Mortality and morbidity associated with new onset acute kidney injury in critically ill COVID-19 infection patients
Dublin Core
Title
Mortality and morbidity associated with new onset acute kidney injury in critically ill COVID-19 infection patients
Subject
Acute renal injury, Covid-19, Dialysis, Chronic renal failure, Mortality
Description
Background The recent global pandemic due to severe acute respiratory syndrome coronavirus-2 resulted in a high
rate of multi-organ failure and mortality in a large patient population across the world. As such, a possible correlation
between acute kidney injury (AKI) and increased mortality rate in these patients has been suggested in literature.
Methods This is a two-year retrospective study of critically ill adult patients infected with COVID-19 that were
admitted to the intensive care unit (ICU) on ventilatory support. Two groups of patients were identified in this study,
those who were directly admitted to the ICU or those who were initially admitted to the Medical Floor and were later
transferred to the ICU due to either worsening respiratory status or change in their hemodynamic conditions. Within
each group, three subgroups were created based on the status of AKI, namely, those who did not develop AKI, those
who developed AKI, and those who with previous history of dialysis dependent AKI.
Results The AKI subgroup had the highest mortality rate in the ICU and Floor patients. Of note, those patients who
were directly admitted to the Floor and were later transferred to the ICU for worsening conditions also experienced a
higher mortality rate if they had developed AKI during their course of hospital stay.
Conclusions This study identified a statistically significant higher mortality in patients who developed AKI than those
who did not develop AKI among critically ill patients.
Trial registration Clinicaltrials.gov registration number NCT05964088. Date of registration: July 24 2023.
Keywords Acute renal injury, Covid-19, Dialysis, Chronic renal failure, Mortality
rate of multi-organ failure and mortality in a large patient population across the world. As such, a possible correlation
between acute kidney injury (AKI) and increased mortality rate in these patients has been suggested in literature.
Methods This is a two-year retrospective study of critically ill adult patients infected with COVID-19 that were
admitted to the intensive care unit (ICU) on ventilatory support. Two groups of patients were identified in this study,
those who were directly admitted to the ICU or those who were initially admitted to the Medical Floor and were later
transferred to the ICU due to either worsening respiratory status or change in their hemodynamic conditions. Within
each group, three subgroups were created based on the status of AKI, namely, those who did not develop AKI, those
who developed AKI, and those who with previous history of dialysis dependent AKI.
Results The AKI subgroup had the highest mortality rate in the ICU and Floor patients. Of note, those patients who
were directly admitted to the Floor and were later transferred to the ICU for worsening conditions also experienced a
higher mortality rate if they had developed AKI during their course of hospital stay.
Conclusions This study identified a statistically significant higher mortality in patients who developed AKI than those
who did not develop AKI among critically ill patients.
Trial registration Clinicaltrials.gov registration number NCT05964088. Date of registration: July 24 2023.
Keywords Acute renal injury, Covid-19, Dialysis, Chronic renal failure, Mortality
Creator
Nina Fischer1
, Xinfei Miao3
, Danielle Weck1
, Jacob Matalon3
, Cameron C. Neeki1
, Troy Pennington2,3, Fanglong Dong1
,
Sarkis Arabian1,3 and Michael M. Neeki2,3*
, Xinfei Miao3
, Danielle Weck1
, Jacob Matalon3
, Cameron C. Neeki1
, Troy Pennington2,3, Fanglong Dong1
,
Sarkis Arabian1,3 and Michael M. Neeki2,3*
Source
https://doi.org/10.1186/s12245-024-00666-6
Date
2024
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Nina Fischer1
, Xinfei Miao3
, Danielle Weck1
, Jacob Matalon3
, Cameron C. Neeki1
, Troy Pennington2,3, Fanglong Dong1
,
Sarkis Arabian1,3 and Michael M. Neeki2,3*, “Mortality and morbidity associated with new onset acute kidney injury in critically ill COVID-19 infection patients,” Repository Horizon University Indonesia, accessed April 12, 2026, https://repository.horizon.ac.id/items/show/12386.