Case-Control Study of Occupational Acute Myeloid Leukemia in the
Republic of Korea

Case-Control Study of Occupational Acute Myeloid Leukemia in the
Republic of Korea

Acute myeloid leukemia
Case-control study
Exposure
Occupation
Risk factors

We conducted a case-control study to identify high-risk occupations and exposure to
occupational hazards for acute myeloid leukemia (AML).
Methods: When patients with AML admitted to the Department of Hematology in the study hospital for
the first time are referred to the Department of Occupational and Environmental Medicine, data on
occupation are collected by investigators to evaluate work-relatedness. Community-based controls were
recruited through an online survey agency, and four controls per case were matched. Occupational information was estimated using structured questionnaires covering 27 specific occupations and 32
exposure agents. Conditional logistic regression analysis was performed by pairing cases and controls.
Results: In the analysis of the risk of AML according to occupational classification, a significant association was found in paint manufacturing or painting work (OR ¼ 2.22, 95% CI: 1.03e4.81) and aircrew
(OR ¼ 6.00, 95% CI: 1.00e35.91) in males, and in pesticide industry (OR ¼ 6.89, 95% CI: 1.69e28.07) and
cokes and steel industry (OR ¼ 2.00, 95% CI: 1.18e22.06) in 60 years old. Moreover, the risk of AML
increased significantly as the cumulative exposure to thinners increased. In the analyses stratified by sex
and age, the association between pesticide exposure and AML was significant in males (OR ¼ 3.28, 95%
CI: 1.10e9.77) and in 60 years old (OR ¼ 6.22, 95% CI: 1.48e26.08).
Conclusion: This case-control study identified high-risk occupational groups in the Republic of
Korea including paint manufacturers and painters, aircrew, and those who are occupationally exposed to
pesticides or paint thinners

Min Young Park 1
, Hyoung-Ryoul Kim 1
, Jun-Pyo Myong 1
, Byung-Sik Cho 2,3
,
Hee-Je Kim 2,3,**, Mo-Yeol Kang

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1Department of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic
of Korea
2Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic
of Korea
3 Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

4 November 2023

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