10 10 198 https://repository.horizon.ac.id/files/original/f32929f7ca4333394483ca36894a781d.pdf 4d131320debf68cf79d963c081976d76 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Utility of pelvic examination in assessing women with bleeding in early pregnancy: a multicenter Canadian emergency department study Subject The topic of the resource Pelvic examination, Emergency department, Pregnancy, Management, Miscarriage, Bleeding in early pregnancy, Diagnostic utility Description An account of the resource Abstract Background Bleeding in early pregnancy is a common emergency department (ED) presentation. Although variability in approaches has been demonstrated, research is relatively uncommon on practices and outcomes. This study investigated the influence of clinical pattern of care, utility, and contribution of pelvic examination aimed at diagnosing and managing bleeding in early pregnancy at three Canadian EDs. Methods After obtaining informed consent, data were collected from adult women who were pregnant and from treating ED physicians using a structured questionnaire. We defined the change in management based on the initial clinical plan at the time of the initial physician assessment in the ED and any subsequent changes made after the pelvic examination was performed. Patient telephone follow-up was supplemented by linking with provincial administrative data for births. Univariable and multivariable binary logistic regression analyses were performed to identify factors associated with a change in patient management following pelvic examination in the ED. Results Overall, 200 women were enrolled. The mean age was 31 years, patients had been bleeding for a median of 1 day and stayed in the ED for a median of 5 h. Of these, 166 (83.0%) received a pelvic examination, including speculum examination and/or bimanual palpation. Pregnancy outcome data were available for 192 pregnancies; 107 (56%) experienced a miscarriage. Factors significantly associated with a change in management after pelvic examination in the univariate logistic regression analysis were brown/dark-red bleeding per vaginam (physician determined), tachycardia, right lower quadrant tenderness, and bimanual palpation. In the multivariate logistic regression analysis, brown/dark-red bleeding per vaginam was independently associated with a reduced likelihood of a change in management after pelvic examination (aOR=0.37; 95% CI: 0.14–0.98). Conclusion Among women presenting to the ED with bleeding in early pregnancy prior to 20 weeks gestation, only brown/dark-red vaginal bleeding, potentially indicative of bleeding resolution, significantly independently influenced the baseline odds of a change in management after pelvic examination. Until the debate on the utility of pelvic examination in the ED for this presentation is resolved, physician preferences and shared decision making Creator An entity primarily responsible for making the resource Steven Fisher1 , Stephanie Couperthwaite1 , Esther H. Yang1,2, Nana Owusu Mensah Essel1 and Brian H. Rowe1,3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00686-2 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text https://repository.horizon.ac.id/files/original/128462c0c261802871762fb629c5200c.pdf 91fc0282e380f8e8ad1bfc79f15868de Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Extended reality training for mass casualty incidents: a systematic review on effectiveness and experience of medical first responders Subject The topic of the resource Disaster preparedness, Emergency medicine education, Disaster training, Extended reality Description An account of the resource Abstract Introduction Mass casualty incidents (MCI) are unforeseeable and complex events that occur worldwide, therefore enhancing the training that medical first responders (MFRs) receive is fundamental to strengthening disaster preparedness and response. In recent years, extended reality (XR) technology has been introduced as a new approach and promising teaching technique for disaster medicine education. Objective To assess the effectiveness of XR simulation as a tool to train MFRs in MCIs, and to explore the perception and experience of participants to these new forms of training. Design Systematic review. Methods This systematic review was conducted in accordance with the “Preferred reporting items for systematic reviews and meta-analyses” (PRISMA) statement. Four databases were searched (MEDLINE, EMBASE, CINAHL and LILACs) using a comprehensive search strategy to identify relevant articles, and MetaQAT was used as a study quality assessment tool. Data from included studies was not pooled for meta-analysis due to heterogeneity. Extracted data was synthesised in a narrative, semi-quantitative manner. Results A total of 18 studies were included from 8 different countries. Studies encompassed a variety of participants (e.g., nurses, paramedics, physicians), interventions (virtual, mixed and augmented reality), comparators (comparison between two groups and single groups with pre-post evaluation), and outcomes (effectiveness and MFR perception). The synthesis of data indicated that XR was an effective