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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
IL-1, IL-6, TNF-α, and MIF in Relative Adrenal Insufficiency in Septic Shock: A Piglet Model</text>
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                <text>adrenal insufficiency, interleukin-1, interleukin-6, macrophage migration inhibition factors, septic shock, tumor necrosis factor-alpha</text>
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                <text>BACKGROUND Inflammatory mediators released during septic shock are involved in the mechanism of adrenal insufficiency. This study investigated the role of interleukin (IL)-6, IL-1, tumor necrosis factor (TNF)-α, and macrophage migration inhibitory factor (MIF) in septic shock with relative adrenal insufficiency (RAI).&#13;
METHODS We conducted a 6-month experimental study in 20 piglets. Following endotoxin administration, their hemodynamics were monitored and blood samples were drawn to test the levels of cytokines IL-1, IL-6, TNF-α, and MIF every 15 min until septic shock onset as well as during a corticotropin stimulation test. Septic shock was managed by administering fluid resuscitation, inotropic drugs, and hydrocortisone. At the end of the study, the piglet models were classified as either RAI or non-RAI. Immunohistochemistry staining was performed on the hypothalamus of the RAI group.&#13;
RESULTS The level of IL-6 at 45 min was higher in the RAI group than the non-RAI group (p = 0.008), and that of IL-1 was similar in the two groups during septic shock. The RAI group had higher TNF-α levels at 15 min (p = 0.002) and at 30 min (p = 0.007) than &#13;
the non-RAI group, and the MIF level during septic shock was higher in the RAI group (p = 0.003) than the non-RAI group. &#13;
CONCLUSIONS Cytokine-induced inflammatory process of adrenal gland reflected in TNF-α level in 15 min and 30 min, IL-6 in 45 min, and MIF in septic shock condition but not in IL-1.</text>
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              <elementText elementTextId="9114">
                <text>Bina Akura, Jose R. L. Batubara, Zakiudin Munasir, Gunanti, Joedo Prihartono, Hindra Irawan Satari, Suzanna Immanuel, Dadang Hudaya Somasetia</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>2020-10-05</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>ISSN : 0853-1773</text>
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                <text>English</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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        <name>adrenal insufficiency, interleukin-1</name>
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        <name>macrophage migration inhibition factors</name>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Dressing versus Non-Dressing Technique for Long-Term Exit-Site Care in Children on Continuous Ambulatory Peritoneal Dialysis: A Single-Center Retrospective Cohort Study </text>
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                <text>child, contact dermatitis, end-stage kidney disease, infection, peritonitis</text>
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                <text>BACKGROUND There is no consensus on the optimal long-term exit-site care strategy in children on long-term peritoneal dialysis (PD) worldwide. Thus, this study aimed to compared the dressing versus non-dressing technique for long-term exit-site care to prevent PD-related infection.&#13;
METHODS This retrospective cohort study involved patients aged &lt;18 years with end-stage kidney disease who were on continuous ambulatory PD at the Cipto Mangunkusumo Hospital between March 2014 and March 2019. Long-term exit-site &#13;
care was initiated within 3 months after the insertion of Tenckhoff catheter. The patients and caregivers can choose to either maintain the dressing method or change to the non-dressing method for the subsequent long-term exit-site care. The follow-up was performed until the following 6 months.&#13;
RESULTS Out of 34 patients, 18 were treated without dressing and 16 with dressing technique. The peritonitis rates were 0.17 and 0.06 episodes per year at risk in the non-dressing and dressing groups; the adjusted incidence rate ratio was 0.4 (95% confidence interval = 0.04–3.25; p = 0.4). Allergic contact dermatitis occurred in 15/18 (83%) patients in the non-dressing group and 11/16 (69%) in the dressing group before long-term exit-site care was applied. Ultimately, no patient in the non-dressing group developed allergic contact dermatitis, whereas 11 (69%) had allergic contact dermatitis in the dressing group at the end of follow-up.&#13;
CONCLUSIONS Non-dressing technique may increase the risk of peritonitis in children on long-term PD; however, it is beneficial for children vulnerable to allergic contact dermatitis.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="9198">
