Effectiveness of resistance training to improve muscle strength and physical performance of patients with diabetes mellitus: a meta-analysis
Dublin Core
Title
Effectiveness of resistance training to improve muscle strength and physical performance of patients with diabetes mellitus: a meta-analysis
Subject
diabetes mellitus, muscle strength, physical performance, resistance training
Description
Introduction: Metabolic disorders in diabetes mellitus (DM) sufferers, caused by insulin resistance, chronic muscle
inflammation, and mitochondrial dysfunction, can affect muscle structure and function and reduce physical
performance (PP). Thus, rehabilitation in the form of resistance training (RT) is needed to overcome these problems.
This study aims to determine the effect of RT on muscle strength (MS; lower and upper limbs) and PP (primary outcome),
as well as body mass index (BMI), VO2 peak, lean muscle mass, HbA1c, blood pressure (BP), and adverse events
(secondary outcome) in patients with DM.
Methods: Six databases were used in a comprehensive search conducted from March to April 2025 to locate relevant
articles. We used Standard Mean Difference (SMD), Mean Difference (MD), and Risk Difference with a 95% Confidence
Interval (CI), to determine the effect of RT. We assess the quality of studies using the Joanna Briggs Institution checklist.
Results: 26 articles randomized controlled trial articles were included, showing that RT has a significant effect on
improving MS (lower and upper limbs), PP (primary outcome), and VO2 peak, LMM (secondary outcome); Additionally,
RT has a significant effect in lowering HbA1c and systolic blood pressure (SBP), but not significantly in reducing diastolic
blood pressure (DBP) (secondary outcome) between the intervention group and control group of patients with DM.
There were no RT-related adverse events.
Conclusions: RT is a rehabilitation recommendation to improve MS and PP and is also a rehabilitative effort for those
living with DM.
inflammation, and mitochondrial dysfunction, can affect muscle structure and function and reduce physical
performance (PP). Thus, rehabilitation in the form of resistance training (RT) is needed to overcome these problems.
This study aims to determine the effect of RT on muscle strength (MS; lower and upper limbs) and PP (primary outcome),
as well as body mass index (BMI), VO2 peak, lean muscle mass, HbA1c, blood pressure (BP), and adverse events
(secondary outcome) in patients with DM.
Methods: Six databases were used in a comprehensive search conducted from March to April 2025 to locate relevant
articles. We used Standard Mean Difference (SMD), Mean Difference (MD), and Risk Difference with a 95% Confidence
Interval (CI), to determine the effect of RT. We assess the quality of studies using the Joanna Briggs Institution checklist.
Results: 26 articles randomized controlled trial articles were included, showing that RT has a significant effect on
improving MS (lower and upper limbs), PP (primary outcome), and VO2 peak, LMM (secondary outcome); Additionally,
RT has a significant effect in lowering HbA1c and systolic blood pressure (SBP), but not significantly in reducing diastolic
blood pressure (DBP) (secondary outcome) between the intervention group and control group of patients with DM.
There were no RT-related adverse events.
Conclusions: RT is a rehabilitation recommendation to improve MS and PP and is also a rehabilitative effort for those
living with DM.
Creator
Priscilla Mary Ntim Babae1
, Awurabena Quayeba Dadzie1
, and Denny Maurits Ruku
, Awurabena Quayeba Dadzie1
, and Denny Maurits Ruku
Source
http://dx.doi.org/10.20473/jn.v20i3.72925
Date
19 August 2025
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Priscilla Mary Ntim Babae1
, Awurabena Quayeba Dadzie1
, and Denny Maurits Ruku, “Effectiveness of resistance training to improve muscle strength and physical performance of patients with diabetes mellitus: a meta-analysis,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/11156.