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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021&#13;
A Case Report of Acute Marchiafava-Bignami Disease: A Rare Clinical Entity in Chronic Alcoholism</text>
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                <text>alcoholics, case reports, corpus callosum, magnetic resonance imaging, Marchiafava-Bignami disease, Wernicke encephalopathy</text>
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                <text>Marchiafava‑Bignami disease (MBD) is a rare neurological disease often associated with a chronic consumption of alcohol and malnutrition, which is characterized by a demyelination and necrosis of the corpus callosum. We present a case of a 21-year�old male with chronic alcoholism who presented with an acute altered sensorium and seizure, which were initially treated as meningoencephalitis. His persistent poor Glasgow coma scale score and ideomotor recovery with encephalitic changes on his electroencephalogram prompted urgent magnetic resonance imaging (MRI) of his brain, which revealed extensive symmetrical hyperintensities in the corpus callosum.  The diagnosis of MBD was made because of the typical MRI findings and after the exclusion of other possible diagnosis. The patient was promptly treated with a parenteral thiamine and showed a good recovery at 3 months follow-up. This case &#13;
highlights the importance of diagnosing and recognizing MBD in a patient with chronic &#13;
alcoholism as prompt treatment could prevent irreversible damage, which could carry high morbidity.</text>
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                <text>Mohd Arif Abdul Malik Khiew, Abdul Hanif Khan Yusof Khan, Wei Chao Loh, Liyana Najwa Inche Mat, Peck Kee Chia, Wan Aliaa Wan Sulaiman, Fan Kee Hoo, Hamidon Basri </text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 2 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021&#13;
A Systematic Review of Intracavernosal Injection of Mesenchymal Stem Cells for Diabetic Erectile Dysfunction</text>
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                <text>diabetes mellitus, erectile dysfunction, mesenchymal stem cells</text>
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                <text>BACKGROUND As current erectile dysfunction (ED) treatments are limited, other treatment such as stem cells should be explored. Hence, this study aimed to review the sources, method of administration, and therapeutic effect of mesenchymal stem cells (MSCs) for diabetic ED treatment. &#13;
METHODS All relevant articles regarding the use of MSCs for diabetic ED were searched in PubMed and Google Scholar databases from December 15, 2019 to January 1, 2020 published in the past 10 years. The keywords were “mesenchymal stem cells” and &#13;
“diabetic ED”. The selection and critical appraisal of the studies were discussed. Diabetic ED was evaluated for functional and structural outcome. Functional outcome in animal studies was assessed by intracavernosal pressure/mean arterial pressure (ICP/MAP) ratio, meanwhile the structural outcome was done microscopically. In human study, the assessments were done using international index of erectile function score (IIEF-5) to erection hardness score and penile Doppler ultrasonography.&#13;
RESULTS There were 10 animal studies and 3 human studies. The studies used MSCs from adipose (n = 6), bone marrow (n = 4), placenta (n = 1), umbilical cord (n = 1), and muscle tissue (n = 1). The MSCs were administrated through intracavernosal injection in all studies. In all animal studies, functional outcome was improved, shown in higher ICP/MAP ratio. Microscopically, there were an increase of cavernosal endothelial cells, vascular endothelial growth factor, nitric oxide synthase, and smooth muscle cells. In human studies, IIEF-5 and erection hardness score were improved. Peak systolic velocity was also higher.&#13;
CONCLUSIONS MSCs may be a promising therapy for diabetic ED; however, long-term safety concerns still need further investigations.</text>
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                <text>Gampo Alam Irdam, Febriyani, Nur Rasyid, Akmal Taher</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="10234">
                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021</text>
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        <name>Diabetes Mellitus</name>
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      <tag tagId="29">
        <name>erectile dysfunction</name>
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      <tag tagId="25">
        <name>Jurnal Internasional</name>
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      <tag tagId="403">
        <name>mesenchymal stem cells</name>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 2 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021&#13;
Accuracy of Pediatric Advanced Life Support Method for Predicting The Depth of Endotracheal Tube in Indonesian Children</text>
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          <element elementId="49">
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                <text>endotracheal tube, pediatrics, resuscitation</text>