                <text>Cahyani Gita Ambarsari, Eka Laksmi Hidayati, Lily Mushahar, Agustina Kadaristiana</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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              <elementText elementTextId="9200">
                <text>2020-10-05</text>
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            <name>Contributor</name>
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              <elementText elementTextId="9201">
                <text>Sri Wahyuni</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9202">
                <text>ISSN : 0853-1773</text>
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                <text>English</text>
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              <elementText elementTextId="9206">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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        <name>contact dermatitis</name>
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        <name>end-stage kidney disease</name>
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        <name>infection</name>
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      <tag tagId="25">
        <name>Jurnal Internasional</name>
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        <name>peritonitis</name>
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                <elementText elementTextId="9073">
                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Comparison of Complications between Transcatheter and Surgical Ventricle Septal Defect Closure: A Single-Center Cohort Study</text>
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          <element elementId="49">
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                <text> complication, surgery, transcatheter, ventricular septal defect</text>
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                <text>BACKGROUND Some ventricular septal defects (VSDs) require an interventional procedure for closure. Transcatheter and surgical closures of VSD have similar effectiveness, but transcatheter VSD closure is considered associated with less complication than surgical closure. This study aimed to compare mid-term or long-term complications of transcatheter and surgical VSD closures.&#13;
METHODS This was a retrospective cohort study compared the complication rates of transcatheter and surgical VSD closures performed in Cipto Mangunkusumo Hospital from January 1, 2010, to April 30, 2017, with 34 subjects in each group. The inclusion criteria were as follows: single lesion outlet perimembranous or doubly committed subarterial VSD, age 2–18 years, body weight &gt;8 kg, and no arrhythmia. &#13;
Electrocardiography and echocardiography were done to collect primary data. Other data were collected from medical records. Mid-term complications occurred 1–24 months after interventional closure. Long-term complications occurred 24 months after interventional closure. Complications were arrhythmia, valve regurgitation, and residual shunt. Data were analyzed by chi-square test.&#13;
RESULTS The rate of worsening valve regurgitation was higher in the transcatheter group than in the surgical group (16 versus 11, p = 0.322). The number of patients with residual shunts were similar between the transcatheter group and surgical group (5 versus 5; p = 1.000). Both complications were found in mid- and long-term. Arrhythmia as a long-term complication occurred in five and seven patients in the ranscatheter &#13;
and surgical groups, respectively (p = 0.752).&#13;
CONCLUSIONS Transcatheter and surgical VSD closures have similar mid- or long-term complications. </text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="9162">
                <text>Deny Salverra Yosy, Mulyadi Muhammad Djer, Sukman Tulus Putra</text>
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              <elementText elementTextId="9163">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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        <name>complication</name>
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        <name>surgery</name>
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        <name>ventricular septal defect</name>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients </text>
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                <text> liquid meal replacement nutrition, low glycemic index, type 2 diabetes mellitus</text>
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                <text>BACKGROUND Liquid meal replacement nutrition (LMRN) contains low glycemic index food (isomaltulose, resistant dextrin, and inulin), which can decrease large blood glucose level fluctuations and reduce food intake. This study aimed to determine the stability of daily blood glucose and the level of appetite sensations after intake of &#13;
LMRN in type 2 diabetes mellitus (DM) patients.&#13;
