Asbestos Exposure and Ovarian Cancer: A Meta-analysis
Dublin Core
Title
Asbestos Exposure and Ovarian Cancer: A Meta-analysis
Subject
Asbestos
Meta-analysis
Ovarian cancer
Meta-analysis
Ovarian cancer
Description
Background: The International Agency for Research on Cancer (IARC) Monograph conducted a systematic
review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study
performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph
on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer.
Methods: A comprehensive search of major journal databases was conducted to identify studies examining
the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC
Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed.
Results: The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a
summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03d4.05; p ¼ 0.0123; 5 studies), with a
significant degree of heterogeneity among the studies (I2 ¼ 72.99%). The combined analysis of 15 studies
before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43d2.06;
p ¼ 0.0349; 15 studies), with a moderate degree of heterogeneity (I2 ¼ 42.99%).
Conclusion: This meta-analysis provides evidence of a significant association between asbestos exposure
and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be
completely ruled out, recent findings suggest a robust correlation between asbestos exposure and
ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and
protect public health
review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study
performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph
on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer.
Methods: A comprehensive search of major journal databases was conducted to identify studies examining
the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC
Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed.
Results: The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a
summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03d4.05; p ¼ 0.0123; 5 studies), with a
significant degree of heterogeneity among the studies (I2 ¼ 72.99%). The combined analysis of 15 studies
before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43d2.06;
p ¼ 0.0349; 15 studies), with a moderate degree of heterogeneity (I2 ¼ 42.99%).
Conclusion: This meta-analysis provides evidence of a significant association between asbestos exposure
and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be
completely ruled out, recent findings suggest a robust correlation between asbestos exposure and
ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and
protect public health
Creator
Seo Young Kim 1
, Ha Kyun Chang 2,**, Ohwi Kwon 1
, JaeYoung Park 1
, Jun-Pyo Myong
, Ha Kyun Chang 2,**, Ohwi Kwon 1
, JaeYoung Park 1
, Jun-Pyo Myong
Source
https://pdf.sciencedirectassets.com/287282/1-s2.0-S2093791124X00025/1-s2.0-S2093791123000744/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjED0aCXVzLWVhc3QtMSJHMEUCIQD4AXl7NYTO7uof3odtfCere47p3FuZ05gtBM9tLAYKHgIgMvSKKZukHQnsIC7AfN%2BNqI6g4GJ8DuEiLzA3BOfw3NUqsgUIBRAFGgwwNTkwMDM1NDY4NjUiDL1BKcpciC1ADknKXyqPBYkoFv2Z4diZWz%2BxuoU9wdX3%2B3ZaYtKlJQCOcOXq0dHseTSGV8fK8G3l3MrlGfjRpQp1K6%2BjvYRK65W2r7bF8HIogSUupa4F29doRPa1ZicO9nZLd0JPMPvl0STbAH9XihE5XDMwdlvqpF7yXcqg2Jw%2BmiGmNOj%2FpExy4D6hKl35d2NJmOICHZIsflG%2F3wjI%2FpGljxBEUOTqsWylmryUsmArEXedoLhQaHBESZWAUl5vGBdgDE4pAAqaX3EbCYfSEGdcAZvNUPIcaCESDwn1ROoACvBpasoHHvTaHbF3dLgiVwIdsrq%2FlJr7tnurTbYdb1j9y2mf0QZzFfpib57EZyIY%2Fh0EOldZM0LQAYV7GwcIvAjnrgS%2FeXLMi5zF%2FP9jZfrcGt2KjnpMAH59e0%2BmcG1y%2BLcWnuxkTzpozgIaJlmhhGLOo7k1eZnuUil%2BAhyzlKT5nHQrgCpunDmPCaYjueJv1N95T%2Byic3jn725i0UFu80ADhqic65LfwIgOpBrv03G6aBRAHMmO1%2F6YQ2hwegEZqXGuMQNsemRzNrhybKh1tO1OXXeYE5bTsSlQW21Lnn9ymVoO4D9dmd97Pevh%2FkMZvB7wNpmhq4FeAEFyhGMYr5HTVAYtz8%2FoigO65D%2BYAdHOqWGEKemn7Igc63T7nxNF6nQhIwlu03lcuRNN4Vzg7FXZajktBp5vS8tR70MOM6%2FXDPcJU29tkS1lf%2B%2Bu5ow18egpllloZAHv%2BcaRAo5lo2TGAaIDnBLZOGuqLfFuiYNy1Pq3%2FhV5KOBT8NBbPNfP6VTPKQwLWcEJ3scCgm%2BHTl4%2BAPgytyTRiKWtu4NnkaK%2FwJLO8Cd6X7j5MBukYROwB00mouBh7SnjkMgj50swxO75zAY6sQHfPoOn1Rt4bmbYE5a9cEg2KuEFOL21eJz5%2FbjD%2BHR1LrAx4cA4qcUa1QVN%2FHTUKx6SAF17noQLXjle8JHmSr6KLBehE%2FghkW5p5Z0ij69iwjYzTLucXQZJbCVthnBfdLj6wpHDcXFTnf3ECT6USKh5WsdVEk5UsFA7TF8YFMEHeJYoD%2Fr45oVVrGgMNNpRLjrtEdvbxh4W8n9TwIvwPEoUgzyPbd%2BKob842bqsLN0rOXU%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20260225T055113Z&X-Amz-SignedHeaders=host&X-Amz-Expires=299&X-Amz-Credential=ASIAQ3PHCVTYVW7ZJPV3%2F20260225%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=626dc0153ea1c3d6743e85e2f66cc16fbe87f6c548afafcefd6ea2a94b4d5bac&hash=efbcef8e26e653ba7b7c9c0e8793db64cd77562ff236d038f76201d7c55254d9&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2093791123000744&tid=spdf-cd684d42-dda6-4a83-9670-ae5ce7db8375&sid=323f66de8e4980408c0be7b-7fe7e7fe55f2gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&rh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0b015e065456040306&rr=9d34edf66a175d0f&cc=id
Publisher
1Department of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic
of Korea
2Department of Obstetrics and Gynecology, Korea University Ansan Hospital, Korea University School of Medicine, Ansan, Republic of Korea
of Korea
2Department of Obstetrics and Gynecology, Korea University Ansan Hospital, Korea University School of Medicine, Ansan, Republic of Korea
Date
23 November 2023
Contributor
FAJAR BAGUS W
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Citation
Seo Young Kim 1
, Ha Kyun Chang 2,**, Ohwi Kwon 1
, JaeYoung Park 1
, Jun-Pyo Myong , “Asbestos Exposure and Ovarian Cancer: A Meta-analysis,” Repository Horizon University Indonesia, accessed April 26, 2026, https://repository.horizon.ac.id/items/show/11650.