13 10 201 https://repository.horizon.ac.id/files/original/990828eeedd05516da10438757985df5.pdf 85db30cc89318f7e95bdcb751fa346b0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Herbicide poisoning causing multiple colonic perforations: case report Subject The topic of the resource 2,4-Dichlorophenoxyacetic acid, Colonic perforation, Herbicide poisoning, Surgery, Case report Description An account of the resource Abstract Introduction Herbicide poisoning, particularly from 2,4-dichlorophenoxyacetic acid (2,4-D), is an uncommon yet significant cause of systemic toxicity, especially in agricultural regions such as Ethiopia. Patients exposed to 2,4-D frequently exhibit symptoms associated with gastrointestinal, muscular, renal, and neurological toxicity. In this report, we describe a case of 2,4-D ingestion that resulted in systemic complications and the exceptionally rare occurrence of multiple colonic perforations. Case presentation A 19-year-old male farmer presented with a loss of consciousness three hours after attempting suicide by ingesting 25 ml of 72% 2,4-D solution. This was preceded by vomiting and epigastric pain. The patient was treated for hypovolemic shock, aspiration pneumonia, and coma secondary to herbicide poisoning. Despite initial stabilization and recovery, the patient developed signs of peritonitis 14 days post-ingestion, which led to the discovery of multiple colonic perforations. Surgical intervention included total colectomy with ileostomy, which was later reversed. This case is notable as the first documented instance of multiple colonic perforations due to 2,4-D poisoning in humans, as confirmed through an extensive literature review. Conclusion This case highlights the importance of vigilance in patients presenting with herbicide poisoning, as early detection and prompt management are essential for improving outcomes in individuals with multiple colonic perforations. Raising community awareness and establishing guidelines for the safe use of herbicides are vital to preventing such incidents. Keywords 2,4-Dichlorophenoxyacetic acid, Colonic perforation, Herbicide poisoning, Surgery, Case report Creator An entity primarily responsible for making the resource Tesfaye Birhanu Abebe1,2*, Daba Iticha Ayana1*, Dereje Gebisa Bedada1 and Eyob Girum Weldeyes1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00875-7 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text https://repository.horizon.ac.id/files/original/feaa02e43ffd83d536e201a8691cc5dc.pdf 0dbdc479057bd40b66d54ad4b9d03e55 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Low‐moderate alcohol use effects on glycemic control of patients presenting in the ED Subject The topic of the resource The prevalence of Type 2 Diabetes Mellitus Description An account of the resource Abstract Background The prevalence of Type 2 Diabetes Mellitus (DM2) is rising, affecting 462 million globally, including 21 million in the U.S. Emergency Department (ED) visits by adults with diabetes in the U.S. increased by 54% from 2012 to 2021 and represent a significant portion of global ED visits. Concurrently, 62% of U.S. adults report lifetime alco- hol consumption. This study aimed to correlate AUDIT-C scores to changes in glucose and HbA1c levels in patients with DM2. Previous research has produced mixed results on whether light-to-moderate alcohol use improves or wors- ens glycemic control. Using a large urban ED dataset, this study seeks to better define this relationship and guide interventions for alcohol use in patients with DM2. Methods Data from Long Island Jewish ED (January 2022–October 2023) was analyzed. Patients were included based on an HbA1c≥6.5 or a secondary discharge diagnosis of DM2. AUDIT-C scores were treated as a categorical variable, as no dose-dependent relationship was observed. Statistical analysis was conducted using SPSS 26. Results Non-zero AUDIT-C scores were significantly associated with increases in POCT-Blood Glucose, estimated average glucose, and HbA1c. A linear regression model showed an R-value of 0.047 (p<0.001) for POCT-Blood Glucose in patients with HbA1c≥6.5. Patients with an AUDIT-C score≥1 had higher mean POCT-Blood Glucose (249.72 vs. 226.48, t=4.240, p<0.001). Estimated average glucose showed an R-value of 0.045 (p<0.001), with a mean difference of 11.872 (t=4.155, p<0.001). For HbA1c, the R-value was 0.036 (p=0.004), with higher levels in patients with AUDIT- C≥1 (8.265 vs. 7.904, t=2.844, p=0.005). The effects were more pronounced in African-American and Asian-American populations. Conclusion Alcohol use, even