1 10 24 https://repository.horizon.ac.id/files/original/53de356e4117989e9eaa139df01d0edc.pdf 021fc384ec8cd3097e8da2232bb1ec69 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Erratum: The Use of High-Resolution Melting Techniques for Mutation Screening of Diseases Caused by Trinucleotide Repeat Expansion, with Emphasis on The AR Gene (Corrections) Subject The topic of the resource The Use of High-Resolution Melting Techniques, Mutation Screening of Diseases Description An account of the resource In the original version of this article, the phrase in the “Conclusions” section was incorrectly typed as “could not be” and should be “could be”. Thus the correct sentence is “This study revealed that CAG repeat expansion in the AR gene in DSD cases is scarce in the Indonesian population; nevertheless, the CAG repeat expansion could be identified in one SBMA case.” The article has now been revised and appeared correctly. Creator An entity primarily responsible for making the resource Achmad Zulfa Juniarto, Mahayu Dewi Ariani, Stefani Harumsari, Nurin Aisyiyah Listyasari, Hardian, Agustini Utari, Sultana Muhammad Hussein Faradz Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Jurnal Internasional Mutation Screening of Diseases The Use of High-Resolution Melting Techniques https://repository.horizon.ac.id/files/original/113cd2e481bf990ac4ec2c88f863cc70.pdf c0a4f31c2d93e59a215c203a0d866816 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Zika, Chikungunya, and Dengue Viral Infections in Human Peripheral Blood Mononuclear Cells: Cell Susceptibility and Gene Expression Subject The topic of the resource chemokines, chikungunya virus, cytokines, dengue virus, mononuclear leukocytes, Zika virus Description An account of the resource BACKGROUND Infections of Zika (ZIKV), dengue (DENV), and chikungunya viruses (CHIKV) are presented with similar clinical symptoms; these often lead to misdiagnosis. Viremia levels and host immune responses may contribute to disease severity. This study was aimed to characterize the ability of ZIKV, CHIKV, and DENV to infect human peripheral blood mononuclear cells (PBMCs) and assess the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-10, and interferon gamma-induced protein (IP)-10 genes in response to the viral infections. METHODS PBMCs were isolated from healthy donors using gradient centrifugation. Cells were infected with Indonesian isolates of ZIKV, CHIKV, and DENV for 48 hours. Plaque assays were performed to measure viable virus titers, while viral genomic RNA and the gene expression of TNF-α, IL-10, and IP-10 were determined using real-time quantitative reverse transcription-polymerase chain reaction. RESULTS The susceptibility of PBMCs to ZIKV, CHIKV, and DENV infection was observed, and the viable virus titer and viral genome quantity were found to be significantly higher in ZIKV and CHIKV. All viruses induced the expression of immune-related proteins. The TNF-α gene was upregulated by all viruses to relatively similar levels. IL-10 expression was highest in response to ZIKV, followed by CHIKV. In contrast, IP-10 expression was highly upregulated in DENV-infected cells and only moderately expressed in ZIKV- and CHIKV-infected cells. CONCLUSIONS ZIKV, CHIKV, and DENV clinical isolates infected PBMCs with different levels of virus infectivity. The gene expression of IL-10 was highly upregulated in ZIKV infection and IP-10 in DENV infection. Creator An entity primarily responsible for making the resource Ahmad Husein Alkaff, Benediktus Yohan, Usman Sumo Friend Tambunan, R. Tedjo Sasmono Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 chemokines chikungunya virus cytokines dengue virus Jurnal Internasional mononuclear leukocytes Zika virus https://repository.horizon.ac.id/files/original/3e4cac2253e2d6365b8c263234cb272c.pdf a34b8afbd971fb23f79dbf625d12a065 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Risk Factors for Asthma Exacerbation among Hajj Pilgrims: A Case Study from DKI Jakarta, Indonesia Subject The topic of the resource asthma, exacerbation, risk factors Description An account of the resource BACKGROUND Hajj pilgrims are prone to asthma exacerbation because of the high transmission rate of respiratory infections, severe environmental factors, and high�intensity activities during the Hajj. Well-controlled asthma status and preventive efforts prior to the Hajj could reduce such exacerbations. This research aimed to determine the risk factors of asthma exacerbation during the Hajj to help establish preventive measures. METHODS Participants were evaluated at community health centers (puskesmas) through history taking, physical examination, and spirometry. The risk factors examined included a history of exacerbation one year before the Hajj, obesity, comorbidities (e.g., diabetes mellitus, hypertension, coronary heart disease), lung