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                  <text>Volume 19 Issue 1 2026</text>
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                <text>A case report: reflections on the formation&#13;
of acute thrombotic events after PCI&#13;
in patients with acute ST-Segment elevation&#13;
myocardial infarction</text>
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                <text>Percutaneous coronary intervention (PCI), Thrombus, CYP2C19</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Abstract&#13;
Platelet gene resistance may result in acute thrombosis, although clinical reports are scarce.This article presents&#13;
a classic case of acute in-stent thrombosis and discusses its diagnostic and therapeutic strategies.The patient,&#13;
a 57-year-old male, was admitted due to chest pain that lasted for one hour. After a thorough examination, he&#13;
was diagnosed with acute ST-segment elevation myocardial infarction. Acute thrombosis rapidly occurred within&#13;
30minutes following emergency coronary stent implantation.&#13;
Keywords Percutaneous coronary intervention (PCI), Thrombus, CYP2C19</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Jiaqiang Yang1&#13;
, Jiaru Yang1&#13;
, Haigang Huang1&#13;
, Jing Wei1&#13;
and Puyue Tang1*</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="138303">
                <text>https://doi.org/10.1186/s12245-025-01103-y</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="138304">
                <text>2026</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138305">
                <text>peri irawan</text>
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              <elementText elementTextId="138307">
                <text>english</text>
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        <name>Percutaneous coronary intervention (PCI), Thrombus, CYP2C19</name>
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              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138073">
                  <text>Volume 19 Issue 1 2026</text>
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              <name>Contributor</name>
              <description>An entity responsible for making contributions to the resource</description>
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                <elementText elementTextId="138074">
                  <text>PERI IRAWAN</text>
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      <elementSet elementSetId="1">
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138513">
                <text>A direct qualitative content analysis on the&#13;
design, implementation, and evaluation&#13;
of prehospital earthquake exercises aligned&#13;
with the HSEEP framework</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138514">
                <text>Preparedness, Prehospital, Earthquake, Exercise</text>
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            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Abstract&#13;
Introduction Disaster exercises are a vital strategy for enhancing Emergency Medical Services (EMS) operational&#13;
preparedness. This study aimed to extract “Golden Keys” for Design, Implementation and Evaluation of earthquake&#13;
exercises aligning these key components with the internationally recognized Homeland Security Exercise and&#13;
Evaluation Program (HSEEP) Framework from the perspective of experienced Iranian prehospital technicians.&#13;
Method A qualitative study was conducted using a directed content analysis. Data were systematically gathered&#13;
through in-depth semi-structured interviews with 11 prehospital technician that purposefully selected based on their&#13;
demonstrated expertise in prehospital exercise management. Data analysis was conducted in five steps following&#13;
Granheim and Lundman’s approach and the study used Lincoln and Guba’s recommendations to assess data&#13;
trustworthiness.&#13;
Result After multiple rounds of data analysis and summarization 386 initial codes, 13 subcategories, and five main&#13;
categories were identified. These main categories included “Exercise Foundation and Program Governance”, “Exercise&#13;
Design, Coordination, and Control”, “Operational Implementation of the Exercise”, “Performance Evaluation and&#13;
Capability Assessment” and “Learning, Workforce Empowerment”, and “System Improvement”.&#13;
Conclusion Earthquake preparedness exercises must be sustained as an ongoing effort to enhance prehospital&#13;
system resilience. The indicators identified in this study provide an actionable, evidence-based framework for EMS&#13;
managers and policymakers to design, implement, and evaluate exercises aligned with system priorities. Translating&#13;
exercise outcomes into actionable evidence facilitates informed decision-making targeted resource allocation and&#13;
evidence-based policy formulation. Future research should focus on contextualizing this framework within localized&#13;
programs and conducting quantitative validation of the proposed indicators.&#13;
Keywords Preparedness, Prehospital, Earthquake, Exercise</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138516">
                <text>Asiye Aminafshar1&#13;
&#13;
, Ali Moradi Chaleshtori2&#13;
&#13;
, Ali Khosravizad3&#13;
&#13;
, Ali Sahebi3* and Hojjat Farahmandnia4*</text>