at moderate levels (AUDIT-C=1), was associated with higher glucose and HbA1c levels in patients with DM2, particularly among African-American and Asian-American populations. These findings suggest the need for substance use interventions at lower AUDIT-C thresholds and further considerations to mitigate future risk in this population. Creator An entity primarily responsible for making the resource Dominick DeMasi1*, Laura Harrison2 , Fredrick A. Davis2 , Adam Berman2 , Sandeep Kapoor2 and Nancy Kwon2 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00874-8 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text The prevalence of Type 2 Diabetes Mellitus https://repository.horizon.ac.id/files/original/b814b2843ea0fe76db5744514f96d569.pdf 02c3f55fdff9846b8a3dd4bb8f41641e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A fatal case of acute Marchiafava-Bignami disease complicated by acute abdomen– a case report Subject The topic of the resource Chronic alcohol consumption, Ethanol toxicity, Altered mental state, Emergency department Description An account of the resource Abstract Background Marchiafava-Bignami Disease (MBD) is a rare disorder characterized by demyelination and necrosis of the corpus callosum, with only 300 documented cases worldwide. Chronic alcohol consumption and vitamin B-complex deficiencies are contributing factors. Acute cases may present with a range of neurological symptoms, including seizures and coma. Subacute and chronic forms can lead to interhemispheric disconnection syndrome and progressive dementia. Case presentation We present the case of a young male patient’s first hospital admission due to an acute decline in conscious level. A detailed history revealed regular alcohol consumption and substandard living conditions. The deterioration in consciousness was attributed to the diagnosis of MBD based on neurological signs, characteristic brain imaging findings, and a history of alcohol use. In addition, a small bowel perforation was also diagnosed. Supportive therapy and thiamine were initiated, and the patient was transferred to surgery for an operation. After two surgeries, the perforation was covered. The patient’s level of consciousness showed slight improvement; however, the psychiatrist noted severe cognitive deficits. Ultimately, the patient entered a septic state and passed away. Conclusion Acute MBD can potentially cause altered mental state, coma, and death; however, cases can be complicated by other emergency conditions. This case demonstrates the importance of a multidisciplinary approach. Keywords Chronic alcohol consumption, Ethanol toxicity, Altered mental state, Emergency department Creator An entity primarily responsible for making the resource Bence Prohászka1*, Novák Pál Kaposi2 , Zsuzsanna Jánosi2 , Bence Gunda3 , Ildikó Pákozdy1 , Szabolcs Gaál-Marschal1 , Dóra Melicher1 , Bánk G. Fenyves1 and Csaba Varga1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00873-9 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Chronic alcohol consumption, Ethanol toxicity, Altered mental state, Emergency department https://repository.horizon.ac.id/files/original/63efb6fb751c1425a935e81d8a056dbc.pdf 7ef524ae1ea1d52ff717bfca72ae6d04 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Posterior ischemic optic neuropathy following continuous renal replacement therapy: a case report Subject The topic of the resource Continuous renal replacement therapy, Posterior ischemic optic neuropathy, Visual loss Description An account of the resource Abstract Background Posterior ischemic optic neuropathy (PION) is a rare cause of acute vision loss in intensive care unit patients. PION following continuous renal replacement therapy (CRRT) hemodialysis has not ever been reported. Here, we report a case of bilateral nonarteritic PION following the initiation of CRRT. Case presentation A 52-year-old man with hypertension and stage 4 chronic kidney disease was admitted due to metabolic acidosis, hyperkalemia, and acute exacerbation of CKD. CRRT caused transient hypotension upon initiation but corrected the metabolic acidosis and hyperkalemia six hours after initiation. Therefore, CRRT was stopped. However, several hours after the cessation of CRRT, the patient experienced sudden, painless vision loss in both eyes. Assessment of his visual acuity revealed the inability to perceive light in both eyes. There were no symptoms or signs of giant cell arteritis. An ophthalmological examination revealed no abnormalities. Magnetic resonance imaging of the brain revealed no compressive lesions or acute