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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients </text>
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                <text> liquid meal replacement nutrition, low glycemic index, type 2 diabetes mellitus</text>
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                <text>BACKGROUND Liquid meal replacement nutrition (LMRN) contains low glycemic index food (isomaltulose, resistant dextrin, and inulin), which can decrease large blood glucose level fluctuations and reduce food intake. This study aimed to determine the stability of daily blood glucose and the level of appetite sensations after intake of &#13;
LMRN in type 2 diabetes mellitus (DM) patients.&#13;
METHODS This randomized, controlled, crossover, and open-labeled study included 30 subjects with type 2 DM. Subjects attended two visit sessions to consume either LMRN or controlled-nutrition solid food (CNSF) for 4 consecutive days. Each subject &#13;
had 2 days of 24-hour periods of blood glucose measurement using a continuous glucose monitoring system and had a 1-week washout period. Glycemic response (GR) and incremental area under the curve (iAUC) were calculated. The satiety level was measured using a visual analog scale.&#13;
RESULTS After 48 hours, LMRN reduced GR compared with CNSF with glucose measurements of 13.72 (30.42) and 17.47 (36.38) mg/dl, respectively. The reduction on iAUC after consuming LMRN (36,891 [30,255.8] mg.min/dl) compared with CNSF (40,641 [38,798.9] mg.min/dl) was also noted. Subjects having LMRN felt less hungry and more satiated than those consuming CNSF. The administration of LMRN does not &#13;
have any serious side effects.&#13;
CONCLUSIONS LMRN provides a greater reduction of GR and longer term of satiety compared with CNSF without causing any serious side effects.</text>
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                <text>Fatimah Eliana, Budi Agung Pranoto</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Antiviral Treatment of COVID-19: A Clinical Pharmacology Narrative Review </text>
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                <text>COVID-19, favipiravir, hydroxychloroquine, lopinavir, oseltamivir, remdesivir</text>
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                <text>The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China,  has become a pandemic in March 2020. Repurposing old and relatively safe drugs becomes an advantageous option to obtain the urgently needed effective treatment. Repurposing chloroquine, hydroxychloroquine, oseltamivir, lopinavir/ritonavir, and favipiravir, and the use of investigational drug remdesivir for treatment of COVID-19, &#13;
are reviewed from the clinical pharmacology perspective, particularly its efficacy and safety. Limited clinical studies of chloroquine, hydroxychloroquine, favipiravir, and remdesivir showed some efficacy in COVID-19 treatment with tolerable adverse effects. Potential serious adverse effect of chloroquine and hydroxychloroquine is &#13;
cardiac arrhythmia. Oseltamivir has no documented activity against SARS-CoV-2, while opinavir/ritonavir showed limited efficacy in COVID-19. Currently, there is no sufficient evidence to recommend any specific anti-COVID-19 treatment. The decision to use these drugs during the COVID-19 pandemic must be based on careful consideration of the potential benefits and risks to the patient.</text>
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                <text>Instiaty, I Gusti Agung Ayu Putu Sri Darmayani, Jefman Efendi Marzuki, Ferina Angelia, William, Angelina Siane, Lela Dwi Sary, Lina Yohanes, Reni Widyastuti, Riki Nova, Dewi Sharon Simorangkir, Lonah, Yolanda Safitri, Gestina Aliska, Anggi Gayatri&#13;
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Bacterial Susceptibility Patterns to Cotrimoxazole in Urinary Tract Infections of Outpatients and Inpatients in Jakarta, Indonesia </text>
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                <text> cotrimoxazole, inpatients, outpatients, urinary tract infections</text>
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                <text>BACKGROUND Cotrimoxazole, which has been one of the drugs of choice for urinary tract infections (UTIs) since 1960, must be evaluated to determine whether it is still a relevant drug for this use. This study aimed to assess the susceptibility patterns to &#13;
cotrimoxazole of the bacteria that cause UTIs from urine samples of female outpatients (community-acquired [CA]-UTI) and inpatients (hospital-acquired [HA]-UTI) in Jakarta.&#13;
METHODS This study was conducted from December 2014 to December 2015. Susceptibility testing of bacteria causing UTIs was conducted on 27 of 311 female outpatient urine samples collected from six clinics in Jakarta, and secondary data &#13;
susceptibility testing was performed on 27 of 107 urine samples of inpatients from hospitals in Jakarta. These samples were examined in the Clinical Microbiology Laboratory, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital.&#13;
RESULTS Susceptibility to cotrimoxazole was reported in 83% of the bacteria causing UTIs in CA-UTI and 44% of the bacteria in HA-UTI patients. Klebsiella pneumoniae was the most common cause of CA-UTI, with all isolates susceptible to cotrimoxazole (100%). Conversely, Escherichia coli was the most common cause of HA-UTI but was only susceptible in some isolates (44%). Bacteria from CA-UTI patients were almost twice as &#13;
susceptible to cotrimoxazole compared with HA-UTI patients (p = 0.003).&#13;
CONCLUSIONS Based on the susceptibility patterns identified, cotrimoxazole can be &#13;
