11 10 201 https://repository.horizon.ac.id/files/original/ea59ba26526885b6f3ee134a0afa9619.pdf cd43a9bf5d17e914504cedcb7abca83a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Frequency of ED visits and mortality among the adults with ESRD on twice-weekly maintenance hemodialysis at tertiary care hospital in Bhutan Subject The topic of the resource The burden of end-stage renal disease (ESRD) is increasing in Bhutan but there is limited data Description An account of the resource Abstract Background The burden of end-stage renal disease (ESRD) is increasing in Bhutan but there is limited data on the emergency department (ED) visits among ESRD patients. This study aims to study the frequency of ED visits and one- year mortality among ESRD patients on twice-weekly maintenance haemodialysis (HD). Methods A prospective cohort study was conducted over the span of year from 1st October 2021 to 30th September 2022 at emergency department of national referral hospital of Bhutan. The ESRD patients were approached for enrollment upon presentation to the ED and followed to hospital discharge or until the end of the study period. Results There was a total of 633 ED visits among the 193 ESRD patients, resulting in an overall mean of 3.3 ED visits per year. The reasons for ED visit were due to renal emergencies in 48.0%, non-renal medical illnesses in 41.2%, and both in 10.8%. Out of the 633 ED visits, 46.4% required emergent HD. The majority (80.4%) of the patients were discharged from the ED after receiving various treatments, including emergent HD. Only 17.4% required admission to the ward or intensive care unit. During the one-year follow-up of the 193 ESRD patients, there were 18 deaths resulting in a one-year mortality rate of 9.3% of which out-of-hospital cardiac arrest (OHCA) accounted for 44.4% (n=8). Conclusion There was high frequency of ED visits due to renal emergencies among ESRD patients undergoing twice-weekly HD at our tertiary care hospital. Additionally, there was high one-year mortality rate and incidence of OHCA among ERSD patients. Creator An entity primarily responsible for making the resource Ugyen Rinzin1*, Shankar LeVine2,3, Melanie Watts2,3, Ugyen Tshering4 and Kipchu Tshering1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00894-4 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text The burden of end-stage renal disease (ESRD) is increasing in Bhutan but there is limited data https://repository.horizon.ac.id/files/original/6f5482a8a5f5cb313ee9f428779fa25d.pdf 605a940fb5ce5f3f930d423e3b1be3cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hypocalcemia associated with adverse outcomes following severe traumatic injury in the Western Cape of South Africa: a secondary analysis of multicenter data from the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study Subject The topic of the resource Global health, Hypocalcemia, Low- and middle-income countries, Resource-limited healthcare, Trauma Description An account of the resource Abstract Background Hypocalcemia precipitated by severe traumatic injury is well-described in the literature and has been associated with numerous adverse outcomes including mortality, transfusion requirement, and coagulopathy severity. The majority of studies to-date have been conducted in well-resourced clinical practice settings. Here, we describe adverse outcomes associated with severe hypocalcemia among a cohort of individuals presenting to emergency care following acute traumatic injury in a resource-limited setting. Methods The present study is a secondary analysis of the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study, a prospective observational multicenter study of adult trauma patients in the Western Cape of South Africa. Individuals for whom a serum calcium level was measured at the time of hospital arrival were included, and the incidence of various adverse outcomes, including 30-day mortality, length of hospital stay, need for ICU admission, severity of organ dysfunction (defined by Sequential Organ Failure Assessment (SOFA) score), and blood transfusion requirement were compared across calcium strata. In total, 1989 individuals met criteria for inclusion. Results The incidence of any hypocalcemia (ionized calcium<1.15 mmol/L) was 52%, while the incidence of severe hypocalcemia (<1.00 mmol/L) was 5%. Adverse outcomes including 30-day mortality (4.0% vs. 2.9%), need