stroke, but magnetic resonance angiography revealed stenosis of both the bilateral carotid artery and the right middle cerebral artery. Administration of a high dose of corticosteroids did not reverse his vision loss. Thus, nonarteritic PION following CRRT was diagnosed. Conclusions PION should be considered if a patient with multiple vascular risk factors complains of sudden painless vision loss without signs of optic disk edema after the initiation of CRRT. Preventing blood pressure drops during the initiation of CRRT in patients with multiple vascular risk factors may prevent PION. Keywords Continuous renal replacement therapy, Posterior ischemic optic neuropathy, Visual loss Creator An entity primarily responsible for making the resource Hiro Takefuji1* and Junpei Komagamine1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00872-w Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Continuous renal replacement therapy, Posterior ischemic optic neuropathy, Visual loss https://repository.horizon.ac.id/files/original/99004801a54518da958ffca889131732.pdf 6f310173af1c50b2f465ff9632665ced Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Trends in CT pulmonary angiography utilization and recurrent imaging in sickle cell disease: a longitudinal study Subject The topic of the resource CT angiography, Pulmonary embolism, Sickle cell disease, Ventilation/perfusion scintigraphy, COVID-19, Bahrain Description An account of the resource Abstract Background Sickle cell disease (SCD) is a common inherited hemoglobinopathy associated with vaso-occlusive events that can mimic pulmonary embolism (PE), leading to the frequent use of computed tomography pulmonary angiography (CTPA). However, trends in CTPA utilization over time remain unclear. This study aims to evaluate temporal trends and recurrent imaging patterns. Methods A retrospective cohort study was conducted at Salmaniya Medical Complex, Bahrain, including SCD patients who underwent CTPA for suspected PE between April 15, 2013, and April 15, 2024. Descriptive statistics were used to report the frequency of recurrent scans, whereas linear regression analysis was employed to assess trends in CTPA utilization over the study period. Results The study included 1,084 patients (median age: 35 years, 55.7% male) with SCD who underwent a total of 1,934 CTPA scans. CTPA utilization remained stable from 2014 to 2020, averaging 10.0–13.6 scans per month. However, a significant surge was observed post-2020, coinciding with the COVID-19 pandemic, peaking in 2023, with an average of 31.3 scans per month, indicating a 2.9-fold increase (p=0.03). During the study period, 415 patients (38.3%) underwent recurrent CTPA scans, with one-third (32.5%, n=276) of these scans occurring within a 6-month interval. Although the PE positivity rate was lower in recurrent scans than in initial scans, the difference was not statistically significant (8.8% vs. 10.5%; p=0.22). Conclusions CTPA utilization among SCD patients remained stable for several years but increased significantly after 2020, coinciding with the COVID-19 pandemic. A substantial proportion of scans were recurrent, with many occurring within a short interval. Moving forward, efforts should focus on mitigating radiation exposure through low-dose protocols and investigating potential factors contributing to the recent increase in scan utilization. Keywords CT angiography, Pulmonary embolism, Sickle cell disease, Ventilation/perfusion scintigraphy, COVID-19, Bahrain Creator An entity primarily responsible for making the resource Ali Hassan1* , Najla Alomani1 , Mawaheb Kalalah2 , Nawra Mujbel1 , Zainab Khamdan3 , Murtadha Alobaydun4 , Mohammed AlAlmai4 , Zuhur Alazmi4 , Abdulelah Musihel4 , Hamad Qabha4 and Jalila Adnan1 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00871-x Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text CT angiography, Pulmonary embolism, https://repository.horizon.ac.id/files/original/9d028485235400659009a5f51f31c53c.pdf 675fa9d540e674b7a67fa4f6f4d55bef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource AI-assisted ophthalmic imaging for early detection of neurodegenerative diseases Subject The topic of the resource Artificial intelligence, AI, Retinal biomarkers, Neurodegeneration, Optical coherence tomography, OCT, Alzheimer's, Parkinson's, Early diagnosis, Ophthalmic imaging Description An account of the resource Abstract Background Artificial intelligence (AI) plays a promising role in ophthalmic imaging by providing innovative, non-invasive tools for the early detection