15 10 198 https://repository.horizon.ac.id/files/original/8558824d74d4a20d86d0fc78c4cf8f07.pdf 89dc7b96d6bd32e312308d5ba0dfc00d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An unexpected case of tetanus in a fully immunized 20‐year‐old female: a case report Subject The topic of the resource Tetanus, Vaccination, Vaccinated Description An account of the resource Background Widespread vaccinations have significantly decreased the number of tetanus cases in developed coun- tries. Today, most cases of tetanus affect the elderly and those with inadequate immunization in developed countries such as Japan. As vaccinations were believed to be nearly 100% effective in preventing tetanus, tetanus in young, immunized individuals were considered unlikely. However, unexpected tetanus infection has been reported in young adequately immunized individuals. Case We herein describe a 20-year-old immunized female who visited our emergency department with trismus and painful muscle spasms that started after receiving a puncture wound to her right foot. A physical examination revealed an elevated body temperature (38°C), trismus, muscle spasms in her right leg and neck, and a puncture wound at the sole of her right foot. Following the development of dyspnea after admission to the intensive care unit, the patient was intubated and mechanically ventilated. She fully recovered after six days in intensive care. Conclusion The present case serves as a stark reminder that tetanus may still occur in young, immunized individuals. Patients with a history of immunization may have a better prognosis than those with no immunizations. Keywords Tetanus, Vaccination, Vaccinated Creator An entity primarily responsible for making the resource Mitsutoshi Okuda1*, Atsushi Morizane1 , Sunao Asaba1 , Saika Tsurui1 , Ryutaro Tsuno1 , Mariko Hatakenaka1 , Tomoko Sugimura1 and Yuichi Saisaka1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00633-1 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Tetanus, Vaccination, Vaccinated https://repository.horizon.ac.id/files/original/5693fea1d4ae5c1d3c9eeb998721a113.pdf de142188ff2ff787eed66078f4c77a2d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnostic utility of capnography in emergency department triage for screening acidemia: a pilot study Subject The topic of the resource Capnography, End-tidal CO2, Respiration, Acidemia, Vital signs Description An account of the resource Abstract Background Capnography is a quantitative and reliable method of determining the ventilatory status of patients. We describe the test characteristics of capnography obtained during Emergency Department triage for screening acidemia. Results We performed an observational, pilot study of adult patients presenting to Emergency Department (ED) triage. The primary outcome was acidemia, as determined by the basic metabolic panel and/or blood gas during the ED visit. Secondary outcomes include comparison of estimated and measured respiratory rates (RR), relationships between end-tidal CO2 (EtCO2) and venous partial pressure of CO2, admission disposition, in-hospital mortality during admission, and capnogram waveform analysis. A total of 100 adult ED encounters were included in the study and acidemia ( HCO− 3 ≤ 22mEq/L or pH < 7.35) was identified in 28 patients. The measured respiratory rate (20.3 ± 6.4 breaths/min) was significantly different from the estimated rate (18.4 ± 1.6 breaths/min), and its area under the receiver operating curve (c-statistic) to predict acidemia was only 0.60 (95% CI 0.51–0.75, p=0.03). A low end-tidal CO2 (EtCO2<32 mmHg) had positive (LR+) and negative (LR−) likelihood ratios of 4.68 (95% CI 2.59–8.45) and 0.34 (95% CI 0.19–0.61) for acidemia, respectively—corresponding to sensitivity 71.4% (95% CI 51.3–86.8) and specificity 84.7% (95% CI 74.3–92.1). The c-statistic for EtCO2 was 0.849 (95% CI 0.76–0.94, p=0.00). Waveform analysis further revealed characteristically abnormal capnograms that were associated with underlying pathophysiology. Conclusions Capnography is a quantitative method of screening acidemia in patients and can be implemented feasibly in Emergency Department triage as an adjunct to vital signs. While it was shown to have only modest ability to predict acidemia, triage capnography has wide generalizability to screen other life-threatening disease processes such as sepsis or can serve as an early indicator of clinical deterioration. Keywords Capnography, End-tidal CO2, Respiration, Acidemia, Vital signs Creator An entity primarily responsible for making the resource Paul Peng1* and Alex F. Manini2 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00631-3 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Capnography, End-tidal CO2, Respiration, Acidemia, Vital signs https://repository.horizon.ac.id/files/original/858d51fe259f6c1d6c15b37f4f766932.pdf acd31238871bd36f22952f3db5e9e1c9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource From symptom onset to ED departure: understanding the acute care chain for patients with