Potential effect of green tea extract for adjuvant
treatment of acute ischemic stroke by s100ß
upregulation in non-thrombolysis patient [state
the method here]
Dublin Core
Title
Potential effect of green tea extract for adjuvant
treatment of acute ischemic stroke by s100ß
upregulation in non-thrombolysis patient [state
the method here]
treatment of acute ischemic stroke by s100ß
upregulation in non-thrombolysis patient [state
the method here]
Subject
acute ischemic stroke, EGCG, green tea extract, S100ß
Description
Introduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and
oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine
the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients.
Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The
subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment,
randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract
350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS),
Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100ß were analysed.
Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to
14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively).
The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score
from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100ß were
statistically significant in day 7 (p=0.006). The difference in S100ß from day 0 to 7 was statistically significant (p=0.001).
Conclusions: The green tea extract, through up-regulation S100ß, can improve the clinical outcomes of acute
ischemic stroke.
oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine
the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients.
Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The
subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment,
randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract
350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS),
Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100ß were analysed.
Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to
14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively).
The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score
from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100ß were
statistically significant in day 7 (p=0.006). The difference in S100ß from day 0 to 7 was statistically significant (p=0.001).
Conclusions: The green tea extract, through up-regulation S100ß, can improve the clinical outcomes of acute
ischemic stroke.
Creator
Abdulloh Machin1
* , Djoko Agus Purwanto2
, Anny Hanifah3
, Isti Suharjanti1
, Muhammad Ja'far
Shodiq4
, M. Fata Fatihuddin1
, Beom Joon Kim5
, and Azizah Amimathul Firdha6
* , Djoko Agus Purwanto2
, Anny Hanifah3
, Isti Suharjanti1
, Muhammad Ja'far
Shodiq4
, M. Fata Fatihuddin1
, Beom Joon Kim5
, and Azizah Amimathul Firdha6
Source
http://dx.doi.org/10.20473/jn.v18i2.45537
Date
19 June 2023
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Abdulloh Machin1
* , Djoko Agus Purwanto2
, Anny Hanifah3
, Isti Suharjanti1
, Muhammad Ja'far
Shodiq4
, M. Fata Fatihuddin1
, Beom Joon Kim5
, and Azizah Amimathul Firdha6, “Potential effect of green tea extract for adjuvant
treatment of acute ischemic stroke by s100ß
upregulation in non-thrombolysis patient [state
the method here],” Repository Horizon University Indonesia, accessed February 13, 2026, https://repository.horizon.ac.id/items/show/10904.
treatment of acute ischemic stroke by s100ß
upregulation in non-thrombolysis patient [state
the method here],” Repository Horizon University Indonesia, accessed February 13, 2026, https://repository.horizon.ac.id/items/show/10904.