of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since early diagnosis is crucial for slowing disease progression and improving patient outcomes, leveraging AI-assisted ophthalmic imaging retinal imaging can enhance detection accuracy and clinical decision-making. Methods This review examines clinical applications of AI in identifying retinal biomarkers associated with neurodegenerative diseases. Relevant data was gathered through a comprehensive literature review using PubMed, ScienceDirect, and Google Scholar to evaluate studies utilizing AI algorithms for retinal imaging analysis, focusing on diagnostic performance, sensitivity, specificity, and clinical relevance. Results AI-assisted ophthalmic imaging retinal imaging enhances the early identification of neurodegenerative diseases by detecting microscopic structural and vascular changes in the retina. Studies have demonstrated that AI models analyzing Optical Coherence Tomography (OCT) and fundus images achieve high diagnostic accuracy. Studies have reported an area under the curve (AUC) of up to 0.918 in PD detection, with sensitivity ranging from 80 to 100% and specificity up to 85%. Similarly, AI-assisted OCT angiography (OCT-A) analysis has successfully identified retinal vascular alterations in AD patients, correlating with cognitive decline and an AUC of 0.73–0.91. These findings highlight AI’s potential to detect preclinical disease stages before significant neurological symptoms manifest. Discussion The integration of AI technologies into ophthalmic imaging holds the potential to improve early diagnosis and transform patient outcomes. However, challenges such as model interpretability, dataset biases, and ethical considerations must be addressed to ensure the responsible integration of AI into clinical practice. Future research should focus on refining AI algorithms, integrating multimodal imaging techniques, and developing predictive biomarkers to optimize early intervention strategies for neurodegenerative diseases. Clinical trial number Not applicable. Keywords Artificial intelligence, AI, Retinal biomarkers, Neurodegeneration, Optical coherence tomography, OCT, Alzheimer's, Parkinson's, Early diagnosis, Ophthalmic imaging Creator An entity primarily responsible for making the resource Hajar Nasir Tukur1,2, Olivier Uwishema1,5* , Hatice Akbay1,3, Dalal Sheikhah1,2 and Inês Filipa Silva Correia1,4 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00870-y Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Artificial intelligence, AI, Retinal biomarkers https://repository.horizon.ac.id/files/original/1fcce4760a4c6ed19f6909139d5410ed.pdf 4d1f02656ace26416382327ed8c3f7ce Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The association of early antibiotic exposure with subsequent development of late-onset sepsis in preterm infants: a systematic review and meta-analysis studies Subject The topic of the resource Preterm infants, Early antibiotic exposure, Late-onset sepsis, Meta-analysis Description An account of the resource Abstract Background Early antibiotic exposure in preterm infants may disrupt gut microbiome development, affecting health. However, its link to late-onset sepsis (LOS) remains unclear. This meta-analysis aims to clarify the association while addressing confounding bias. Methods This systematic review and meta-analysis, conducted per PRISMA guidelines, utilized PubMed, Scopus, Google Scholar, and Web of Science for comprehensive literature retrieval. Studies comparing preterm infants with sterile blood cultures who received early antibiotics (short or prolonged) to those without, using LOS as the primary outcome, were included. Comparisons between short- and prolonged-course antibiotics were also considered. Only studies with adjusted analyses for confounders were considered. Adjusted odds ratios (aOR) were meta-analyzed, and the prediction interval (PI) was calculated using R software. Results Ten studies met the eligibility criteria, comprising a total sample size of 55,089 preterm infants. Among these, nine studies included 33,549 preterm infants and compared prolonged antibiotic exposure to short exposure. Prolonged exposure was not significantly associated with LOS (pooled aOR=1.2, 95% CI 0.99–1.46, P=0.066, PI=0.66 to 2.19, I2 = 67%). Limiting the analysis to five studies with sample sizes over 1,000 reduced heterogeneity (I2 = 30%) and provided a more precise confidence interval (pooled aOR=1.03, 95% CI 0.91–1.15). Four studies, involving 41,938 preterm infants, examined preterm infants exposed to prolonged antibiotics versus those not exposed and