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                <text>The consideration of a patient’s treatment preference may be essential in determining&#13;
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unable to capture these effects, the two-stage randomized preference design provides an&#13;
important tool for researchers seeking to understand the role of patient preferences. In&#13;
addition to the treatment effect, these designs seek to estimate the role of preferences&#13;
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these studies. To aid in the design, functions are provided to estimate the required sample&#13;
size and to estimate the study power when a sample size is fixed. In addition, analysis&#13;
functions are provided to determine the significance of each effect using either raw data or&#13;
summary statistics. The package is able to incorporate either an unstratified or stratified&#13;
preference design. The functionality of the package is demonstrated using data from&#13;
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smear</text>
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                <text>Data analysis projects invariably involve a series of steps such as reading, cleaning,&#13;
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approach, we typically break down these tasks into manageable chunks by employing separate files of statistical, programming or text processing syntax for each step including the&#13;
final report. Real world data analysis often requires an iterative process because many&#13;
of these steps may need to be repeated any number of times. Manually repeating these&#13;
steps is problematic in that some necessary steps may be left out or some reported results&#13;
may not be for the most recent data set or syntax.&#13;
GNU Make may be used to automate the mundane task of regenerating output given&#13;
dependencies between syntax and data files. In addition to facilitating the management&#13;
of and documenting the workflow of a complex data analysis project, such automation&#13;
can help minimize errors and make the project more reproducible. It is relatively simple&#13;
to construct Makefiles for small data analysis projects. As projects increase in size,&#13;
difficulties arise because GNU Make does not have inbuilt rules for statistical and related&#13;
software. Without such rules, Makefiles can become unwieldy and error-prone.&#13;
This article addresses these issues by providing GNU Make pattern rules for R, Sweave,&#13;
rmarkdown, SAS, Stata, Perl and Python to streamline management of data analysis and&#13;
reporting projects. Rules are used by adding a single line to project Makefiles. Additional&#13;
flexibility is incorporated for modifying standard program options. An overall strategy is&#13;
outlined for Makefile construction and illustrated via simple and complex examples.</text>
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                <text> optimization, mathematical programming, linear programming, quadratic programming, convex programming, nonlinear programming, mixed integer programming, R.</text>
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                <text>Optimization plays an important role in many methods routinely used in statistics,&#13;
machine learning and data science. Often, implementations of these methods rely on&#13;
highly specialized optimization algorithms, designed to be only applicable within a specific application. However, in many instances recent advances, in particular in the field of&#13;
convex optimization, make it possible to conveniently and straightforwardly use modern&#13;
solvers instead with the advantage of enabling broader usage scenarios and thus promoting&#13;
reusability. This paper introduces the R optimization infrastructure ROI which provides&#13;
an extensible infrastructure to model linear, quadratic, conic and general nonlinear optimization problems in a consistent way. Furthermore, the infrastructure administers many&#13;
different solvers, reformulations, problem collections and functions to read and write optimization problems in various formats</text>
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International AG</text>
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                <text>CVXR: An R Package for Disciplined Convex Optimization</text>
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                <text>convex optimization, disciplined convex optimization, optimization, regression,&#13;
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                <text>CVXR is an R package that provides an object-oriented modeling language for convex&#13;
optimization, similar to CVX, CVXPY, YALMIP, and Convex.jl. It allows the user to&#13;
formulate convex optimization problems in a natural mathematical syntax rather than&#13;
the restrictive form required by most solvers. The user specifies an objective and set of&#13;
constraints by combining constants, variables, and parameters using a library of functions with known mathematical properties. CVXR then applies signed disciplined convex&#13;
programming (DCP) to verify the problem’s convexity. Once verified, the problem is&#13;
converted into standard conic form using graph implementations and passed to a cone&#13;
solver such as ECOS or SCS. We demonstrate CVXR’s modeling framework with several&#13;
applications</text>
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                <text>This article describes the R package BOIN, which implements a recently developed&#13;
methodology for designing single-agent and drug-combination dose-finding clinical trials&#13;
using Bayesian optimal interval designs (Liu and Yuan 2015; Yuan, Hess, Hilsenbeck,&#13;
