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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Prognosis of Advanced Stage Non-Small-Cell Lung Cancer Patients Receiving Chemotherapy: Adenocarcinoma versus Squamous Cell Carcinoma </text>
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                <text> chemotherapy, histology, lung cancer, prognosis</text>
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                <text>BACKGROUND In Indonesia, lung cancer is one of the most prevalent solid cancer with the highest mortality rate. However, studies to identify prognostic factors associated with mortality are lacking. Thus, this study was aimed to determine the association of histological subtypes and prognosis of advanced stage non-small-cell lung cancer (NSCLC) patients receiving chemotherapy. &#13;
METHODS This study focused on a retrospective cohort consisting of 60 patients with advanced stage NSCLC and treated with chemotherapy. Patients with NSCLC stage IIIB or stage IV, age ≥18 years, and good performance status were recruited. The outcomes were one-year mortality and treatment response. Gender, age, body mass index, &#13;
staging, and performance status were evaluated. Chi-square and Fisher’s exact tests were used.&#13;
RESULTS Two common histological subtypes, adenocarcinoma (68.3%) and squamous cell carcinoma (31.7%), were observed among all subjects. Four patients (6.7%) died during one-year observation period. Mortality rate was higher in squamous cell carcinoma (10.5%) patients than in adenocarcinoma (4.9%). Underweight patients had higher risk of death (relative risk [RR] = 1.09, 95% confidence interval [CI] = 1.00–1.19) and disease progression (RR = 1.30, 95% CI = 1.12–1.51). In adenocarcinoma, metastasis was a risk for progressive disease (RR = 1.35, 95% CI = 1.09–1.66). In squamous cell carcinoma, men had a lower risk of disease progression (RR = 0.11, 95% CI = 0.03–0.41).&#13;
CONCLUSIONS Squamous cell carcinoma had comparable one-year mortality and disease progression rate with adenocarcinoma type in advanced stage NSCLC. However, underweight patients had a higher risk of mortality and disease progression.</text>
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                <text>Noorwati Soetandyo, Arif Riswahyudi Hanafi, Sri Agustini, Dian Triana Sinulingga&#13;
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Genes Predisposing to Type 1 Diabetes Mellitus and Pathophysiology: A Narrative Review</text>
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                <text> autoimmunity, hyperglycemia, insulin, pancreas, type 1 diabetes mellitus</text>
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                <text>The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the interest of all stakeholders. Therefore this review articulates T1DM suspect genes and their pathophysiology. Notable electronic databases, including Medline, Scopus, PubMed, and Google-Scholar were searched for relevant information. The search identified over 73 genes suspected in the pathogenesis of T1DM, with human leukocyte antigen, insulin gene, and cytotoxic T lymphocyte-associated antigen 4 accounting for most of the cases. Mutations in these genes, along with environmental factors, may produce a defective immune response in the pancreas, resulting in β-cell autoimmunity, insulin deficiency, and hyperglycemia. The mechanisms leading to these cellular reactions are gene-specific and, if targeted in diabetic individuals, may lead to improved treatment. Medical practitioners are advised to formulate treatment procedures that target these genes in patients with T1DM.</text>
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                <text>Tajudeen Yahaya, Titilola Salisu</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Eating Behavior Affects Cardio-Metabolic Risk in High School Teenagers in A Developing Country </text>
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                <text>blood pressure, body mass index, cardiovascular, eating behavior, risk, teenagers</text>
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                <text>BACKGROUND Modernization negatively changes lifestyle, characterized by excessive eating and reduced energy consumption, and concurrently increases the cardio�metabolic risk. This study was aimed to evaluate the association between eating &#13;
behavior and cardio-metabolic risk factors including body mass index (BMI) in percentile, blood pressure (BP) in percentile, waist circumference, and heart rate in total subjects and gender sub-groups.&#13;
METHODS This analytical cross-sectional study was done from July to November 2018. High schools in four provinces of Indonesia and students were selected using purposive sampling. Subjects’ profiles were collected from interview and cardio-metabolic parameters were measured at the study sites. Data were analyzed with chi-square and &#13;
independent t-test.&#13;
RESULTS Subjects who were overweight/obese and had high BP accounted for 27.1% and 9.3–12.0% of the total subjects (n = 768), respectively. Subjects who having breakfast tended to have lower BMI (p = 0.006), and the lower consumption of western meals had lower heart rate (p = 0.02). Male subjects had more meal frequency and had less quantity of snacks than female subjects (p&lt;0.001). Male subjects with routine intake of vegetables had low heart rate (p = 0.03). Female subjects with routine breakfast had better BMI (p&lt;0.001), and lower diastolic BP (p = 0.004) and waist circumference (p = 0.02), whereas those who consumed Western &#13;
meals had higher heart rate (p = 0.046) and waist circumference (p = 0.001).&#13;
CONCLUSIONS Eating behaviors are likely to affect cardio-metabolic risk factors, and the effects vary within gender groups. </text>