METHODS This randomized, controlled, crossover, and open-labeled study included 30 subjects with type 2 DM. Subjects attended two visit sessions to consume either LMRN or controlled-nutrition solid food (CNSF) for 4 consecutive days. Each subject &#13;
had 2 days of 24-hour periods of blood glucose measurement using a continuous glucose monitoring system and had a 1-week washout period. Glycemic response (GR) and incremental area under the curve (iAUC) were calculated. The satiety level was measured using a visual analog scale.&#13;
RESULTS After 48 hours, LMRN reduced GR compared with CNSF with glucose measurements of 13.72 (30.42) and 17.47 (36.38) mg/dl, respectively. The reduction on iAUC after consuming LMRN (36,891 [30,255.8] mg.min/dl) compared with CNSF (40,641 [38,798.9] mg.min/dl) was also noted. Subjects having LMRN felt less hungry and more satiated than those consuming CNSF. The administration of LMRN does not &#13;
have any serious side effects.&#13;
CONCLUSIONS LMRN provides a greater reduction of GR and longer term of satiety compared with CNSF without causing any serious side effects.</text>
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                <text>Fatimah Eliana, Budi Agung Pranoto</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
The Scientist Challenge from COVID-19 (Editorial)</text>
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                <text>In this era of the coronavirus diseases 2019 (COVID-19) pandemic, the existence of scientific &#13;
evidence that may support not only clinical but also &#13;
regulatory decisions become more prominent. The &#13;
rapid flow of scientific evidence that emerges since &#13;
the pandemic, has made us question whether in an &#13;
emergency situation like this, we might have sacrificed some steps of scientific methods.</text>
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                <text>Grace Wangge</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Sentinel Lymph Node Biopsy for Breast Cancer using Methylene Blue: A New Anatomical Landmark Involving Intercostobrachial and Medial Pectoral Nodes </text>
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                <text>breast neoplasm, intercostobrachial, methylene blue, sentinel lymph node biopsy</text>
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                <text>BACKGROUND Sentinel lymph node biopsy (SLNB) using blue dye is becoming popular in Indonesia given that knowledge on new anatomical landmarks involving intercostobrachial and medial pectoral nodes have replaced the need for radioisotope &#13;
tracers. This study aimed to evaluate the utility of the proposed landmark involving intercostobrachial and medial pectoral nodes to determine axillary lymph node status during SLNB.&#13;
METHODS A prospective study was conducted involving 55 patients with early-stage breast cancer who had clinically negative lymph nodes (T1–T2, cN0) between 2018 and 2019 at Cipto Mangunkusumo Hospital. During SLNB, methylene blue 1% was injected at the subareolar area to identify intercostobrachial and medial pectoral nodes followed by axillary lymph node dissection (ALND). Histopathological results of sentinel nodes &#13;
(SNs) were then compared to those of other axillary nodes.&#13;
RESULTS SNs were identified in 54 patients (98%), 33 (61%) of whom had both intercostobrachial and medial pectoral SNs. Among patients with SNs, there were 1 patient without intercostobrachial SNs, 10 patients without medial pectoral SNs, and &#13;
1 patient with medial pectoral SNs but no intercostobrachial SNs. Accordingly, SNs had a negative predictive value (NPV) of 96.77% for axillary metastasis (95% confidence interval = 81.54–99.51), with a false negative rate of 4.7%. No serious adverse events was observed.&#13;
CONCLUSIONS The high identification rate and NPV, as well as the low false negative rate of the new anatomical landmark involving ntercostobrachial and medial pectoral nodes during SLNB, suggest its reliability in determining axillary lymph node status.</text>
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                <text>I Gusti Ngurah Gunawan Wibisana, Muliyadi</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Antiviral Treatment of COVID-19: A Clinical Pharmacology Narrative Review </text>
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                <text>The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China,  has become a pandemic in March 2020. Repurposing old and relatively safe drugs becomes an advantageous option to obtain the urgently needed effective treatment. Repurposing chloroquine, hydroxychloroquine, oseltamivir, lopinavir/ritonavir, and favipiravir, and the use of investigational drug remdesivir for treatment of COVID-19, &#13;
are reviewed from the clinical pharmacology perspective, particularly its efficacy and safety. Limited clinical studies of chloroquine, hydroxychloroquine, favipiravir, and remdesivir showed some efficacy in COVID-19 treatment with tolerable adverse effects. Potential serious adverse effect of chloroquine and hydroxychloroquine is &#13;
