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                  <text>Prosiding SiKesNas 2023 Transformasi Kesehatan untuk Mewujudkan Indonesia Emas 2045</text>
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                  <text>Sri Wahyuni</text>
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                <text>UJI IN SILICO SENYAWA DAUN BELIMBING WULUH (Averrhoa bilimbi L.) SEBAGAI ANTIKANKER KOLOREKTAL SERTA PREDIKSI PROFIL FARMAKOKINETIK DAN TOKSISITAS</text>
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                <text> Kanker Kolorektal, Daun Belimbing Wuluh, In silico, Farmakokinetik, Toksisitas</text>
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                <text>Kanker merupakan penyakit yang menjadi ancaman terhadap kesehatan manusia yang &#13;
ditandai dengan ploriferasi sel atau pembelahan sel yang tidak terkendali. Terapi perawatan &#13;
kanker kolorektal menggunakan obat 5-Fluorouracil (5-FU) sebagai kontrol positif atau ligan &#13;
standar pembanding yang dapat membantu meningkatkan kelangsungan hidup pasien pada &#13;
berbagai jenis kanker. Berdasarkan efek samping yang di timbulkan, hal ini kemudian mendorong &#13;
masyarakat untuk beralih pengobatan ke bahan alam atau obat tradisional. Daun belimbing &#13;
wuluh (Averrhoa bilimbi L) merupakan salah satu jenis tanaman yang dikenal oleh masyarakat &#13;
sebagai salah satu sumber pengobatan tradisional. Penelitian ini bertujuan untuk mengetahui &#13;
potensi senyawa kimia yang terkandung dalam daun belimbing wuluh (Averrhoa bilimbi L) &#13;
sebagai antikanker kolorektal dengan metode in silico, serta prediksi profil farmakokinetik &#13;
(ADME) dan nilai toksisitas. Hasil penelitian ini adalah senyawa 7 (1,4-Dimethylnaphthalene) &#13;
memiliki nilai ΔGbinding paling rendah terhadap 3 protein yaitu Chk1:-6,2 (Kkal/mol), Cyclin A:-&#13;
3,6 (Kkal/mol), Apoptosis Regulator Bcl-2:-6,2 (Kkal/mol). Prediksi profil farmakokinetik dengan &#13;
hasil yaitu senyawa 3 (1,4-Diethylbenzene) yang memenuhi parameter ADME. Prediksi toksisitas &#13;
menunjukkan 6 senyawa uji termasuk dalam kategori 1 yaitu toksisitas rendah (Low Class), dan &#13;
13 senyawa memiliki hasil negatif terhadap genotoksik maupun nongenotoksik karsinogen &#13;
sehingga tidak bersifat karsinogenik.</text>
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                <text>Jayanti Putri Pratama, Nurrizka Kurniawati, Susanti Erikania</text>
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                <text>www.sikesnas,fikes .udb.ac.id</text>
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                <text>Universitas Duta Bangsa Surakarta</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>25 Juni 2023</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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                <text>Sri Wahyuni</text>
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                <text>e-ISSN : 2964-674X</text>
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                <text>Indonesian</text>
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            <name>Type</name>
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        <name>Daun Belimbing Wuluh</name>
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        <name>Farmakokinetik</name>
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        <name>In silico</name>
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        <name>Kanker Kolorektal</name>
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        <name>Toksisitas</name>
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                  <text>Prosiding SiKesNas 2023 Transformasi Kesehatan untuk Mewujudkan Indonesia Emas 2045</text>
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                  <text>Sri Wahyuni</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>EVALUASI PENERAPAN DIGITAL GOVERNMENT SERVICE (DGS) DENGAN METODE TASK TECHNOLOGY FIT (TTF)</text>
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            <description>The topic of the resource</description>
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                <text> Evaluasi, TTF, DGS.</text>
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                <text>Digital Government Service (DGS) merupakan aplikasi untuk mempermudah pelayanan &#13;
kesehatan di Puskesmas Sedayu I dan diterapkan mulai September 2021. Kendala pada DGS &#13;
seperti eror dan masalah jaringan di pemerintah daerah. DGS sedang eror P-care juga ikut eror.&#13;
Penggunaan DGS belum sepenuhnya digunakan secara maksimal. Tujuan penelitian ini yaitu &#13;
mengevaluasi pengguna terhadap penerapan DGS dengan metode Task Technology Fit (TTF) di &#13;
Puskesmas Sedayu I.Penelitian ini menggunakan metode deskriptif kuantitatif dengan rancangan &#13;
cross sectional. Subjek penelitian ini adalah 31 petugas yangmenggunakan DGS. Objek penelitian &#13;