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                <text>Rita Suhadi, Phebe Hendra, Dita Maria Virginia, Christianus Heru Setiawan</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Multifocal Recurrence of Medulloblastoma: A Long Follow-Up Case Study</text>
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                <text>intra-axial mass, long follow-up, medulloblastoma, recurrence</text>
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                <text>Medulloblastoma is the most common malignant brain tumor in pediatric patients. Leptomeningeal dissemination often occurs in the spinal canal and rarely into the supratentorial as an extra-axial lesion. This study followed an 8-year progression of &#13;
multifocal medulloblastoma recurrence as supratentorial metastasis that mimics an intra-axial mass of the temporal lobe. Pathologic examination of the temporal mass showed densely packed small round blue cells that are distributed in a ribboning pattern with areas of necrosis, rosette formation, and mitosis. Ki-67 immunohistochemical staining of the tumor showed a high proliferation index of 40% and revealed positive results for synaptophysin and negative results for glial fibrillary acidic protein and &#13;
β-catenin. A long follow-up is essential to diagnose the recurrence and elucidate the progression of medulloblastoma.</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Wilms’ Tumor 1 Protein Expression in Embryonal and Alveolar Rhabdomyosarcoma and Its Association with Clinical Prognostic Factors: A Cross-Sectional Study</text>
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              <elementText elementTextId="8371">
                <text>alveolar, embryonal, prognostic factor, rhabdomyosarcoma, Wilms tumor</text>
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                <text>BACKGROUND Embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) are the two major histological types commonly found in the pediatric population, which have different morphology and genetic profile. Wilms’ tumor 1 (WT1) is an antigen highly expressed in solid tumors, including rhabdomyosarcoma, and a &#13;
potential immunotherapy target. Only a few studies have attempted to determine WT1 expression in rhabdomyosarcoma. This study was conducted to demonstrate WT1 expression in ERMS, ARMS and associate it with established prognostic factors.&#13;
METHODS A cross-sectional study was conducted at the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta using archival data from January 2011 to December 2017. 30 from 102 ERMS cases and 16 from 28 ARMS cases were included in this study. Data of age, tumor size, &#13;
and location were collected. All cases were stained by WT1 immunohistochemistry. The expression was assessed semiquantitatively using histoscore (H-score) formula. An independent t-test was used to compare WT1 expression between ERMS and ARMS. Correlation analysis was used to evaluate the relationship between WT1 expression and &#13;
prognostic factors. &#13;
RESULTS All ERMS and ARMS cases expressed WT1 in diffuse, moderate to strong staining. ERMS show higher WT1 expression than ARMS (H-score 179.9 versus 149.5) (p = 0.014). Strong WT1 expression mostly found in patient age &lt;20 years and non favourable location. Moderate WT1 expression mostly found in cases with tumor size &gt;5 cm.&#13;
CONCLUSIONS WT1 expression was higher in ERMS cases than in ARMS cases, which the expressions were similar in different age, tumor size, and location groups. </text>
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                <text>Aina Angelina, Nurjati Chairani Siregar, Riesye Arisanty</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Association between Axillary Lymph Node Involvement and Clinicopathological Features of Breast Cancer among Indonesian Women</text>
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                <text> breast cancer, lymph node metastases, lymphovascular space invasion, tumor stage</text>
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                <text>BACKGROUND Some clinicopathological features play roles in the spread of breast cancer to axillary lymph node (ALN). However, their roles as predictive factors are not well-established. This study was conducted to determine the correlation between the clinicopathological features of breast cancer and the risk of ALN involvement in Indonesian women.&#13;
METHODS This cross-sectional study was conducted in Margono Soekarjo Hospital using archival data from January 2017 to June 2018. All subjects with breast cancer who had undergone modified radical mastectomies without any evidence of distant metastasis were included. Chi-square and Fisher’s exact tests were performed to assess the relationship between ALN involvement and age, menopausal status, laterality, tumor size, tumor stage, histological type, tumor grade, lymphovascular space invasion (LVSI), skin or nipple infiltration, perineural invasion, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status. The odds ratio of each variable was evaluated using ordinal regression analysis.&#13;
RESULTS Stage 3 breast cancer had the worst status of ALN involvement compared with stage 1 (OR = 3.49; 95% CI = 1.51–8.08) and stage 2 (OR = 3.04; 95% CI = 1.32–6.98). Likewise, positive LVSI also had the worst status of ALN involvement compared with negative LVSI (OR = 8.68; 95% CI = 4.23–17.81).&#13;
CONCLUSIONS Tumor stage and LVSI could be considered as independent predictive factors of ALN involvement in patients with breast cancer, especially among Indonesian women.</text>
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                <text>Dody Novrial, Gita Nawangtantrini, Hidayat Sulistyo, Henida Dwi Sari, Wahyu Djatmiko</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Streptococcussuis Meningitis Related to Processing and Consuming Raw Pork during Balinese Tradition, Mebat</text>