cardiac arrhythmia. Oseltamivir has no documented activity against SARS-CoV-2, while opinavir/ritonavir showed limited efficacy in COVID-19. Currently, there is no sufficient evidence to recommend any specific anti-COVID-19 treatment. The decision to use these drugs during the COVID-19 pandemic must be based on careful consideration of the potential benefits and risks to the patient.</text>
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                <text>Instiaty, I Gusti Agung Ayu Putu Sri Darmayani, Jefman Efendi Marzuki, Ferina Angelia, William, Angelina Siane, Lela Dwi Sary, Lina Yohanes, Reni Widyastuti, Riki Nova, Dewi Sharon Simorangkir, Lonah, Yolanda Safitri, Gestina Aliska, Anggi Gayatri&#13;
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Nine-Segment Laminectomy is Safe for The Resection of A Schwannoma Extending from C-2 to T-3: A Rare Case Report</text>
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                <text> kyphosis, laminectomy, schwannoma</text>
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                <text>Cervical spine schwannoma, which is long and entirely intracanal, is rare to be found. Its rarity and atypical feature leads to difficulty in diagnosing and managing cases because of the scarcity of available literature. The surgical removal of this type of &#13;
schwannomas via multisegment laminectomy is a great challenge because of various risks of postoperative complications. This report describes cervical spine schwannoma that was initially was not suspected as schwannoma and was subject to surgical removal via nine-segment laminectomy. In one year after surgery, motor function returned to normal strength, no new neurological deficits occurred, and no kyphotic deformity, which is a common complication of multisegment laminectomy.</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Short-Term Follow-up after Percutaneous Patent Ductus Arteriosus Occlusion between Low and High Weight Pediatric Patients: A Single Center Experience</text>
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                <text>catheterization, patent ductus arteriosus, treatment outcome</text>
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                <text>BACKGROUND Device occlusion is a preferred treatment for patent ductus arteriosus (PDA) in adult and children patients; however, the exact limit of body weight requirement has not been established. This study aimed to describe the outcome and safety of transcatheter PDA occlusion in low and high weight pediatric patients.&#13;
METHODS This was a retrospective study in Sanglah Hospital, Denpasar, Bali, Indonesia, in patients aged &lt;12 years who had undergone transcatheter PDA occlusions from 2010 to 2017. Data were obtained from the registry including baseline characteristics (age, sex, body weight, and height), procedural-specific data (PDA characteristics, pulmonary and systemic pressures, and flow ratio intra-procedure), and procedural &#13;
complications. Success rate and adverse events at 24 hours, 1 month, and 3 months after the procedure were assessed.&#13;
RESULTS A total of 175 subjects were grouped into two categories: low weight, ≤6 kg (n = 50) and high weight, &gt;6 kg (n = 125). The success rates (complete closure) in the ≤6 and &gt;6 kg groups were, 90.0% and 75.9% at 24 hours follow-up, 92.9% and 85.5% at 1 month, and 95.8% and 91.1% at 3 months, respectively. Major complications related to the procedure in patients ≤6 kg included transient dysrhythmia (n = 6) and massive bleeding (n = 2), and complications in patients &gt;6 kg were transient dysrhythmia (n = 14), massive bleeding (n = 1), embolization (n = 1), and death (n = 1).&#13;
CONCLUSIONS Transcatheter PDA occlusion had similar success rate and safety in both low and high weight pediatric patients.</text>
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                <text>Ni Putu Eka Suwitri, Ni Putu Veny Kartika Yantie, Eka Gunawijaya</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Retraction: Periodic Acid-Schiff and Alcian Blue Immunohistochemistry to Detect Mucin in Mucinous Breast Carcinoma</text>
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                <text>We, the authors, are regretfully retracting our article,¹ “Periodic acid-Schiff and alcian blue immunohistochemistry to detect mucin in mucinous &#13;
breast carcinoma” which was previously published in the Medical Journal of Indonesia because of errors in the data input and some terms errors. Due to this error, the conclusions and interpretations are incorrect and may mislead the readers.</text>
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                <text>Primariadewi Rustamadji, Jason Wibowo, Belinda &#13;
Murtani, Christy Magdalena</text>
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                <text>ISSN : 0853-1773</text>
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