              </elementText>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="138517">
                <text>https://doi.org/10.1186/s12245-026-01135-y</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138518">
                <text>2026</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138519">
                <text>peri irawan</text>
              </elementText>
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          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="138520">
                <text>pdf</text>
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          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138521">
                <text>english</text>
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            <description>The nature or genre of the resource</description>
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    <tagContainer>
      <tag tagId="15806">
        <name>Preparedness, Prehospital, Earthquake, Exercise</name>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138073">
                  <text>Volume 19 Issue 1 2026</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="37">
              <name>Contributor</name>
              <description>An entity responsible for making contributions to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138074">
                  <text>PERI IRAWAN</text>
                </elementText>
              </elementTextContainer>
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          </elementContainer>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138189">
                <text>Abdominal computed tomography use in the&#13;
emergency department among children&#13;
with abdominal pain: a retrospective analysis</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138190">
                <text>Abdominal pain, Abdominal computed tomography, Emergency department, Children</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138191">
                <text>Abstract&#13;
Background Acute abdominal pain is a common cause of visits to the pediatric emergency departments (ED). In&#13;
recent years, abdominal computed tomography (CT) has emerged as an increasingly used imaging modality due&#13;
to its diagnostic value in the evaluation of abdominal pain. This study aimed to determine the frequency of CT use&#13;
among children presenting to the ED with abdominal pain, and to identify the factors associated with CT use.&#13;
Methods A single-center, retrospective review of medical records was conducted, including children aged 3 to 15&#13;
years who presented to the ED at the American University of Beirut Medical Center (AUBMC) with abdominal pain&#13;
between January 1st and December 31, 2014. Demographic, clinical and laboratory data were collected and analyzed&#13;
to assess predictors of CT use.&#13;
Results A total of 451 patients were included in the study, of whom 11.8% underwent abdominal CT. Appendicitis&#13;
was the most common abnormal finding (26%) seen on the abdominal CT scans followed by mesenteric adenitis&#13;
(25%), while one-quarter of CT scans yielded normal findings. Older age, right lower quadrant (RLQ) pain, leukocytosis,&#13;
and evaluation by an emergency medicine physician were significant predictors of CT use.&#13;
Conclusion This study sheds the light on the potential overuse of abdominal CT scan in children presenting to ED&#13;
with abdominal pain, exposing this vulnerable population to unnecessary radiation and adding financial burden.&#13;
Thus, these findings underscore the importance of implementing institutional guidelines and promoting the use of&#13;
non-ionizing imaging modalities.&#13;
Keywords Abdominal pain, Abdominal computed tomography, Emergency department, Children</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138192">
                <text>Sarah Khafaja1&#13;
&#13;
, Sarah Salam Rizk1&#13;
&#13;
, Samer El Hayek1&#13;
&#13;
and Nadine Yazbeck1,2*</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="138193">
                <text>https://doi.org/10.1186/s12245-025-01087-9</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138194">
                <text>2026</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138195">
                <text>peri irawan</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138196">
                <text>pdf</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138197">
                <text>english</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <description>The nature or genre of the resource</description>
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                <text>text</text>
              </elementText>
            </elementTextContainer>
          </element>
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    <tagContainer>
      <tag tagId="15779">
        <name>Abdominal pain, Abdominal computed tomography, Emergency department, Children</name>
      </tag>
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  <item itemId="12979" public="1" featured="1">
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138073">
                  <text>Volume 19 Issue 1 2026</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="37">
              <name>Contributor</name>
              <description>An entity responsible for making contributions to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138074">
