1 10 17 https://repository.horizon.ac.id/files/original/520e51fdd2674ce0eada15028be1aa90.jpg c06067c959d328f5ce99c88daed59409 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Still Image A static visual representation. Examples include paintings, drawings, graphic designs, plans and maps. Recommended best practice is to assign the type Text to images of textual materials. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cover Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 https://repository.horizon.ac.id/files/original/999fd81812ba5398ba8aeb2f7b94f3c8.pdf 3ed3b4c56e3195ec40e8e54692cecc3d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Efficacy of Adjuvant Intrastromal and Combination of Intrastromal and Intracameral Voriconazole in Aspergillus Fumigatus-Induced Moderate Fungal Keratitis in Rabbits Subject The topic of the resource Aspergillus fumigatus, fungal keratitis, intrastromal, voriconazole Description An account of the resource BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it. METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment. RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus spores in both eyes. CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits. Creator An entity primarily responsible for making the resource Dyah Tjintya Sarika, Melva Louisa, Anna Rozaliyani, Evelina, Made Susiyanti Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Aspergillus fumigatus fungal keratitis intrastromal Jurnal Internasional voriconazole https://repository.horizon.ac.id/files/original/84ced1ab3d59a2ca70998dd2aa919794.pdf 02ff06f0ae35ec2dbee6f651b20a21f7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Elevated Extracellular CO2 Level Affects The Adaptive Transcriptional Response and Survival of Human Peripheral Blood Mononuclear Cells Toward Hypoxia and Oxidative Stress Subject The topic of the resource elevated CO2 , extracellular pH, oxidative stress, PBMC, reactive oxygen species Description An account of the resource BACKGROUND High carbon dioxide (CO2) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2 level increases CO2 level in the blood, and over-accumulation of CO2 induces an adaptive response that requires modulation of gene expression. This study aimed to investigate the adaptive transcriptional response toward hypoxia and oxidative stress in human peripheral blood mononuclear cells (PBMCs) exposed to elevated CO2 level in vitro and its association with cell viability. METHODS PBMCs were treated in 5% CO2 and 15% CO2 , representatives a high CO₂ level condition for 24 and 48 hours. Extracellular pH (pHe) was measured with a pH meter. The levels of reactive oxygen species were determined by measuring superoxide and hydrogen peroxide with dihydroethidium and dichlorofluorescin-diacetate assay. The mRNA expression levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, nuclear factor (NF)-κB, and manganese superoxide dismutase (MnSOD) were analyzed using a real�time reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell survival was determined by measuring cell viability. RESULTS pHe increased in 24 hours after 15% CO₂ treatment, and then decreased in 48 hours. Superoxide and hydrogen peroxide levels increased after the 24- and 48-hour of high CO₂ level condition. The expression levels of NF-κB, MnSOD, HIF-1α, and HIF-2α decreased in 24 hours and increased in 48 hours. The increased antioxidant mRNA expression in 48 hours showed that the PBMCs were responsive under high CO2 conditions. Elevated CO2 suppressed cell viability significantly in 48 hours. CONCLUSIONS After 48 hours of high CO₂ level condition, PBMCs showed an upregulation in genes related to hypoxia and oxidative stress to overcome the effects of CO2 elevation. Creator An entity primarily responsible for making the resource Septelia Inawati Wanandi, Sekar Arumsari, Edwin Afitriyansyah, Resda Akhra Syahrani, Idham Rafly Dewantara, Luthfian Aby Nurachman, Ihya Fakhrurizal Amin, Putera Dewa Haryono, Kenny Budiman, Adrianus Jonathan Sugiharta, Amino Aytiwan Remedika, Farhan Hilmi Taufikulhakim, Febriana Catur Iswanti, Jason Youngbin Lee, Debabrata Banerjee Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 elevated CO2 extracellular pH Jurnal Internasional oxidative stress PBMC reactive oxygen species https://repository.horizon.ac.id/files/original/ebe2e3b4c09a1ac33bce5d9e975b2431.pdf 228aefdc8a3d5a35a517bf4ed7295279 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 A Case of Third Degree Hemorrhagic Shock