12 10 201 https://repository.horizon.ac.id/files/original/b114d0195905e18fd0a4913dbd6390cb.pdf fb6088b7d107b5b51d2953b1959246d1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fatal pediatric case of Kounis syndrome and sepsis: a case report Subject The topic of the resource Case report, Children, Kounis syndrome, Sepsis Description An account of the resource Abstract Background Kounis syndrome is a hypersensitivity reaction that induces acute coronary artery events, nevertheless its pediatric occurrence remains rare and often underdiagnosed. This report describes a fatal case of Kounis syndrome triggered by ceftriaxone-lidocaine administration in a child, in the context of sepsis and multiple organ dysfunction syndrome. Case presentation A 4-year girl with a history of cyclic vomiting syndrome, was admitted to the ICU with severe lethargy and pallor 30 min after the second intramuscular injection of ceftriaxone, which had been prescribed for vomiting, diarrhea, and fever. Her laboratories were pertinent for a metabolic acidosis, neutrophilic leukocytosis, renal dysfunction, elevated cardiac markers (troponin I and cardiac-type creatine phosphokinase), EKG signs of myocardial ischemia, bilateral bronchopneumonia, and right lower multifocal pneumonia. Despite intensive management, the patient’s condition continued to deteriorated, which lead to multiple organ dysfunction and eventual death. Conclusion This case highlights the need for heightened clinical awareness of Kounis syndrome in pediatric settings, especially in patients with underlying infections. This case underscores the fatal potential of undiagnosed Kounis syndrome in the pediatric population and highlights the urgent need for enhanced vigilance and multidisciplinary preparedness. Keywords Case report, Children, Kounis syndrome, Sepsis Creator An entity primarily responsible for making the resource Tamara Berezna1 , Olha Synoverska1 , Nadiya Fomenko1 , Iryna Pylyuk1 , Khrystyna Lazurkevych1 , Viktoria Bedei2 and Taras Kotyk3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00886-4 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Case report, Children, Kounis syndrome, Sepsis https://repository.horizon.ac.id/files/original/abb0bf1b30d85d6bb963ad731f8a6a8e.pdf 216321b841d04287156f5f5159aacc11 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Assessing artificial intelligence-generated patient discharge information for the emergency department: a pilot study Subject The topic of the resource Large Language model, Patient discharge information, Artificial intelligence, Emergency department, Readability Description An account of the resource Abstract Background Effective patient discharge information (PDI) in emergency departments (EDs) is vital and often more crucial than the diagnosis itself. Patients who are well informed at discharge tend to be more satisfied and experience better health outcomes. The combination of written and verbal instructions tends to improve patient recall. However, creating written discharge materials is both time-consuming and costly. With the emergence of generative artificial intelligence (AI) and large language models (LMMs), there is potential for the efficient production of patient discharge documents. This study aimed to investigate several predefined key performance indicators (KPIs) of AI-generated patient discharge information. Methods This study focused on three significant patients’ complaints in the ED: nonspecific abdominal pain, nonspecific low back pain, and fever in children. To generate the brochures, we used an English query for ChatGPT using the GPT-4 LLM and DeepL software to translate the brochures to Dutch. Five KPIs were defined to assess these PDI brochures: quality, accessibility, clarity, correctness and usability. The brochures were evaluated for each KPI by 8 experienced emergency physicians using a rating scale from 1 (very poor) to 10 (excellent). To quantify the readability of the brochures, frequently used indices were employed: the Flesch Reading Ease, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook, and Coleman-Liau Index on the translated text. Results The brochures generated by ChatGPT/GPT-4 were well received, scoring an average of 7 to 8 out of 10 across all evaluated aspects. However, the results also indicated a need for some revisions to perfect these documents. Readability analysis indicated that brochures require high school- to college-level comprehension, but this is likely an overestimation due to context-specific