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                  <text>Medical Journal of Indonesia Vol. 29 No. 2 2020 FKUI</text>
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                <text>Cover Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
A Case Series of Eight Scoliosis Patients undergone Pedicle Screw Placement with Freehand Technique: Study for Safety and Accuracy </text>
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                <text>BACKGROUND Pedicle screws and rods are routinely inserted in the vertebrae thoracic to lumbar in scoliosis reconstruction surgery to gain deformity correction and fusion. Intraoperative imaging is often needed to ensure accuracy, but surgical time will be longer and there will be more radiation exposure. Meanwhile, freehand technique is accepted as safe. This study was aimed to evaluate the accuracy of screw insertion in the freehand technique used in adolescent scoliosis surgery. &#13;
METHODS This case series evaluated a total of 127 pedicle screws inserted using the freehand technique in 8 out of 28 adolescent scoliosis patients from 2011 to 2016 whom agreed for computed tomography (CT) scan follow-up from 2011 to 2016 in Dr. Seotomo Hospital, Surabaya. The accuracy and safety of the freehand technique were evaluated postoperatively in each patient using a CT scan. A successful screw was considered accurate if it was within the vertebral body and inside the safety zone (within the limit of 2–4 mm to the medial or lateral side of the vertebral body. &#13;
RESULTS Of the 127 screws inserted, 106 (83.5%) were accurately placed, and 110 (86.6%) were within the safe zone. According to the level of the spine, in the upper and middle thoracic spine, the inserted screws were accurate in 69.4% and 74.9% within the safety zone, whereas in the lower thoracic and lumbar spine, 94.0% and 95.0% within the safety zone.&#13;
CONCLUSIONS The freehand technique in scoliosis reconstructive surgery performed by experienced surgeons is accurate and safe.</text>
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                <text>Komang Agung Irianto, Marquee Kenny Tumbelaka</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Causes of Mortality in A Neonatal Intensive Care Unit in Iran: One Year Data</text>
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                <text>BACKGROUND Neonatal mortality rate is a major health index. Approximately, 65% of all deaths in the first year of life occur during this 4-week period. The present study was conducted to investigate the mortality rates and causes of death in a neonatal intensive care unit (NICU) in Ahvaz, Iran in a year.&#13;
METHODS This cross-sectional study was conducted in the NICU of Sina Hospital in Ahvaz. Medical records were studied, and data from 1,040 newborns admitted to the NICU within one year (March 2016 to March 2017) were collected following a checklist. Relevant data of 123 died newborns were collected. Data were analyzed using SPSS, version 20 (SPSS Inc., USA).&#13;
RESULTS The mortality rate was 11.82% (123 cases) out of 1,040 newborns admitted to NICU. Most of the newborns (48.8%) died on days 1–7. The causes of death were respiratory distress syndrome (RDS) (34.1%), asphyxia (25.2%), anomalies (10.6%), sepsis (7.3%), intracerebral hemorrhage (8.1%), pulmonary hemorrhage (7.3%), and other causes (6.4%), such as hydrops, severe pneumothorax, severe renal failure, and others.&#13;
CONCLUSIONS The mortality rate in the NICU of this center was similar to that in other Iranian provinces. The most common causes of NICU mortality included prematurity and its complications, such as asphyxia and RDS. Thus, a strategic plan for reducing preterm delivery and asphyxia are necessary.</text>
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                <text>Milad Azami, Shamim Jasemi, Yosef Khalifpur, Gholamreza Badfar</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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Cover, Editorial Board, Daftar Isi</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Cybersex Addiction: An Overview of The Development and Treatment of A Newly Emerging Disorder</text>
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                <text> addictive behavior, internet, pornography, sexual online</text>
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                <text>Cybersex addiction is a non-substance related addiction that involves online sexual activity on the internet. Nowadays, various kinds of things related to sex or pornography are easily accessible through internet media. In Indonesia, sexuality is usually assumed taboo but most young people have been exposed to pornography. It can lead to an addiction with many negative effects on users, such as relationships, money, and psychiatric problems like major depression and anxiety disorders. A few &#13;
instruments may be used to detect cybersex behavior. This review was aimed to provide a comprehensive discussion about cybersex addiction in Indonesian society and the importance of its screening for this condition to enable its early detection and subsequent management.</text>
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                <text>I Gusti Ngurah Agastya, Kristiana Siste, Martina Wiwie Setiawan Nasrun, Irmia Kusumadewi</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Cytotoxic Effect of Natural Cuttlefish Bone Xenograft: An in Vitro and in Vivo Study</text>
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                <text>BACKGROUND Commercialized synthetic bone grafts are commonly used to replace the bone defect. Cuttlefish bone is naturally available and widely studied, but the specific cytotoxicity test has not been conducted. This study aimed to evaluate the cytotoxicity of the xenograft compared to commercial grafts.&#13;
