GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults
Dublin Core
Title
GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults
Subject
diabetes mellitus, fitness, GABA, health risk, serotonin
Description
Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and
physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk.
Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get
socio-economy, daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-
locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure,
3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2
independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek
differences between genotypes and correlation strength between variables, respectively (significant if p<0.05).
Results: Both gene’s genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively);
GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG
between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6
(η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237).
Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good
association with the FBG and physical fitness levels.
physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk.
Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get
socio-economy, daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-
locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure,
3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2
independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek
differences between genotypes and correlation strength between variables, respectively (significant if p<0.05).
Results: Both gene’s genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively);
GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG
between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6
(η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237).
Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good
association with the FBG and physical fitness levels.
Creator
Viskasari P. Kalajanti1
, Mariana Wahjudi
2
, Kusuma E. Purwantari1
, Visuddho1
,
Peppy Nawangsasi3
, Rury T. Oktariza4
, Krisnawan A. Pradana1
, Dzanuar Rahmawan5
, and
Bambang E. Suwito6
, Mariana Wahjudi
2
, Kusuma E. Purwantari1
, Visuddho1
,
Peppy Nawangsasi3
, Rury T. Oktariza4
, Krisnawan A. Pradana1
, Dzanuar Rahmawan5
, and
Bambang E. Suwito6
Source
http://dx.doi.org/10.20473/jn.v18i1.43770
Date
29 March 2023
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Viskasari P. Kalajanti1
, Mariana Wahjudi
2
, Kusuma E. Purwantari1
, Visuddho1
,
Peppy Nawangsasi3
, Rury T. Oktariza4
, Krisnawan A. Pradana1
, Dzanuar Rahmawan5
, and
Bambang E. Suwito6, “GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/10870.