Correlation between Neutrophil/ Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke
patients

Correlation between Neutrophil/ Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke
patients

cognitive; HDL; LDL; location; NLR; stroke

Background: Stroke is the leading cause of long-term disability with
significant clinical and socioeconomic impact worldwide. Hyperlipidemia and
inflammation play major roles in ischemic stroke. This research focuses on
the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR),
lipid profile, and lesion location, with vascular cognitive impairment (VCI).
These factors may serve as potential predictors for VCI.
Purpose: This research aims to study the correlation between NLR, lipid
profile, and lesion location with vascular cognitive impairment. In addition,
this research aims to explore those potential biomarkers as predictors of
vascular cognitive impairment.
Methods: This was a cross-sectional study which included 107 patients
diagnosed with ischemic stroke from February 2022 to January 2023 with
a history of admission to the hospital within 72 hours. After they signed an
informed consent form, every patient had history taking, physical exam,
lipid profile, routine blood test, Mini Mental State Examination (MMSE) and
Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first
hospital day. Statistical tests were done with Spearman correlation method.
Results: The data distribution was not normal for INR and MoCA-INA values
(p<0.05). Total cholesterol was insignificantly (p=0.092) correlated with
MoCA-INA score with low correlation value (r=-0.293). HDL was significantly
(p=0.035) correlated with MoCA-INA score with moderate correlation value
(r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score
with low correlation value (r=-0.387). Triglycerides was insignificantly
(p=0.440) correlated with MoCA-INA score with very weak correlation value
(r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score
with moderate correlation value (r=-0.412).

Conclusions: Lipid profile is correlated with cognitive impairment in post-
stroke patients, with HDL being a protective factor, and LDL as risk factor.

NLR was associated with worse cognitive function and LDL was directly
proportional to NLR. Lesion location reporting was highly heterogeneous
and more uniformed reporting is recommended for future research.

Ira Ristinawati1* , Kenneth Tan2 , Benedictus Benedictus2 , Muhammad
Hafizhan1 , Stefanus Erdana Putra1 , Suroto Suroto1 , Diah Kurnia
Mirawati1 , Subandi Subandi1 , Rivan Danuaji1 , Pepi Budianto1 , Yetty
Hambarsari1 , Baarid Luqman Hamidi1 , Hanindia Riani Prabaningtyas1
, Ervina Arta Jayanti Hutabarat1 , Teddy Tejomukti1 , Raden Andi Ario
Tedjo1

http://jkp.fkep.unpad.ac.id/index.
php/jkp

August 23, 2024

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