;
were followed hourly until extravasation, medication discontinuation, death, or CVC placement. Extravasation&#13;
incidence with 95% confidence intervals (CI) were calculated using Poisson exact tests.&#13;
Results: 64 patients were analysed. The median age was 49 (Interquartile Range [IQR]:33-65) and 55% were&#13;
female. Distributive shock was the most frequent aetiology (47%). Intravenous (IV) location was most commonly&#13;
antecubital fossa/upper arm (31%) and forearm/hand (43%). IV gauges ≤18 were used in 58% of locations. Most&#13;
patients were treated with adrenaline (66%) and noradrenaline (41%), and 11% received multiple vasopressors.&#13;
The median treatment duration was 19 hours (IQR:8.5-37). Treatment discontinuation was predominantly due&#13;
to mortality (41%) or resolution of instability (36%). There were two extravasation events (2.9%), both limited&#13;
to soft tissue swelling. Extravasation incidence was 0.8 events per 1000 patient-hours (95% CI:0.2-2.2).&#13;
&#13;
Conclusion: Extravasation incidence with peripheral vasopressors was low, even with long use durations, sug-&#13;
gesting peripheral infusions may be an acceptable approach when barriers exist to CVC placement.</text>
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                <text>Catalina G. Marques , Lucien Mwemerashyak, Kyle Martin, Oliver Tang, Chantal Uwamahoro , Vincent Ndebwaniman, Doris Uwamahoro , Katelyn Moretti , Vinay Sharma, Sonya Naganathan, Ling Jing, Stephanie C. Garbern, Menelas Nkeshiman, Adam C. Levine, Adam R. Aluisio</text>
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                <text>https://doi.org/10.1016/j.afjem.2022.03.006</text>
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                <text>28 March 2022</text>
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                <text>peri irawan</text>
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        <name>Rwanda Vasoactive agents Peripheral vasopressors Extravasation Resuscitation Global health</name>
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                  <text>Jurnal Internasional Afrika vol. 12 issue 2 2022</text>
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                <text>Jurnal Internasional vol.12 issue 2  2022</text>
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