and Gilbert 2016). The BOIN designs are novel “model-assisted” phase I trial designs&#13;
that can be implemented simply and transparently, similar to the 3 + 3 design, but yield&#13;
excellent performance comparable to those of more complicated, model-based designs.&#13;
The BOIN package provides tools for designing, conducting, and analyzing single-agent&#13;
and drug-combination dose-finding trials</text>
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                <text>We present the R package PResiduals for residual analysis using the probability-scale&#13;
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model diagnostics, tests of conditional associations, and covariate-adjustment for Spearman’s rank correlation. These tests and measures of conditional association are applicable&#13;
to any orderable variable. They use order information but do not require assigning scores&#13;
to ordered categorical variables or transforming continuous variables, and therefore, can&#13;
achieve a good balance between robustness and efficiency. We illustrate the usage of the&#13;
PResiduals package with a publicly available dataset</text>
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                <text>Merck &amp; CO., Inc.</text>
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                <text>Empirical Bayes inference assumes an unknown prior density g(θ) has yielded (unobservables) Θ1, Θ2, . . . , ΘN , and each Θi produces an independent observation Xi from&#13;
pi(Xi&#13;
|Θi). The marginal density fi(Xi) is a convolution of the prior g and pi&#13;
. The Bayes&#13;
deconvolution problem is one of recovering g from the data. Although estimation of g – so&#13;
called g-modeling – is difficult, the results are more encouraging if the prior g is restricted&#13;
to lie within a parametric family of distributions. We present a deconvolution approach&#13;
where g is restricted to be in a parametric exponential family, along with an R package&#13;
deconvolveR designed for the purpose</text>
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                <text>Balasubramanian Narasimhan</text>
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                <text>Fajar bagus W</text>
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                <text>Boosting Functional Regression Models with FDboost</text>
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                <text>: functional data analysis, function-on-function regression, function-on-scalar regression, gradient boosting, model-based boosting, scalar-on-function regression.</text>
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                <text>The R add-on package FDboost is a flexible toolbox for the estimation of functional&#13;
regression models by model-based boosting. It provides the possibility to fit regression&#13;
models for scalar and functional response with effects of scalar as well as functional covariates, i.e., scalar-on-function, function-on-scalar and function-on-function regression&#13;
models. In addition to mean regression, quantile regression models as well as generalized&#13;
additive models for location scale and shape can be fitted with FDboost. Furthermore,&#13;
boosting can be used in high-dimensional data settings with more covariates than observations. We provide a hands-on tutorial on model fitting and tuning, including the&#13;
visualization of results. The methods for scalar-on-function regression are illustrated&#13;
with spectrometric data of fossil fuels and those for functional response regression with a&#13;
data set including bioelectrical signals for emotional episodes</text>
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                <text>A large number of statistical decision problems in the social sciences and beyond can&#13;
be framed as a (contextual) multi-armed bandit problem. However, it is notoriously hard&#13;
to develop and evaluate policies that tackle these types of problems, and to use such&#13;
policies in applied studies. To address this issue, this paper introduces StreamingBandit, a Python web application for developing and testing bandit policies in field studies.&#13;
StreamingBandit can sequentially select treatments using (online) policies in real time.&#13;
Once StreamingBandit is implemented in an applied context, different policies can be&#13;
tested, altered, nested, and compared. StreamingBandit makes it easy to apply a multitude of bandit policies for sequential allocation in field experiments, and allows for the&#13;
quick development and re-use of novel policies. In this article, we detail the implementation logic of StreamingBandit and provide several examples of its use</text>
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                <text>We present the R package BASS as a tool for nonparametric regression. The primary&#13;
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performing global sensitivity analyses of these models. The BASS framework is similar to&#13;
that of Bayesian multivariate adaptive regression splines (BMARS) from Denison, Mallick,&#13;
and Smith (1998), but with many added features. The software is built to efficiently&#13;
handle significant amounts of data with many continuous or categorical predictors and&#13;
with functional response. Under our Bayesian framework, most priors are automatic but&#13;
these can be modified by the user to focus on parsimony and the avoidance of overfitting.&#13;
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Markov chain Monte Carlo (RJMCMC) methods used to perform inference. We discuss&#13;
the implementation of these features and present the performance of BASS in a number&#13;
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