reasons as well as features inherent to the Dutch language. Conclusion Our findings indicate that AI tools such as LLM could represent a new opportunity to quickly produce patient discharge information brochures. However, human review and editing are essential to ensure accurate and reliable information. A follow-up study with more topics and validation in the intended population is necessary to assess their performance. Keywords Large Language model, Patient discharge information, Artificial intelligence, Emergency department, Readability Creator An entity primarily responsible for making the resource Ruben De Rouck1,2* , Evy Wille3 , Allison Gilbert4 and Nick Vermeersch1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00885-5 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Large Language model, Patient discharge information, Artificial intelligence, Emergency department, Readability https://repository.horizon.ac.id/files/original/a6c28d19ea827787d69817afe9bc2397.pdf c639d62eaac417cb4b66ee1ccf3fe1c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Systemic sclerosis with chronic megacolon complicated by bowel obstruction: a case report Subject The topic of the resource Systemic sclerosis, Megacolon, Constipation, Chronic intestinal pseudo-obstruction Description An account of the resource Abstract Background Systemic sclerosis (SS) is a systemic connective tissue disease characterized by changes in the collagen structure that lead to fibrosis of the skin and internal organs. The gastrointestinal (GI) tract is most commonly affected, and it significantly impacts the daily lives of patients. A fatal complication of GI involvement is chronic megacolon, which has been detected in only a few patients in recent years. Case presentation A 51-year-old female with a 10-year history of poorly controlled SS had suffered constipation, abdominal bloating, vomiting, and fever for two weeks and eventually developed chronic megacolon. Conservative treatments and medications failed to relieve the symptoms and resolve the condition. The patient ultimately required surgical intervention. This case highlights the importance of timely evaluation and management of SS-related GI complications. Conclusions Procedures such as colonoscopy are instrumental in monitoring disease progression and providing therapeutic relief. Frequent physical examinations may help predict the failure of conservative approaches and guide clinicians toward surgical interventions to prevent life-threatening complications. Keywords Systemic sclerosis, Megacolon, Constipation, Chronic intestinal pseudo-obstruction Creator An entity primarily responsible for making the resource Zhe-Jia Liu1 , Jung-Chun Lin2 and Yi-Chiao Cheng3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00884-6 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Systemic sclerosis, Megacolon, Constipation, Chronic intestinal pseudo-obstruction https://repository.horizon.ac.id/files/original/750d6230030945b4df364b9f9369d36c.pdf 5ea91900a10cfe5c3c8a5ef77049553b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A rare case of upper gastrointestinal hemorrhage due to tuberculous lymphadenitis fistulized in the duodenum Subject The topic of the resource Fistulization, Hemorrhage, Lymphadenitis, Tuberculosis Description An account of the resource Abstract Introduction Abdominal tuberculosis is less prevalent than pulmonary tuberculosis. Tuberculous lymphadenitis accounts for fewer than 5% of abdominal cases. An unusual complication is the fistulization of a tuberculous lymph node into the digestive tract, with an even rarer association with upper gastrointestinal bleeding. Case Report A 63-year-old male with a history of rectal adenocarcinoma surgery presented with severe gastrointestinal bleeding that required multiple transfusions. Endoscopic attempts failed to locate the bleeding source, but CT angiogram revealed a hemorrhagic necrotic mesenteric lymph node with a fistula to the second part of the duodenum. The patient underwent surgery, which involved resecting the lymph nodes and disconnecting the fistula. Histopathological findings confirmed tuberculous mesenteric lymphadenitis, and the patient was subsequently started on HRZE therapy. Six months postoperatively, there was no recurrence of bleeding. Discussion Gastroduodenal tuberculosis is infrequent due to factors such as the high acidity of the gastric environment and limited lymphoid tissue. Symptoms may mimic other abdominal conditions, making diagnosis challenging. Common