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                <text>foodborne disease, meningitis, polymerase chain reaction, Streptococcus suis</text>
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                <text>Streptococcus suis is a zoonotic pathogen that can infect humans, especially meningitis. S. suis meningitis has been commonly diagnosed in Bali, which is associated with the consumption of raw pork. We reported case of S. suis meningitis that could have occurred due to the ingestion of undercooked pork during a traditional ceremony, &#13;
which also involved two more patients with similar symptoms. A 62-year-old male was brought to the emergency unit because of decreased consciousness (Glasgow coma scale 14/15) in the last 8 hours before admission. He also had a headache, high fever, and stiff neck. Examination of cerebrospinal fluid revealed the presence of S. suis infection and was confirmed by polymerase chain reaction. The patient was administered ceftriaxone and showed a clinical improvement on the third day without any hearing problem </text>
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                <text>IGM Ardika Aryasa, Ni Putu Ayu Widiasari, Ni Made Susilawathi, Ni Nengah Dwi Fatmawati, I Made Oka Adnyana, Anak Agung Raka Sudewi, Ni Made Adi Tarini</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
Risk Factor for Mycobacterium Leprae Detection in Household Contacts with Leprosy Patients: A Study in Papua, East Indonesia</text>
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                <text>households, leprosy, Mycobacterium leprae, polymerase chain reaction</text>
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                <text>BACKGROUND In the era of leprosy eradication, Jayapura is still one of the biggest leprosy pockets in Papua, Indonesia. The trend for leprosy case detection rate has remained relatively stable over recent years. This study was aimed to detect &#13;
Mycobacterium leprae in household contacts and to evaluate the associated factors with the detection.&#13;
METHODS This cross-sectional study recruited household contacts of leprosy patients who were diagnosed consecutively from March to August 2015 in Hamadi Point of Care, Jayapura. The leprosy patients were diagnosed using polymerase chain reaction (PCR). For each leprosy patient, up to four household contacts that had no symptom were included. Every household contact received screening through DNA detection of M. leprae extracted from nasal swab specimens and examined using PCR. Factors for bacteria detection included intensity, time duration and number of contacts living together in the same house, and random blood glucose levels were evaluated. Bivariate analysis was used to associate them with M. leprae detection in household contacts.&#13;
RESULTS From 107 household contacts of 35 patients who had leprosy, M. leprae was detected in 19.6%. Household contacts with leprosy patients for &gt;1 year was a risk factor for detection (OR = 12.45; 95% CI = 1.595–97.20; p = 0.002). Blood glucose (p = 0.444), ethnic (p = 0.456), sleeping proximity to leprosy case (p = 0.468) and relatives (p = 0.518) give no effect to M. leprae detection in household contacts.&#13;
CONCLUSIONS Among the various risk factors studied, duration of living together with the patient significantly increased the risk of M. leprae transmission. </text>
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                <text>Hana Krismawati, Antonius Oktavian, Yustinus Maladan, Tri Wahyuni</text>
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              <elementText elementTextId="8320">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            <elementTextContainer>
              <elementText elementTextId="8322">
                <text>Sri Wahyuni</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="8323">
                <text>ISSN : 0853-1773</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="8325">
                <text>English</text>
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            <elementTextContainer>
              <elementText elementTextId="8327">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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        <name>Jurnal Internasional</name>
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                <elementText elementTextId="8211">
                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="8286">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
First Trimester Maternal Upper Arm Circumference Correlated to Placental Size and Neonatal Anthropometry</text>
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            </elementTextContainer>
          </element>
          <element elementId="49">
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              <elementText elementTextId="8287">
                <text>birth weight, maternal nutrition, pregnancy outcome</text>
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                <text>BACKGROUND First maternal nutrition, represented by anthropometrics, is an important factor for fetal growth. This study aimed to determine the correlation between maternal nutritional status of first trimester pregnant women with placental size and neonatal anthropometry.&#13;
METHODS A retrospective cohort study (N = 134) was conducted in Jakarta and Riau during August–September 2017. Correlation between first trimester maternal nutritional status, placental size (placental weight and volume), and neonatal anthropometry (birth weight, birth length, head circumference, and abdominal circumference) were &#13;
examined using Spearman's correlation test.&#13;
