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                  <text>Medical Journal of Indonesia Vol. 30 No. 3 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021&#13;
Effect of Hyperglycemia on Fertility in Streptozotocin-Induced Diabetic Male Wistar Rats: Focus on Glucose Transporters and Oxidative Stress </text>
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                <text> GLUT1, GLUT3, glutathione peroxidase, infertility, MCT4, Nrf2</text>
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                <text>BACKGROUND Glucose transporters (GLUTs) and oxidant metabolism are associated with the mechanism of infertility. This study evaluated the impact of hyperglycemia on glucose and oxidant metabolisms of Sertoli cells (SCs). &#13;
METHODS This study was an animal study to investigate the expression of messenger RNA monocarboxylate transporter 4 (MCT4), GLUT1, GLUT3, nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione peroxidase, catalase (CAT), and lactate dehydrogenase A (LDHA) of Wistar rats testes that were induced hyperglycemia. Reverse transcription polymerase chain reaction analysis was used. Hyperglycemic state in the Wistar rats was induced by streptozotocin. 24 rats were divided into 3 groups: non-hyperglycemia (control), 2-week, and 4-week hyperglycemic state. All data were collected and analyzed using SPSS version 15.0 (IBM Corp., USA). &#13;
RESULTS The expression of glucose transporter (GLUT1 and GLUT3), lactate transporter (MCT4), and cellular defense protein against oxidant (Nrf2 and CAT) was significantly increased in the 2-week and 4-week hyperglycemic state groups with &#13;
p&lt;0.01, respectively.&#13;
CONCLUSIONS Hyperglycemic state affects the metabolism of SCs. Alteration of GLUTs and oxidative metabolism may indicate metabolic alterations by a prolonged exposure to hyperglycemia that may be responsible for diabetes-related male infertility.</text>
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                <text>Sakti Ronggowardhana Brodjonegoro, Tanaya Ghinorawa, Nickanor Kaladius Reumy Wonatorey, Andy Zulfiqqar, Didik  Setyo Heriyanto</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>2021-10-12</text>
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                <text>Sri Wahyuni</text>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 3 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021&#13;
A Case Report of Moyamoya Disease in Children Treated with Encephalo-Duro-Myo-Arterio-Pericranial Synangiosis</text>
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                <text>encephalo-duro-myo-arterio-pericranial synangiosis, moyamoya disease, stroke, surgery, transient ischemic attack</text>
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                <text>Moyamoya disease that manifests during childhood may pose a special challenge for surgeons. We report a case of a 10-year-old girl who suffered from moyamoya disease and was successfully treated with encephalo-duro-myo-arterio-pericranial synangiosis (EDMAPS). She presented with a recurrent transient ischemic attack that worsened for 1 year. She was aphasic globally (sensory and motor) and had slightly weak right &#13;
extremities. Her magnetic resonance angiography and computed tomography angiography showed the typical features of moyamoya disease with bilateral stenosis at the terminal internal carotid artery, bilaterally abnormal vascular networks, and a left ischemic event involving the temporoparietal region. She was recovered well after underwent bilateral EDMAPS, fully regained her language function after 3 months, and gathered her strength back. Therefore, EDMAPS could be a good, safe, and effective treatment for moyamoya disease in children.</text>
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                <text>Julius July</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021</text>
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                  <text>Medical Journal of Indonesia Vol. 30 No. 3 2021 FKUI</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021&#13;
Safety of Augmentation Cystoplasty in Patients with Bladder Abnormalities Undergoing Renal Transplantation: A systematic Review </text>
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                <text>cystoplasty, efficacy, renal transplantation, safety</text>
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                <text>BACKGROUND Augmentation cystoplasty (AC) has been recently proposed to improve a bladder condition before or after a renal transplantation for an optimal allograft function. Until now, AC in adults with end-stage renal disease (ESRD) is uncommon &#13;
and rarely practiced. This study aimed to investigate the safety of AC in patients with bladder abnormalities who required renal transplantation.&#13;
METHODS Studies of patients with ESRD and abnormal bladder who underwent AC were searched in ProQuest, PubMed, EBSCO, and Cochrane Library online databases. Only studies published in English from January 1985 to May 2020 were included. The keywords used were renal transplantation, bladder dysfunction, cystoplasty, and their synonyms. Data were extracted by two independent authors who selected, screened, &#13;
and assessed the articles’ eligibility and quality. The outcomes were graft survival rate and complications of AC.&#13;
RESULTS A total of 19 articles were included. AC improved an intravesical pressure, a bladder capacity, and a compliance in patients with ESRD and bladder abnormalities, allowing patients to undergo the renal transplantation. Even though AC in patients with renal transplantation resulted in a significantly higher urinary tract infection rate than patients who underwent renal transplantation only, performing AC after renal transplantation was considered safe.&#13;
CONCLUSIONS AC was considered safe for patients with bladder abnormalities who underwent renal transplantation.</text>
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                <text>Bobby Sutojo, Gampo Alam Irdam</text>
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                <text>Fakultas Kedokteran Universitas Indonesia</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>ISSN : 0853-1773</text>
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                <text>Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 3 2021</text>
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