complications include gastric outlet obstruction and perforation, while gastrointestinal bleeding is rare. This case of hemorrhagic tuberculous lymphadenitis with fistulization highlights the need for a high index of suspicion and the role of imaging in diagnosing uncommon bleeding sources. While anti-tuberculosis therapy remains the primary treatment, surgery is warranted in cases involving refractory bleeding or fistulization. Conclusion This case emphasizes the importance of a multidisciplinary approach to abdominal tuberculosis with atypical presentations. Awareness of rare complications is essential for prompt diagnosis and management. Keywords Fistulization, Hemorrhage, Lymphadenitis, Tuberculosis Creator An entity primarily responsible for making the resource Souhaib Atri1 , Mahdi Hammami1*, Anis Belhadj2 , Faouzi Chebbi2 , Youssef Chaker1 and Montassar Kacem1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00883-7 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text https://repository.horizon.ac.id/files/original/01363630480870544b86d812f1fd36dc.pdf 57b310f27f4cc7b9548612300f8171d4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epidemiology and management of urological emergencies in a tertiary care setting in Scandinavia Subject The topic of the resource Catheter, Computed tomography, Emergency unit, Hematuria, Loin pain, Primary care healthcare, Ultrasound, Urinary tract infection, Urological emergencies Description An account of the resource Abstract Objective To develop a baseline database detailing the distribution of urological emergencies and to define their epidemiological profile in a tertiary care setting, with the hope of providing important data for health planning. Design, settings and participants A retrospective study was conducted on all patients presenting with urological emergencies at the Emergency Department (ED) of the NU Hospital Group in Trollhättan, Sweden throughout 2019. Medical records of identified patients were reviewed retrospectively to summarize pertinent information. Main results In 2019, 2 433 patients visited the ED with urological complaints, with 71% being male. Most patients (83%) were self-referred and 15% referred by general practitioners (GPs). Loin pain, infectious symptoms, and lower urinary tract symptoms were the most common complaints. Urinary and genital infections (UGIs) were the most frequent diagnoses (37%), followed by urolithiasis (24%). 28% of patients required admission, particularly for UGIs (42%). Self-referred patients had a higher admission rate compared to those referred by GPs. Radiological investigations were performed in 48% of cases, though 65% showed no urological pathology. Conclusions Most patients self-referred to the ED, and many required hospitalization, particularly for UGIs. Enhancing the management of urological emergencies in primary care and refining guidelines for acute imaging could contribute to more efficient use of healthcare resources. Keywords Catheter, Computed tomography, Emergency unit, Hematuria, Loin pain, Primary care healthcare, Ultrasound, Urinary tract infection, Urological emergencies Creator An entity primarily responsible for making the resource Adin Osmancevic1 , Alma Petersson2 , Anna Duverin1 , Bina Merzaai3 , Ella Hedlund4 , Giovanni Morera Porras5 , Isabella Albinsson6 , Jasmine AL-Hadad5 , Salome Olsson7 , Daniel Vestberg5,8, Erik Sagen1,8,9 and Suleiman Abuhasanein1,8,9* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00882-8 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Catheter, Computed tomography, https://repository.horizon.ac.id/files/original/cf1c2dab2444fe4be63f2be7a763d4fc.pdf 9f6bcd2ace80b40fc8c174af2083b4cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Implementation of autonomous decision protocols for emergency medical dispatchers: caller satisfaction survey and evolution of practices Subject The topic of the resource Emergency medical service, Dispatch protocols, Emergency medical dispatchers, Satisfaction Description An account of the resource Abstract Background Access to emergency care is becoming increasingly challenging due to rising demand and limited resources, such as shortage of general practitioners (GP). In France, emergency medical services (EMS) have experienced a 23% increase in call volume over the past decade. To address this, French dispatch systems are evolving, with Emergency Medical Dispatchers (EMDs) empowered to make certain medical decisions through Autonomous Decision Protocols (ADP). These ADP