undifferentiated complaints: a prospective observational study Subject The topic of the resource Acute care chain, Patient journey, Undifferentiated complaints Description An account of the resource Background For most acute conditions, the phase prior to emergency department (ED) arrival is largely unexplored. However, this prehospital phase has proven an important part of the acute care chain (ACC) for specific time-sensitive conditions, such as stroke and myocardial infarction. For patients with undifferentiated complaints, exploration of the prehospital phase of the ACC may also offer a window of opportunity for improvement of care. This study aims to explore the ACC of ED patients with undifferentiated complaints, with specific emphasis on time in ACC and patient experience. Methods This Dutch prospective observational study, included all adult (≥18 years) ED patients with undifferentiated complaints over a 4-week period. We investigated the patients’ journey through the ACC, focusing on time in ACC and patient experience. Additionally, a multivariable linear regression analysis was employed to identify factors independently associated with time in ACC. Results Among the 286 ED patients with undifferentiated complaints, the median symptom duration prior to ED visit was 6 days (IQR 2–10), during which 58.6% of patients had contact with a healthcare provider before referral. General Practitioners (GPs) referred 80.4% of the patients, with the predominant patient journey (51.7%) involving GP referral followed by self-transportation to the ED. The median time in ACC was 5.5 (IQR 4.0-8.4) hours of which 40% was spent before the ED visit. GP referral and referral to pulmonology were associated with a longer time in ACC, while referral during evenings was associated with a shorter time in ACC. Patients scored both quality and duration of the provided care an 8/10. Conclusion Dutch ED patients with undifferentiated complaints consulted a healthcare provider in over half of the cases before their ED visit. The median time in ACC is 5.5 h of which 40% is spent in the prehospital phase. Those referred by a GP and to pulmonology had a longer, and those in the evening a shorter time in ACC. The acute care Creator An entity primarily responsible for making the resource Lieke Claassen1*, Laura Magdalena Ritter1 , Gideon Hubertus Petrus Latten1 , Noortje Zelis2 , Jochen Willo Lennert Cals3 and Patricia Maria Stassen4 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00629-x Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Acute care chain, Patient journey, Undifferentiated complaints https://repository.horizon.ac.id/files/original/e113f17d98cabd16030b3de1c4fa2739.pdf f276160d667ca3fd6ea00dc206c54c99 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emergency department responses to nursing shortages Subject The topic of the resource COVID-19, Pandemics, Workforce, Nurses, Hospital emergency service Description An account of the resource Abstract Background The COVID-19 pandemic exacerbated the nursing shortage, which is predicted to continue to worsen with significant numbers of nurses planning to retire within the next 5 years. There remains a lack of published infor- mation regarding recommended interventions for emergency departments (EDs) facing a sudden nursing shortage. Methods We queried emergency department leaders from the American College of Emergency Physicians to exam- ine the impact of nursing shortages on EDs and to gather real-world interventions employed to mitigate the effects of the shortage. Results Most respondents (98.5%) reported nursing shortages, with 83.3% describing prolonged shortages lasting more than 12 months, with negative impacts such as misses/near-misses (93.9%) and increasing left without being seen rates (90.9%). ED leaders reported a range of interventions, including operational flow changes, utilizing alterna- tive staff to fill nurse roles, recruitment of new nurses, and retention strategies for existing nurses. They employed tem- porary and permanent pay increases as well as efforts to improve the ED work environment and techniques to hire new nurses from atypical pipelines. Conclusion We report a patchwork of solutions ED leaders utilized which may have variable efficacy among different EDs; personalization is essential when selecting interventions during a sudden nursing shortage. Keywords COVID-19, Pandemics, Workforce, Nurses, Hospital emergency service Creator An entity primarily responsible for making the resource Nicole R. Hodgson1*, Richard Kwun2 , Chad Gorbatkin3 , Jeanie Davies4 , Jonathan Fisher4 and on behalf of the ACEP Emergency Medicine Practice Committee Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00628-y Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text COVID-19, Pandemics, Workforce, Nurses, Hospital emergency service https://repository.horizon.ac.id/files/original/94ced92e710158c2d6c39a3eccd12581.pdf 9850adc659b41a5c35dd5410b6ceec77 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An AI-based