tool for prehospital MCI training by means of improved triage accuracy, triage time, treatment accuracy, performance correctness and/or knowledge acquired. These XR systems were well perceived by MFRs, who expressed their interest and satisfaction towards this learning experience and emphasized its usefulness and relevance. Conclusion This research supports the usefulness and significance of XR technology that allows users to enhance their skills and confidence when facing forthcoming disasters. The findings summarize recommendations and suggestions for the implementation, upgrade and/or assessment of this novel and valuable teaching method. Keywords Disaster preparedness, Emergency medicine education, Disaster training, Extended reality Creator An entity primarily responsible for making the resource María del Carmen Cardós-Alonso1,2* , Lucía Otero-Varela3,4 , María Redondo1 , Miriam Uzuriaga1 , Myriam González1 , Tatiana Vazquez1 , Alberto Blanco1 , Salvador Espinosa1 and Ana María Cintora-Sanz1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00685-3 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Disaster preparedness, Emergency medicine education, Disaster training, Extended reality https://repository.horizon.ac.id/files/original/c60fc5ac1ea65a85e6c05b8d50112d2b.pdf 40d4841fe5ba4e54188e72a86780bf2d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnostic laparoscopy with indocyanine green fluorescence test for the evaluation of intestinal perfusion in abdominal blunt injury: a case report Subject The topic of the resource Indocyanine green (ICG) fluorescence test, Intestinal blood perfusion, Mesenteric hematoma, Abdominal blunt injury Description An account of the resource Abstract Background The indocyanine green (ICG) fluorescence test has become a standard test in surgical procedures, facilitating the assessment of blood perfusion in real-time. While its utility in emergency surgeries for evaluating anastomotic blood supply is well-established, its application in trauma cases, especially those involving mesenteric hematoma, remains underexplored. Herein, we present a case to illustrate the efficacy of the ICG fluorescence test in such scenarios. Case presentation A 51-year-old man with uncontrolled hypertension suffered blunt abdominal trauma following a motor vehicle accident. We used the intra-operative ICG fluorescence test to chart the surgical plan for the patient. A combination of diagnostic laparoscopy with ICG fluorescence testing effectively excluded bowel ischemia, leading to the avoidance of intestinal resection and the need for a temporary ostomy. The patient resumed enteral nutrition. Conclusions Our case underscores the efficacy of ICG fluorescence testing in assessing bowel viability and guiding surgical strategies in trauma patients with mesenteric hematoma. By facilitating real-time visualization of blood perfusion, ICG testing enables the adoption of conservative treatments in patients who would traditionally require more invasive surgical interventions, with minimal effect on operation time and cost. Keywords Indocyanine green (ICG) fluorescence test, Intestinal blood perfusion, Mesenteric hematoma, Abdominal blunt injury Creator An entity primarily responsible for making the resource Ze-Rui Li1 , Yi-Chiao Cheng2 and Zhi-Jie Hong3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00684-4 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Indocyanine green (ICG) fluorescence test, Intestinal blood perfusion https://repository.horizon.ac.id/files/original/660a16a1e2271c908394d99932c867e1.pdf a80e1cacf80a3a2f3a904709976fbe8a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Safety of adenosine for pediatric tachyarrhythmia treatment in the emergency department: a multi-hospital 10-year cross- sectional study Subject The topic of the resource Adenosine, Supraventricular tachycardia, Tachydysrhythmia, Arrhythmia Description An account of the resource Abstract Background Supraventricular tachycardia is the most common dysrhythmia in children. Initial vagal maneuvers are successful less than half of the time. Adenosine, a potent AV nodal blocker with a short half-life, is recommended as first line pharmacotherapy. Minor side effects from adenosine are common, but report of serious side effects such as sustained ventricular tachycardia, torsades de pointes, syncope or hypotension are confined to small case series or studies greater than 20 years old. We aimed to specifically identify the incidence of serious side effects of adenosine in children in the emergency department. Methods Between 2002 and 2022, all children less than 18 years old who received adenosine for tachyarrhythmia treatment in two emergency departments were included. The electronic record was reviewed for demographic information, patient history, treatments given, and side effects or complications were observed. Electrocardiograms before, during and after adenosine administration were reviewed. Results 77 patients met inclusion criteria. There were 74 patients with an initial rhythm of typical SVT. The other three patients included one with a junctional rhythm, one with atrial fibrillation, and one with an undetermined narrow complex tachycardia. 