A Pilot Study of Diabetes Distress with Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c of Diabetic Patients
Dublin Core
Title
A Pilot Study of Diabetes Distress with Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c of Diabetic Patients
Subject
Diabetes; HbA1c; IGF-I; IGFBP-3
Description
Background: Diabetes distress refers to the emotional and psychological burden
experienced by individuals in managing their condition, which can influence
physiological outcomes and overall well-being. However, the relationship between
HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding
protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive.
Purpose: The objective of this study was to evaluate the association of IGF-I,
IGFBP-3, and HbA1c with diabetes distress in diabetic patients.
Methods: A cross-sectional design with purposive sampling was used to recruit
subjects from the public health center in Kendari City, Southeast Sulawesi,
Indonesia, from May to November 2021. A total of 30 diabetic patients were
recruited for the study. Distress data were collected using the Indonesian version
of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured
using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I
and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent
Assay) kit method. The data were analyzed using regression analysis.
Results: Most respondents had moderate distress, with a DDS score of 53.4%, a
high IGF-I level of 76.7%, and a low IGFBP-3 level of 76.7%. As many as 60% of
respondents had an HbA1c level above 6.4%. IGF-I (ρ-value=0.024) and IGFBP-3
levels (ρ-value=0.042) showed a significant correlation with diabetes distress.
However, HbA1c levels did not significantly correlate with diabetes distress (ρ-
value=0.155).
Conclusion: IGF-I and IGFBP-3 levels were associated with diabetes distress, but
HbA1c was not. Patients with higher distress were found to have elevated serum
levels of IGF-I and IGFBP-3. Future research should focus on stress management
strategies that support efforts to prevent disease and complications associated with
diabetes mellitus.
experienced by individuals in managing their condition, which can influence
physiological outcomes and overall well-being. However, the relationship between
HbA1c, insulin growth factor-I (IGF-I), and insulin-like growth factor binding
protein-3 (IGFBP-3) with diabetes distress in diabetic patients remains elusive.
Purpose: The objective of this study was to evaluate the association of IGF-I,
IGFBP-3, and HbA1c with diabetes distress in diabetic patients.
Methods: A cross-sectional design with purposive sampling was used to recruit
subjects from the public health center in Kendari City, Southeast Sulawesi,
Indonesia, from May to November 2021. A total of 30 diabetic patients were
recruited for the study. Distress data were collected using the Indonesian version
of the Diabetes Distress Scale (DDS) questionnaire. HbA1c levels were measured
using High-Performance Liquid Chromatography (HPLC). Serum levels of IGF-I
and IGFBP-3 were measured using the ELISA (Enzyme-Linked Immunosorbent
Assay) kit method. The data were analyzed using regression analysis.
Results: Most respondents had moderate distress, with a DDS score of 53.4%, a
high IGF-I level of 76.7%, and a low IGFBP-3 level of 76.7%. As many as 60% of
respondents had an HbA1c level above 6.4%. IGF-I (ρ-value=0.024) and IGFBP-3
levels (ρ-value=0.042) showed a significant correlation with diabetes distress.
However, HbA1c levels did not significantly correlate with diabetes distress (ρ-
value=0.155).
Conclusion: IGF-I and IGFBP-3 levels were associated with diabetes distress, but
HbA1c was not. Patients with higher distress were found to have elevated serum
levels of IGF-I and IGFBP-3. Future research should focus on stress management
strategies that support efforts to prevent disease and complications associated with
diabetes mellitus.
Creator
Tahiruddin Tahiruddin1
, Diah Indriastuti2, Syahrul Syahrul3, Andi Masyitha Irwan3, Satriya Pranata4
, Diah Indriastuti2, Syahrul Syahrul3, Andi Masyitha Irwan3, Satriya Pranata4
Source
https://doi.org/10.14710/nmjn.v15i1.58052
Date
23 February 2025
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Tahiruddin Tahiruddin1
, Diah Indriastuti2, Syahrul Syahrul3, Andi Masyitha Irwan3, Satriya Pranata4, “A Pilot Study of Diabetes Distress with Insulin Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and HbA1c of Diabetic Patients,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/11308.