multiphase framework for improving the mechanical ventilation availability in emergency departments during respiratory disease seasons: a case study Subject The topic of the resource Artificial Intelligence (AI), Random Forest (RF), Discrete-Event-Simulation (DES), Emergency Department (ED), Mechanical ventilation, Healthcare Description An account of the resource Background Shortages of mechanical ventilation have become a constant problem in Emergency Departments (EDs), thereby affecting the timely deployment of medical interventions that counteract the severe health complications experienced during respiratory disease seasons. It is then necessary to count on agile and robust methodological approaches predicting the expected demand loads to EDs while supporting the timely allocation of ventilators. In this paper, we propose an integration of Artificial Intelligence (AI) and Discrete-event Simulation (DES) to design effective interventions ensuring the high availability of ventilators for patients needing these devices. Methods First, we applied Random Forest (RF) to estimate the mechanical ventilation probability of respiratory- affected patients entering the emergency wards. Second, we introduced the RF predictions into a DES model to diagnose the response of EDs in terms of mechanical ventilator availability. Lately, we pretested two different interventions suggested by decision-makers to address the scarcity of this resource. A case study in a European hospital group was used to validate the proposed methodology. Results The number of patients in the training cohort was 734, while the test group comprised 315. The sensitivity of the AI model was 93.08% (95% confidence interval, [88.46 −96.26%]), whilst the specificity was 85.45% [77.45 −91.45%]. On the other hand, the positive and negative predictive values were 91.62% (86.75 −95.13%) and 87.85% (80.12 −93.36%). Also, the Receiver Operator Characteristic (ROC) curve plot was 95.00% (89.25 −100%). Finally, the median waiting time for mechanical ventilation was decreased by 17.48% after implementing a new resource capacity strategy. Conclusions Combining AI and DES helps healthcare decision-makers to elucidate interventions shortening the waiting times for mechanical ventilators in EDs during respiratory disease epidemics and pandemics. Keywords Artificial Intelligence (AI), Random Forest (RF), Discrete-Event-Simulation (DES), Emergency Department (ED), Mechanical ventilation, Healthcare Creator An entity primarily responsible for making the resource Miguel Ortiz-Barrios1,2*, Antonella Petrillo3 , Sebastián Arias-Fonseca2 , Sally McClean4 , Fabio de Felice3 , Chris Nugent4 and Sheyla-Ariany Uribe-López5 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00626-0 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Artificial Intelligence (AI), Random Forest (RF), https://repository.horizon.ac.id/files/original/1c813c46f4da6e7f1747ee4cbcbe78ce.pdf 0c0662d2818326664f5c1d4b9159abc0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correction: Patient-controlled analgesia morphine for the management of acute pain in the emergency department: a systematic review and meta-analysis Subject The topic of the resource the wrong figure appeared as Fig. Description An account of the resource In this article [1], the wrong figure appeared as Fig. 8. The incorrect and correct versions of Fig. 8 are shown below: Incorrect Correct The original article [1] has been corrected. Creator An entity primarily responsible for making the resource Muhammad Baihaqi Oon1 , Nik Nik Ab. Rahman Hisamuddin1,3*, Norhayati Mohd Noor2 and Mohd Boniami Yazid1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00625-1 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text the wrong figure appeared as Fig. https://repository.horizon.ac.id/files/original/d53d4d52653110fe18d29825ca46f3be.pdf 89c69dbcd9f7b069bf3f0c94dcb63a5c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliometric analysis of ChatGPT in medicine Subject The topic of the resource The emergence of artificial intelligence (AI) chat programs has opened two distinct paths, Description An account of the resource Abstract Introduction The emergence of artificial intelligence (AI) chat programs has opened two distinct paths, one enhancing interaction and another potentially replacing personal understanding. Ethical and legal concerns arise due to the rapid development of these programs. This paper investigates academic discussions on AI in medicine, analyzing the context, frequency, and reasons behind these conversations. Methods The study collected data from the Web of Science database on articles containing the keyword “ChatGPT” published from January to September 2023, resulting in 786 medically related journal articles. The inclusion criteria were peer-reviewed articles in English related to medicine. Results The United States led in publications (38.1%), followed by India (15.5%) and China (7.0%). Keywords such as “patient” (16.7%), “research” (12%), and “performance” (10.6%) were