found no significant association (aOR=0.91, 95% CI 0.82–1.02, P=0.1, PI=0.72 to 1.16, I2 = 0). All four studies had sample sizes exceeding 1,000. Additionally, these studies compared preterm infants with short antibiotic exposure to non- exposure, revealing a slightly lower risk of LOS (aOR=0.87, 95% CI 0.77–0.98, P=0.024, I2 = 0) and a PI of 0.76 to 1.14. Creator An entity primarily responsible for making the resource YF Shamseldin1* , Heba Khaled2 , Muhammed Abdiwahab3 , Maha K. Abu Radwan4 , Abdalfattah Sabra5 , Mona Mohammed6 , Sarah EL-Sayegh7 , Dina Abdel Rasoul Helal8 , Mahmoud E. Kamal9 , Ahmed Hassan10 and Ahmed Azzam11 Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00869-5 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Preterm infants, Early antibiotic exposure, Late-onset sepsis, Meta-analysis https://repository.horizon.ac.id/files/original/411e9f204ebc5f90a3af1ab79ac62659.pdf 479d86ddddd063f91516debab7bb0a18 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Recurrent Wunderlich syndrome in systemic lupus erythematosus: a case report Subject The topic of the resource Wunderlich syndrome, Spontaneous renal hemorrhage, Connective tissue disease, Systemic lupus erythematosus, Transcatheter arterial embolization Description An account of the resource Abstract Background Wunderlich syndrome (WS) is a rare condition characterized by spontaneous renal hemorrhage in the absence of obvious trauma or iatrogenic injury. Given that most WS cases are life-threatening and require prompt intervention, timely identification and resolution are essential. Patients with connective tissue diseases (CTDs) account for a small proportion of reported WS cases; however, owing to the specific pathogenic mechanisms and treatments associated with CTDs, these patients exhibit distinctive pathological traits and clinical features in WS. Case presentation We present the identification and treatment process of WS in a patient with systemic lupus erythematosus. This patient suffered from sudden abdominal pain and a drastic decline in hemoglobin level accompanied by confusion of consciousness. After the abdominal computerized tomography scan revealed the presence of a renal hematoma, transcatheter arterial embolization was performed on her. Unexpectedly, three days later, the patient had severe anemia and consciousness disorders again. Highly suspecting renal rebleeding, we performed a repeated angiography for the patient. After confirming the bleeding, embolization was carried out again. The renal bleeding stopped, and the patient’s hemoglobin level gradually stabilized. Regrettably, this patient ultimately died due to multiple systemic infections. Conclusions WS that occurs in CTDs can evolve into critical and severe conditions. Infection, immune complex deposition, thrombocytopenia, abnormal coagulation function, complement activation, autoantibodies production, and glucocorticoid treatment in patients with CTDs are potentially linked to the development of WS. The treatment strategies for WS should be guided by hemodynamic status. Keywords Wunderlich syndrome, Spontaneous renal hemorrhage, Connective tissue disease, Systemic lupus erythematosus, Transcatheter arterial embolization Creator An entity primarily responsible for making the resource Yingzi Zhu1 and Lingli Dong1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00868-6 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Wunderlich syndrome, Spontaneous renal hemorrhage https://repository.horizon.ac.id/files/original/bd80ca35e9da7012b1ac0024bb9571af.pdf 2999a12301da0029941bd1b9ea1317ae Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early neurological wake‐up test in intubated patients with traumatic brain injury Subject The topic of the resource Traumatic brain injury, Mechanical ventilation, Sedation, Neurological wake-up test, Prognosis Description An account of the resource Abstract Background Daily wake-up has been implemented widely in intensive care units (ICU) and could improve the patients’ prognosis. However, little is known about the benefit of early neurological wake-up test (ENWT) in patients with acute traumatic brain injury (TBI). We aimed to investigate the role of ENWT as a clinical monitoring tool for TBI and its association with prognosis. Methods This is an observational retrospective study included intubated and continuously sedated TBI in ICU, and all data were extracted from three tertiary hospitals from China. The main exposure of interest was ENWT, defined as ces- sation of sedation within 24 h after admission. The primary outcome was 