                  <text>PERI IRAWAN</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138503">
                <text>Accuracy of ultrasound for intussusception&#13;
in pediatric emergency presentations:&#13;
&#13;
a systematic review and diagnostic meta-&#13;
analysis</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138504">
                <text>Intussusception, Emergency department, Pediatrics, Surgery, Point-of-care ultrasound</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138505">
                <text>Abstract&#13;
Introduction Intussusception is a common cause of acute abdominal emergencies in children. This systematic&#13;
review and diagnostic meta-analysis aimed to determine the diagnostic accuracy of ultrasound for intussusception&#13;
in pediatric emergency presentations, providing pooled estimates for sensitivity, specificity, predictive values, and&#13;
diagnostic odds ratios to inform clinical practice.&#13;
Methods Adhering to PRISMA-DTA guidelines, a comprehensive search was conducted in PubMed, Scopus,&#13;
Cochrane Library, and Web of Science up to July 2025. Bayesian bivariate random-effects meta-analyses were&#13;
performed to estimate pooled sensitivity, specificity, and other measures, with subgroup and meta-regression&#13;
analyses to explore heterogeneity.&#13;
Results A total of 44 studies comprising 4,142 pediatric patients were included in the quantitative synthesis. The&#13;
pooled sensitivity of ultrasound for diagnosing intussusception was 96.3% (95% credible interval [CrI] 94.9–97.5%),&#13;
and the pooled specificity was 95.7% (95% CrI 93.3–97.5%). The area under the hierarchical summary receiver&#13;
operating characteristic curve (AUC) was 0.81–0.82, indicating good discriminative ability. Positive predictive value&#13;
(PPV) ranged from 54.1% at 5% prevalence to 99.8% at 95% prevalence, while negative predictive value (NPV)&#13;
decreased from 99.8% to 57.7% across the same prevalence range. The overall certainty of evidence for sensitivity and&#13;
specificity was rated as high, with moderate certainty for prevalence due to substantial heterogeneity.&#13;
Conclusion Ultrasound demonstrates excellent diagnostic performance for pediatric intussusception in emergency&#13;
settings, with high sensitivity and specificity maintained across patient subgroups and operator backgrounds. These&#13;
findings support the continued use of ultrasound as the first-line diagnostic modality in both high- and low-resource&#13;
environments and highlight the importance of structured training to optimize its accuracy. Future research should&#13;
focus on multicenter prospective studies, standardization of ultrasound protocols, and the integration of artificial&#13;
intelligence to further enhance diagnostic reliability.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="138506">
                <text>Mohammed Alsabri1,2* , Shree Rath3 , Mohamed Amr Elkarargy4&#13;
&#13;
, Amira A. Aboali5&#13;
&#13;
, Khaled Abouelmagd6&#13;
,&#13;
&#13;
Abdelaziz Abdelaziz Abdelftah Ramadan7&#13;
&#13;
, Luis L. Gamboa8&#13;
&#13;
, Patrick Yoo9&#13;
&#13;
and Yisha Cheng9</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="138507">
                <text>https://doi.org/10.1186/s12245-026-01134-z</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="138508">
                <text>2026</text>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138509">
                <text>peri irawan</text>
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                <text>Background Spontaneous intracerebral hemorrhage (ICH) is a catastrophic form of stroke affecting more than 3.3&#13;
million individuals worldwide each year and accounting for approximately 10–20% of all strokes globally. Although&#13;
less common than acute ischemic stroke, ICH carries a disproportionate burden of morbidity and mortality, with&#13;
30-day case fatality rates approaching 40–50%. Therapeutic advances for ICH have progressed more slowly than&#13;
for ischemic stroke, and management remains largely supportive. Patients frequently present to the emergency&#13;
department (ED) in critical condition, making early recognition and rapid, guideline-concordant intervention essential&#13;
to improving outcomes.&#13;
Review This narrative review summarizes the most recent American Heart Association/American Stroke Association&#13;
(AHA/ASA) guidelines for the acute management of spontaneous ICH, with emphasis on practical ED application.&#13;
Hypertension remains the most important modifiable risk factor, particularly in younger patients, while cerebral&#13;
amyloid angiopathy predominates in older adults. Additional risk factors include anticoagulant and antiplatelet&#13;
therapy, alcohol and illicit drug use, smoking, advanced age, and genetic predisposition. Primary brain injury results&#13;
from hematoma mass effect and elevated intracranial pressure, followed by secondary injury driven by edema,&#13;
inflammation, and oxidative stress. Because hematoma expansion commonly occurs within the first hours after&#13;
symptom onset and strongly predicts mortality, early ED management prioritizes rapid neuroimaging, controlled&#13;
blood pressure reduction, timely anticoagulation reversal, seizure management, metabolic and temperature control,&#13;