due to Total Subacute Uterine Inversion after Delivery Subject The topic of the resource postpartum hemorrhage, risk factor, uterine inversion Description An account of the resource Uterine inversion is a rare, but life-threatening obstetric emergency. We describe a case of total subacute uterine inversion in settings with limited resources. A multiparous (P4) 29-year-old woman with history of delivery assisted by a traditional birth attendant who used the fundal pressure technique 4 days before admission was referred due to postpartum hemorrhage. She had low blood pressure, tachycardia, and lethargic. A protruding mass from the vaginal introitus with active bleeding was visible. She diagnosed with third degree hemorrhagic shock due to total subacute uterine inversion. Resuscitation was initiated immediately and manual uterine repositioning was performed under general anesthesia. After two failed attempts, a laparotomy was performed to apply traction to the round ligaments and an incision on the cervical ring by using Allis clamps. The inversion was resolved. Next, subtotal hysterectomy was done to stop bleeding and infection. Creator An entity primarily responsible for making the resource William Timotius Wahono, Angela Putri, Yudianto Budi Saroyo, Antonius Joko Nugroho, Ruth Sally, Sugianto Parulian Simanjuntak, Samuel Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Jurnal Internasional postpartum hemorrhage risk factor uterine inversion https://repository.horizon.ac.id/files/original/881abd7858375ad415c2439fe5f31fe3.pdf a59bc8ca2a1a5f3b38b1b36071b2ae8b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Rapid Advancement in Cancer Genomic Big Data in The Pursuit of Precision Oncology Subject The topic of the resource cancer genetic database, oncology, personalized medicine Description An account of the resource In the current big data era, massive genomic cancer data are available for open access from anywhere in the world. They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. For convenient analysis, user-friendly tools, such as the Tumor Immune Estimation Resource (TIMER), which can be used to analyze tumor-infiltrating immune cells comprehensively, are also emerging. In clinical practice, clinical sequencing has been recommended for patients with cancer in many countries. Despite its many challenges, it enables the application of precision medicine, especially in medical oncology. In this review, several efforts devoted to accomplishing precision oncology and applying big data for use in Indonesia are discussed. Utilizing open access genomic data in writing research articles is also described. Creator An entity primarily responsible for making the resource Tiara Bunga Mayang Permata, Sri Mutya Sekarutami, Endang Nuryadi, Angela Giselvania, Soehartati Gondhowiardjo Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 cancer genetic database Jurnal Internasional oncology personalized medicine https://repository.horizon.ac.id/files/original/7b60857a375e72a67cbd9695880396d4.pdf 3a9d2b84b726f02fe8c01289beaf8aa2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 A Randomized Controlled Trial of Infraorbital Block using Ketamine 1% for Intra- and Postoperative Analgesia in Children for Ambulatory Cleft Lip Correction Subject The topic of the resource cleft lip, ketamine, postoperative pain Description An account of the resource BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods. METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration. RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p>0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031). CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction. Creator An entity primarily responsible for making the resource Andi Ade Wijaya Ramlan, Apriliana Ratnaningrum, Arif Hari Martono Marsaban Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 cleft lip Jurnal Internasional ketamine postoperative pain https://repository.horizon.ac.id/files/original/e4cb9560dfa40b0fd71b982c2ba367d3.pdf 893508d797a684e5000ce38728705d44 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 A Randomized Controlled Trial of Combination of Peppermint, Lavender, and Turmeric Oil for Antipruritic Agent in Pregnant Women Subject The topic of the resource essential oils, lavender, peppermint, pregnancy, pruritus, turmeric Description An account of the resource BACKGROUND Pruritus is the most common dermatological complaint that occurs during pregnancy, which is around 14–20%. No research