28-day mortality. Propensity score matching (PSM) was performed at a 1:1 ratio. Multivariable analyses were further used to adjust for residual confounders. Results The pre-matched and propensity score-matched cohorts included 1386 and 704 patients, respectively. In the PSM analysis, 28-day mortality was 24.7% (87/352) in the ENWT group and 37.2% (131/352) in the control group. ENWT was associated with lower 28-day mortality (hazard ratio [HR], 0.57; 95% CI, 0.44–0.76; P<0.001). ENWT was also associated with lower in-hospital mortality (odds ratio [OR], 0.54; 95% CI, 0.38–0.77; P=0.001), and higher discharge-home rate (OR, 1.83; 95% CI, 1.19–2.83; P=0.006). A sensitivity analysis using the entire cohort also dem- onstrated lower 28-day mortality (HR, 0.58; 95% CI, 0.44–0.75; P<0.001). However, it should be noted that ENWT was related to a higher rate of delirium during ICU stay (OR, 1.66; 95% CI, 1.21–2.26; P=0.001). Further analysis demon- strated that tracheostomy during ICU stay led to a significant difference in 28-day mortality. Conclusion ENWT was associated with a lower risk-adjusted 28-day mortality in acute TBI patients. A higher rate of tracheostomy may partly contribute to this relationship. Keywords Traumatic brain injury, Mechanical ventilation, Sedation, Neurological wake-up test, Prognosis Creator An entity primarily responsible for making the resource Meng Jiang1*†, Chang‐li Li2†, Xiao‐peng Wu3†, Xing‐chen Lin1 , Yuan‐run Zhu4 , Li‐gang Xu5 and Xiao‐feng Yang1* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00867-7 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Traumatic brain injury, Mechanical ventilation, Sedation, Neurological wake-up test, Prognosis https://repository.horizon.ac.id/files/original/289c8ca704979b11700753c74d239f37.pdf 0735be480c0245b120739846b10bc5be Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Volume 18 Issue 1 2025 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An original closed reduction technique for acute shoulder dislocation: the wrist- clamping and shoulder-lifting Subject The topic of the resource Shoulder, Shoulder dislocation, Anterior shoulder dislocation, Reduction technique, Closed manual reduction, Acute Description An account of the resource Abstract Background Acute anterior shoulder dislocation is one of the most common injuries in emergency medicine and orthopaedics. The aim of this study is to introduce a new closed reduction technique: the wrist-clamping and shoulder-lifting, for manual reduction of acute anterior shoulder dislocation. Patients and methods The patient is instructed to a sitting position, the doctor hold the wrist of the arm with both hands, slowly rotated the arm to 90-degree of abduction and 60-degree of external rotation with gentle strength. After the shoulder muscles were relaxed by continuous traction, the wrist of the arm was clamped with knee joints when the arm was in 45-degree of abduction and 60-degree of external rotation. Then place hands on axilla and lift shoulder upward until the reduction is complete. Results Thirty-six dislocated shoulders were successfully reduced with this technique, without fracture and iatrogenic neurovascular complications. No sedation, anesthesia, or intra-articular injection were used in all patients. All reduction procedures were performed by a single operator without assistance, and meantime for reduction was 3 min (range 1–8 min). Conclusions The wrist-clamping and shoulder-lifting technique is a safe, simple, effective, gentle, fast and single- operator for anterior shoulder dislocations. Without sedation, anaesthesia, or intra-articular injection. This closed reduction technique enables orthopedists and emergency physicians to reduce the anterior shoulder dislocation smoothly and quickly, and provide a reliable and alternative reduction technique. Keywords Shoulder, Shoulder dislocation, Anterior shoulder dislocation, Reduction technique, Closed manual reduction, Acute Creator An entity primarily responsible for making the resource Wanwu Dai1†, Lei Liu2†, Shuang Zong1†, Yong Zhou1†, Jun Zheng1† and Xingyan Li3* Source A related resource from which the described resource is derived https://doi.org/10.1186/s12245-025-00866-8 Date A point or period of time associated with an event in the lifecycle of the resource 2025 Contributor An entity responsible for making contributions to the resource Peri Irawan Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource english Type The nature or genre of the resource text Shoulder, Shoulder dislocation, Anterior shoulder dislocation, Reduction