function, smoking, fitness level, and influenza vaccination. Asthma exacerbation while in Saudi Arabia was determined through direct observations by authors and physicians assigned to Hajj pilgrim groups and analysis of data obtained from questionnaires distributed to the pilgrims before their departure. Odds ratios (OR) were calculated using logistic regression. RESULTS Among 68 pilgrims with asthma, exacerbation occurred in 27 (40%) pilgrims. Risk of asthma exacerbation was significantly increased in the pilgrims with a history of exacerbation one year before the Hajj (OR = 4.27; 95% confidence interval [CI] = 1.156–15.829; p = 0.029) and obesity grade II (OR = 4.02; 95% CI = 1.151–14.097; p = 0.029). Other factors, including smoking, comorbidities, lung function, fitness level, obesity grade I, and influenza vaccination, were not significantly related to exacerbation. CONCLUSIONS Obesity grade II and history of asthma exacerbation one year before the Hajj are strong factors for asthma exacerbation during Hajj pilgrims. Creator An entity primarily responsible for making the resource Anshari Saifuddin, Ujainah Zaini Nasir, Iris Rengganis, Hamzah Shatri Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 asthma exacerbation Jurnal Internasional risk factors https://repository.horizon.ac.id/files/original/4384501ef93e5ce719db2c74cd37309f.pdf db49f098939e5bdab47ce4d02b0536ba Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Hajj Health Management in Indonesia (Commentary) Subject The topic of the resource Hajj Health Management, Indonesia Description An account of the resource The Hajj, one of the five pillars of Islam, is a “once in a lifetime” mandatory worship for all Muslims. However, only those who meet certain conditions, collectively called “conditions of obligation,” are obliged to perform the Hajj. These conditions are Islam religion, baligh or maturity, freedom, and istithaah or capability. Creator An entity primarily responsible for making the resource Eka Jusup Singka, Innes Ericca Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Hajj Health Management Indonesia Jurnal Internasional https://repository.horizon.ac.id/files/original/fa2c17b75a92ff58f7f4e14e966f0630.pdf 8720b9775b6b0c7f1d8fb793de5d2816 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Cybersex Addiction: An Overview of The Development and Treatment of A Newly Emerging Disorder Subject The topic of the resource addictive behavior, internet, pornography, sexual online Description An account of the resource Cybersex addiction is a non-substance related addiction that involves online sexual activity on the internet. Nowadays, various kinds of things related to sex or pornography are easily accessible through internet media. In Indonesia, sexuality is usually assumed taboo but most young people have been exposed to pornography. It can lead to an addiction with many negative effects on users, such as relationships, money, and psychiatric problems like major depression and anxiety disorders. A few instruments may be used to detect cybersex behavior. This review was aimed to provide a comprehensive discussion about cybersex addiction in Indonesian society and the importance of its screening for this condition to enable its early detection and subsequent management. Creator An entity primarily responsible for making the resource I Gusti Ngurah Agastya, Kristiana Siste, Martina Wiwie Setiawan Nasrun, Irmia Kusumadewi Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 addictive behavior internet Jurnal Internasional pornography sexual online https://repository.horizon.ac.id/files/original/299971e73aa1ca69cf6cfdd4e3470d63.pdf 571a577ae6008169e021ce1acba75651 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 The Implementation of Health Istithaah to The Pilgrims with Tuberculosis: A cross-Sectional Study in Jakarta, Indonesia Subject The topic of the resource eligibility, pilgrims, tuberculosis Description An account of the resource BACKGROUND Based on the regulation of the Indonesian Ministry of Health No. 15 of 2016 about health istithaah for the Hajj, patients with tuberculosis (TB) can be categorized into ineligible or temporarily ineligible pilgrims. This study aimed to know the characteristics of pilgrims with TB and determined their level of fitness for fulfilling the health istithaah. METHODS A cross-sectional study of pilgrims from Jakarta who were receiving TB treatment during the Hajj in 2018 was conducted with consecutive sampling. The secondary data was collected from the Hajj Integrated Computer Health System 2018, TB registered form, and six-minute walk test (the fitness level data) conducted by the District Hajj Health Team at district health centers in DKI Jakarta and Pondok Gede before the Hajj embarkation in June–July 2018. The questionnaire to the Indonesian Hajj Health Team