related to herbal products to reduce some of the characteristics of pruritus at once has been conducted. This study aimed to assess the effect of blending oil to reduce pruritus based on visual analog scale (VAS). METHODS This was a single-blind, randomized clinical trial that included 57 pregnant women who were at 25–38 weeks of gestation, had a pruritus during pregnancy, a single pregnancy, a level I and II pruritus and a moderate to severe pruritus based on VAS. Pruritus scores were measured using VAS in both the treatment and control groups. The treatment and control groups applied blending oil and placebo, respectively, twice a day after bathing for 2 weeks. Mann–Whitney U, paired t, and chi-square tests were used for the analysis. RESULTS Pruritus reduction in pregnant women who received blending oil was higher than those using placebo (61.08% versus 12.41%, p<0.05). 83% of subjects using blending oils had a reduction of pruritus by >25 mm. Pregnant women who used placebo had a six times greater risk of experiencing pruritus than those who used blending oil (RR = 5.8, 95% CI = 2.613–12.874). CONCLUSIONS Blending oil can be used topically to treat a pruritus in pregnant women Creator An entity primarily responsible for making the resource Fransisca Retno Asih, Farid Husin, Oki Suwarsa, Irda Fidrianny, Dany Hilmanto Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 essential oils Jurnal Internasional lavender peppermint pregnancy pruritus turmeric https://repository.horizon.ac.id/files/original/9b917325b217f2f70e1acc65f4852d81.pdf 765e0b0f9e8bbf523925974ca0715a97 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Factors Associated with Delay in Diagnosis among Tuberculosis Patients in The North of Iran Subject The topic of the resource delayed diagnosis, Iran, tuberculosis Description An account of the resource BACKGROUND Recognizing factors that affect delay in diagnosis in patients with pulmonary tuberculosis (TB) is critical. This study aimed to identify such factors among TB patients in the north of Iran. METHODS In this retrospective cohort study, we reviewed patient’s medical records from the TB registration system of the Health Deputy of Mazandaran University of Medical Sciences, Sari, Iran that was responsible for the TB registry in the province from 2007 to 2017. All hospitals affiliated with the university, including private hospitals, reported TB cases directly to the health deputy. Patient’s gender, age, TB smear result, TB type, imprisonment, diabetes, nationality, residence area, and drug use were considered factors of delay in diagnosis, which was defined as a delay of >30 days between symptom onset and diagnosis. Data from 3,453 patients were analyzed using the chi-square test and logistic regression models. RESULTS The frequency of patients with delay in diagnosis was 67.7%. There was no association between delay in diagnosis and gender (p = 0.194), TB type (p = 0.140), and diabetes (p = 0.198). On the other hand, old age (≥60 years) was related to delay in diagnosis (OR = 1.37; 95% CI = 1.12–1.68; p = 0.002). The chance of delay in diagnosis in prisoners was lower than in non-prisoners (OR = 0.62; 95% CI = 0.46–0.82; p = 0.001). CONCLUSIONS Old age was a risk factor for delay in diagnosis, and interestingly, prisoners had been diagnosed significantly faster. Creator An entity primarily responsible for making the resource Mahmood Moosazadeh, Motahareh Kheradmand, Mohsen Aarabi, Mahdi Afshari, Mohammadreza Parsaee, Asghar Nezammahalleh, Amirhossein Hessami Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 delayed diagnosis Iran Jurnal Internasional tuberculosis https://repository.horizon.ac.id/files/original/8519bce95184db083f132d30c449af64.pdf f2946c6dc48e71122dc6d0ab823d7e02 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 A Prognostic Model of Excessive Lung Function Decline among Québec Apprentices: A cohort Exposed to Occupational Sensitizing Agents Subject The topic of the resource excessive decline, lung function, model, prognosis Description An account of the resource BACKGROUND Forced expiratory volume in 1 second (FEV1 ) decline as a predictor of lung-related health problems is widely observed, but not fully investigated. This study aimed to develop models to predict FEV1 decline among apprentices exposed to sensitizing agents. METHODS Of 692 apprentices recruited and followed in 3.6–17.3 years, 292 were exposed to low-molecular-weight agents. The analysis was restricted to 357 apprentices