Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Cardiac Manifestations and Diagnostic Imaging in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19: A Systematic Review
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Title
Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Cardiac Manifestations and Diagnostic Imaging in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19: A Systematic Review
Clinical Research Cardiac Manifestations and Diagnostic Imaging in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19: A Systematic Review
Subject
cardiovascular, COVID-19, echocardiography, pediatrics, PIMS-TS
Description
BACKGROUND Several studies have reported pediatric inflammatory multisystem
syndrome temporally associated with COVID-19 (PIMS-TS) cases with their cardiac
manifestations, but only few studies synthesize the cardiovascular characteristics in
children with PIMS-TS. However, detecting cardiac abnormalities is crucial in improving
patients' outcomes and reducing mortality. This review aimed to summarize the
overall symptoms, laboratory, and workup findings in PIMS-TS patients, focusing on
cardiovascular manifestations.
METHODS We searched 4 medical databases (PubMed, Science Direct, Medline, and
Scielo) and 4 preprint databases (Medrxiv, Research Square, SSRN, and Biorxiv). The
literature search was done on November 8, 2021. All case reports, case series, cross-
sectional studies, cohort studies, and possible clinical trials published from December
2020 onward that studied PIMS-TS on cardiac manifestation (aged 0–18 years) were
included. Studies on multisystem inflammatory syndrome in children, animal studies,
and studies without full-text availability were excluded. This review was registered in
PROSPERO (CRD42021194468).
RESULTS 59 studies were included with a total of 698 patients. The most common
cardiovascular findings were the presence of cardiogenic shock (37%) and hypotension
(8.5%). Almost all laboratory values were deranged. Cardiac computed tomography
scan mostly showed normal results (56%), followed by cardiomegaly with pericardial
effusion (14%). Electrocardiography showed normal findings (46%), ST-segment
abnormalities (32%), and abnormal T wave (12%). Echocardiography findings showed
left ventricle dysfunction (40.6%), which can be considered most significant, followed
by pericardial effusion together with pericarditis (11.4%) and tricuspid regurgitation
(6.9%).
CONCLUSIONS This review found various cardiac abnormalities that may develop during
PIMS-TS. Due to these findings, we should be more vigilant and not underestimate the
consequences in pediatric COVID-19 patients.
syndrome temporally associated with COVID-19 (PIMS-TS) cases with their cardiac
manifestations, but only few studies synthesize the cardiovascular characteristics in
children with PIMS-TS. However, detecting cardiac abnormalities is crucial in improving
patients' outcomes and reducing mortality. This review aimed to summarize the
overall symptoms, laboratory, and workup findings in PIMS-TS patients, focusing on
cardiovascular manifestations.
METHODS We searched 4 medical databases (PubMed, Science Direct, Medline, and
Scielo) and 4 preprint databases (Medrxiv, Research Square, SSRN, and Biorxiv). The
literature search was done on November 8, 2021. All case reports, case series, cross-
sectional studies, cohort studies, and possible clinical trials published from December
2020 onward that studied PIMS-TS on cardiac manifestation (aged 0–18 years) were
included. Studies on multisystem inflammatory syndrome in children, animal studies,
and studies without full-text availability were excluded. This review was registered in
PROSPERO (CRD42021194468).
RESULTS 59 studies were included with a total of 698 patients. The most common
cardiovascular findings were the presence of cardiogenic shock (37%) and hypotension
(8.5%). Almost all laboratory values were deranged. Cardiac computed tomography
scan mostly showed normal results (56%), followed by cardiomegaly with pericardial
effusion (14%). Electrocardiography showed normal findings (46%), ST-segment
abnormalities (32%), and abnormal T wave (12%). Echocardiography findings showed
left ventricle dysfunction (40.6%), which can be considered most significant, followed
by pericardial effusion together with pericarditis (11.4%) and tricuspid regurgitation
(6.9%).
CONCLUSIONS This review found various cardiac abnormalities that may develop during
PIMS-TS. Due to these findings, we should be more vigilant and not underestimate the
consequences in pediatric COVID-19 patients.
Creator
Gilbert Sterling Octavius, Ricardo Tan, Teodorus Alfons Pratama, Charista Lydia Budiputri, Fellisa Meliani, Rivaldo Steven Heriyanto, Rusli Muljadi, Andry Juliansen
Source
https://doi.org/10.13181/mji.oa.225754
Date
Accepted: January 25, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Gilbert Sterling Octavius, Ricardo Tan, Teodorus Alfons Pratama, Charista Lydia Budiputri, Fellisa Meliani, Rivaldo Steven Heriyanto, Rusli Muljadi, Andry Juliansen, “Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Cardiac Manifestations and Diagnostic Imaging in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19: A Systematic Review,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1042.
Clinical Research Cardiac Manifestations and Diagnostic Imaging in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19: A Systematic Review,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1042.