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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Prognostic Model of Excessive Lung Function Decline among Québec Apprentices: A cohort Exposed to Occupational Sensitizing Agents </text>
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                <text> excessive decline, lung function, model, prognosis</text>
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                <text>BACKGROUND Forced expiratory volume in 1 second (FEV1 ) decline as a predictor of &#13;
lung-related health problems is widely observed, but not fully investigated. This study aimed to develop models to predict FEV1  decline among apprentices exposed to sensitizing agents.&#13;
METHODS Of 692 apprentices recruited and followed in 3.6–17.3 years, 292 were exposed to low-molecular-weight agents. The analysis was restricted to 357 apprentices with complete lung function assessment at the end of their training with a minimum of 5-year follow-up. According to the American Thoracic Society guideline, a mean FEV₁ decline &gt;60 ml/year was defined as “accelerated.” Descriptive statistics and Cox regression analysis were utilized to determine its predictors. To develop the prognostic models, we used a logistic regression analysis adjusted for the follow-up duration. The &#13;
accuracy of the models was quantified using calibration and discrimination measures.&#13;
RESULTS Of 357 subjects, 62 (17.4%) had an excessive FEV1  decline post-apprenticeship. &#13;
The questionnaire model (model 1), which included male sex, wheezing, and exposure to isocyanate or animal allergens during the apprenticeship, showed a reasonable discriminative ability (area under the receiver operating characteristics curve [AUC] &#13;
of 0.67, 95% CI = 0.59–0.75). Adding the percent-predicted FEV₁ value at the end of apprenticeship significantly increased the discriminative ability of the model (model 4) (AUC = 0.762, 95% CI = 0.694–0.829) with a good calibration and reasonable internal validity.&#13;
CONCLUSIONS We developed a model for accelerated lung function decline with a good &#13;
accuracy and internal validity. However, external validation of the model is necessary.</text>
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                <text>Alfi Afadiyanti Parfi, Mahsa Taghiakbari, Meshack Achore, Denyse Gautrin, Gleb Bezgin, Eva Suarthana</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Hydroxychloroquine in The Treatment of COVID-19 Disease: A Systematic Review and Meta-Analysis </text>
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                <text>COVID-19, hydroxychloroquine, mortality, SARS-CoV-2</text>
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                <text>BACKGROUND Given the urgency of finding a specific treatment for coronavirus disease 2019 (COVID-19), several approaches have been carried out, including the use of chloroquine (CQ) and hydroxychloroquine (HCQ). This study was aimed to &#13;
systematically evaluate the available evidence on the effectiveness of HCQ in the treatment of COVID-19 disease.&#13;
METHODS We searched 3 databases (PubMed, Google Scholar, and ClinicalTrials) until May 31, 2020 for clinical studies in patients diagnosed with COVID-19 comparing conventional treatment with and without HCQ combined with or without azithromycin. The risk of bias assessment and quality evaluation was carried out according to the &#13;
Cochrane recommendations.&#13;
RESULTS 5 articles (1 randomized clinical trial [RCT], 1 non-RCT, and 3 cohort studies) were included. The main outcome measure in 2 articles was the virological conversion determined by reverse transcription-polymerase chain reaction; however, the findings of both studies were contrary. The main objective of the other studies was to determine the effects of HCQ on COVID-19 mortality, and the studies showed similar results. &#13;
In general, the studies showed methodological limitations, risk of bias, and variable quality. A meta-analysis from 2,041 patients showed the odds ratio of mortality for patients having HCQ and standard care was 1.38 (95% CI 0.93–2.04).&#13;
CONCLUSIONS Considering the limited data available and the very low-to-moderate quality of the studies included in this systematic review, the evidence suggests that the HCQ administration does not decrease the risk of death from COVID-19.</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Amahirany Manzo-Toledo, Rafael Torres-Rosas, Hugo Mendieta-Zerón, Lourdes Arriaga-Pizano, Liliana Argueta�Figueroa</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="9953">
                <text>Sri Wahyuni</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9954">
                <text>ISSN : 0853-1773</text>
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            <name>Language</name>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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        <name>COVID-19</name>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Randomized Controlled Trial of Infraorbital Block using Ketamine 1% for Intra- and Postoperative Analgesia in Children for Ambulatory Cleft Lip Correction</text>
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                <text>cleft lip, ketamine, postoperative pain</text>
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                <text>BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods.&#13;
METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each &#13;
group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration.&#13;
RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p&gt;0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031).&#13;
CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for &#13;
intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction.</text>
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                <text>Andi Ade Wijaya Ramlan,  Apriliana Ratnaningrum,  Arif Hari Martono Marsaban</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <name>Rights</name>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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              <name>Title</name>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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            <name>Title</name>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Efficacy of Adjuvant Intrastromal and Combination of Intrastromal and Intracameral Voriconazole in Aspergillus Fumigatus-Induced Moderate Fungal Keratitis in Rabbits</text>
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                <text>Aspergillus fumigatus, fungal keratitis, intrastromal, voriconazole</text>
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                <text>BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it.&#13;
METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and &#13;
intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment.&#13;
RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus &#13;
spores in both eyes. &#13;
CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits.</text>
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                <text>Dyah Tjintya Sarika, Melva Louisa, Anna Rozaliyani, Evelina, Made Susiyanti&#13;
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Randomized Controlled Trial of Combination of Peppermint, Lavender, and Turmeric Oil for Antipruritic Agent in Pregnant Women</text>
