Short Term Outcome and Associated Factors among Stroke Patients Given Thrombolysis
Dublin Core
Title
Short Term Outcome and Associated Factors among Stroke Patients Given Thrombolysis
Subject
thrombolysis, outcome, Philippines, patients, Stroke
Description
The study aimed to investigate the short-term outcome and associated factors among acute ischemic
stroke patients given rTPA (Recombinant tissue plasminogen activator). This is a hospital-based cross-sectional
retrospective study among 107 acute stroke patients given rTPA for a span of 3 years. A favorable outcome is
defined as the modified Rankin Scale (MRS) 0 to 2, while a score > 2 is defined as a poor outcome. Mortality and
adverse events were also documented. The majority (57%) had favorable outcomes on discharge. Initial stroke
severity, stroke etiology, and presence of symptomatic Intracerebral hemorrhage (ICH) were significant factors
for discharge outcome. There was no significance as to age group and as to needle time of 0-3 hours versus 3-4.5
hours. The symptomatic ICH rate is 5.6%. The overall mortality rate is 15.88% (47% due to malignant
infarction, 17.6% due to symptomatic intracerebral hemorrhage (sICH), 23.52% due to basilar artery
occlusion (BAO), and 11.7% due to medical causes). With a dose of 0.6mg/kg, our data indicate favorable
discharge outcomes of thrombolysis. A high baseline NIHSS, cardioembolic stroke etiology, and the presence of
sICH are seen in patients with poor outcomes. The rate of sICH is consistent with other literature, however with
high mortality (100%). Overall mortality is high primarily due to malignant infarct. Institutions must be capacitated to address outcomes and complications of thrombolysis.
stroke patients given rTPA (Recombinant tissue plasminogen activator). This is a hospital-based cross-sectional
retrospective study among 107 acute stroke patients given rTPA for a span of 3 years. A favorable outcome is
defined as the modified Rankin Scale (MRS) 0 to 2, while a score > 2 is defined as a poor outcome. Mortality and
adverse events were also documented. The majority (57%) had favorable outcomes on discharge. Initial stroke
severity, stroke etiology, and presence of symptomatic Intracerebral hemorrhage (ICH) were significant factors
for discharge outcome. There was no significance as to age group and as to needle time of 0-3 hours versus 3-4.5
hours. The symptomatic ICH rate is 5.6%. The overall mortality rate is 15.88% (47% due to malignant
infarction, 17.6% due to symptomatic intracerebral hemorrhage (sICH), 23.52% due to basilar artery
occlusion (BAO), and 11.7% due to medical causes). With a dose of 0.6mg/kg, our data indicate favorable
discharge outcomes of thrombolysis. A high baseline NIHSS, cardioembolic stroke etiology, and the presence of
sICH are seen in patients with poor outcomes. The rate of sICH is consistent with other literature, however with
high mortality (100%). Overall mortality is high primarily due to malignant infarct. Institutions must be capacitated to address outcomes and complications of thrombolysis.
Creator
Florilyn Joyce C. Bentrez
Source
https://doi.org/10.23917/bik.v18i1.5547
Publisher
Universitas Muhammadiyah Surakarta
Date
2025
Contributor
Sri Wahyuni
Rights
p-ISSN: 1979-2697
e-ISSN: 2721-1797
e-ISSN: 2721-1797
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Florilyn Joyce C. Bentrez, “Short Term Outcome and Associated Factors among Stroke Patients Given Thrombolysis,” Repository Horizon University Indonesia, accessed February 12, 2026, https://repository.horizon.ac.id/items/show/10794.