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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Case of Third Degree Hemorrhagic Shock due to Total Subacute Uterine Inversion after Delivery </text>
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                <text>Uterine inversion is a rare, but life-threatening obstetric emergency. We describe a case of total subacute uterine inversion in settings with limited resources. A multiparous (P4) 29-year-old woman with history of delivery assisted by a traditional birth attendant who used the fundal pressure technique 4 days before admission was referred due &#13;
to postpartum hemorrhage. She had low blood pressure, tachycardia, and lethargic. A protruding mass from the vaginal introitus with active bleeding was visible. She diagnosed with third degree hemorrhagic shock due to total subacute uterine &#13;
inversion. Resuscitation was initiated immediately and manual uterine repositioning was performed under general anesthesia. After two failed attempts, a laparotomy was performed to apply traction to the round ligaments and an incision on the cervical ring by using Allis clamps. The inversion was resolved. Next, subtotal hysterectomy was done to stop bleeding and infection.</text>
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                <text>William Timotius Wahono,  Angela Putri, Yudianto Budi Saroyo,  Antonius Joko Nugroho, Ruth Sally, Sugianto Parulian Simanjuntak, Samuel</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Prognostic Model of Excessive Lung Function Decline among Québec Apprentices: A cohort Exposed to Occupational Sensitizing Agents </text>
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                <text> excessive decline, lung function, model, prognosis</text>
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                <text>BACKGROUND Forced expiratory volume in 1 second (FEV1 ) decline as a predictor of &#13;
lung-related health problems is widely observed, but not fully investigated. This study aimed to develop models to predict FEV1  decline among apprentices exposed to sensitizing agents.&#13;
METHODS Of 692 apprentices recruited and followed in 3.6–17.3 years, 292 were exposed to low-molecular-weight agents. The analysis was restricted to 357 apprentices with complete lung function assessment at the end of their training with a minimum of 5-year follow-up. According to the American Thoracic Society guideline, a mean FEV₁ decline &gt;60 ml/year was defined as “accelerated.” Descriptive statistics and Cox regression analysis were utilized to determine its predictors. To develop the prognostic models, we used a logistic regression analysis adjusted for the follow-up duration. The &#13;
accuracy of the models was quantified using calibration and discrimination measures.&#13;
RESULTS Of 357 subjects, 62 (17.4%) had an excessive FEV1  decline post-apprenticeship. &#13;
The questionnaire model (model 1), which included male sex, wheezing, and exposure to isocyanate or animal allergens during the apprenticeship, showed a reasonable discriminative ability (area under the receiver operating characteristics curve [AUC] &#13;
of 0.67, 95% CI = 0.59–0.75). Adding the percent-predicted FEV₁ value at the end of apprenticeship significantly increased the discriminative ability of the model (model 4) (AUC = 0.762, 95% CI = 0.694–0.829) with a good calibration and reasonable internal validity.&#13;
CONCLUSIONS We developed a model for accelerated lung function decline with a good &#13;
accuracy and internal validity. However, external validation of the model is necessary.</text>
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                <text>Alfi Afadiyanti Parfi, Mahsa Taghiakbari, Meshack Achore, Denyse Gautrin, Gleb Bezgin, Eva Suarthana</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Randomized Controlled Trial of Combination of Peppermint, Lavender, and Turmeric Oil for Antipruritic Agent in Pregnant Women</text>
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                <text>BACKGROUND Pruritus is the most common dermatological complaint that occurs during pregnancy, which is around 14–20%. No research related to herbal products to reduce some of the characteristics of pruritus at once has been conducted. This study aimed to assess the effect of blending oil to reduce pruritus based on visual analog scale (VAS).&#13;
METHODS This was a single-blind, randomized clinical trial that included 57 pregnant women who were at 25–38 weeks of gestation, had a pruritus during pregnancy, a single pregnancy, a level I and II pruritus and a moderate to severe pruritus based on VAS. Pruritus scores were measured using VAS in both the treatment and control groups. The treatment and control groups applied blending oil and placebo, respectively, twice a day after bathing for 2 weeks. Mann–Whitney U, paired t, and chi-square tests were used for the analysis.&#13;
RESULTS Pruritus reduction in pregnant women who received blending oil was higher than those using placebo (61.08% versus 12.41%, p&lt;0.05). 83% of subjects using blending oils had a reduction of pruritus by &gt;25 mm. Pregnant women who used placebo had a six times greater risk of experiencing pruritus than those who used blending oil (RR = &#13;