with complete lung function assessment at the end of their training with a minimum of 5-year follow-up. According to the American Thoracic Society guideline, a mean FEV₁ decline >60 ml/year was defined as “accelerated.” Descriptive statistics and Cox regression analysis were utilized to determine its predictors. To develop the prognostic models, we used a logistic regression analysis adjusted for the follow-up duration. The accuracy of the models was quantified using calibration and discrimination measures. RESULTS Of 357 subjects, 62 (17.4%) had an excessive FEV1 decline post-apprenticeship. The questionnaire model (model 1), which included male sex, wheezing, and exposure to isocyanate or animal allergens during the apprenticeship, showed a reasonable discriminative ability (area under the receiver operating characteristics curve [AUC] of 0.67, 95% CI = 0.59–0.75). Adding the percent-predicted FEV₁ value at the end of apprenticeship significantly increased the discriminative ability of the model (model 4) (AUC = 0.762, 95% CI = 0.694–0.829) with a good calibration and reasonable internal validity. CONCLUSIONS We developed a model for accelerated lung function decline with a good accuracy and internal validity. However, external validation of the model is necessary. Creator An entity primarily responsible for making the resource Alfi Afadiyanti Parfi, Mahsa Taghiakbari, Meshack Achore, Denyse Gautrin, Gleb Bezgin, Eva Suarthana Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Sri Wahyuni Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 excessive decline Jurnal Internasional lung function model prognosis https://repository.horizon.ac.id/files/original/a1d07c5a3912fb33ba28c1b80991660d.pdf 7c250d7dc76e7a81f717c54b162468c8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical Journal of Indonesia Vol. 30 No. 1 2021 FKUI Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 Validation of EuroSCORE II to Predict Mortality in Post-Cardiac Surgery Patients in East Java Tertiary Hospital Subject The topic of the resource cardiac surgery, mortality, prognosis, treatment outcome Description An account of the resource BACKGROUND The European system for cardiac operative risk evolution (EuroSCORE) II is one of the established risk models used to predict mortality after cardiac surgery. However, its application as a mortality predictor for Indonesian adult cardiac surgery is still unknown. This study aimed to examine the validation of EuroSCORE II in predicting mortality following cardiac surgery in Indonesian adults. METHODS This retrospective cohort study collected data from the medical records and the database of the Department of Thoracic Cardiac and Vascular Surgery at Soetomo General Hospital, Surabaya. Data on the EuroSCORE II variables were collected for patients aged >18 years who underwent coronary artery bypass, heart valve, heart tumors, aortic surgeries, or a combination of these surgeries between January 2016 and December 2018. In-hospital mortality prediction was calculated using the online calculator at www.euroscore.org. The calibration of the EuroSCORE II model was conducted using the Hosmer–Lemeshow test, and discrimination analysis was done using receiver operating characteristic (ROC) curves with area under the ROC curve (AUC) calculation. RESULTS A total of 213 patients met the inclusion criteria and were analyzed for this study. Mortality was 8.9%. The predicted and actual mortalities were 1.74% and 8.9%, respectively. The significance (p-value) of the Hosmer–Lemeshow test was 0.55, indicating good calibration. The AUC of ROC curve was 0.85 (95% CI = 0.77–0.92, p<0.001), suggesting good discrimination. CONCLUSIONS EuroSCORE II has a good calibration and discrimination for cardiac surgery in Indonesian adults. Creator An entity primarily responsible for making the resource Yan Efrata Sembiring, Adhitya Ginting, Puruhito, Budiono Publisher An entity responsible for making the resource available Fakultas Kedokteran Universitas Indonesia Date A point or period of time associated with an event in the lifecycle of the resource 2021-03-31 Contributor An entity responsible for making contributions to the resource Fakultas Kedokteran Universitas Indonesia Rights Information about rights held in and over the resource ISSN : 0853-1773 Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Text Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021 cardiac surgery Jurnal Internasional mortality prognosis treatment outcome