during pilgrimage was also included as additional data. RESULTS Thirty-one pilgrims received TB treatment and completed the intensive phase of TB treatment, but 29 pilgrims had no symptoms. Among them, 2 patients had MDR-TB. Most of them were male aged ≥40 years old. Twelve pilgrims with TB have a sufficient fitness. All pilgrims were able to run the pillars of the Hajj. CONCLUSIONS Pilgrims with TB, including MDR-TB, who had completed the intensive phase with a negative sputum smear test were declared eligible for the Hajj with assistance. Creator An entity primarily responsible for making the resource Ibnu Mas’ud, Ujainah Zaini Nasir, Ceva Wicaksono Pitoyo, Ikhwan Rinaldi Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 eligibility Jurnal Internasioanal pilgrims tuberculosis https://repository.horizon.ac.id/files/original/8edcc306470e580492ea74c2b6f35fa1.pdf 57f3973e8b7ea24cd32bf6403b252490 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 A Case Series of Eight Scoliosis Patients undergone Pedicle Screw Placement with Freehand Technique: Study for Safety and Accuracy Subject The topic of the resource pedicle screws, scoliosis Description An account of the resource BACKGROUND Pedicle screws and rods are routinely inserted in the vertebrae thoracic to lumbar in scoliosis reconstruction surgery to gain deformity correction and fusion. Intraoperative imaging is often needed to ensure accuracy, but surgical time will be longer and there will be more radiation exposure. Meanwhile, freehand technique is accepted as safe. This study was aimed to evaluate the accuracy of screw insertion in the freehand technique used in adolescent scoliosis surgery. METHODS This case series evaluated a total of 127 pedicle screws inserted using the freehand technique in 8 out of 28 adolescent scoliosis patients from 2011 to 2016 whom agreed for computed tomography (CT) scan follow-up from 2011 to 2016 in Dr. Seotomo Hospital, Surabaya. The accuracy and safety of the freehand technique were evaluated postoperatively in each patient using a CT scan. A successful screw was considered accurate if it was within the vertebral body and inside the safety zone (within the limit of 2–4 mm to the medial or lateral side of the vertebral body. RESULTS Of the 127 screws inserted, 106 (83.5%) were accurately placed, and 110 (86.6%) were within the safe zone. According to the level of the spine, in the upper and middle thoracic spine, the inserted screws were accurate in 69.4% and 74.9% within the safety zone, whereas in the lower thoracic and lumbar spine, 94.0% and 95.0% within the safety zone. CONCLUSIONS The freehand technique in scoliosis reconstructive surgery performed by experienced surgeons is accurate and safe. Creator An entity primarily responsible for making the resource Komang Agung Irianto, Marquee Kenny Tumbelaka Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Jurnal Internasional pedicle screws scoliosis https://repository.horizon.ac.id/files/original/884ed44859eb8474cb7aafcbb1051615.pdf 3cdd85cddfd0780340f437a4e815ab59 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Cytotoxic Effect of Natural Cuttlefish Bone Xenograft: An in Vitro and in Vivo Study Subject The topic of the resource bone substitute, cuttlefish bone, cytotoxicity tests, xenograft Description An account of the resource BACKGROUND Commercialized synthetic bone grafts are commonly used to replace the bone defect. Cuttlefish bone is naturally available and widely studied, but the specific cytotoxicity test has not been conducted. This study aimed to evaluate the cytotoxicity of the xenograft compared to commercial grafts. METHODS We performed an in vitro test evaluating the viability of human mesenchymal stem cells (hMSCs) when cultured for 48 hours with the tested materials (cuttlefish bone graft and fabricated PerOssal®). The trypsinized itochondrial activity of the viable hMSC was assayed based on colorimetry of the formazan color change. The tested material was considered nontoxic if >70% of the hMSCs were viable. The in vivo cytotoxic effect was evaluated by implanting the graft material in the femoral muscle of New Zealand (NZ) white rabbits. Nine rabbits were used in each test (cuttlefish bone, PerOssal®, and NaCl 0.9%). The systemic acute pyrogenic effect was evaluated based on 72 hours body weight changes and rectal temperature changes every 30 min in the first 3 hours and 72 hours post-implantation. RESULTS The mean percentage of hMSC viability when cultured with cuttlefish bone graft and PerOssal® was comparable (93.47% and 105.37%, respectively, p = 0.240). The in vivo cytotoxicity on NZ rabbit was similar between all tested materials, as shown by the minor changes in body weight (<10% body weight, p = 0.391) and rectal temperature (<0.5°C, p = 0.127). CONCLUSIONS Cuttlefish bone xenograft and fabricated