RESULTS High maternal body mass index and upper arm circumference (UAC) are weakly correlated with high birth weight (r = 0.281, p&lt;0.001 and r = 0.271, p&lt;0.001), birth length (r = 0.176, p = 0.022 and r= 0.238, p = 0.002), head circumference (r = 0.251, p = 0.001 and r = 0.297, p&lt;0.001), abdominal circumference (r = 0.227, p = 0.003 and r= 0.226, p = 0.003), placental weight (r = 0.198, p = 0.01 and r = 0.228, p&lt;0.001), and placental volume (r = 0.194, p = 0.01 and r = 0.203, p = 0.008). In addition, high maternal height is also weakly correlated with high birth weight (r = 0.157, p = 0.043) and birth length (r = 0.158, p = 0.041).&#13;
CONCLUSIONS UAC can be reliably used to assess the nutritional status of pregnant women and to predict placental and newborn sizes. </text>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="8289">
                <text>Noroyono Wibowo, Rima Irwinda, Lazuardy Rachman</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="8290">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="8291">
                <text>2020-03-26</text>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="8292">
                <text>Sri Wahyuni</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="8293">
                <text>ISSN : 0853-1773</text>
              </elementText>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="8294">
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            <description>A language of the resource</description>
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              <elementText elementTextId="8295">
                <text>English</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="8297">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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        <name>birth weight</name>
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      <tag tagId="25">
        <name>Jurnal Internasional</name>
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        <name>maternal nutrition</name>
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        <name>pregnancy outcome</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="8211">
                  <text>Medical Journal of Indonesia Vol. 29 No. 1 2020 FKUI</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
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          <element elementId="50">
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              <elementText elementTextId="8265">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020&#13;
A Randomized Controlled Trial of High Parenteral Protein Feeding in Septic Children: The Role of Tumor Necrosis Factor-Alpha-308 Polymorphism</text>
              </elementText>
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          </element>
          <element elementId="49">
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              <elementText elementTextId="8266">
                <text> children, high protein, outcome assessment, sepsis</text>
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            <description>An account of the resource</description>
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                <text>BACKGROUND Septic children cause high protein degradation and inadequate nutritional intake would worsen the outcomes. In addition, there are conflicting results of association between tumor necrosis factor-α (TNFA)-308 polymorphism and poorer outcomes. This study was aimed to investigate the impact of high protein feeding in &#13;
septic children and to examine the role of the TNFA-308 polymorphism in outcome of sepsis.&#13;
METHODS In this randomized controlled trial, septic children were randomly assigned to receive either high protein feeding (amino acid of 4 g/kg of body weight [kgBW]/day) or standard nutrient (amino acid of 2 g/kgBW/day) for three days in the pediatric intensive care unit of four hospitals in Indonesia. The patient’s enrollment was done &#13;
between April 2016 and May 2017. The primary outcome was the pediatric logistic organ dysfunction (PELOD) score. TNFA-308 polymorphism was investigated using restriction &#13;
fragment length polymorphism method in both groups. PELOD score was analyzed as mean differences and gene polymorphism was analyzed with mortality in a subgroup.&#13;
RESULTS There were 40 children in each group. PELOD score on day-1 (22.4 versus 20.5, p = 0.429), day-2 (20.5 versus 19.8, p = 0.815), and day-3 (18.8 versus 19.8, p = 0.772) were not lower in high protein feeding compared to standard feeding. TNFA�308 polymorphism had no role in mortality of both groups (high protein, p = 0.426; standard, p = 0.456).&#13;
CONCLUSIONS From this study, researchers concluded that a high protein intervention did not significantly decrease the PELOD score, length of stay, and duration of ventilator use in both groups. </text>
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                <text>Gema Nazri Yanni, Amir Sjarifuddin Madjid, Aryono Hendarto, Sri Widia Azraki Jusman, Zakiudin Munasir, Hindra Irawan Satari, Iswari Setianingsih, Munar Lubis, Sudigdo Sastroasmoro </text>
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              <elementText elementTextId="8269">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            <name>Date</name>
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            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="8271">
                <text>Sri Wahyuni</text>
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            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="8272">
                <text>ISSN : 0853-1773</text>
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            <name>Language</name>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 1 2020</text>
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        <name>children</name>
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        <name>outcome assessment</name>
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        <name>sepsis</name>
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