were designed for most frequent and simple emergency situations such as low back pain, epistaxis, head and limb injury, anxiety, and allowed EMDs to recommend medical advice, send an ambulance or refer the caller to a dispatching doctor. Aim This study aimed to assess callers’ satisfaction with decisions made by EMDs using ADPs compared to decisions made by medical doctors with similar chief complaint. Material & method The study was prospective, involving all ADP calls from September to October 2023. All calls concerning ADPs and dispatched by EMDs were included. Callers were called back within a few days of the call in order to obtain their experience using a questionnaire. Retrospective patient files concerning similar chief complaints handled in the traditional way, over the same period in the previous year, were used for comparison. Results A total of 358 calls were analyzed, with 217 (61%) callers completing a satisfaction survey. The results showed high satisfaction, with an average score of 8.6/10. The most common chief complaints were head and limb injuries, and the vast majority (90%) of callers felt their expectations were met. Only a small percentage (4%) required a second opinion or follow up due to worsening symptoms. Conclusion The findings suggest that ADPs improved efficiency by providing standardized medical advice, reducing unnecessary ambulance dispatches, and saving medical resources. Callers who benefited from ADPs were generally satisfied with the service, with satisfaction rates comparable to those found in international studies. Expanding ADPs Creator An entity primarily responsible for making the resource Clarence Fischer1 , Gaëlle le Bail1 , Anna Ozguler1,2*, Jérémie Boutet1 , Charles Groizard1 , Michel Baer1,2 and Thomas Loeb1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00880-w Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text dispatchers, Satisfaction https://repository.horizon.ac.id/files/original/fcb1be5466244f650432841a3106b32c.pdf 21ce2edc0be5265bd301ff740b2585de Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Small cell lung cancer case report: acute tumor lysis syndrome after chemotherapy and management strategies for high-risk patients Subject The topic of the resource Small cell lung cancer, Tumor Lysis syndrome, Acute renal failure, Hyperuricemia Description An account of the resource Abstract Background In the treatment of small cell lung cancer (SCLC), acute tumor lysis syndrome (ATLS) is one of the oncologic emergencies that requires particular attention. Previous studies have generally indicated that ATLS increases mortality risk during treatm ent. Therefore, early identification of ATLS, along with proactive prevention and symptomatic management, is particularly crucial. Methods In this report, we detail the clinical management of a patient with SCLC and multiple metastases who was identified as being at relatively high risk for ATLS due to a large tumor burden and concurrent liver and kidney dysfunction. Results Despite rapid tumor progression, the treatment team implemented aggressive hydration and urine alkalinization as pretreatment measures and personalized dose-reduced chemotherapy based on the standard EC regimen. Nevertheless, the patient developed ATLS, which progressed rapidly, and despite intensive treatment, the condition remained irreversible. Conclusion This case highlights that in some SCLC patients, pre-chemotherapy evaluation reveals a higher risk for tumor lysis syndrome, and adjusting treatment strategies for these patients requires further investigation. This suggests that managing such high-risk patients in clinical practice requires more cases and optimized treatment strategies to guide management. Therefore, this case is presented to offer insights into this perspective. Clinical trial number Not applicable. Keywords Small cell lung cancer, Tumor Lysis syndrome, Acute renal failure, Hyperuricemia Creator An entity primarily responsible for making the resource Ying Han1,4*†, Peng Yue2,3† and Zuguo Yuan1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00879-3 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Small cell lung cancer, Tumor Lysis syndrome, Acute renal failure, Hyperuricemia https://repository.horizon.ac.id/files/original/3497d46e93c673afa27740b5183017f1.pdf c0db8a7dec05e1a7daeb17e5cb8cb7a4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The effect of music therapy on treating patients pain and anxiety in emergency department: a randomized controlled trial