Key Predictors of Medication Adherence Among Diagnosed Pulmonary Tuberculosis Patients: A Cross-Sectional Study
Dublin Core
Title
Key Predictors of Medication Adherence Among Diagnosed Pulmonary Tuberculosis Patients: A Cross-Sectional Study
Subject
Adherence; drug side effects; knowledge; medication; support
systems; tuberculosis
systems; tuberculosis
Description
Background: Medication adherence remains a critical challenge in tuberculosis
(TB) control, particularly in Indonesia, which ranks second globally in TB incidence.
Most existing studies focus on single-factor analyses rather than a comprehensive
multifactorial assessment of adherence predictors among Indonesian TB patients.
Purpose: This study aimed to identify and quantify key predictors of medication
adherence among diagnosed pulmonary tuberculosis patients with particular
emphasis on sociodemographic factors, clinical variables, and psychosocial
determinants.
Methods: A cross-sectional study was conducted involving 150 pulmonary TB
patients recruited through consecutive sampling. Data were collected using
validated instruments, including the 8-item Morisky Medication Adherence Scale
(MMAS-8) for adherence, the Knowledge About Tuberculosis Questionnaire
(KATUB-Q) for TB knowledge, a structured questionnaire for drug side effects, the
Treatment Motivation Questionnaire for motivation, the Multidimensional Scale of
Perceived Social Support (MSPSS) for support systems, and the TB-related Stigma
Scale for stigma measurement. Statistical analyses included descriptive statistics,
Chi-square tests, and ordinal logistic regression to evaluate relationships between
variables and adherence levels.
Results: Only 20% of participants demonstrated high adherence, while 50.7%
exhibited low adherence. Significant predictors of adherence included early
adulthood (OR = 0.061, 95% CI 0.004−0.857, p = 0.038) and middle adulthood (OR
= 0.052, 95% CI 0.005−0.565, p = 0.015), indicating lower adherence compared to
late elderly. Other predictors were poor TB knowledge (OR = 0.316, 95% CI 0.154–
0.650, p = 0.002), motivation (OR = 0.244, 95% CI 0.108–0.553, p < 0.001), family
support (OR = 0.470, 95% CI 0.232–0.952, p = 0.036), healthcare worker support
(OR = 0.349, 95% CI 0.204–0.840, p = 0.015), and drug side effects (OR = 5.294,
95% CI 2.134–13.126, p < 0.001). Younger adults showed lower adherence rates
compared to older populations, while patients with better knowledge and stronger
support systems demonstrated higher adherence.
Conclusion: Key predictors of medication adherence were age, TB knowledge,
motivation, family support, healthcare worker support, and drug side effects.
Younger patients, those with poor knowledge, moderate motivation, inadequate
support systems, and severe side effects demonstrated significantly lower adherence
rates. These findings highlight the need for targeted, multifactorial interventions to
improve TB treatment outcomes.
(TB) control, particularly in Indonesia, which ranks second globally in TB incidence.
Most existing studies focus on single-factor analyses rather than a comprehensive
multifactorial assessment of adherence predictors among Indonesian TB patients.
Purpose: This study aimed to identify and quantify key predictors of medication
adherence among diagnosed pulmonary tuberculosis patients with particular
emphasis on sociodemographic factors, clinical variables, and psychosocial
determinants.
Methods: A cross-sectional study was conducted involving 150 pulmonary TB
patients recruited through consecutive sampling. Data were collected using
validated instruments, including the 8-item Morisky Medication Adherence Scale
(MMAS-8) for adherence, the Knowledge About Tuberculosis Questionnaire
(KATUB-Q) for TB knowledge, a structured questionnaire for drug side effects, the
Treatment Motivation Questionnaire for motivation, the Multidimensional Scale of
Perceived Social Support (MSPSS) for support systems, and the TB-related Stigma
Scale for stigma measurement. Statistical analyses included descriptive statistics,
Chi-square tests, and ordinal logistic regression to evaluate relationships between
variables and adherence levels.
Results: Only 20% of participants demonstrated high adherence, while 50.7%
exhibited low adherence. Significant predictors of adherence included early
adulthood (OR = 0.061, 95% CI 0.004−0.857, p = 0.038) and middle adulthood (OR
= 0.052, 95% CI 0.005−0.565, p = 0.015), indicating lower adherence compared to
late elderly. Other predictors were poor TB knowledge (OR = 0.316, 95% CI 0.154–
0.650, p = 0.002), motivation (OR = 0.244, 95% CI 0.108–0.553, p < 0.001), family
support (OR = 0.470, 95% CI 0.232–0.952, p = 0.036), healthcare worker support
(OR = 0.349, 95% CI 0.204–0.840, p = 0.015), and drug side effects (OR = 5.294,
95% CI 2.134–13.126, p < 0.001). Younger adults showed lower adherence rates
compared to older populations, while patients with better knowledge and stronger
support systems demonstrated higher adherence.
Conclusion: Key predictors of medication adherence were age, TB knowledge,
motivation, family support, healthcare worker support, and drug side effects.
Younger patients, those with poor knowledge, moderate motivation, inadequate
support systems, and severe side effects demonstrated significantly lower adherence
rates. These findings highlight the need for targeted, multifactorial interventions to
improve TB treatment outcomes.
Creator
Rika Sarfika1
, Endang Martini2, Siti Yuliharni1
, I Made Moh. Yanuar Saifudin3
, Endang Martini2, Siti Yuliharni1
, I Made Moh. Yanuar Saifudin3
Source
https://doi.org/10.14710/nmjn.v15i2.70345
Date
30 August 2025
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Rika Sarfika1
, Endang Martini2, Siti Yuliharni1
, I Made Moh. Yanuar Saifudin3, “Key Predictors of Medication Adherence Among Diagnosed Pulmonary Tuberculosis Patients: A Cross-Sectional Study,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/11323.