prevalent. The Cureus Journal of Medical Science (11.8%) had the most publications, followed by the Annals of Biomedical Engineering (8.3%). August 2023 had the highest number of publications (29.3%), with significant growth between February to March and April to May. Medical General Internal (21.0%) was the most common category, followed by Surgery (15.4%) and Radiology (7.9%). Discussion The prominence of India in ChatGPT research, despite lower research funding, indicates the platform’s popularity and highlights the importance of monitoring its use for potential medical misinformation. China’s interest in ChatGPT research suggests a focus on Natural Language Processing (NLP) AI applications, despite public bans on the platform. Cureus’ success in publishing ChatGPT articles can be attributed to its open-access, rapid publication model. The study identifies research trends in plastic surgery, radiology, and obstetric gynecology, emphasizing the need for ethical considerations and reliability assessments in the application of ChatGPT in medical practice. Conclusion ChatGPT’s presence in medical literature is growing rapidly across various specialties, but concerns related to safety, privacy, and accuracy persist. More research is needed to assess its suitability for patient care and implications for non-medical use. Skepticism and thorough review of research are essential, as current studies may face retraction as more information emerges. Creator An entity primarily responsible for making the resource Sharanya Gande1 , Murdoc Gould2 and Latha Ganti3,4* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00624-2 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text The emergence of artificial intelligence (AI) chat programs has opened two distinct paths, https://repository.horizon.ac.id/files/original/8db022ae0b86d83682dbceb2033ad338.pdf 33039766a8c54988567429e2fa1fa973 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Randomized controlled open-label trial to evaluate prioritization software for the secondary triage of patients in the pediatric emergency department Subject The topic of the resource Patient flow, Patient prioritization, Pediatric emergency department, Second triage, Usage assessment Description An account of the resource Abstract Background The continual increase in patient attendance at the emergency department (ED) is a worldwide health issue. The aim of this study was to determine whether the use of a secondary prioritization software reduces the patients’ median length of stay (LOS) in the pediatric ED. Methods A randomized, controlled, open-label trial was conducted over a 30-day period between March 15th and April 23rd 2021 at Lille University Hospital. Work days were randomized to use the patient prioritization software or the pediatric ED’s standard dashboard. All time intervals between admission and discharge were recorded prospectively by a physician not involved in patient care during the study period. The study’s primary endpoint was the LOS in the pediatric ED, which was expected to be 15 min shorter in the intervention group than in the control group. The secondary endpoints were specific time intervals during the stay in the pediatric ED and levels of staff satisfaction. Results 1599 patients were included: 798 in the intervention group and 801 in the control group. The median [interquartile range] LOS was 172 min [113–255] in the intervention group and 167 min [108–254) in the control group (p=0.46). In the intervention group, the time interval between admission to the first medical evaluation for high-priority patients and the time interval between the senior physician’s final evaluation and patient discharge were shorter (p<0.01). The median satisfaction score was 68 [55–80] (average). Conclusion The patients’ total LOS was not significantly shorter on days of intervention. However, use of the electronic patient prioritization tool was associated with significant decreases in some important time intervals during care in the pediatric ED. Creator An entity primarily responsible for making the resource Thomas Lun1 , Jessica Schiro2 , Emeline Cailliau3 , Julien Tchokokam1 , Melany Liber1 , Claire de Jorna1 , Alain Martinot1,4 and François Dubos1,4* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00623-3 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Patient flow, Patient prioritization, Pediatric emergency department, Second triage, Usage assessment https://repository.horizon.ac.id/files/original/8481da96d257ebb2c5de4928c073f637.pdf af3b1ba34e5bc7b42022bcad393aea8d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The state of emergency medicine in Greece: at critical momentum Subject The topic of the resource Emergency medicine development, Greece Description An account of the resource Greece is a parliamentary republic in southeastern Europe populated by over 10 million permanent residents: 9 million reside on the mainland, with almost 4 million in the greater Athens area. The remaining 1 million populate the over 