5.8, 95% CI = 2.613–12.874).&#13;
CONCLUSIONS Blending oil can be used topically to treat a pruritus in pregnant women </text>
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                <text>Fransisca Retno Asih, Farid Husin, Oki Suwarsa, Irda Fidrianny, Dany Hilmanto</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
A Randomized Controlled Trial of Infraorbital Block using Ketamine 1% for Intra- and Postoperative Analgesia in Children for Ambulatory Cleft Lip Correction</text>
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                <text>BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods.&#13;
METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each &#13;
group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration.&#13;
RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p&gt;0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031).&#13;
CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for &#13;
intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction.</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Corrigendum: A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears (Corrections)</text>
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                <text>In the original version of this article, the affiliation &#13;
of Grace Wangge was incorrectly typed as  "Southeast Asian Ministers of Education Organization”. It should be corrected as follows “Southeast Asian Ministers of Education Organization-Regional Center of Food and &#13;
Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia (PKGR UI), Jakarta, Indonesia”.</text>
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                <text>Made Susiyanti, Manoa Panjaitan, Grace Wangge, &#13;
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Cover, Editorial Board, Contents, Instructions for Authors, Final Checklist &amp; Submission Form, </text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Efficacy of Adjuvant Intrastromal and Combination of Intrastromal and Intracameral Voriconazole in Aspergillus Fumigatus-Induced Moderate Fungal Keratitis in Rabbits</text>
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                <text>BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it.&#13;
METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and &#13;
intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment.&#13;
RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus &#13;
spores in both eyes. &#13;
CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits.</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9827">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Elevated Extracellular CO2 Level Affects The Adaptive Transcriptional Response and Survival of Human Peripheral Blood Mononuclear Cells Toward Hypoxia and Oxidative Stress</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="9828">
                <text>elevated CO2 , extracellular pH, oxidative stress, PBMC, reactive oxygen species</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>BACKGROUND High carbon dioxide (CO2) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2  level increases CO2&#13;
 level in the blood, and over-accumulation of CO2&#13;
 induces an adaptive response that requires modulation of gene expression. This study aimed to investigate the adaptive transcriptional response toward hypoxia and oxidative stress in human &#13;
peripheral blood mononuclear cells (PBMCs) exposed to elevated CO2 level in vitro and its association with cell viability.&#13;
METHODS PBMCs were treated in 5% CO2&#13;
 and 15% CO2 , representatives a high CO₂ level &#13;
condition for 24 and 48 hours. Extracellular pH (pHe) was measured with a pH meter. The levels of reactive oxygen species were determined by measuring superoxide and hydrogen peroxide with dihydroethidium and dichlorofluorescin-diacetate assay. The mRNA expression levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, nuclear factor &#13;
(NF)-κB, and manganese superoxide dismutase (MnSOD) were analyzed using a real�time reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell survival was determined by measuring cell viability.&#13;
RESULTS pHe increased in 24 hours after 15% CO₂ treatment, and then decreased in 48 hours. Superoxide and hydrogen peroxide levels increased after the 24- and 48-hour of high CO₂ level condition. The expression levels of NF-κB, MnSOD, HIF-1α, and HIF-2α decreased in 24 hours and increased in 48 hours. The increased antioxidant &#13;
mRNA expression in 48 hours showed that the PBMCs were responsive under high CO2 conditions. Elevated CO2  suppressed cell viability significantly in 48 hours. &#13;
CONCLUSIONS After 48 hours of high CO₂ level condition, PBMCs showed an upregulation in genes related to hypoxia and oxidative stress to overcome the effects of CO2  elevation.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="9830">
                <text>Septelia Inawati Wanandi, Sekar Arumsari, Edwin Afitriyansyah, Resda Akhra Syahrani, Idham Rafly Dewantara,  Luthfian Aby Nurachman, Ihya Fakhrurizal Amin, Putera Dewa Haryono, Kenny Budiman, Adrianus Jonathan Sugiharta, Amino Aytiwan Remedika, Farhan Hilmi Taufikulhakim, Febriana Catur Iswanti, Jason Youngbin Lee, Debabrata Banerjee</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="9831">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