Subject The topic of the resource Music therapy, Pain management, Anxiety reduction, Emergency department Description An account of the resource Abstract Background Music therapy (MT) is a recognized modality for pain and anxiety reduction. Although its efficacy has been demonstrated in various clinical settings, its application in emergency departments (ED) remains controversial. This study aims to study the effects of MT in reducing pain and anxiety among patients visiting the ED with pain complaints. Methods A single-center, randomized controlled trial was conducted at Ramathibodi Hospital, Bangkok, from July 2023 to September 2024. During each month of the study period, three days were randomly selected for the MT group, and another three days were designated for the non-MT group. All participants received standard analgesia and completed pre- and post-session questionnaires to assess pain, anxiety, satisfaction, and ED service quality before and one hour after analgesia. The MT group received MT sessions, each lasting 30–40 min. Results Sixty-three patients participated (31 MT group, 32 control group). The MT group showed a significant reduction in pain scores of 1.52 points compared to 0.09 in the non-MT group (p 0.002). Anxiety score was also significantly reduced in the MT group by 1.87 points compared to 0.44 points in the non-MT group (p 0.026). The most significant improvements were observed in non-trauma-related pain and anxiety. Satisfaction scores increased in both groups (0.48 vs. 0.47 points; p 0.946), with no significant difference. However, MT significantly improved perceived ED service quality (0.98 vs. 0.10 points; p 0.001). Conclusion In this study, we found that music therapy, when combined with standard analgesia, effectively reduced pain and anxiety in patients presenting to the ED, particularly those with non-trauma-related pain. Clinical trial number TCTR20231109003. Registration site Thai Clinical Trials Registry. URL: https://www.thaiclinicaltria ls.org/show/TCTR20231109003. Date of approval: 20 June 2023. Keywords Music therapy, Pain management, Anxiety reduction, Emergency department Creator An entity primarily responsible for making the resource Chuenruthai Angkoontassaneeyarat1 , Panatsaya Detsurang1 , Piraya Vichiensanth1 , Phanorn Chalermdamrichai1 , Arrug Wibulpolprasert1 , Natsinee Athinartrattanapong1 , Phatthranit Phattharapornjaroen1 , Natee Chiengchana2 , Wiputh Kehasuwan2 , Gritsada Huncharoen2 , Kanokkan Pothilert3 , Preedaporn Thipnangrong3 , Sirinat Loungnarin3 and Chaiyaporn Yuksen1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00878-4 Date A point or period of time associated with an event in the lifecycle of the resource pdf Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Music therapy, Pain management, Anxiety reduction, Emergency department https://repository.horizon.ac.id/files/original/37af215974f8a281f3be283bfd48cf21.pdf 1fd0700e521c8862d16d005ff8c60a0a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emergency medical services utilization in acute stroke in Qatar - an observational cohort study Subject The topic of the resource Emergency medical services, Stroke, EMS utilization, Qatar Description An account of the resource Abstract Introduction Timely recanalization improves long-term outcomes in acute ischemic stroke (IS) patients, but most patients present outside the therapeutic window. Emergency Medical Services (EMS) can reduce pre-hospital delay and increase the likelihood of recanalization. We aim to determine the characteristic variations amongst suspected acute stroke patients using EMS. Methods This retrospective observational study included all suspected acute stroke patients admitted to a national tertiary care hospital in Qatar from January 2014 to September 2020. We evaluated demographics, clinical features, treatment impact, and associated factors in EMS versus non-EMS transported groups. Results During the study period, 11,892 patients presented with suspected stroke. Of these, 65.1% used EMS (EMS group) for transportation to the hospital. Median age was comparable between EMS and non-EMS group [52 years; IQR 43–63 vs. 43–62, p<0.05]. Male to female ratio was 3:1. EMS use in the Qatari population (59.2%) was relatively low. Patients with hemorrhagic stroke (82.4%) had significantly higher EMS use as compared to IS (65.7%) and cerebral venous thrombosis (64.7%); p<0.001. Symptom onset to ED presentation time was lower in EMS users, with 41.0% arriving within 4.5 h vs. 24.3% in the non-EMS