Estimating the 10-year fracture risk
among persons with HIV and persons
without HIV: A comparative study

Estimating the 10-year fracture risk
among persons with HIV and persons
without HIV: A comparative study

FRAXTM, hip fractures, HIV, osteoporotic fractures, 10-year risk
of fracture

Background: The risk of osteoporotic fracture among persons with HIV was
higher than the persons without HIV. Traditional factors are also found as
the risk factor affecting fracture risk among persons with HIV and general
population. Predicting the fracture risk among the high-risk group is important
to develop a comprehensive fracture prevention program.
Purpose: This study aimed to compare the estimation of the 10-year fracture
risk between persons with HIV and persons without HIV using the FRAXTM
algorithm.
Methods: This study recruited 245 participants from August to November
2023, while 221 participants agreed to participate. The participants consist
of 107 persons with HIV and 114 persons without HIV. The estimation of the
ten-year probability of major osteoporotic and hip fractures was calculated
using the FRAXTM algorithm. The participant’s characteristics related to
osteoporotic fracture risk was analyzed using a Chi-Square analysis.
Results: The overall mean score of 10-year probability of major osteoporotic
fracture (MOF) was 3.1% (SD 1.9) for the HIV group and 2.7% (SD 2.3) for
non-HIV. For the 10-year probability, hip fracture (HF) risk was 0.5% (SD 0.5)
for the HIV group and 0.6% (SD 0.9) for non-HIV. For MOF, HIV persons with
fracture history showed a lower score (3.5%) compared to persons without
HIV (5.3%). Smoker HIV persons showed the same MOF score (4.6% vs.
4.6%) but lower HF score (0.8% vs. 1.6%) when comparing to persons
without HIV, respectively. HIV persons with glucocorticoid use showed a
higher MOF probability score than persons without HIV (2.8% vs 2.7%).
Conclusion: The 10-year fracture risk was higher among persons with HIV
compared to persons without HIV. Fracture history, smoking behavior, and
glucocorticoid use were identified as the potential factors associated with the
risk. Further analysis using multivariate regression analysis may require to
confirm the factors associated with high fracture risk.

Iqbal Pramukti1

* , Kusman Ibrahim2 , Mamat Lukman1 , Hasniatisari

Harun2 , Andri Nugraha3,4 , Chung-Ying Lin5,6,7

http://jkp.fkep.unpad.ac.id/index.
php/jkp

: April 28, 2025

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