PerOssal® have a similar non�cytotoxic effects on hMSCs and non-pyrogenic systemic effects on rabbits. Creator An entity primarily responsible for making the resource Komang Agung Irianto, Suyenci Limbong Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 bone substitute cuttlefish bone cytotoxicity tests Jurnal Internasional xenograft https://repository.horizon.ac.id/files/original/860a5e9b48d8a8613ca3713f9ecb3310.pdf 7455ba60d70e2034ef7a1c2775154709 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 Factors Associated with Outcome of Acute Encephalitis in Children: A Retrospective Study of Three Referral Hospitals Subject The topic of the resource child, encephalitis, risk factors, seizures Description An account of the resource BACKGROUND Encephalitis is more frequent in children and has a poor outcome. There was no data on encephalitis in children in Indonesia, so this study was aimed to evaluate clinical presentation and diagnostic examination of children with acute encephalitis, and factors related to outcome. METHODS This was a retrospective study of medical records between 2014 and 2018 in three referral hospitals in Jakarta and Tangerang. Clinical presentation at admission, cerebrospinal fluid analysis, neuroimaging, and lectroencephalography (EEG) were documented. Outcome was determined at hospital discharge and classified as poor for severe neurological abnormalities at discharge or died. Logistic regression was used to evaluate associated factors with the outcome. RESULTS A total of 190 children were included and most were age >1 year (71%). Most subjects presented with fever (90%) and seizures (87%). Of those who had seizures, 80% experienced generalized seizures. Focal neurological deficit was seen in 90 patients (47%). EEG was positive in 90% subjects (n = 27/30). Probable cases were found in 51% of all subjects. The mortality was 23%. Focal seizures (odds ratio [OR] = 3.305, 95% confidence interval [CI] = 1.122–9.742) and age >1 year (OR = 3.076, 95% CI = 1.388–6.803) were risk factors for a poor outcome. CONCLUSIONS Acute encephalitis occurred most often in children aged >1 year. Fever and seizures were the most common symptoms. EEG was better than other examinations for confirming diagnosis of encephalitis. Focal seizures and age >1 year were associated with a three-fold increased risk for a poor outcome. Creator An entity primarily responsible for making the resource Lucyana Alim Santoso, Dwi Putro Widodo, Zakiudin Munasir Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 child encephalitis Jurnal Internasional risk factors seizures https://repository.horizon.ac.id/files/original/502070cb1ab3cb24ec49582e4ed5881d.pdf d85eb26f97605b3d16b0fe2334a38965 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 MLH1 and MSH2 Mismatch Repair Protein Profile using Immunohistochemistry in Nepalese Colorectal Cancer Patients Subject The topic of the resource colorectal cancer, immunohistochemistry, mismatch repair, MutL homolog 1, MutS homolog 2 Description An account of the resource BACKGROUND Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, caused by germline mutations or genetic defects in mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6, and epithelial cellular adhesion molecule), is an autosomal dominant condition accounting for 2–5% of all colorectal carcinomas (CRCs). Reports on MMR loss in many populations are available; however, there are no reports on the frequency of MMR protein expression in Nepalese cohorts. Therefore, this study was aimed to assess the expression profiles of MLH1 and MSH2 protein by immunohistochemistry (IHC) in Nepalese CRC patients. METHODS This retrospective study used archived formalin-fixed paraffin-embedded tissue blocks from 43 Nepalese CRC patients. IHC staining was performed using MLH1 and MSH2 antibodies. IHC scoring analysis was assessed using semiquantitative scoring. RESULTS Of the 43 CRC patients, 8 (18.6%) showed loss of staining for MLH1 antibody, 5 (11.6%) showed loss of staining for MSH2 antibody, and 4 (9.3%) showed loss of staining for both MLH1 and MSH2 antibodies. CONCLUSIONS IHC is a potential screening method of determining the MMR expression profile of Nepalese CRC patients. IHC can be performed in local clinical laboratories to find MMR protein defects in selected cases prior to expensive molecular tests. Creator An entity primarily responsible for making the resource Matrika Bhattarai, Wan Khairunnisa Wan Juhari, Raju Lama, Chin Bahadur Pun, Wardah Yusof, Wan Faiziah Wan Abdul Rahman, Andee Dzulkarnaen Zakaria, Khairul Bariah Ahmad Amin Noordin, Tilak R. Shrestha, Bin Alwi Zilfalil Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2020-07-02 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020 colorectal cancer immunohistochemistry Jurnal Internasional mismatch repair MutL homolog 1 MutS homolog 2