and prompt neurosurgical consultation when indicated. Emerging evidence supports bundled, time-sensitive care&#13;
pathways to reduce delays and optimize outcomes.&#13;
Conclusion Optimal ICH outcomes depend on rapid, structured, guideline-concordant ED care focused on limiting&#13;
hematoma expansion and secondary injury. Standardized workflows and bundled interventions represent effective&#13;
strategies for improving survival and functional outcomes while avoiding premature prognostication in the acute&#13;
phase.&#13;
Keywords Acute intracerebral hemorrhage, Blood pressure management, Anticoagulation reversal</text>
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                <text>Background Spontaneous intracerebral hemorrhage (ICH) is a catastrophic form of stroke affecting more than 3.3&#13;
million individuals worldwide each year and accounting for approximately 10–20% of all strokes globally. Although&#13;
less common than acute ischemic stroke, ICH carries a disproportionate burden of morbidity and mortality, with&#13;
30-day case fatality rates approaching 40–50%. Therapeutic advances for ICH have progressed more slowly than&#13;
for ischemic stroke, and management remains largely supportive. Patients frequently present to the emergency&#13;
department (ED) in critical condition, making early recognition and rapid, guideline-concordant intervention essential&#13;
to improving outcomes.&#13;
Review This narrative review summarizes the most recent American Heart Association/American Stroke Association&#13;
(AHA/ASA) guidelines for the acute management of spontaneous ICH, with emphasis on practical ED application.&#13;
Hypertension remains the most important modifiable risk factor, particularly in younger patients, while cerebral&#13;
amyloid angiopathy predominates in older adults. Additional risk factors include anticoagulant and antiplatelet&#13;
therapy, alcohol and illicit drug use, smoking, advanced age, and genetic predisposition. Primary brain injury results&#13;
from hematoma mass effect and elevated intracranial pressure, followed by secondary injury driven by edema,&#13;
inflammation, and oxidative stress. Because hematoma expansion commonly occurs within the first hours after&#13;
symptom onset and strongly predicts mortality, early ED management prioritizes rapid neuroimaging, controlled&#13;
blood pressure reduction, timely anticoagulation reversal, seizure management, metabolic and temperature control,&#13;
and prompt neurosurgical consultation when indicated. Emerging evidence supports bundled, time-sensitive care&#13;
pathways to reduce delays and optimize outcomes.&#13;
Conclusion Optimal ICH outcomes depend on rapid, structured, guideline-concordant ED care focused on limiting&#13;
hematoma expansion and secondary injury. Standardized workflows and bundled interventions represent effective&#13;
strategies for improving survival and functional outcomes while avoiding premature prognostication in the acute&#13;
phase.&#13;
Keywords Acute intracerebral hemorrhage, Blood pressure management, Anticoagulation reversal</text>
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                <text>Acute toxic encephalopathy induced&#13;
by organic solvent exposure: a case report&#13;
of diagnostic challenges and occupational&#13;
health implications</text>
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                <text>Acute toxic encephalopathy induced&#13;
by organic solvent exposure: a case report&#13;
of diagnostic challenges and occupational&#13;
health implications</text>
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                <text>Abstract&#13;
Background Toxic encephalopathy, which results from exposure to neurotoxic substances, poses a considerable&#13;
clinical challenge, especially for occupational groups like painters and construction workers.&#13;
Case presentation This case report describes a 35-year-old female painter who experienced acute toxic&#13;
encephalopathy, presenting with severe headache, nausea, and vomiting. Initially, her condition was misdiagnosed as&#13;
cervical spondylosis. However, recognizing her occupational exposure to organic solvents was essential for arriving at&#13;
the correct diagnosis. This case highlights the importance of thorough evaluations, particularly detailed occupational&#13;
histories, to avoid misdiagnosis and ensure timely management of such conditions. Neuroimaging results showed&#13;
bilateral symmetric white matter changes, which supported the diagnosis of organic solvent toxicity. This finding&#13;
aligns with existing literature that discusses how lipid solubility can disrupt neuronal function. The patient's positive&#13;
outcome following prompt treatment underscores the critical need for early recognition of toxic encephalopathy, as it&#13;
can significantly improve recovery chances.&#13;
Conclusion This case enhances our understanding of the complexities associated with diagnosing acute&#13;
encephalopathy caused by organic solvents and underscores the urgent need for healthcare providers to be more&#13;
aware of occupational hazards.&#13;
Keywords Acute toxic encephalopathy, Neurotoxic substance exposure, Organic solvent exposure</text>
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                <text>Mengfei Han1&#13;
, Yi Ren1&#13;