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                <text>BACKGROUND The pediatric advanced life support (PALS) method can predict the depth of endotracheal tube (ETT) in pediatric patients easily, but it has limitations due to variations in the children’s characteristics, especially the racial consideration. This study compared the accuracy of ETT depth prediction based on the PALS methods in &#13;
Indonesian children.&#13;
METHODS Patients aged 0–12 years, who underwent elective surgery with oral intubation, were recruited consecutively based on their ages: 0–24 months and 25 months–12 years for this cross-sectional study in Cipto Mangunkusumo Hospital, Jakarta, Indonesia from June to August 2014. Bland–Altman analysis was used to compare the two measurement methods: PALS method to predict the ETT depth accuracy and auscultation method to confirm the position of the ETT. Furthermore, correlation analysis was done to examine the relationship of age, weight, height, and &#13;
ETT internal diameter with ETT depth.&#13;
RESULTS 50 patients were recruited in each group. Bland–Altman test of ETT depth in the 0–24 months age group showed a 1.18 cm mean difference from confirmation using the auscultation method (limits of agreement −0.71 to 3.08). The 25 months–12 years age group showed a 1.11 cm mean difference with limits of agreement were −0.95 to 3.17 from confirmation using the auscultation method. Age and weight had the strongest correlation value to ETT depth in the 25 months–12 years age group (R2&#13;
 = 62.3%).&#13;
CONCLUSIONS The PALS method is inaccurate for predicting ETT depth in Indonesian children aged 0–12 years old compared with the auscultation method.</text>
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                <text>Andi Ade Wijaya Ramlan, Adhrie Sugiharto, Agus Mutakim</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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Analysis of SARS-CoV-2 Nucleocapsid Protein Sequence Variations in ASEAN Countries</text>
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                <text>BACKGROUND Nucleocapsid (N) protein is one of four structural proteins of SARS-CoV-2 which is known to be more conserved than spike protein and is highly immunogenic. This study aimed to analyze the variation of the SARS-CoV-2 N protein sequences in ASEAN countries, including Indonesia.&#13;
METHODS Complete sequences of SARS-CoV-2 N protein from each ASEAN country were obtained from Global Initiative on Sharing All Influenza Data (GISAID), while the reference sequence was obtained from GenBank. All sequences collected from December 2019 to March 2021 were grouped to the clade according to GISAID, and two &#13;
representative isolates were chosen from each clade for the analysis. The sequences were aligned by MUSCLE, and phylogenetic trees were built using MEGA-X software based on the nucleotide and translated AA sequences.&#13;
RESULTS 98 isolates of complete N protein genes from ASEAN countries were analyzed. The nucleotides of all isolates were 97.5% conserved. Of 31 nucleotide changes, 22 led to amino acid (AA) substitutions; thus, the AA sequences were 94.5% conserved. The phylogenetic tree of nucleotide and AA sequences shows similar branches. Nucleotide &#13;
variations in clade O (C28311T); clade GR (28881–28883 GGG&gt;AAC); and clade GRY (28881–28883 GGG&gt;AAC and C28977T) lead to specific branches corresponding to the clade within both trees.&#13;
CONCLUSIONS The N protein sequences of SARS-CoV-2 across ASEAN countries are highly conserved. Most isolates were closely related to the reference sequence originating from China, except the isolates representing clade O, GR, and GRY which formed specific branches in the phylogenetic tree.</text>
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                <text>Sri Wahyuni</text>
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Cover, Editorial Board, Contents, Instructions for Authors, Final Checklist &amp; Submission Form</text>
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                <text>Sri Wahyuni</text>
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Delivery Routes in Pregnancy with COVID-19 and The Risk of Intrapartum Vertical Transmission: A Meta-Analysis</text>
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              <elementText elementTextId="10261">
                <text> COVID-19, delivery, meta-analysis, pregnancy, vertical transmission</text>
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                <text>BACKGROUND Mode of delivery has become an important highlight in managing pregnancy with coronavirus disease 2019 (COVID-19) due to the possible risk of viral transmission from mother to baby, especially during the peripartum period. This study aimed to review the mode of delivery and the possible risk of vertical transmission related to delivery routes in pregnant women with COVID-19.&#13;
METHODS Literature research was conducted using PubMed, Scopus, Embase, and EBSCO database with the following keywords: SARS-CoV-2, COVID-19, pregnancy, vertical transmission, and delivery. The extracted data were as follows: author, country, study design number of cases, maternal age, mode of delivery, and the SARS-CoV-2 status in neonates.&#13;
RESULTS Of 11 studies found, vaginal birth was reported in 218 cases (34.53%) and cesarean delivery was reported in 385 women (65.47%). The indication for cesarean delivery was majority due to COVID-19 related condition (53.61%). In total, 8 neonates who confirmed positive for COVID-19 by real-time polymerase chain reaction assay were reported. The pooled odds ratio (95% confidence interval) for SARS-CoV-2-positive neonates in cesarean delivery compared with vaginal birth was 0.622 (0.237–1.633) with p = 0.335.&#13;
