Can D-dimer predict length of hospital stay in COVID-19 survivors? A cross-
sectional study
Dublin Core
Title
Can D-dimer predict length of hospital stay in COVID-19 survivors? A cross-
sectional study
sectional study
Subject
COVID-19; D-dimer; length of hospital stay
Description
Background: COVID-19 has been shown to increase the risk of thrombosis,
where this mechanism occurs due to cell damage that triggers the release
of various proinflammatory cytokines and chemokines, thereby activating
the coagulation cascade. Thus, an increase D-dimer levels in COVID-19
patients occurs. Patients’ length of hospital stay (LOS) is pivotal in order
to improve patient care, lower overall expenses, and distribute resources
effectively.
Purpose: This study aims to identify the association between D-dimer and
other parameters as a predictor of LOS in COVID-19 survivors.
Methods: This observational analytic study included COVID-19 patients
who were admitted to Universitas Sebelas Maret Hospital in Sukoharjo,
Indonesia, from November 2020 to January 2021. The data were taken from
the medical records of patients diagnosed with COVID-19. Age, gender,
comorbidities, admission oxygen saturation, D-dimer, neutrophil-lymphocyte
ratio (NLR), haemoglobin, platelet count, white blood cells (WBC), estimated
glomerular filtration rate (eGFR), and LOS were analysed in this study.
Binary logistic regression was applied to determine the correlation between
potential predictors on LOS.
Results: A total 104 patients was included in the final analysis. The median
LOS was 13 days (IQR 9-17 days). There was an increase of D-dimer in 79
patients with the median 759.39 ng/ml. Patients with prolonged LOS tend
to have higher D-dimer levels (Median 924.95 vs 591.54 ng/ml, p = 0.018).
However, D-dimer and other parameters were not associated with prolonged
LOS in COVID-19 survivors (D-dimer p = 0.188; Age p = 0.138; Diabetes
mellitus p = 0.172; NLR p = 0.859; Platelet count p = 0.097).
Conclusion: D-dimer levels do not accurately predict prolonged LOS in
COVID-19 survivors. Therefore, we suggest D-dimer solely should not be
used as a tool to predict a patient’s LOS.
where this mechanism occurs due to cell damage that triggers the release
of various proinflammatory cytokines and chemokines, thereby activating
the coagulation cascade. Thus, an increase D-dimer levels in COVID-19
patients occurs. Patients’ length of hospital stay (LOS) is pivotal in order
to improve patient care, lower overall expenses, and distribute resources
effectively.
Purpose: This study aims to identify the association between D-dimer and
other parameters as a predictor of LOS in COVID-19 survivors.
Methods: This observational analytic study included COVID-19 patients
who were admitted to Universitas Sebelas Maret Hospital in Sukoharjo,
Indonesia, from November 2020 to January 2021. The data were taken from
the medical records of patients diagnosed with COVID-19. Age, gender,
comorbidities, admission oxygen saturation, D-dimer, neutrophil-lymphocyte
ratio (NLR), haemoglobin, platelet count, white blood cells (WBC), estimated
glomerular filtration rate (eGFR), and LOS were analysed in this study.
Binary logistic regression was applied to determine the correlation between
potential predictors on LOS.
Results: A total 104 patients was included in the final analysis. The median
LOS was 13 days (IQR 9-17 days). There was an increase of D-dimer in 79
patients with the median 759.39 ng/ml. Patients with prolonged LOS tend
to have higher D-dimer levels (Median 924.95 vs 591.54 ng/ml, p = 0.018).
However, D-dimer and other parameters were not associated with prolonged
LOS in COVID-19 survivors (D-dimer p = 0.188; Age p = 0.138; Diabetes
mellitus p = 0.172; NLR p = 0.859; Platelet count p = 0.097).
Conclusion: D-dimer levels do not accurately predict prolonged LOS in
COVID-19 survivors. Therefore, we suggest D-dimer solely should not be
used as a tool to predict a patient’s LOS.
Creator
Matthew Aldo Wijayanto1* , Risalina Myrtha2 , Dwi Rahayu3 , Graciella
Angelica Lukas1
Angelica Lukas1
Source
http://jkp.fkep.unpad.ac.id/index.
php/jkp
php/jkp
Date
August 01, 2023
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Matthew Aldo Wijayanto1* , Risalina Myrtha2 , Dwi Rahayu3 , Graciella
Angelica Lukas1, “Can D-dimer predict length of hospital stay in COVID-19 survivors? A cross-
sectional study,” Repository Horizon University Indonesia, accessed February 10, 2026, https://repository.horizon.ac.id/items/show/10631.
sectional study,” Repository Horizon University Indonesia, accessed February 10, 2026, https://repository.horizon.ac.id/items/show/10631.