, Kongbo Lv1&#13;
, Li Wang2&#13;
and Zhizhou Yang1*</text>
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                <text>Adapting a novel emergency triage tool to a resource-limited hospital in Nepal</text>
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          <element elementId="49">
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Background Effective triage is critical for prioritizing emergency care. However, many low- and middle-income&#13;
countries lack standardized triage systems. Nepal has been working to introduce the WHO’s Interagency Integrated&#13;
Triage Tool (IITT) into emergency departments nationwide. Still, successful implementation requires context-specific&#13;
adaptations to address operational realities and resource constraints.&#13;
Objective This study aimed to collaboratively adapt the IITT for use in the Dhulikhel Hospital Emergency Department&#13;
by incorporating frontline staff insights to develop a feasible, sustainable triage workflow.&#13;
Methods Five focus groups composed of doctors, nurses, and paramedics were conducted. Through semi-structured&#13;
discussions, we explored staff perceptions of areas for improvement in the existing triage processes. Participants then&#13;
generated site-specific workflow models through iterative brainstorming sessions, progressively refining the design&#13;
into a final consensus-based model.&#13;
Results Participants, representing over 80% of clinical staff, identified key barriers to effective triage, including&#13;
inconsistent communication, unclear handoff responsibilities, and insufficient training. The final triage workflow&#13;
addressed many critical challenges raised in discussion sessions, provided a standardized and customized triage&#13;
process, and resulted in high reported confidence in its utility.&#13;
Conclusion This study demonstrates the value of a bottom-up, staff-centered approach to triage system&#13;
development and implementation. Our focus group design offers a practical, replicable framework for low-resource&#13;
emergency departments seeking to implement the IITT or similar protocols into their ED operations. Future efforts&#13;
should focus on validating the workflow’s impact on patient outcomes and triage efficiency and investing in&#13;
thorough and longitudinal training to support sustained adoption.&#13;
Keywords Triage, Emergency department, Quality improvement, Nepal, Global health</text>
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                <text>Yael Weiner1*, Claire Therriault1*, Tina Duwal2&#13;
&#13;
, Samjhana Basnet2&#13;
&#13;
, Roshana Shrestha2&#13;
&#13;
and Sanu Krishna Shrestha2*</text>
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      <tag tagId="16065">
        <name>Triage, Emergency department, Quality improvement, Nepal, Global health</name>
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                  <text>Volume 19 Issue 1 2026</text>
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                <text>Anaphylactic shock following intravenous&#13;
ranitidine in rural Nepal: a case report</text>
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                <text>Abstract&#13;
Background Ranitidine, a histamine-2 (H2) receptor antagonist, is widely used for acid-peptic disorders. Although&#13;
generally safe, it is a rare but recognized cause of drug-induced anaphylaxis, with an estimated incidence of 0.2–0.7%&#13;
for H2 receptor blockers and proton pump inhibitors. We report a near-fatal case of ranitidine-induced anaphylactic&#13;
shock successfully managed in a rural hospital.&#13;
Case presentation A 35-year-old female developed sudden shortness of breath, hypotension, and drowsiness within&#13;
minutes of receiving a 50 mg intravenous (IV) dose of ranitidine for epigastric discomfort at a local clinic. She had no&#13;
prior exposure to ranitidine or known allergies. On arrival, her blood pressure was 60 mmHg systolic, pulse 130/min,&#13;
and SpO2 60%. She had diffused urticaria and wheezing. A diagnosis of anaphylactic shock was made. Immediate&#13;
management included high-flow oxygen, intramuscular epinephrine (0.5 mg, 1:1000), followed by intravenous&#13;
hydrocortisone. Significant improvement occurred within 10 minutes and she was discharged after 24 hours of&#13;
observation.&#13;
Conclusion This case highlights that ranitidine, although commonly used, can rarely trigger severe anaphylactic&#13;
shock even in patients without prior exposure or known allergies. Early recognition of the reaction and timely&#13;
administration of intramuscular epinephrine were key to the patient’s rapid recovery. Awareness of this potential&#13;
adverse reaction is important for all clinicians who administer H2-receptor antagonists.&#13;
Keywords Ranitidine, Anaphylaxis, Epinephrine, Shock</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138292">
                <text>Rojee Shrestha1*, Ashal Timalsina1*, Arjun Gaire1&#13;
&#13;
, Roshan Acharya1&#13;
&#13;
, Anupa Subedi1&#13;
&#13;
and Aayusha Suwal1</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="138293">
                <text>https://doi.org/10.1186/s12245-025-01101-0</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138294">
                <text>2026</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138295">
