Epidemiology of oncologic emergency in Ethiopia: a systematic review and meta- analysis
Dublin Core
Title
Epidemiology of oncologic emergency in Ethiopia: a systematic review and meta- analysis
Subject
Oncologic, Emergency, Febrile, Neutropenia, Policies and strategies
Description
Background Oncologic emergency is a serious clinical experience that presents significant challenges to patients
and caregivers. A comprehensive understanding of the overall magnitude of oncologic emergencies is critical.
However, existing literatures are fragmented and varying in the report of results. Therefore, this study aims to
determine the overall magnitude of oncologic emergency in Ethiopia
Methods Comprehensive literature search was conducted from various sources. A random-effects meta-analysis was
conducted using DerSimonian-Laird to estimate the pooled effect size. Heterogeneity was checked using I2
statistic.
Sub group and sensitivity analysis was conducted to mitigate heterogeneity. Funnel plot and egger’s regression test
was used to check publication bias and small study effect.
Results This study included 23 studies involving a total of 6755 cancer patients. The pooled prevalence of oncologic
emergency across in Ethiopia was 30.87% (95%CI 23.72–38.02). Substantial heterogeneity (I2=98.5%) across the
studies were identified. The 95% prediction interval ranged from 5.62% to 67.40%, reflecting the expected prevalence
in a new study. Comorbidity, advanced age, being on cancer treatment, and metastasis were significant predictors of
oncologic emergency.
Conclusion Advancing innovations in early detection and prompt intervention is critical to reduce the burden of
oncologic emergency on patients and the health care system. A notable challenge encountered was the variability in
definitions and measurement of oncologic emergencies across included studies.
Keywords Oncologic, Emergency, Febrile, Neutropenia, Policies and strategies
and caregivers. A comprehensive understanding of the overall magnitude of oncologic emergencies is critical.
However, existing literatures are fragmented and varying in the report of results. Therefore, this study aims to
determine the overall magnitude of oncologic emergency in Ethiopia
Methods Comprehensive literature search was conducted from various sources. A random-effects meta-analysis was
conducted using DerSimonian-Laird to estimate the pooled effect size. Heterogeneity was checked using I2
statistic.
Sub group and sensitivity analysis was conducted to mitigate heterogeneity. Funnel plot and egger’s regression test
was used to check publication bias and small study effect.
Results This study included 23 studies involving a total of 6755 cancer patients. The pooled prevalence of oncologic
emergency across in Ethiopia was 30.87% (95%CI 23.72–38.02). Substantial heterogeneity (I2=98.5%) across the
studies were identified. The 95% prediction interval ranged from 5.62% to 67.40%, reflecting the expected prevalence
in a new study. Comorbidity, advanced age, being on cancer treatment, and metastasis were significant predictors of
oncologic emergency.
Conclusion Advancing innovations in early detection and prompt intervention is critical to reduce the burden of
oncologic emergency on patients and the health care system. A notable challenge encountered was the variability in
definitions and measurement of oncologic emergencies across included studies.
Keywords Oncologic, Emergency, Febrile, Neutropenia, Policies and strategies
Creator
Astewle Andargie Baye1*, Gebre Kassaw Yirga1
, Yirgalem Abere1
, Mengistu Ewunetu1
, Yeshiambaw Eshetie1
,
Birara Ayichew Tilaye2
and Gebrehiwot Berie Mekonnen2
, Yirgalem Abere1
, Mengistu Ewunetu1
, Yeshiambaw Eshetie1
,
Birara Ayichew Tilaye2
and Gebrehiwot Berie Mekonnen2
Source
https://doi.org/10.1186/s12873-025-01430-6
Date
2026
Contributor
Peri Irawan
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Astewle Andargie Baye1*, Gebre Kassaw Yirga1
, Yirgalem Abere1
, Mengistu Ewunetu1
, Yeshiambaw Eshetie1
,
Birara Ayichew Tilaye2
and Gebrehiwot Berie Mekonnen2, “Epidemiology of oncologic emergency in Ethiopia: a systematic review and meta- analysis,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12027.