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                <text>Perbandingan Kadar Flavonoid dan Aktivitas Antioksidan pada Kulit Bawang Merah (Allium ascalonicum) dan Kulit Bawang Bombay (Allium cepa)</text>
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                <text>aktivitas antioksidan; DPPH; kulit bawang bombay; kulit bawang merah; total flavonoid</text>
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                <text>Abstrak. Pemanfaatan sumber daya alam, khususnya dari limbah pertanian, memiliki potensi besar dalam &#13;
pengembangan produk fungsional karena limbah tersebut masih mengandung senyawa bioaktif yang bermanfaat.&#13;
Bawang dikenal kaya akan kandungan fitokimia dan aktivitas antioksidan yang tinggi, dan kulit bawang diketahui &#13;
mengandung kandungan fitokimia yang lebih tinggi dibandingkan dengan bagian umbi bawang. Hal ini &#13;
menyebabkan kulit bawang sangat berpotensi untuk dimanfaatkan sebagai bahan fungsional. Penelitian ini &#13;
bertujuan untuk menetapkan dan mengetahui kadar flavonoid dan aktivitas antioksidan dari kulit bawang merah &#13;
(Allium ascalonicum) dan kulit bawang bombay (Allium cepa). Penetapan kadar flavonoid dilakukan dengan &#13;
menggunakan spektrofotometri UV-Vis metode kolorimetri, dan penetapan aktivitas antioksidan menggunakan &#13;
microplate reader metode DPPH (2,2-difenil-1-pikrihidrazil). Penetapan aktivitas antioksidan sampel kulit &#13;
bawang dilihat dari hasil uji secara kualitatif yang dinyatakan dalam nilai IC50 atau inhibition concentration. &#13;
Berdasarkan hasil data penelitian, kulit bawang merah (Allium ascalonicum) memiliki rata-rata kandungan &#13;
flavonoid sebesar 176,2472 mgQE/g dengan nilai IC50 sebesar 54,8949 ppm, dan kulit bawang bombay (Allium cepa) memiliki rata-rata kandungan flavonoid sebesar 207,5205 mgQE/g dengan nilai IC50 sebesar 46,2653 ppm.</text>
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                <text>Maria Putri Kirana, Restry Sinansari, Diana, Maria Anabella Jessica</text>
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                <text>DOI: https://doi.org/10.61132/prosemnasikk.v2i2.81</text>
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                <text>Asosiasi Riset Ilmu Kesehatan Indonesia</text>
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                <text>Desember 2025</text>
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                <text>Sri Wahyuni</text>
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                <text>e-ISSN: 3063-5284; p-ISSN: 3063-5306</text>
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                  <text>Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan Vol. 2 No. 2 2025</text>
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                <text>Eksplorasi Senyawa Daun Kitolod (Isotoma longiflora) sebagai Agen Potensial untuk Kanker Prostat: Studi Farmakoinformatika</text>
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                <text>Isotoma longiflora, kanker prostat, farmakoinformatika, protein target, molecular docking</text>
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                <text>Abstrak. Kanker prostat merupakan salah satu kanker yang paling banyak terjadi pada pria dan banyak dikaitkan &#13;
dengan disfungsi regulasi androgen, proliferasi sel, serta proses inflamasi. Isotoma longiflora diketahui &#13;
mengandung senyawa bioaktif, namun keterlibatannya dalam mekanisme molekuler kanker prostat belum &#13;
sepenuhnya dipahami. Penelitian ini bertujuan mengidentifikasi protein target senyawa Isotoma longiflora yang &#13;
berhubungan dengan kanker prostat serta memprediksi jalur molekuler yang terlibat. Metode yang digunakan &#13;
meliputi integrasi data target protein dari GeneCards, analisis Venn, pemetaan jaringan interaksi protein (PPI), &#13;
klasterisasi, analisis Gene Ontology dan KEGG, serta molecular docking terhadap protein kunci. Hasil penelitian &#13;
menunjukkan terdapat 21 protein tumpang tindih yang berpotensi menjadi target Isotoma longiflora, dengan &#13;
ESR1, CDK2, dan CASP9 sebagai protein hub utama. Enrichment pathway mengungkap keterlibatan jalur &#13;
androgen receptor, MAPK, PI3K–Akt, p53, serta metabolisme steroid yang relevan dengan progresi kanker &#13;
prostat. Molecular docking menunjukkan senyawa seperti Peonidin 3-(6’’-acetyl)glucoside, lobellin, dan (-)-&#13;
Gallocatechin-3-O-gallate memiliki afinitas ikatan kuat terhadap ESR1, CDK2, dan CASP9. Temuan ini &#13;
mengimplikasikan bahwa Isotoma longiflora berpotensi sebagai kandidat sumber senyawa antikanker prostat melalui modulasi multi-target jalur proliferasi, apoptosis, dan inflamasi.</text>
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                <text>Muthia Nurhidayah</text>
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              <elementText elementTextId="131165">
                <text>DOI: https://doi.org/10.61132/prosemnasikk.v2i2.82</text>
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                <text>Asosiasi Riset Ilmu Kesehatan Indonesia</text>
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                <text>Desember 2025</text>
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                <text>Sri Wahyuni</text>
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="131169">
                <text>e-ISSN: 3063-5284; p-ISSN: 3063-5306</text>
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        <name>Isotoma longiflora</name>
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                  <text>Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan Vol. 2 No. 2 2025</text>
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                  <text>Sri Wahyuni</text>
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                <text>Rekayasa Nanoselulosa Bakteri sebagai Platform Nano-Biomaterial untuk Terapi Obat dan Antimikroba: Perspektif Pengobatan Modern</text>
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                <text>selulosa nano bakteri; komposit nano antibakteri; pengiriman obat; aktivitas antibiofilm; resistensi &#13;
antimikroba</text>
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            <description>An account of the resource</description>
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                <text>Abstrak. Resistensi antimikroba (AMR) terus meningkat secara global dan menurunkan efektivitas terapi &#13;
konvensional, sehingga diperlukan platform biomaterial inovatif untuk meningkatkan kinerja antimikroba. &#13;
Bacterial nanocellulose (BNC) muncul sebagai kandidat unggul berkat struktur nanofibril berpori, kemurnian &#13;
tinggi, dan biokompatibilitas superior. BNC memiliki kapasitas muatan besar, stabilitas mekanik baik, dan &#13;
kemampuan pelepasan terkontrol, menjadikannya matriks ideal untuk penghantaran obat maupun imobilisasi &#13;
nanopartikel. Modifikasi BNC dengan AgNP, ZnO, CuO, antibiotik, serta senyawa bioaktif seperti quercetin, &#13;
kurkumin, dan enzim lytik telah menunjukkan peningkatan signifikan terhadap aktivitas antibakteri dan &#13;
antibiofilm. Studi in vitro melaporkan zona hambat luas, reduksi biofilm hingga 95%, dan peningkatan efektivitas &#13;
obat melalui mekanisme pelepasan terkontrol dan interaksi ROS. Uji in vivo pada model luka menunjukkan &#13;
percepatan penyembuhan, penurunan beban bakteri hingga 4 log CFU, serta regenerasi jaringan yang lebih baik. &#13;
Meskipun demikian, data toksisitas jangka panjang, penetrasi biofilm multispecies, dan standardisasi protokol &#13;
masih terbatas. Sintesis literatur menegaskan bahwa BNC merupakan platform nanobiomaterial multifungsi yang &#13;
menjanjikan untuk terapi infeksi modern, namun translasi klinis membutuhkan validasi in vivo komprehensif dan harmonisasi metodologis.</text>
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                <text>Zakia Asrifah Ramly</text>
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