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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Erratum: Amniotic Membrane Transplantation for Infectious Corneal Ulcer Treatment: A Cohort Metrospective Study (Corrections)</text>
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                <text>In the original version of this article, some sentences in the first and second paragraphs of results were missing. The last sentence of first paragraph of results on page 381 (right column, line &#13;
8 from top of paragraph) should end with “The most &#13;
common local predisposing factors for corneal ulcer &#13;
were nonsurgical trauma (22 eyes with metal cutting fragments, foreign body particles, and nail or wire scratches), followed by contact lens use (14 eyes), eyelid function disorders (5 eyes with lagophthalmos, entropion, or chronic blepharitis), ocular surface disorders (5 eyes with a history of Stevens–Johnson syndrome [SJS]), irradiation-induced dry eye (1 eye), allergic conjunctivitis (1 eye), and surgical trauma (2 eyes with phacoemulsification and pterygium avulsion). Five eyes had a history of topical steroid use, and two subjects were known to have diabetes. The median ulcer size was 3.1 (0.7–9) mm. Seventeen (34%) ulcers were accompanied by hypopyon. Twelve &#13;
eyes with perforations have a median of 1.5 (0.9–5.5) mm in diameter, and descemetocele was observed in six eyes. No endophthalmitis was recorded. The median duration of onset was 14 (2–120) days. Twenty�two cases developed symptoms over 2 weeks, and 15 (68.2%) were classified as severe. The median time from the first visit to surgery was 1 (1–90) day. The median follow-up time was 11.4 (3–94.4) weeks.” Also, the first sentence of second paragraph of results on page 382 (right column, line 1 from top of paragraph) &#13;
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cultures from 25 eyes, dominated by Gram-positive &#13;
cocci (Table 2).</text>
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Corrigendum: A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears (Corrections)</text>
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Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia (PKGR UI), Jakarta, Indonesia”.</text>
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The Challenges of A Small Medical Journal to Have An International Recognition in Indonesia: Editors' Perspectives (Editorial)</text>
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                <text>Most of the journals in Indonesia are small journals &#13;
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Hydroxychloroquine in The Treatment of COVID-19 Disease: A Systematic Review and Meta-Analysis </text>
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                <text>BACKGROUND Given the urgency of finding a specific treatment for coronavirus disease 2019 (COVID-19), several approaches have been carried out, including the use of chloroquine (CQ) and hydroxychloroquine (HCQ). This study was aimed to &#13;
systematically evaluate the available evidence on the effectiveness of HCQ in the treatment of COVID-19 disease.&#13;
METHODS We searched 3 databases (PubMed, Google Scholar, and ClinicalTrials) until May 31, 2020 for clinical studies in patients diagnosed with COVID-19 comparing conventional treatment with and without HCQ combined with or without azithromycin. The risk of bias assessment and quality evaluation was carried out according to the &#13;
Cochrane recommendations.&#13;
RESULTS 5 articles (1 randomized clinical trial [RCT], 1 non-RCT, and 3 cohort studies) were included. The main outcome measure in 2 articles was the virological conversion determined by reverse transcription-polymerase chain reaction; however, the findings of both studies were contrary. The main objective of the other studies was to determine the effects of HCQ on COVID-19 mortality, and the studies showed similar results. &#13;
In general, the studies showed methodological limitations, risk of bias, and variable quality. A meta-analysis from 2,041 patients showed the odds ratio of mortality for patients having HCQ and standard care was 1.38 (95% CI 0.93–2.04).&#13;
CONCLUSIONS Considering the limited data available and the very low-to-moderate quality of the studies included in this systematic review, the evidence suggests that the HCQ administration does not decrease the risk of death from COVID-19.</text>
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                <text>Amahirany Manzo-Toledo, Rafael Torres-Rosas, Hugo Mendieta-Zerón, Lourdes Arriaga-Pizano, Liliana Argueta�Figueroa</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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Middle Cerebral Artery Territory Infarction in A COVID-19 Patient: A Case Report</text>
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                <text> case reports, COVID-19, ischemic stroke, middle cerebral artery</text>
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                <text>Coronavirus disease 2019 (COVID-19) mainly invades the respiratory system, yet previous reports have shown unusual manifestations of COVID-19, including cerebrovascular events. However, detailed case reports are still lacking. A 57-year-old &#13;