used as a treatment for CA-UTI but not for HA-UTI patients in Jakarta, Indonesia.</text>
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                <text>Yeva Rosana, Dwiana Ocviyanti, Wafridha Akbar</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Comparison of Complications between Transcatheter and Surgical Ventricle Septal Defect Closure: A Single-Center Cohort Study</text>
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                <text> complication, surgery, transcatheter, ventricular septal defect</text>
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                <text>BACKGROUND Some ventricular septal defects (VSDs) require an interventional procedure for closure. Transcatheter and surgical closures of VSD have similar effectiveness, but transcatheter VSD closure is considered associated with less complication than surgical closure. This study aimed to compare mid-term or long-term complications of transcatheter and surgical VSD closures.&#13;
METHODS This was a retrospective cohort study compared the complication rates of transcatheter and surgical VSD closures performed in Cipto Mangunkusumo Hospital from January 1, 2010, to April 30, 2017, with 34 subjects in each group. The inclusion criteria were as follows: single lesion outlet perimembranous or doubly committed subarterial VSD, age 2–18 years, body weight &gt;8 kg, and no arrhythmia. &#13;
Electrocardiography and echocardiography were done to collect primary data. Other data were collected from medical records. Mid-term complications occurred 1–24 months after interventional closure. Long-term complications occurred 24 months after interventional closure. Complications were arrhythmia, valve regurgitation, and residual shunt. Data were analyzed by chi-square test.&#13;
RESULTS The rate of worsening valve regurgitation was higher in the transcatheter group than in the surgical group (16 versus 11, p = 0.322). The number of patients with residual shunts were similar between the transcatheter group and surgical group (5 versus 5; p = 1.000). Both complications were found in mid- and long-term. Arrhythmia as a long-term complication occurred in five and seven patients in the ranscatheter &#13;
and surgical groups, respectively (p = 0.752).&#13;
CONCLUSIONS Transcatheter and surgical VSD closures have similar mid- or long-term complications. </text>
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                <text>Deny Salverra Yosy, Mulyadi Muhammad Djer, Sukman Tulus Putra</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Cover, Editorial Board, Contents, Instructions for Authors, Final Checklist &amp;Submission Form</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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            <description>A name given to the resource</description>
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              <elementText elementTextId="9195">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Dressing versus Non-Dressing Technique for Long-Term Exit-Site Care in Children on Continuous Ambulatory Peritoneal Dialysis: A Single-Center Retrospective Cohort Study </text>
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                <text>child, contact dermatitis, end-stage kidney disease, infection, peritonitis</text>
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                <text>BACKGROUND There is no consensus on the optimal long-term exit-site care strategy in children on long-term peritoneal dialysis (PD) worldwide. Thus, this study aimed to compared the dressing versus non-dressing technique for long-term exit-site care to prevent PD-related infection.&#13;
METHODS This retrospective cohort study involved patients aged &lt;18 years with end-stage kidney disease who were on continuous ambulatory PD at the Cipto Mangunkusumo Hospital between March 2014 and March 2019. Long-term exit-site &#13;
care was initiated within 3 months after the insertion of Tenckhoff catheter. The patients and caregivers can choose to either maintain the dressing method or change to the non-dressing method for the subsequent long-term exit-site care. The follow-up was performed until the following 6 months.&#13;
RESULTS Out of 34 patients, 18 were treated without dressing and 16 with dressing technique. The peritonitis rates were 0.17 and 0.06 episodes per year at risk in the non-dressing and dressing groups; the adjusted incidence rate ratio was 0.4 (95% confidence interval = 0.04–3.25; p = 0.4). Allergic contact dermatitis occurred in 15/18 (83%) patients in the non-dressing group and 11/16 (69%) in the dressing group before long-term exit-site care was applied. Ultimately, no patient in the non-dressing group developed allergic contact dermatitis, whereas 11 (69%) had allergic contact dermatitis in the dressing group at the end of follow-up.&#13;
CONCLUSIONS Non-dressing technique may increase the risk of peritonitis in children on long-term PD; however, it is beneficial for children vulnerable to allergic contact dermatitis.</text>
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                <text>Cahyani Gita Ambarsari, Eka Laksmi Hidayati, Lily Mushahar, Agustina Kadaristiana</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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              <elementText elementTextId="9200">
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            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="9201">
                <text>Sri Wahyuni</text>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9202">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
IL-1, IL-6, TNF-α, and MIF in Relative Adrenal Insufficiency in Septic Shock: A Piglet Model</text>