CONCLUSIONS Cesarean delivery is more common than vaginal delivery in patient with SARS-CoV-2 infection. Any delivery route is not related to possible risk of intrapartum vertical transmission, and cesarean delivery should be carried out based on the obstetric indication.</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021&#13;
Efficacy and Safety of Platinum Chain and Gold Weight Implants for Paralytic  Lagophthalmos: A Systematic Review</text>
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              <elementText elementTextId="10249">
                <text>paralytic lagophthalmus, prostheses and implants, surgical technique</text>
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                <text>BACKGROUND Surgery has been proposed as a treatment of paralytic lagophthalmos. However, no consensus has been reached on the best treatment. This study was aimed to investigate the efficacy and safety between platinum chain and gold weight implants to treat paralytic lagophthalmos.&#13;
METHODS This study used all randomized controlled trials or observational studies &#13;
(prospective or retrospective) using platinum chain and gold weight implants for paralytic lagophthalmos surgery that were published from 1990 to 2020 in the PubMed, Cochrane, and Google Scholar databases. Efficacy was indicated by the reduction of ≥3 in lagophthalmos, and safety was measured based on complications after surgery.&#13;
RESULTS The efficacy of platinum chain and gold weight implants were 60–100% and 10–93.6%, respectively. The complications of platinum chain implant were 0–2.9% of extrusion and 0–3.3% of migration. However, gold weight implant had 0–13.3% of migration.&#13;
CONCLUSIONS Both platinum chain and gold weight implants have similar efficacy to treat paralytic lagophthalmos. However, gold weight implant has a higher rate of complication.</text>
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                <text>Yunia Irawati, Tjahjono Darminto Gondhowiardjo, Hardyanto Soebono</text>
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                <text>Sri Wahyuni</text>
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Gastrointestinal Disorders in COVID-19 Patients: A Great Imitator</text>
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                <text>Up to this point, the coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Some studies with a large number of cases have reported its clinical manifestations, concluding that the disease is a great imitator. Patients may present with symptoms other than the main symptoms of respiratory tract infections, such as diarrhea, &#13;
abdominal pain, nausea, or vomiting, which may sometimes cause a delayed treatment in managing COVID-19 patients. Reports of various hospitals have also demonstrated gastrointestinal complaints as a clinical manifestation in those patients. The patients may come with gastrointestinal symptoms as their early clinical manifestation, or the &#13;
gastrointestinal symptoms may be found in hospitalized COVID-19 patients, which indeed can be explained since the SARS-CoV-2, an etiologic agent of COVID-19 infection, can obviously be found along the gastrointestinal tract. Hence, the virus can be found in fecal and anal, and therefore, rectal swabs can be used as a diagnostic tool for &#13;
COVID-19 infection.</text>
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                <text>Ari Fahrial Syam</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021</text>
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High Visibility of Outdoor Tobacco Advertisements around Health Facilities in East Java, Indonesia: A Geospatial Analysis</text>
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                <text>BACKGROUND Indonesian tobacco control initiatives are minimal despite having the second-highest adult male smoking prevalence in the world, with less than 10% of districts/cities banning outdoor tobacco advertisements. This research aimed to provide evidence on the presence of outdoor tobacco advertisements near health &#13;
facilities in Surabaya where there is no outdoor advertising ban.&#13;
METHODS Data collection was carried out in Surabaya from October to November 2018. Data of government (public) and private health facilities were obtained from the city health office. Two spatial data analyses were carried out: a buffer analysis near the healthcare facilities and an advertisement hotspot analysis using ArcMap 10.6.&#13;
RESULTS From 308 tobacco advertisements that were identified, there were billboards (63%), banners (31%), and videoboards (7%). Of 142 public and 1,242 private health facilities in Surabaya, 26% and 31% had advertisements within 300 m and 63% and 70% were within advertisement hotspots, respectively. Furthermore, 5% of advertisements &#13;
were within 300 m from public health facilities and 21% of them were within 300 m from private health facilities.&#13;
CONCLUSIONS Outdoor tobacco advertisements were widespread throughout the city, prominently around public and private health facilities.</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 2 2021</text>
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