male presented with sudden unconsciousness and right side lateralization for 6 hours before hospital admission. His test results were positive for severe acute respiratory syndrome coronavirus 2 infection. The head computed tomography (CT) scan showed &#13;
infarction within the middle cerebral artery region. The scan was repeated 48 hours after admission and showed a massive infarct in the left hemisphere with hemorrhagic transformation. A chest CT showed the appearance of bronchopneumonia with &#13;
ground-glass opacities in both lungs. The patient's condition was rapidly deteriorating, and he died on the third day after admission. Our findings suggest that ischemic vascular events may simultaneously develop due to the progression of COVID-19. A &#13;
hypercoagulable state and vascular endothelial dysfunction have been proposed as complications of COVID-19 and are risk factors of thrombotic vascular events .</text>
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                <text>Rizaldy Pinzon, Vincent Ongko Wijaya, Dessy Paramitha</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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              <elementText elementTextId="9941">
                <text>Sri Wahyuni</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9942">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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            <description>A name given to the resource</description>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management</text>
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            <description>The topic of the resource</description>
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              <elementText elementTextId="9924">
                <text>COVID-19, free radicals, uric acid, xanthine oxidase</text>
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            <description>An account of the resource</description>
            <elementTextContainer>
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                <text>The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, &#13;
including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.</text>
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            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
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                <text>Irandi Putra Pratomo, Anna Ariane, Aryo Tedjo, Rudi Heryanto, Rafika Indah Paramita</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            <description>An entity responsible for making contributions to the resource</description>
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                <text>Sri Wahyuni</text>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9930">
                <text>ISSN : 0853-1773</text>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="9932">
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            <elementTextContainer>
              <elementText elementTextId="9934">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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              <name>Title</name>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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              <elementText elementTextId="9911">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Validation of EuroSCORE II to Predict Mortality in Post-Cardiac Surgery Patients in East Java Tertiary  Hospital</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
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              <elementText elementTextId="9912">
                <text>cardiac surgery, mortality, prognosis, treatment outcome</text>
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                <text>BACKGROUND The European system for cardiac operative risk evolution (EuroSCORE) II is one of the established risk models used to predict mortality after cardiac surgery. However, its application as a mortality predictor for Indonesian adult cardiac surgery is still unknown. This study aimed to examine the validation of EuroSCORE II in predicting mortality following cardiac surgery in Indonesian adults. &#13;
METHODS This retrospective cohort study collected data from the medical records and the database of the Department of Thoracic Cardiac and Vascular Surgery at Soetomo General Hospital, Surabaya. Data on the EuroSCORE II variables were collected for patients aged &gt;18 years who underwent coronary artery bypass, heart valve, heart tumors, aortic surgeries, or a combination of these surgeries between January 2016 and December 2018. In-hospital mortality prediction was calculated using the online calculator at www.euroscore.org. The calibration of the EuroSCORE II model was conducted using the Hosmer–Lemeshow test, and discrimination analysis was done using receiver operating characteristic (ROC) curves with area under the ROC curve (AUC) calculation.&#13;
RESULTS A total of 213 patients met the inclusion criteria and were analyzed for this study. Mortality was 8.9%. The predicted and actual mortalities were 1.74% and 8.9%, respectively. The significance (p-value) of the Hosmer–Lemeshow test was 0.55, &#13;