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                <text>adrenal insufficiency, interleukin-1, interleukin-6, macrophage migration inhibition factors, septic shock, tumor necrosis factor-alpha</text>
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                <text>BACKGROUND Inflammatory mediators released during septic shock are involved in the mechanism of adrenal insufficiency. This study investigated the role of interleukin (IL)-6, IL-1, tumor necrosis factor (TNF)-α, and macrophage migration inhibitory factor (MIF) in septic shock with relative adrenal insufficiency (RAI).&#13;
METHODS We conducted a 6-month experimental study in 20 piglets. Following endotoxin administration, their hemodynamics were monitored and blood samples were drawn to test the levels of cytokines IL-1, IL-6, TNF-α, and MIF every 15 min until septic shock onset as well as during a corticotropin stimulation test. Septic shock was managed by administering fluid resuscitation, inotropic drugs, and hydrocortisone. At the end of the study, the piglet models were classified as either RAI or non-RAI. Immunohistochemistry staining was performed on the hypothalamus of the RAI group.&#13;
RESULTS The level of IL-6 at 45 min was higher in the RAI group than the non-RAI group (p = 0.008), and that of IL-1 was similar in the two groups during septic shock. The RAI group had higher TNF-α levels at 15 min (p = 0.002) and at 30 min (p = 0.007) than &#13;
the non-RAI group, and the MIF level during septic shock was higher in the RAI group (p = 0.003) than the non-RAI group. &#13;
CONCLUSIONS Cytokine-induced inflammatory process of adrenal gland reflected in TNF-α level in 15 min and 30 min, IL-6 in 45 min, and MIF in septic shock condition but not in IL-1.</text>
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                <text>Bina Akura, Jose R. L. Batubara, Zakiudin Munasir, Gunanti, Joedo Prihartono, Hindra Irawan Satari, Suzanna Immanuel, Dadang Hudaya Somasetia</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Infectivity and Viability of Dengue Virus Infected Hepatocytes Cocultured with Peripheral Blood Mononuclear Cells from A Healthy Subject</text>
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                <text>dengue, hepatocytes, in vitro, liver, monocytes</text>
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                <text>BACKGROUND Dengue virus (DENV) can infect and replicate in monocytes, resulting in antibody-dependent enhancement. The liver is the main target of DENV, and the infection mechanisms of DENV include direct cytopathic effects (CPEs) of the virus, mitochondrial dysfunction, and effect of cellular and humoral immune factors in the liver. This study was aimed to explore the infectivity of DENV and viability of human hepatocytes using Huh 7it-1 cells cocultured with peripheral blood mononuclear cells (PBMCs).&#13;
METHODS Huh 7it-1 cells were infected with dengue virus serotype-2 (DENV-2) New Guinea C strain at multiplicity of infection of 0.5 and 1 FFU/cell, and cocultured in vitro with and without adherent PBMCs. The infectivity of DENV was assessed by immunoperoxidase staining. The viability of Huh 7it-1 cells was assessed using &#13;
3-(4,5-dimethylthiazol-2-yl)-2,5-iphenyltetrazolium bromide (MTT, a tetrazole) assay and trypan blue staining. Data were statistically analyzed by Shapiro–Wilk and analysis of variance for normality significances.&#13;
RESULTS The result showed that addition of PBMCs to DENV-2 infected Huh 7it-1 cells decreased the infectivity of DENV (15–37%). DENV-2 infection decreased the viability of Huh 7it-1 cells (15.5–20.8%). Despite the decrease in infectivity of DENV, the addition of PBMCs increased the Huh 7it-1 cells viability (4.5–10.2%).&#13;
CONCLUSIONS Addition of PBMCs to Huh 7it-1 cells that are infected with DENV-2 decreased the infectivity of DENV and increased Huh 7it-1 cells viability.</text>
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                <text>Sekar Asri Tresnaningtyas, Fithriyah Sjatha, Beti Ernawati Dewi</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>English</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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                  <text>Medical Journal of Indonesia Vol. 29 No. 3 2020 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020&#13;
Nine-Segment Laminectomy is Safe for The Resection of A Schwannoma Extending from C-2 to T-3: A Rare Case Report</text>
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                <text> kyphosis, laminectomy, schwannoma</text>
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                <text>Cervical spine schwannoma, which is long and entirely intracanal, is rare to be found. Its rarity and atypical feature leads to difficulty in diagnosing and managing cases because of the scarcity of available literature. The surgical removal of this type of &#13;
schwannomas via multisegment laminectomy is a great challenge because of various risks of postoperative complications. This report describes cervical spine schwannoma that was initially was not suspected as schwannoma and was subject to surgical removal via nine-segment laminectomy. In one year after surgery, motor function returned to normal strength, no new neurological deficits occurred, and no kyphotic deformity, which is a common complication of multisegment laminectomy.</text>
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                <text>Mohamad Saekhu, Nuryati Chairani Siregar, Kevin Gunawan, Setyo Widi Nugroho</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="9106">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020</text>
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