ini adalah evaluasi kinerja dan pemanfaatan DGS. Teknik dalam pengumpulan data dilakukan &#13;
dengan pengamatan dan kuesioner. Hasil penelitian menunjukkan bahwa tingkat persetujuan &#13;
responden terhadap kinerja DGS adalah 75,94% sedangkan tingkat persetujuan terhadap &#13;
pemanfaatan DGS adalah 76,86%. Faktor penyebab tidak maksimalnya kinerja (performance) &#13;
dan pemanfaatan (utilization) pada penggunaan DGS antara lain faktor man (manusia), dan &#13;
machine (mesin). Kesimpulan penelitian ini yaitu Tingkat persetujuan responden terhadap kinerja &#13;
(performance) pada pengguna DGS di Puskesmas Sedayu I mencapai 75,94%, Tingkat &#13;
persetujuan responden terhadap pemanfaatan (utilization) pada pengguna DGS di Puskesmas&#13;
Sedayu I mencapai 76,86%, Faktor-faktor penyebab tidak maksimalnya pemanfaatan (utilization) &#13;
dan kinerja (performance) pada penggunaan DGS antara lain terdapat petugas tidak aktif, &#13;
terdapat kesalahan pada DGS, tidak terdapat SOP/pedoman penggunaan DGS.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Andhy Sulistyo, Hendra Rohman, Risa Mei Astuti</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>www.sikesnas,fikes .udb.ac.id</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="133295">
                <text>Universitas Duta Bangsa Surakarta</text>
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            <name>Date</name>
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                <text>25 Juni 2023</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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                <text>Sri Wahyuni</text>
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            <name>Rights</name>
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                <text>e-ISSN : 2964-674X</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Indonesian</text>
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            <description>The nature or genre of the resource</description>
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              <name>Title</name>
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                  <text>Prosiding SiKesNas 2023 Transformasi Kesehatan untuk Mewujudkan Indonesia Emas 2045</text>
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                <text>ANALISIS MINIMAL BIAYA PASIEN DIABETES MELITUS TIPE 2 DI INSTALASI RAWAT JALAN RSUD DR. MOEWARDI SURAKARTA PERIODE JANUARI- MARET 2023</text>
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                <text>CMA, diabetes melitus, farmakoekonomi, insulin, pasien rawat jalan</text>
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            <description>An account of the resource</description>
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                <text>Diabetes melitus merupakan suatu penyakit kelainan metabolik yang ditandai dengan &#13;
hiperglikemia karena sekresi insulin yang rusak. Diabetes melitus tipe 2 ditandai dengan &#13;
resistensi insulin perifer dan penurunan produksi insulin. Menurut organisasi International &#13;
Diabetes Federation (IDF) memperhitungkan terdapat 463 juta orang di seluruh dunia menderita&#13;
diabetes melitus pada tahun 2019. Pasien diabetes melitus tipe 2 juga memerlukan terapi seumur &#13;
hidupnya sehingga membutuhkan biaya yang cukup besar untuk terapi pengobatannya. Analisis &#13;
farmakoekonomi dalam peningkatan efisiensi atau penggunaan biaya secara lebih rasional sangat &#13;
diperlukan. Untuk itu, penelitian ini bertujuan untuk memberikan informasi mengenai minimal &#13;
biaya terapi kepada pasien diabetes melitus tipe 2 di instalasi rawat jalan RSUD Dr. Moewardi &#13;
Surakarta pada periode Januari – Maret 2023. Metode yang digunakan dalam analisis biaya &#13;
penelitian ini adalah Cost Minimization Analysis (CMA). Hasil penelitian ini diketahui distribusi &#13;
pengobatan hiperglikemik yang paling banyak digunakan untuk pasien diabetes melitus tipe 2 di &#13;
instalasi rawat jalan RSUD Dr. Moewardi Surakarta adalah terapi kombinasi insulin analog &#13;
basal dan insulin analog prandial/Premixed sebanyak 30 pasien (33%) serta monoterapi insulin &#13;
analog basal/prandial/Premixed sebanyak 11 pasien (12%). Hasil analisis biaya dengan metode &#13;
Cost Minimization Analysis (CMA) didapatkan hasil Rp 1.282.626,- dan Rp 1.173.120,-</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Annisa Kusuma Wardhani, Kusumaningtyas Siwi Artini,Tatiana Siska Wardani</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>www.sikesnas,fikes .udb.ac.id</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text> Universitas Duta Bangsa Surakarta</text>
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                <text>25 Juni 2023</text>
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                <text>Sri Wahyuni</text>
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                <text>e-ISSN : 2964-674X</text>
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