49 patients had cardiac rhythm monitoring during adenosine administration. 17 of these patients had three or more consecutive ventricular beats following adenosine, however no patients required treatment. No patients had syncope. One patient had brief hypotension after adenosine that normalized without intervention. Four patients were electrically cardioverted after adenosine, all for persistent dysrhythmias: two for persistent SVT with hypotension, one for atrial fibrillation and one for an undetermined rhythm. Twelve patients were placed on continuous antiarrhythmic medication for persistent SVT. Age, gender, prior SVT history, initial adenosine dose, and need for additional doses were not significant risk factors for a prolonged sinus pause or greater than two ventricular beats. Conclusions Adenosine treatment in typical supraventricular tachycardia in pediatric patients is safe. Keywords Adenosine, Supraventricular tachycardia, Tachydysrhythmia, Arrhythmia Creator An entity primarily responsible for making the resource Melanie M. Randall1*, Tristen Burt2 , Scott Cruise2 , Michael K. Mesisca2 and Thomas Minahan2 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00683-5 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text https://repository.horizon.ac.id/files/original/68baeef94ada7d5a8436a67e1ca90641.pdf 4acf4c7e929b52ef091a43b96d9a81ae Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource U‐shaped correlation of lymphocyte count with all‐cause hospital mortality in sepsis and septic shock patients: a MIMIC‐IV and eICU‐CRD database study Subject The topic of the resource Sepsis, Lymphocyte counts, Prediction, Restricted cubic spline, Intensive care unit Description An account of the resource Abstract Background In sepsis, the relationship between lymphocyte counts and patient outcomes is complex. Lymphocyto- penia and lymphocytosis significantly influence survival, illustrating the dual functionality of lymphocytes in respond- ing to infections. This study investigates this complex interaction, focusing on how variations in lymphocyte counts correlate with all-cause hospital mortality among sepsis patients. Methods This retrospective cohort study analyzed data from two extensive critical care databases: the Medical Infor- mation Mart for Intensive Care IV 2.0 (MIMIC-IV 2.0) from Beth Israel Deaconess Medical Center, Boston, Massachusetts, and the eICU Collaborative Research Database (eICU-CRD), which was Multi-center database from over 200 hospitals across the United States conducted by Philips eICU Research Institute. We included adult patients aged 18 years and older who met the Sepsis-3 criteria, characterized by documented or suspected infection and a Sequential Organ Failure Assessment (SOFA) score of 2 or higher. Sepsis patients were categorized into quartiles based on lym- phocyte counts. The primary outcome was all-cause mortality in the hospital, with 90 and 60-day all-cause mortality as the secondary outcomes. Univariable and multivariable Cox proportional hazard regressions were utilized to assess lymphocyte counts’ impact on hospital mortality. An adjusted restricted cubic spline (RCS) analysis was performed to elucidate this relationship further. Subgroup analyses were also conducted to explore the association across various comorbidity groups among sepsis and septic shock patients. Results Our study included 37,054 patients, with an observed in-hospital mortality rate of 16.6%. Univariable and multivariable Cox proportional hazard regression models showed that lymphocyte counts were indepen- dently associated with in-hospital mortality (HR=1.04, P<0.01; HR=1.06, P<0.01). RCS regression analysis revealed a U-shaped relationship between lymphocyte levels and hospital mortality risk in sepsis and septic shock patients (P for overall<0.001, P for nonliner<0.01; P for overall=0.002, P for nonliner=0.014). Subgroup analyses revealed that elevated lymphocyte counts correlated with increased hospital mortality among sepsis patients with liver disease and requiring renal replacement therapy (P for overall=0.021, P for nonliner=0.158; P for overall=0.025, P for non- liner=0.759). These findings suggest that lymphocytes may have enhanced prognostic value in specific subsets of critically ill sepsis patients. Creator An entity primarily responsible for making the resource Guyu Zhang1 , Tao Wang1 , Le An1 , ChenChen Hang1 , XingSheng Wang1 , Fei Shao1 , Rui Shao1 and Ziren Tang1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00682-6 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Sepsis, Lymphocyte counts, Prediction, Restricted cubic spline, Intensive care unit https://repository.horizon.ac.id/files/original/1d5657c10f87cfd4c455e8edf6786ab2.pdf e829624e8e5d943720c65246914a23a3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of decision tree classification algorithms in predicting mortality of COVID‐19 patients Subject The topic of the resource Decision tree, CART, C5.0, CHAID, Logistic regression, COVID-19 mortality, Predictive factors Description An account of the resource Abstract Introduction