METHODS We performed an in vitro test evaluating the viability of human mesenchymal stem cells (hMSCs) when cultured for 48 hours with the tested materials (cuttlefish bone graft and fabricated PerOssal®). The trypsinized itochondrial activity of the viable hMSC was assayed based on colorimetry of the formazan color change. The &#13;
tested material was considered nontoxic if &gt;70% of the hMSCs were viable. The in vivo cytotoxic effect was evaluated by implanting the graft material in the femoral muscle of New Zealand (NZ) white rabbits. Nine rabbits were used in each test (cuttlefish bone, PerOssal®, and NaCl 0.9%). The systemic acute pyrogenic effect was evaluated &#13;
based on 72 hours body weight changes and rectal temperature changes every 30 min in the first 3 hours and 72 hours post-implantation.&#13;
RESULTS The mean percentage of hMSC viability when cultured with cuttlefish bone graft and PerOssal® was comparable (93.47% and 105.37%, respectively, p = 0.240). The in vivo cytotoxicity on NZ rabbit was similar between all tested materials, as shown by the minor changes in body weight (&lt;10% body weight, p = 0.391) and rectal temperature (&lt;0.5°C, p = 0.127).&#13;
CONCLUSIONS Cuttlefish bone xenograft and fabricated PerOssal® have a similar non�cytotoxic effects on hMSCs and non-pyrogenic systemic effects on rabbits.</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Erratum: The Use of High-Resolution Melting Techniques for Mutation Screening of Diseases Caused by Trinucleotide Repeat Expansion, with Emphasis on The AR Gene (Corrections)</text>
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                <text>In the original version of this article, the phrase in the “Conclusions” section was incorrectly typed as “could not be” and should be “could be”. Thus the correct sentence is “This study revealed that CAG repeat expansion in the AR gene in DSD cases is scarce in the Indonesian population; nevertheless, the CAG repeat expansion could be identified in one SBMA case.” The article has now been revised and appeared correctly.</text>
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                <text>Achmad Zulfa Juniarto, Mahayu Dewi Ariani, Stefani Harumsari, Nurin Aisyiyah Listyasari, Hardian, Agustini Utari, Sultana Muhammad Hussein Faradz</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Factors Associated with Outcome of Acute Encephalitis in Children: A Retrospective Study of Three Referral Hospitals </text>
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                <text>BACKGROUND Encephalitis is more frequent in children and has a poor outcome. There was no data on encephalitis in children in Indonesia, so this study was aimed to evaluate clinical presentation and diagnostic examination of children with acute encephalitis, and factors related to outcome.&#13;
METHODS This was a retrospective study of medical records between 2014 and 2018 in three referral hospitals in Jakarta and Tangerang. Clinical presentation at admission, cerebrospinal fluid analysis, neuroimaging, and lectroencephalography (EEG) were documented. Outcome was determined at hospital discharge and classified as poor for severe neurological abnormalities at discharge or died. Logistic regression was used to evaluate associated factors with the outcome.&#13;
RESULTS A total of 190 children were included and most were age &gt;1 year (71%). Most subjects presented with fever (90%) and seizures (87%). Of those who had seizures, 80% experienced generalized seizures. Focal neurological deficit was seen in 90 patients (47%). EEG was positive in 90% subjects (n = 27/30). Probable cases were found in 51% of all subjects. The mortality was 23%. Focal seizures (odds ratio [OR] = 3.305, 95% confidence interval [CI] = 1.122–9.742) and age &gt;1 year (OR = 3.076, 95% CI = 1.388–6.803) were risk factors for a poor outcome.&#13;
CONCLUSIONS Acute encephalitis occurred most often in children aged &gt;1 year. Fever and seizures were the most common symptoms. EEG was better than other examinations for confirming diagnosis of encephalitis. Focal seizures and age &gt;1 year were associated with a three-fold increased risk for a poor outcome.</text>
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                <text>Lucyana Alim Santoso, Dwi Putro Widodo, Zakiudin Munasir</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020&#13;
Final Checklist &amp; Submission Form</text>
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Hajj Health Istithaah Amid The COVID-19 Pandemic (Commentary)</text>
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                <text>The Hajj, which refers to the annual Islamic &#13;
pilgrimage to Makkah, is a mandatory religious duty for Muslims as long as they are physically and financially capable and can continue to support their family during their absence. Another pilgrimage-related mass gathering event is Umrah. Muslims perform the Hajj during a specific season in the 12th month of the Hijrah calendar, that is, from the 9th until the 12th of Dhu al-Hijjah. By contrast, the Umrah can be performed at any time of the year. The Umrah is also considered a minor pilgrimage because it is similar to the Hajj in the sense that the necessary events take place in holy cities, such as Makkah or Mecca and Madinah, but do not include &#13;
the rituals performed in Arafah and Mina. Although the Umrah is not compulsory, it is highly recommended and considered an alternative before Hajj, which has a prolonged waiting period.</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020</text>
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