indicating good calibration. The AUC of ROC curve was 0.85 (95% CI = 0.77–0.92, p&lt;0.001), suggesting good discrimination.&#13;
CONCLUSIONS EuroSCORE II has a good calibration and discrimination for cardiac surgery in Indonesian adults.</text>
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                <text>Yan Efrata Sembiring, Adhitya Ginting, Puruhito, Budiono </text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            <name>Rights</name>
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            <elementTextContainer>
              <elementText elementTextId="9918">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Prognostic Model of Excessive Lung Function Decline among Québec Apprentices: A cohort Exposed to Occupational Sensitizing Agents </text>
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                <text>BACKGROUND Forced expiratory volume in 1 second (FEV1 ) decline as a predictor of &#13;
lung-related health problems is widely observed, but not fully investigated. This study aimed to develop models to predict FEV1  decline among apprentices exposed to sensitizing agents.&#13;
METHODS Of 692 apprentices recruited and followed in 3.6–17.3 years, 292 were exposed to low-molecular-weight agents. The analysis was restricted to 357 apprentices with complete lung function assessment at the end of their training with a minimum of 5-year follow-up. According to the American Thoracic Society guideline, a mean FEV₁ decline &gt;60 ml/year was defined as “accelerated.” Descriptive statistics and Cox regression analysis were utilized to determine its predictors. To develop the prognostic models, we used a logistic regression analysis adjusted for the follow-up duration. The &#13;
accuracy of the models was quantified using calibration and discrimination measures.&#13;
RESULTS Of 357 subjects, 62 (17.4%) had an excessive FEV1  decline post-apprenticeship. &#13;
The questionnaire model (model 1), which included male sex, wheezing, and exposure to isocyanate or animal allergens during the apprenticeship, showed a reasonable discriminative ability (area under the receiver operating characteristics curve [AUC] &#13;
of 0.67, 95% CI = 0.59–0.75). Adding the percent-predicted FEV₁ value at the end of apprenticeship significantly increased the discriminative ability of the model (model 4) (AUC = 0.762, 95% CI = 0.694–0.829) with a good calibration and reasonable internal validity.&#13;
CONCLUSIONS We developed a model for accelerated lung function decline with a good &#13;
accuracy and internal validity. However, external validation of the model is necessary.</text>
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                <text>Alfi Afadiyanti Parfi, Mahsa Taghiakbari, Meshack Achore, Denyse Gautrin, Gleb Bezgin, Eva Suarthana</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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              <elementText elementTextId="9906">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Factors Associated with Delay in Diagnosis among Tuberculosis Patients in The North of Iran</text>
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                <text>BACKGROUND Recognizing factors that affect delay in diagnosis in patients with pulmonary tuberculosis (TB) is critical. This study aimed to identify such factors among TB patients in the north of Iran.&#13;
METHODS In this retrospective cohort study, we reviewed patient’s medical records from the TB registration system of the Health Deputy of Mazandaran University of Medical Sciences, Sari, Iran that was responsible for the TB registry in the province from 2007 to 2017. All hospitals affiliated with the university, including private hospitals, &#13;
reported TB cases directly to the health deputy. Patient’s gender, age, TB smear result, TB type, imprisonment, diabetes, nationality, residence area, and drug use were considered factors of delay in diagnosis, which was defined as a delay of &gt;30 days &#13;
between symptom onset and diagnosis. Data from 3,453 patients were analyzed using the chi-square test and logistic regression models.&#13;
RESULTS The frequency of patients with delay in diagnosis was 67.7%. There was no association between delay in diagnosis and gender (p = 0.194), TB type (p = 0.140), and diabetes (p = 0.198). On the other hand, old age (≥60 years) was related to delay &#13;
in diagnosis (OR = 1.37; 95% CI = 1.12–1.68; p = 0.002). The chance of delay in diagnosis in prisoners was lower than in non-prisoners (OR = 0.62; 95% CI = 0.46–0.82; p = 0.001).&#13;
CONCLUSIONS Old age was a risk factor for delay in diagnosis, and interestingly, prisoners had been diagnosed significantly faster. </text>
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              <elementText elementTextId="9890">
                <text>Mahmood Moosazadeh, Motahareh Kheradmand,  Mohsen Aarabi, Mahdi Afshari, Mohammadreza Parsaee, Asghar Nezammahalleh, Amirhossein Hessami</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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