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            </elementTextContainer>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9832">
                <text>2021-03-31</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9833">
                <text>Sri Wahyuni</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9834">
                <text>ISSN : 0853-1773</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="9835">
                <text>PDF</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9836">
                <text>English</text>
              </elementText>
            </elementTextContainer>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="9837">
                <text>Text</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="9838">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
              </elementText>
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      <tag tagId="362">
        <name>elevated CO2</name>
      </tag>
      <tag tagId="363">
        <name>extracellular pH</name>
      </tag>
      <tag tagId="25">
        <name>Jurnal Internasional</name>
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      <tag tagId="364">
        <name>oxidative stress</name>
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        <name>PBMC</name>
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        <name>reactive oxygen species</name>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="9813">
                  <text>Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9983">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021&#13;
Erratum: Amniotic Membrane Transplantation for Infectious Corneal Ulcer Treatment: A Cohort Metrospective Study (Corrections)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
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              <elementText elementTextId="9984">
                <text>Amniotic membrane transplantation , infectious corneal ulcer treatment</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9985">
                <text>In the original version of this article, some sentences in the first and second paragraphs of results were missing. The last sentence of first paragraph of results on page 381 (right column, line &#13;
8 from top of paragraph) should end with “The most &#13;
common local predisposing factors for corneal ulcer &#13;
were nonsurgical trauma (22 eyes with metal cutting fragments, foreign body particles, and nail or wire scratches), followed by contact lens use (14 eyes), eyelid function disorders (5 eyes with lagophthalmos, entropion, or chronic blepharitis), ocular surface disorders (5 eyes with a history of Stevens–Johnson syndrome [SJS]), irradiation-induced dry eye (1 eye), allergic conjunctivitis (1 eye), and surgical trauma (2 eyes with phacoemulsification and pterygium avulsion). Five eyes had a history of topical steroid use, and two subjects were known to have diabetes. The median ulcer size was 3.1 (0.7–9) mm. Seventeen (34%) ulcers were accompanied by hypopyon. Twelve &#13;
eyes with perforations have a median of 1.5 (0.9–5.5) mm in diameter, and descemetocele was observed in six eyes. No endophthalmitis was recorded. The median duration of onset was 14 (2–120) days. Twenty�two cases developed symptoms over 2 weeks, and 15 (68.2%) were classified as severe. The median time from the first visit to surgery was 1 (1–90) day. The median follow-up time was 11.4 (3–94.4) weeks.” Also, the first sentence of second paragraph of results on page 382 (right column, line 1 from top of paragraph) &#13;
should begin with “Microorganisms were found in &#13;
cultures from 25 eyes, dominated by Gram-positive &#13;
cocci (Table 2).</text>
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            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9986">
                <text>Vega Casalita, Rina La Distia Nora, Lukman Edwar, Made Susiyanti, Ratna Sitompul</text>
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            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="9987">
                <text>Fakultas Kedokteran Universitas Indonesia</text>
              </elementText>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9988">
                <text>2021-03-31</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="9989">
                <text>Sri Wahyuni</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9990">
                <text>ISSN : 0853-1773</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="9991">
                <text>PDF</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="9992">
                <text>English</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Text</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="9994">
                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021</text>
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        <name>Amniotic membrane transplantation</name>
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        <name>infectious corneal ulcer treatment</name>
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        <name>Jurnal Internasional</name>
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