for ICU admission (17% vs. 5.9%), maximum total SOFA score within 7 days (4 vs. 2), and need for blood product transfusion (35% vs. 18%), were all significantly more common in the severe hypocalcemia group as compared with others Creator An entity primarily responsible for making the resource Christiaan A. Rees1 , Jessica L. Wild2 , Mengli Xiao2 , Lani L. Finck3 , Jessica B. Oudakker4 , Hendrick J. Lategan5 , George Oosthuizen5 , Shaheem de Vries6 , Janette Verster7 , Mohammed Mayet8 , Lesley Hodsdon8 , Karlien Doubell8 , Leigh Wagner8 , L’Oreal Snyders8 , Denise Lourens8 , Elmin Steyn5 , Julia M. Dixon3 , Steven G. Schauer9 and Nee- Kofi Mould-Millman3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00893-5 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Global health, Hypocalcemia, Low- and middle-income countries, Resource-limited healthcare, Trauma https://repository.horizon.ac.id/files/original/dc7d7a00d7c28c03646b44a8709cad6e.pdf 605a940fb5ce5f3f930d423e3b1be3cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hypocalcemia associated with adverse outcomes following severe traumatic injury in the Western Cape of South Africa: a secondary analysis of multicenter data from the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study Subject The topic of the resource Global health, Hypocalcemia, Low- and middle-income countries, Resource-limited healthcare, Trauma Description An account of the resource Abstract Background Hypocalcemia precipitated by severe traumatic injury is well-described in the literature and has been associated with numerous adverse outcomes including mortality, transfusion requirement, and coagulopathy severity. The majority of studies to-date have been conducted in well-resourced clinical practice settings. Here, we describe adverse outcomes associated with severe hypocalcemia among a cohort of individuals presenting to emergency care following acute traumatic injury in a resource-limited setting. Methods The present study is a secondary analysis of the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study, a prospective observational multicenter study of adult trauma patients in the Western Cape of South Africa. Individuals for whom a serum calcium level was measured at the time of hospital arrival were included, and the incidence of various adverse outcomes, including 30-day mortality, length of hospital stay, need for ICU admission, severity of organ dysfunction (defined by Sequential Organ Failure Assessment (SOFA) score), and blood transfusion requirement were compared across calcium strata. In total, 1989 individuals met criteria for inclusion. Results The incidence of any hypocalcemia (ionized calcium<1.15 mmol/L) was 52%, while the incidence of severe hypocalcemia (<1.00 mmol/L) was 5%. Adverse outcomes including 30-day mortality (4.0% vs. 2.9%), need for ICU admission (17% vs. 5.9%), maximum total SOFA score within 7 days (4 vs. 2), and need for blood product transfusion (35% vs. 18%), were all significantly more common in the severe hypocalcemia group as compared with others Creator An entity primarily responsible for making the resource Christiaan A. Rees1 , Jessica L. Wild2 , Mengli Xiao2 , Lani L. Finck3 , Jessica B. Oudakker4 , Hendrick J. Lategan5 , George Oosthuizen5 , Shaheem de Vries6 , Janette Verster7 , Mohammed Mayet8 , Lesley Hodsdon8 , Karlien Doubell8 , Leigh Wagner8 , L’Oreal Snyders8 , Denise Lourens8 , Elmin Steyn5 , Julia M. Dixon3 , Steven G. Schauer9 and Nee- Kofi Mould-Millman3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00893-5 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Global health, Hypocalcemia, Low- and middle-income countries, Resource-limited healthcare, Trauma https://repository.horizon.ac.id/files/original/bbb9863fb1a58f5f05bcdd24a40db7d0.pdf 479b179926b2ef894b52787ebaaaa000 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A pilot study of coughing into the shirt to disrupt respiratory pathogen transmission Subject The topic of the resource Scientific evidence is lacking for the respiratory etiquette maneuver of coughing into the elbow. Description An account of the resource Abstract Background Scientific evidence is lacking for the respiratory etiquette maneuver of coughing into the elbow. This pilot study introduces and evaluates a novel maneuver " coughing into the shirt” comparing effectiveness of containing respiratory plumes to existing respiratory etiquette strategies. Methods In this open-bench, observational respiratory etiquette pilot study, five healthcare workers performed four respiratory etiquette maneuvers including: unobstructed, into the elbow, into a mask, and into the shirt. Observational data for the cough maximal plume area, an area calculation, were collected using slow-motion video recording. The various respiratory plume areas of the participants were compared to the unobstructed maneuver, assessing the percent reduction of the maximal plume area. Results All respiratory etiquette maneuvers significantly reduced the maximal plume area as compared to the unobstructed condition (F(3,12)=18.56, P<0.005). Comparing the maximal plume area of the unobstructed maneuver to the “into the shirt” maneuver, we found a 95.4% decrease for the “into the shirt” respiratory etiquette maneuver (P<0.005). There was no statistically significant difference when comparing the obstructive maneuvers to each other. Additionally, the maximal plume area from the “into the shirt” maneuver was 35.75% less than the “into the elbow” maneuver (P=0.15). Comparing the maximal plume area of the “into the shirt” maneuver to the “into the mask” maneuver, results were inconclusive, with an average difference of 2.24% (P=0.66). Conclusions Coughing into the shirt may offer superior containment of the respiratory plume than coughing into the elbow. Larger studies are warranted to validate these findings and guide future public health recommendations. Study design Open bench, observational, cough etiquette pilot study comparing the into the shirt respiratory etiquette maneuver to other respiratory etiquette maneuvers. Creator An entity primarily responsible for making the resource Matthew D. Steimle1 , Jacob Steenblik2*, Brandon D. King3 , Amy A. Gooch4 , Jeremy Baird3 , Jane Yee3 , Valerio Pascucci5 , Margaret Carlson6 and Patrick Ockerse3 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00892-6 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Scientific evidence is lacking for the respiratory etiquette maneuver of coughing into the elbow. https://repository.horizon.ac.id/files/original/2fed24b0e136cb66f03c6f18e96f8f41.pdf 5d255b5eb3c45fdc4e9d65a4e4483ac0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A retrospective study to predict failure of high‐flow oxygen therapy for acute hypoxic respiratory failure Subject The topic of the resource Failure of high-flow oxygen therapy, Acute hypoxic respiratory failure, A retrospective study Description An account of the resource Abstract Objective This study aimed to analyze the characteristics of patients who fail high-flow nasal cannula(HFNC) therapy for acute hypoxemic respiratory failure(AHRF) and to identify predictors of treatment failure. Methods This single-center, retrospective, observational study analyzed clinical data from 388 patients with AHRF. Patients were divided into two groups: the HFNC success group (HFNC-S, n=256) and the HFNC failure group (HFNC-F, n=132). The primary endpoint was the need for escalation of respiratory support to tracheal intubation in the enrolled patients. The demographic data, laboratory tests, blood gas analysis data, CT severity scores, and dis- ease severity scores were analysed to determine the difference between patients who were successful and those who failed HFNC treatment. Univariate and multivariate logistic regression models were used to assess potential predictors of failure of HFNC for patients with acute hypoxaemic respiratory failure. Results The mean age of patients enrolled was 67.97±14.40 years. The HFNC-F group had significantly higher PSI(Pneumonia Severity Index) score, CURB(Confusion, Urea, Respiratory Rate, Blood Pressure, and Age)-65 score, CPIS(Clinical Pulmonary Infection Score) score, CT score and SOFA(Sequential Organ Failure Assessment) scores com- pared to the HFNC-S group. Within 12 h of the initiation of treatment, the HFNC-F group exhibited significantly lower oxygen saturation index (PaO2/FiO2) and significantly higher respiratory rate. Additionally, the HFNC-F group exhib- ited significantly higher levels of C-reactive protein (CRP), platelet count (PLT), D-dimer, interleukin-10 (IL-10), total bilirubin (TB) and creatinine (CB), but lower albumin levels. Multivariate analysis identified CT score, SOFA score, interleukin-1β (IL-1β), and albumin as independent predictors of HFNC failure. Conclusion HFNC is effective for treating AHRF. CT score, SOFA score, IL-1β, and albumin are independent predictors of HFNC failure. Keywords Failure of high-flow oxygen therapy, Acute hypoxic respiratory failure, A retrospective study Creator An entity primarily responsible for making the resource Mingming Xue1†, Fengqing Liao1†, Feixiang Xu1†, Yumei Chen1 , Sheng Wang1 , Yannan Zhou1 , Hailin Ding1 , Su Lu1 , Chenling Yao1*, Zhenju Song1* and Mian Shao1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00891-7 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Failure of high-flow oxygen therapy, Acute hypoxic respiratory failure, A retrospective study https://repository.horizon.ac.id/files/original/2fa191de5f71012928774d22ee5c1802.pdf 475031e0b8b7df15bc8276cb7a2e1057 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Utility of core to peripheral temperature gradient using infrared thermography in the assessment of patients with sepsis and septic shock in the emergency medicine department Subject The topic of the resource Sepsis, Infrared thermography, Peripheral perfusion, Septic shock, Microcirculation, Resuscitation Description An account of the resource Abstract Objective Sepsis is a disease affecting microcirculation, reflected in temperature changes between the core and the skin. This study explores correlation of this gradient using infrared thermography (IRT) with mortality and markers of hypoperfusion in patients admitted with sepsis and septic shock and its changes with resuscitation. Design We conducted a prospective, single center observational study on patients admitted in the Department of Emergency Medicine of a tertiary care center in Karnataka, India. These patients were enrolled based on the inclusion criteria and infrared thermography was performed and cases were followed up after 28 days. Adults presenting to the emergency medicine department with clinically suspected sepsis or septic shock were enrolled and infrared thermography was performed. A final sample size of 187 cases was analyzed after retrospectively excluding patients with any exclusion criteria. Interventions Patients underwent thermal imaging of all four limbs on arrival and after 3 hours of resuscitation. Core temperature was measured using a tympanic thermometer. Infrared thermography was performed, and limb temperature was extracted from the images. Other parameters including mean arterial pressure and lactate were recorded and SOFA score was calculated. Outcome measure(s) The temperature gradients were correlated with 7 and 28-day mortality along with markers of hypoperfusion including mean arterial pressure and serum lactate levels. Results A total of 187 patients were included, with a mean SOFA score of 5. Forty four patients (23.5%) died within 7-days. 28-day mortality was 31%. Temperature gradients of core to knee>8.85°F (p=0.003) and core to great toe>12.25°F (p=0.020) on arrival were found to be correlated with 7-day mortality. Core to knee temperature gradient was found to correlate with 48-hour mortality(p<0.013). Core to index finger gradient on arrival correlated with vasopressor requirement within 48h (p=0.020). Core to index finger temperature gradient had a negative Creator An entity primarily responsible for making the resource Vrinda Lath1 , Prithvishree Ravindra1 , Freston Marc Sirur1 , Rachana Bhat1 , Avinash Bhat2 , Karthik Naik2 , Ramya R2 and Jayaraj Mymbilly Balakrishnan1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00890-8 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Sepsis, Infrared thermography, Peripheral perfusion, Septic shock, Microcirculation, Resuscitation https://repository.horizon.ac.id/files/original/22a2869ae8689627f33b1cdae88f4138.pdf 89067640ef7d0f0c677ab32ec59264df Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnostic challenges in pulmonary lymphomatous spread mimicking ARDS in an AIDS patient: a case report Subject The topic of the resource ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma Description An account of the resource Abstract Background Immunocompromised individuals, particularly those with AIDS, are at increased risk of developing lymphoproliferative tumours and opportunistic infections. Radiologic findings alone may not always distinguish between these entities. Case presentation We describe the case of a patient with acquired immunodeficiency syndrome (AIDS) with rapidly worsening dyspnoea and clinical signs suggestive of acute respiratory distress syndrome (ARDS). Despite initial concerns for ARDS, autopsy revealed an advanced-stage, aggressive lymphoma as the underlying cause. This case highlights the challenge of differentiating ARDS from lymphoma in AIDS patients, especially when atypical radiologic findings, such as nodular opacities, are present. Conclusions The diagnosis of ARDS relies on imaging, oxygenation abnormalities, and clinical timing. However, various infectious and non-infectious conditions can mimic ARDS, making an accurate differential diagnosis essential. This case adds to the literature by underscoring the importance of considering lymphoproliferative disorders in AIDS patients presenting with respiratory distress, especially in the absence of typical lymphoma-related symptoms. Keywords ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma Creator An entity primarily responsible for making the resource Elisa Baratella1 , Giorgio Berlot2 , Maurizio Pinamonti3* and Rossana Bussani3,4 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00889-1 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma https://repository.horizon.ac.id/files/original/2c68fb657dd661f8bae912adda5649cc.pdf 89067640ef7d0f0c677ab32ec59264df Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnostic challenges in pulmonary lymphomatous spread mimicking ARDS in an AIDS patient: a case report Subject The topic of the resource ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma Description An account of the resource Abstract Background Immunocompromised individuals, particularly those with AIDS, are at increased risk of developing lymphoproliferative tumours and opportunistic infections. Radiologic findings alone may not always distinguish between these entities. Case presentation We describe the case of a patient with acquired immunodeficiency syndrome (AIDS) with rapidly worsening dyspnoea and clinical signs suggestive of acute respiratory distress syndrome (ARDS). Despite initial concerns for ARDS, autopsy revealed an advanced-stage, aggressive lymphoma as the underlying cause. This case highlights the challenge of differentiating ARDS from lymphoma in AIDS patients, especially when atypical radiologic findings, such as nodular opacities, are present. Conclusions The diagnosis of ARDS relies on imaging, oxygenation abnormalities, and clinical timing. However, various infectious and non-infectious conditions can mimic ARDS, making an accurate differential diagnosis essential. This case adds to the literature by underscoring the importance of considering lymphoproliferative disorders in AIDS patients presenting with respiratory distress, especially in the absence of typical lymphoma-related symptoms. Keywords ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma Creator An entity primarily responsible for making the resource Elisa Baratella1 , Giorgio Berlot2 , Maurizio Pinamonti3* and Rossana Bussani3,4 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00889-1 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text ARDS, AIDS, Immunosuppression, Ground glass opacities, Diffuse large B cell lymphoma https://repository.horizon.ac.id/files/original/52bf1820bc194af16586881418ba64a2.pdf 4dadacdec3100bf4983b9cecd58b92a5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Procalcitonin and C-reactive protein as early diagnostic markers of sepsis or septic shock in children who presented with fever to the pediatric emergency department at a tertiary hospital, in Riyadh, Saudi Arabia Subject The topic of the resource Sepsis, Fever, Procalcitonin, C-reactive protein, Pediatric emergency, And bacterial infections Description An account of the resource Abstract Background Sepsis is a leading cause of morbidity and mortality in children, requiring early recognition for timely intervention. Traditional biomarkers like C-reactive protein (CRP) are widely used but have limitations in specificity and early detection. Procalcitonin (PCT) has emerged as a promising alternative for differentiating bacterial infections from viral illnesses. This study aims to evaluate the diagnostic performance of PCT and CRP in identifying sepsis among febrile pediatric patients presenting to the emergency department (ED). Methods We conducted a retrospective, observational study at a tertiary hospital from