The accurate prediction of COVID-19 mortality risk, considering influencing factors, is crucial in guiding effective public policies to alleviate the strain on the healthcare system. As such, this study aimed to assess the effi- cacy of decision tree algorithms (CART, C5.0, and CHAID) in predicting COVID-19 mortality risk and compare their performance with that of the logistic model. Methods This retrospective cohort study examined 5080 cases of COVID-19 in Babol, a city in northern Iran, who tested positive for the virus via PCR from March 2020 to March 2022. In order to check the validity of the findings, the data was randomly divided into an 80% training set and a 20% testing set. The prediction models, such as Logistic regression models and decision tree algorithms, were trained on the 80% training data and tested on the 20% testing data. The accuracy of these methods for the test samples was assessed using measures like ROC curve, sensitivity, specificity, and AUC. Results The findings revealed that the mortality rate for COVID-19 patients who were admitted to hospitals was 7.7%. Through cross validation, it was determined that the CHAID algorithm outperformed other decision tree and logistic regression algorithms in specificity, and precision but not sensitivity in predicting the risk of COVID-19 mortality. The CHAID algorithm demonstrated a specificity, precision, accuracy, and F-score of 0.98, 0.70, 0.95, and 0.52 respectively. All models indicated that factors such as ICU hospitalization, intubation, age, kidney disease, BUN, CRP, WBC, NLR, O2 sat, and hemoglobin were among the factors that influenced the mortality rate of COVID-19 patients. Conclusions The CART and C5.0 models had outperformed in sensitivity but CHAID demonstrates a better perfor- mance compared to other decision tree algorithms in specificity, precision, accuracy and shows a slight improvement over the logistic regression method in predicting the risk of COVID-19 mortality in the population under study. Keywords Decision tree, CART, C5.0, CHAID, Logistic regression, COVID-19 mortality, Predictive factors Creator An entity primarily responsible for making the resource Zahra Mohammadi‐Pirouz1 , Karimollah Hajian‐Tilaki2,3*, Mahmoud Sadeghi Haddat‐Zavareh4 , Abazar Amoozadeh3 and Shabnam Bahrami1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00681-7 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Decision tree, CART, C5.0, CHAID, Logistic regression, COVID-19 mortality, Predictive factors https://repository.horizon.ac.id/files/original/010973d13506c6eff86404010d2f5e56.pdf f6be5b4e51d43a1afdd62412d0e6fd58 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Incidence, characteristics, and prehospital outcomes of out-of-hospital cardiac arrest in Qatar: a nationwide gender-based investigation Subject The topic of the resource OHCA, Incidence, Gender, ROSC, Qatar, Middle East Description An account of the resource Abstract Background Research on incidence and characteristics of Out-of-Hospital Cardiac Arrest (OHCA) in the Middle East is limited. We assessed the incidence, prehospital characteristics, and outcomes of OHCA in Qatar, a Middle Eastern country. Subsequently, we performed gender-specific analysis. Methods This was a retrospective examination of data obtained from the OHCA registry at Hamad Medical Corporation (HMC) in Qatar from 2017 to 2022. We included adults, non-traumatic, EMS-treatment OHCA. We calculated the incidence of adult OHCA and conducted descriptive analyses for prehospital characteristics, and prehospital outcomes presented by return of spontaneous circulation (ROSC). We evaluated gender differences in prehospital characteristics and ROSC using Student’s t-test and the Chi-Square test as appropriate. Furthermore, we conducted a multivariable logistic regression analysis to investigate the correlation between gender and achieving ROSC. Results We included 4,306 adult OHCA patients, with 869 (20.2%) being females. The mean annual incidence of adult OHCA was 27.4 per 100,000 population-year. Males had a higher annual incidence of OHCA than females. Among all cases, 36.3% occurred in a public location, 25.8% had an initial shockable rhythm, and 28.8% achieved ROSC. Males had a higher proportion of bystander CPR, arrests in public locations, and initial shockable rhythms. While unadjusted analysis showed no significant gender differences in achieving ROSC, adjusted analysis revealed that male gender was associated with higher odds of achieving ROSC (adjusted OR male vs. female 1.38, 95% CI 1.15–1.66, p<0.001). Conclusions Approximately 720 adults undergo non-traumatic OHCA in Qatar every year, with a higher incidence observed in males. Male gender was associated with higher odds of achieving ROSC. Further gender-specific research in OHCA intervention and outcome in the Middle East is required. Keywords OHCA, Incidence, Gender, ROSC, Qatar, Middle East Creator An entity primarily responsible for making the resource Emad Awad1,2,3, Hassan Farhat4,5, Rakan Shami2 , Nooreh Gholami2 , Bothina Mortada2 , Niki Rumbolt2 , Adnaan Azizurrahman2 , Abdul Rahman Arabi6 and Guillaume