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                <text>BACKGROUND Pruritus is the most common dermatological complaint that occurs during pregnancy, which is around 14–20%. No research related to herbal products to reduce some of the characteristics of pruritus at once has been conducted. This study aimed to assess the effect of blending oil to reduce pruritus based on visual analog scale (VAS).&#13;
METHODS This was a single-blind, randomized clinical trial that included 57 pregnant women who were at 25–38 weeks of gestation, had a pruritus during pregnancy, a single pregnancy, a level I and II pruritus and a moderate to severe pruritus based on VAS. Pruritus scores were measured using VAS in both the treatment and control groups. The treatment and control groups applied blending oil and placebo, respectively, twice a day after bathing for 2 weeks. Mann–Whitney U, paired t, and chi-square tests were used for the analysis.&#13;
RESULTS Pruritus reduction in pregnant women who received blending oil was higher than those using placebo (61.08% versus 12.41%, p&lt;0.05). 83% of subjects using blending oils had a reduction of pruritus by &gt;25 mm. Pregnant women who used placebo had a six times greater risk of experiencing pruritus than those who used blending oil (RR = &#13;
5.8, 95% CI = 2.613–12.874).&#13;
CONCLUSIONS Blending oil can be used topically to treat a pruritus in pregnant women </text>
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                <text>Fransisca Retno Asih, Farid Husin, Oki Suwarsa, Irda Fidrianny, Dany Hilmanto</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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The Challenges of A Small Medical Journal to Have An International Recognition in Indonesia: Editors' Perspectives (Editorial)</text>
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                <text>Most of the journals in Indonesia are small journals &#13;
published by their own institutions or societies. It is &#13;
tough for us to obtain an international recognition. &#13;
As stated by Ana and Matko Marusic from Croatian &#13;
Medical Journal, small journals “cover a wide array of journals that are outside the mainstream and published in the hope that they will be read and recognized internationally although in reality they achieve mostly a local readership”.  There are some proofs that a journal has an international recognition, such as publishing several authors from abroad, getting indexed in Medline, Scopus, or Web of Science, and having more citations from outside articles than from the journal itself. Hence, the editors of the journal need to solve these issues to achieve this international recognition.</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management</text>
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                <text>The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, &#13;
including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Corrigendum: A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears (Corrections)</text>
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                <text>In the original version of this article, the affiliation &#13;
of Grace Wangge was incorrectly typed as  "Southeast Asian Ministers of Education Organization”. It should be corrected as follows “Southeast Asian Ministers of Education Organization-Regional Center of Food and &#13;
Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia (PKGR UI), Jakarta, Indonesia”.</text>
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                <text>Made Susiyanti, Manoa Panjaitan, Grace Wangge, &#13;
Tjahjono Darminto Gondhowiardjo</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Factors Associated with Delay in Diagnosis among Tuberculosis Patients in The North of Iran</text>
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                <text>delayed diagnosis, Iran, tuberculosis</text>
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                <text>BACKGROUND Recognizing factors that affect delay in diagnosis in patients with pulmonary tuberculosis (TB) is critical. This study aimed to identify such factors among TB patients in the north of Iran.&#13;
METHODS In this retrospective cohort study, we reviewed patient’s medical records from the TB registration system of the Health Deputy of Mazandaran University of Medical Sciences, Sari, Iran that was responsible for the TB registry in the province from 2007 to 2017. All hospitals affiliated with the university, including private hospitals, &#13;
reported TB cases directly to the health deputy. Patient’s gender, age, TB smear result, TB type, imprisonment, diabetes, nationality, residence area, and drug use were considered factors of delay in diagnosis, which was defined as a delay of &gt;30 days &#13;
between symptom onset and diagnosis. Data from 3,453 patients were analyzed using the chi-square test and logistic regression models.&#13;
RESULTS The frequency of patients with delay in diagnosis was 67.7%. There was no association between delay in diagnosis and gender (p = 0.194), TB type (p = 0.140), and diabetes (p = 0.198). On the other hand, old age (≥60 years) was related to delay &#13;
in diagnosis (OR = 1.37; 95% CI = 1.12–1.68; p = 0.002). The chance of delay in diagnosis in prisoners was lower than in non-prisoners (OR = 0.62; 95% CI = 0.46–0.82; p = 0.001).&#13;
CONCLUSIONS Old age was a risk factor for delay in diagnosis, and interestingly, prisoners had been diagnosed significantly faster. </text>
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              <elementText elementTextId="9890">
                <text>Mahmood Moosazadeh, Motahareh Kheradmand,  Mohsen Aarabi, Mahdi Afshari, Mohammadreza Parsaee, Asghar Nezammahalleh, Amirhossein Hessami</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Middle Cerebral Artery Territory Infarction in A COVID-19 Patient: A Case Report</text>
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                <text>Coronavirus disease 2019 (COVID-19) mainly invades the respiratory system, yet previous reports have shown unusual manifestations of COVID-19, including cerebrovascular events. However, detailed case reports are still lacking. A 57-year-old &#13;
male presented with sudden unconsciousness and right side lateralization for 6 hours before hospital admission. His test results were positive for severe acute respiratory syndrome coronavirus 2 infection. The head computed tomography (CT) scan showed &#13;
infarction within the middle cerebral artery region. The scan was repeated 48 hours after admission and showed a massive infarct in the left hemisphere with hemorrhagic transformation. A chest CT showed the appearance of bronchopneumonia with &#13;
ground-glass opacities in both lungs. The patient's condition was rapidly deteriorating, and he died on the third day after admission. Our findings suggest that ischemic vascular events may simultaneously develop due to the progression of COVID-19. A &#13;
hypercoagulable state and vascular endothelial dysfunction have been proposed as complications of COVID-19 and are risk factors of thrombotic vascular events .</text>
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                <text>Rizaldy Pinzon, Vincent Ongko Wijaya, Dessy Paramitha</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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