transported group (p<0.05). Patients with unilateral weakness (66.4%), aphasia (78.2%), neglect (78.2%), dysarthria (68.4%), loss of consciousness (83.3%), and seizures (83.9%) were more likely to use EMS than alternative modes of transportation. Patients attending via EMS had higher rates of thrombolysis than others (82.4% vs. 17.6%; p<0.001) and a shorter door-to-needle time (56.4±38.2 min vs. 75.7±43.8 min; p<0.001). Conclusion EMS utilization in acute stroke patients was high and was associated with rapid and higher rates of therapeutic intervention. However, younger age, Arab ethnicity, and less obvious stroke symptoms were associated with lower EMS use, emphasizing the need for targeted public health interventions to improve EMS activations. Keywords Emergency medical services, Stroke, EMS utilization, Qatar Creator An entity primarily responsible for making the resource Zain A. Bhutta1,2*, Naveed Akhtar3 , Tim Harris4,5,12, Maaret Castren2 , Yahia Imam3,8, Sameer A. Pathan1,4,6, Guillaume Alinier7,8,9,10, Saadat Kamran3 , Peter A. Cameron11 and Tuukka Puolakka2,12 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00877-5 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Emergency medical services, Stroke, EMS utilization, Qatar https://repository.horizon.ac.id/files/original/88cf96d287a85ee4d9e2684d663c7172.pdf f2dfcf40ae922586e3926e55e19bd61a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Stem cell therapy use in patients with dementia: a systematic review Subject The topic of the resource Dementia, Stem cell therapy, Preclinical studies, Transgenic animal models, Neuroinflammation, Amyloid- beta Description An account of the resource Abstract Background Stem cell therapy (SCT) is increasingly recognized for its potential in managing cognitive impairment, particularly that of dementia. The application of SCT aims to restore cognitive functioning in people living with dementia. Beyond pre-clinical studies, several clinical trials have evaluated specific stem cell (SC) types for their efficacy in treating dementia. Aims & Objectives To assess the status and efficacy of pre-clinical and clinical studies utilizing SCs as a therapeutic approach for dementia. Methods A systematic review was conducted using two electronic databases: MEDLINE and Embase. We reviewed studies on the application of SCs in dementia, focusing on the following aspects: Animal models used in pre-clinical studies, tissue sources of SCs and donor species, and administrative routes and outcome assessments. Included papers comprised randomized control trials (RCTs) and original studies, while those involving adjuvant therapies for dementia were excluded. Quality assessment criteria included relevance to the research question, type of SCs, stage of SC transplantation, duration and route of administration, methods for outcome assessment, and the total number of animals implicated. Results A total of 32 papers were included, encompassing 21 clinical trials and 11 preclinical studies. The preclinical studies employed various transgenic animal models to evaluate SCT outcomes. Animal models of dementia, particularly transgenic mice, have proven instrumental in replicating human disease mechanisms. These models facilitate understanding of pathophysiology and preclinical testing of therapeutic interventions. Studies utilizing SCT demonstrated notable improvements in spatial memory, reduced neuroinflammation, and protection against amyloid-beta (Aβ) toxicity. Key mechanisms included modulation of inflammation, microglial immune responses, neurogenesis support, and anti-amyloidogenic effects. Preclinical studies predominantly employed human placenta- derived mesenchymal stem cells (PD-MSCs), umbilical cord-derived MSCs (U-MSCs), and induced pluripotent stem cell-derived neuronal precursors. Administration routes varied, with stereotactic and intravenous injections targeting affected brain regions. Reductions in inflammatory markers such as IL-1β, TNF-α, and increases in anti-inflammatory cytokines like IL-4 and IL-10 were observed. These outcomes emphasize the immunomodulatory and neuroprotective capacities of SCT. Creator An entity primarily responsible for making the resource Olivier Uwishema1* , Malak Ghezzawi1,2 , Magda Wojtara1,3 , Ignatius N Esene4 and Kehinde Obamiro5 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00876-6 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Dementia, Stem cell therapy, Preclinical studies, Transgenic animal models, Neuroinflammation, Amyloid- beta