Alinier4,7,8,9* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00679-1 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text OHCA, Incidence, Gender, ROSC, Qatar, Middle East https://repository.horizon.ac.id/files/original/0da78148b77f1d57b39be2b44a684693.pdf 3313dcfedaeaaaae8cbfda3b1c763716 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early colonic-preparation and salvage laparoscopic appendectomy (ECSLA)- innovative protocol for the management of magnets ingestion Subject The topic of the resource Magnets, Ingestion, Pediatric Description An account of the resource Early colonic-preparation and salvage laparoscopic appendectomy (ECSLA)- innovative protocol for the management of magnets ingestion Creator An entity primarily responsible for making the resource Ortal Schaffer1,2, Adi Kenoshi1,2 and Osnat Zmora1,2* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00678-2 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Magnets, Ingestion, Pediatric https://repository.horizon.ac.id/files/original/110634189abb451ee65354abcee974a9.pdf 44a52279a02c818d5729bc84301fdea0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Dabigatran accumulation in acute kidney injury: is more better than less to prevent bleeding? A case report Subject The topic of the resource Dabigatran is an oral anticoagulant that is mainly renally excreted. Despite its efficacy in preventing Description An account of the resource Abstract Dabigatran is an oral anticoagulant that is mainly renally excreted. Despite its efficacy in preventing thromboembolic events, concerns arise regarding bleeding complications in patients with acute kidney injury. Idarucizumab is its specific antidote and reverses quickly and effectively dabigatran anticoagulation effects in situations of severe bleeding or pending surgical procedures, but its benefit beyond these two indications remains uncertain. We present a case of a woman with atrial fibrillation anticoagulated by dabigatran and admitted with Streptococcus agalactiae meningitis, acute kidney injury and dabigatran accumulation. Idarucizumab was not administered initially as she did not meet its current strict indications. However, subsequently, significant bleeding necessitated its use. A rebound increase in dabigatran concentration was associated with an intracranial hemorrhage, but the combination of additional doses of idarucizumab with hemodialysis lowered the dabigatran concentration and prevented significant rebound increases. Further investigation into the optimal management of dabigatran accumulation and acute kidney injury-associated bleeding is needed to enhance patient outcomes and safety. Early initiation of hemodialysis together with idarucizumab administration may be crucial in preventing life- threatening bleeding events in these patients. Creator An entity primarily responsible for making the resource Rafik Matbouli1 , Olivier Pantet2 , Julien Castioni3 , Nima Vakilzadeh4 , Lorenzo Alberio5 and Olivier Hugli1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00677-3 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Dabigatran is an oral anticoagulant that is mainly renally excreted. Despite its efficacy in preventing https://repository.horizon.ac.id/files/original/b889b2ab90fc71a7014c245c779699e1.pdf 521db152260ee1ee7abca2085128dd11 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Catecholamine concentration as a predictor of mortality in emergency surgical patients Subject The topic of the resource Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality Description An account of the resource Abstract Background Trauma and emergency surgery are major causes of morbidity and mortality. The objective of this study was to determine whether serum levels of epinephrine and norepinephrine are associated with aging and mortality. Methods This was a prospective observational cohort study conducted in a surgical critical care unit. We included 90 patients who were admitted for postoperative care, because of major trauma, or both. We collected demographic and clinical variables, as well as serum levels of epinephrine and norepinephrine. Results For patients in the >60-year age group, the use of vasoactive drugs was found to be associated with an undetectable epinephrine level (OR [95% CI]=6.36 [1.12, 36.08]), p=0.05). For the patients with undetectable epinephrine levels, the in-hospital mortality was higher among those with a norepinephrine level≥2006.5 pg/mL (OR [95% CI]=4.00 [1.27, 12.58]), p=0.03). Conclusions There is an association between age and mortality. Undetectable serum epinephrine, which is more common in older patients, could contribute to poor outcomes. The use of epinephrine might improve the clinical prognosis in older surgical patients with shock. Keywords Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality Creator An entity primarily responsible for making the resource João Isuk Suh1 , Daiane Leite da Roza2 , Filipe Matheus Cadamuro3 , Luiz Marcelo Sá Malbouisson3 , Talita Rojas Sanches1 and Lúcia Andrade1,4* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00676-4 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality