Meta-analysis of the prevalence of restless leg syndrome and associated risk factors in chronic kidney disease patients
Dublin Core
Title
Meta-analysis of the prevalence of restless leg syndrome and associated risk factors in chronic kidney disease patients
Subject
chronic kidney disease, meta-analysis, prevalence, renal disease, restless leg syndrome
Description
Introduction: Restless legs syndrome (RLS) presents as a sleep-related issue in individuals with chronic kidney
disease (CKD), contributing to heightened sleep disturbances and diminished quality of life. Consequently, this meta-
analysis was conducted to assess the prevalence of RLS among CKD patients.
Methods: A comprehensive search for articles published between inception and September 2023 was conducted
across CINAHL, Cochrane, Embase, Ovid-MEDLINE, PubMed, Scopus, and Web of Science databases. A Comprehensive
Meta-Analysis (CMA) software version 3.0 with random effects models was used for pooled prevalence and prediction
interval analysis. Heterogeneity was assessed using the I2 test and Cochran's Q-statistic. The quality of the studies
was evaluated using Hoy's risk of bias. Additionally, moderator analyses were performed to investigate variations in
the prevalence estimates among the included studies.
Results: A total of 97 studies were included in this meta-analysis with 315,875 participants. The pooled prevalence
of RLS among CKD patients was 25% (95%CI: 20% to 32%). In terms of the demographic breakdown, the prevalence
of RLS was nearly comparable in adults and children/adolescents at 25% and 21%, respectively. The prediction interval
indicated a potential future RLS prevalence ranging from 1% to 88%. Notably, iron and phosphorus levels emerged as
significant moderating factors influencing the prevalence of RLS.
Conclusions: Roughly 25% of individuals with chronic kidney disease (CKD) encounter restless legs syndrome (RLS).
It is imperative to foster collaboration among healthcare professionals to facilitate proactive management and early
assessment of RLS, thereby enhancing the overall quality of life for CKD patients.
disease (CKD), contributing to heightened sleep disturbances and diminished quality of life. Consequently, this meta-
analysis was conducted to assess the prevalence of RLS among CKD patients.
Methods: A comprehensive search for articles published between inception and September 2023 was conducted
across CINAHL, Cochrane, Embase, Ovid-MEDLINE, PubMed, Scopus, and Web of Science databases. A Comprehensive
Meta-Analysis (CMA) software version 3.0 with random effects models was used for pooled prevalence and prediction
interval analysis. Heterogeneity was assessed using the I2 test and Cochran's Q-statistic. The quality of the studies
was evaluated using Hoy's risk of bias. Additionally, moderator analyses were performed to investigate variations in
the prevalence estimates among the included studies.
Results: A total of 97 studies were included in this meta-analysis with 315,875 participants. The pooled prevalence
of RLS among CKD patients was 25% (95%CI: 20% to 32%). In terms of the demographic breakdown, the prevalence
of RLS was nearly comparable in adults and children/adolescents at 25% and 21%, respectively. The prediction interval
indicated a potential future RLS prevalence ranging from 1% to 88%. Notably, iron and phosphorus levels emerged as
significant moderating factors influencing the prevalence of RLS.
Conclusions: Roughly 25% of individuals with chronic kidney disease (CKD) encounter restless legs syndrome (RLS).
It is imperative to foster collaboration among healthcare professionals to facilitate proactive management and early
assessment of RLS, thereby enhancing the overall quality of life for CKD patients.
Creator
Nur Aini1,2,* , Fitria Endah Janitra1,3
, Alfiani Rahmi Putri1
, Nelsensius Klau Fauk4
, and Hidayat Arifin1,
, Alfiani Rahmi Putri1
, Nelsensius Klau Fauk4
, and Hidayat Arifin1,
Source
http://dx.doi.org/10.20473/jn.v19i2.54993
Date
May 2024,
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Nur Aini1,2,* , Fitria Endah Janitra1,3
, Alfiani Rahmi Putri1
, Nelsensius Klau Fauk4
, and Hidayat Arifin1,, “Meta-analysis of the prevalence of restless leg syndrome and associated risk factors in chronic kidney disease patients,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/11010.