Paracetamol overdose causing acute kidney injury without hepatotoxicity: a case report
Dublin Core
Title
Paracetamol overdose causing acute kidney injury without hepatotoxicity: a case report
Subject
Acute kidney injury, Acute tubular necrosis, Nephrotoxicity, Paracetamol overdose
Description
Abstract
Background Paracetamol is a widely used analgesic and antipyretic. Paracetamol-induced hepatotoxicity is well
known, but nephrotoxicity without hepatotoxicity is rarely seen.
Case presentation We present a case of acute kidney injury without hepatotoxicity in paracetamol overdose. A
15-year-old girl was admitted 48 h after she had taken 10 g of paracetamol. She was complaining of abdominal pain
and vomiting. Her blood level of creatinine was 1.20 mg/dL on admission, with a peak at 3.67 mg/dL 3 days later. The
liver blood tests and blood paracetamol level were negative. She did not receive N-acetyl cysteine and was treated
with intravenous fluid (crystalloid). The ultrasonography of the kidneys was normal. Her renal function returned
almost to baseline 7 days after admission. It was concluded that the diagnosis was an acute kidney injury caused by
acute tubular necrosis due to paracetamol overdose.
Conclusion This case shows that nephrotoxicity can occur without hepatotoxicity in paracetamol overdose.
Keywords Acute kidney injury, Acute tubular necrosis, Nephrotoxicity, Paracetamol overdose
Background Paracetamol is a widely used analgesic and antipyretic. Paracetamol-induced hepatotoxicity is well
known, but nephrotoxicity without hepatotoxicity is rarely seen.
Case presentation We present a case of acute kidney injury without hepatotoxicity in paracetamol overdose. A
15-year-old girl was admitted 48 h after she had taken 10 g of paracetamol. She was complaining of abdominal pain
and vomiting. Her blood level of creatinine was 1.20 mg/dL on admission, with a peak at 3.67 mg/dL 3 days later. The
liver blood tests and blood paracetamol level were negative. She did not receive N-acetyl cysteine and was treated
with intravenous fluid (crystalloid). The ultrasonography of the kidneys was normal. Her renal function returned
almost to baseline 7 days after admission. It was concluded that the diagnosis was an acute kidney injury caused by
acute tubular necrosis due to paracetamol overdose.
Conclusion This case shows that nephrotoxicity can occur without hepatotoxicity in paracetamol overdose.
Keywords Acute kidney injury, Acute tubular necrosis, Nephrotoxicity, Paracetamol overdose
Creator
Micha Saad1* and Julien Flament2
Source
https://doi.org/10.1186/s12245-024-00662-w
Date
2024
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Micha Saad1* and Julien Flament2, “Paracetamol overdose causing acute kidney injury without hepatotoxicity: a case report,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12381.