                <text>peri irawan</text>
              </elementText>
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            <name>Format</name>
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              <elementText elementTextId="138296">
                <text>pdf</text>
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            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138297">
                <text>english</text>
              </elementText>
            </elementTextContainer>
          </element>
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              </elementText>
            </elementTextContainer>
          </element>
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      <tag tagId="15788">
        <name>Ranitidine, Anaphylaxis, Epinephrine, Shock</name>
      </tag>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="138073">
                  <text>Volume 19 Issue 1 2026</text>
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              </elementTextContainer>
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            <element elementId="37">
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              <description>An entity responsible for making contributions to the resource</description>
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                  <text>PERI IRAWAN</text>
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    <elementSetContainer>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138239">
                <text>Anti-NMDA receptor encephalitis&#13;
with coexisting autoimmune GFAP&#13;
astrocytopathy presenting with psychiatric&#13;
symptoms leading to a suicide attempt: a case&#13;
report</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138240">
                <text>Glial fibrillary acidic protein astrocytopathy (GFAP-A), Autoimmune encephalitis, Psychiatric symptoms,&#13;
Suicide attempt, Hyponatremia</text>
              </elementText>
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          <element elementId="41">
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            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138241">
                <text>Abstract&#13;
Background Distinguishing altered consciousness owing to an underlying organic disorder from a psychiatric&#13;
etiology can be challenging in patients presenting at the emergency department after a suicide attempt.&#13;
Case presentation The patient was a 52-year-old woman who jumped from the third floor of her house. She&#13;
sustained a small subdural hematoma in the left cerebellar tentorium and a fracture of the right first rib. She was&#13;
admitted to our tertiary emergency and critical care center for further evaluation of the head injury and remained&#13;
clinically stable. On hospital day 2, the patient was diagnosed with severe depression by a psychiatrist and was&#13;
transferred to a psychiatric ward. However, she developed disturbances of consciousness and cognitive impairment&#13;
that could not be explained by psychiatric illness thereafter. Further workup revealed anti-N-methyl-D-aspartate&#13;
receptor (anti-NMDAR) encephalitis and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy as the&#13;
etiology. High-dose intravenous methylprednisolone therapy together with high-dose intravenous immunoglobulin&#13;
was initiated. Disturbances of consciousness and cognitive impairment did not fully recover; however, she was&#13;
transferred to another hospital on day 149.&#13;
Conclusion Apart from psychiatric causes, organic etiologies should be considered in patients who have attempted&#13;
suicide if psychiatric interventions cannot explain cognitive abnormalities. This approach facilitates timely diagnosis&#13;
and management of treatable diseases such as coexisting anti-NMDAR encephalitis and autoimmune GFAP&#13;
astrocytopathy.&#13;
Keywords Glial fibrillary acidic protein astrocytopathy (GFAP-A), Autoimmune encephalitis, Psychiatric symptoms,&#13;
Suicide attempt, Hyponatremia</text>
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            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138242">
                <text>Soichiro Kano1&#13;
&#13;
, Ryo Kamidani1,2*, Takahito Miyake1&#13;
&#13;
, Tomohide Ando3&#13;
&#13;
, Yuto Tamaoki1,4, Yoya Ono3&#13;
&#13;
, Masato Shiba1,5,&#13;
&#13;
Akio Kimura3&#13;
&#13;
, Shozo Yoshida1&#13;
&#13;
, Takayoshi Shimohata3&#13;
&#13;
and Hideshi Okada1,6</text>
              </elementText>
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          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="138243">
                <text>https://doi.org/10.1186/s12245-025-01095-9</text>
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            </elementTextContainer>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="138244">
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                <text>peri irawan</text>
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          <element elementId="44">
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            <description>A language of the resource</description>
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        <name>Glial fibrillary acidic protein astrocytopathy (GFAP-A), Autoimmune</name>
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