January 2022 to January 2024. A total of 208 children aged 1 month to 14 years with fever (≥38 °C) were included. Patients were categorized into sepsis (n=84) and non-sepsis (n=124) groups based on clinical assessment and blood culture results. Biomarker levels, patient demographics, clinical outcomes, and disposition were analyzed. Results Elevated PCT and CRP levels were significantly associated with sepsis. PCT demonstrated earlier elevation compared to CRP, correlating with higher rates of PICU admission (34.7% vs. 11.1%, p<0.001). Blood culture positivity was a strong predictor of severe sepsis (OR: 9.369, p<0.0003). Logistic regression identified high-grade fever, chronic disease, and viral co-infections as additional risk factors. Conclusion PCT is a superior early biomarker for detecting invasive bacterial infections compared to CRP. Incorporating PCT in sepsis protocols can improve early diagnosis, guiding prompt and appropriate management in pediatric ED settings. Keywords Sepsis, Fever, Procalcitonin, C-reactive protein, Pediatric emergency, And bacterial infections Creator An entity primarily responsible for making the resource Altaf Bhat1 , Nehal Alsadhan1 , Norah Alsadhan2 , Dimah Alnowaiser1 , Imran Gattoo1 , Mohammed Hussain1 , Rafa Alotbi1 , Sattam Alruwaili3 and Yara AlGoraini1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00888-2 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Sepsis, Fever, Procalcitonin, C-reactive protein, Pediatric emergency, And bacterial infections https://repository.horizon.ac.id/files/original/5d6b1c51f7682a755f12f1bbcead3b43.pdf 000610215b13829ac2c958fc5b8243ed Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Stroke prophylaxis after US emergency department diagnosis and discharge of patients with atrial fibrillation and flutter from 21 hospitals Subject The topic of the resource Atrial fibrillation, Atrial flutter, Oral anticoagulation, Stroke prophylaxis, Emergency department Description An account of the resource Abstract Background Oral anticoagulation (OAC) reduces stroke and mortality risk in patients with non-valvular atrial fibrilla- tion/flutter (AF). Patterns of OAC initiation upon discharge from US emergency departments (ED) are poorly under- stood. We sought to examine stroke prophylaxis actions upon, and shortly following, ED discharge of stroke-prone AF patients. Methods We included all adults with a primary diagnosis of non-valvular AF, high stroke risk (CHA2DS2-VASc≥2), low/intermediate bleeding risk (HAS-BLED<4), and no recent (<90 days) OAC at discharge from 21 community EDs (2010–2017). Annual rates of appropriate stroke prevention action (OAC Action) were calculated for eligible dis- charges and as defined as an OAC prescription or anticoagulation management service consultation within 14 days of ED discharge. We modeled OAC Action using a parsimonious Poisson regression with identity link adjusting for sex, age, race/ethnicity, stroke risk score (CHA2DS2-VASc), year of visit, provider race/ethnicity, number of ED beds, and presence of an outpatient observation unit, with the patient as a random effect. Results We studied 9,603 eligible ED discharges (mean age 73.1±11.4 years, 62.3% female), and mean CHA2DS2-VASc score 3.5±1.5. From 2010 to 2017, OAC Action increased from 21.0% to 33.5%. Factors associated with lower OAC initiation included the following: female sex (-3.6%, 95% CI -5.4 to -1.9), age≥85 vs<64 years (-3.8%, 95% CI -6.7 to -1.0%), ED beds, n=20 to 29 (-5.3%, 95% CI -8.36 to -2.4%), 30–49 (-3.8, 95% CI -6.5 to -1.2%), and 50+(-7.1%, 95% CI -10.6 to -3.7%); with referent being the male sex,<40 years, and fewer than 20 beds (18.1%, 95% CI 12.8 to 23.4). OAC initiation in 2017 was greater than in 2010 (16.0%, 95% CI 12.3 to 19.7%). Conclusion Within a community-based ED population of AF patients at high stroke risk, rates of appropriate stroke prevention action increased over the 7-year study period. Rates of AF thromboprophylaxis may be improved Creator An entity primarily responsible for making the resource Bory Kea1,2,14* , E. Margaret Warton3 , Candice E. Kutz4 , Erin Kinney5 , Dustin W. Ballard3,6,7, Mary E. Reed3 , Gregory Y. H. Lip8,9,10, Merritt Raitt11, Benjamin C. Sun12, David R. Vinson3,6,13 and on behalf of the KP CREST Network Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00887-3 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text