1200 Greek islands. In addition, more than 160,000 asylum-seekers reached Greece in 2022, and more than 25 million tourists have visited Greece in the last two years. Modern Greek Emergency Medicine (EM) is now in its 4th decade. The Greek government has focused the last few years on enhancing the quality of emergency services provided in public hospitals. Emergency Departments (EDs) are being modernized, undergraduate medical education gradually incorporates EM, and a specialty training program in emergency nursing has been established. However, the late recognition of the critical importance of EM as a specialty in Greece has resulted in the subsequent need to create three alternative pathways to EM, none of which are direct from residency. The first is a 24-month Emer- gency Medicine fellowship after completing a residency in another specialty and then passing the national exam. The second is for physicians who have worked in a public hospital ED (Gr: Ethniko Systima Ygeias (ESY) ESY for at least three years and successfully passed the national exam. The third, which no longer exists, is a ‘grandfather’ pathway for those physicians who worked in an ESY ED for five years prior to the creation of the fellowship training program. As a result, there is a critical shortage of EM-trained physicians, resulting in most care being provided by physicians without formal training in EM. This is further confounded by the country’s challenging geography, with frequent air transfers from the islands to mainland hospitals. Creating an EM Residency training program is a critical next step to overcoming many of the challenges facing EM provision in Greece today: it would address the shortage of EM- trained providers, decrease the need for costly ground and air transfers, and improve the quality of emergency care throughout Greece. Creator An entity primarily responsible for making the resource Dimitrios Tsiftsis1*, Andrew Ulrich2 , George Notas3 , Anna Patrikakou4 and Eleanor Reid2 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00622-4 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Emergency medicine development, Greece https://repository.horizon.ac.id/files/original/d81e7a1814514699029299a6129e7c6e.pdf ec21f67a910d36f0790de8c3e53c9cdb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 17 Issue 1 2024 Contributor An entity responsible for making contributions to the resource peri irawan Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Single intravenous dose ondansetron induces QT prolongation in adult emergency department patients: a prospective observational study Subject The topic of the resource Ondansetron, QT prolongation, Prediction, Emergency department Description An account of the resource Background Ondansetron is one of the most commonly used drugs in the emergency department (ED) for treating nausea and vomiting, particularly in intravenous (IV) form. Nevertheless, it has been shown to prolong QT interval and increase the risk of ventricular dysrhythmias. This study evaluated the associations between single IV ondansetron dosage and subsequent QTc prolongation in the ED. Methods In this prospective observational study, a total number of 106 patients presenting to the ED in a 3-month period with nausea and vomiting treated with IV ondansetron were enrolled. QT and QTc intervals were measured at baseline (QT0 and QTc0), and 60 min (QT60 and QTc60) following a single-dose administration of ondansetron at 4 or 8 mg doses. To evaluate the predictive ability of these variables, we employed receiver operating characteristic (ROC) curve analyses. Results The predictive models for QTc prolongation 1-hour post-ondansetron administration showed the following: at baseline, the area under curve of 0.70 for QT, 0.71 for QTc, and 0.64 for dosage. Conversely, a QTc0=375 msec indicated a QTc60>480 msec with a specificity of 97%. Additionally, a QTc0 of 400 msec had a sensitivity of 100% in predicting a QTc60<480 msec, while a QTc0>460 msec predicted a QTc60>480 msec with a specificity of 98%. Moreover, 8 mg doses were associated with higher rates of QTc60 prolongation, while 4 mg doses favored maintaining QTc60 within normal limits. Conclusions Our study demonstrates the predictive capacity of QT0, QTc0, and ondansetron dosage in forecasting QTc60 prolongation (>480 msec) post-ondansetron administration. These findings advocate for their incorporation into clinical protocols to enhance safety monitoring in adult ED patients. Keywords Ondansetron, QT prolongation, Prediction, Emergency department Creator An entity primarily responsible for making the resource Mohammad Rezaei Zadeh Rukerd1 , Fatemeh Rafiei Shahrbabaki2 , Mitra Movahedi2 , Amin Honarmand2 , Pouria Pourzand2* and Amirhossein Mirafzal2* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-024-00621-5 Date A point or period of time associated with an event in the lifecycle of the resource 2024 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Ondansetron, QT prolongation, Prediction, Emergency department