Catecholamine concentration as a predictor of mortality in emergency surgical patients
Dublin Core
Title
Catecholamine concentration as a predictor of mortality in emergency surgical patients
Subject
Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality
Description
Abstract
Background Trauma and emergency surgery are major causes of morbidity and mortality. The objective of this study
was to determine whether serum levels of epinephrine and norepinephrine are associated with aging and mortality.
Methods This was a prospective observational cohort study conducted in a surgical critical care unit. We included 90
patients who were admitted for postoperative care, because of major trauma, or both. We collected demographic and
clinical variables, as well as serum levels of epinephrine and norepinephrine.
Results For patients in the >60-year age group, the use of vasoactive drugs was found to be associated with
an undetectable epinephrine level (OR [95% CI]=6.36 [1.12, 36.08]), p=0.05). For the patients with undetectable
epinephrine levels, the in-hospital mortality was higher among those with a norepinephrine level≥2006.5 pg/mL (OR
[95% CI]=4.00 [1.27, 12.58]), p=0.03).
Conclusions There is an association between age and mortality. Undetectable serum epinephrine, which is more
common in older patients, could contribute to poor outcomes. The use of epinephrine might improve the clinical
prognosis in older surgical patients with shock.
Keywords Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality
Background Trauma and emergency surgery are major causes of morbidity and mortality. The objective of this study
was to determine whether serum levels of epinephrine and norepinephrine are associated with aging and mortality.
Methods This was a prospective observational cohort study conducted in a surgical critical care unit. We included 90
patients who were admitted for postoperative care, because of major trauma, or both. We collected demographic and
clinical variables, as well as serum levels of epinephrine and norepinephrine.
Results For patients in the >60-year age group, the use of vasoactive drugs was found to be associated with
an undetectable epinephrine level (OR [95% CI]=6.36 [1.12, 36.08]), p=0.05). For the patients with undetectable
epinephrine levels, the in-hospital mortality was higher among those with a norepinephrine level≥2006.5 pg/mL (OR
[95% CI]=4.00 [1.27, 12.58]), p=0.03).
Conclusions There is an association between age and mortality. Undetectable serum epinephrine, which is more
common in older patients, could contribute to poor outcomes. The use of epinephrine might improve the clinical
prognosis in older surgical patients with shock.
Keywords Norepinephrine, Epinephrine, SOFA, SAPS, ICU outcome, Vasopressors, Mortality
Creator
João Isuk Suh1
, Daiane Leite da Roza2
, Filipe Matheus Cadamuro3
, Luiz Marcelo Sá Malbouisson3
,
Talita Rojas Sanches1
and Lúcia Andrade1,4*
, Daiane Leite da Roza2
, Filipe Matheus Cadamuro3
, Luiz Marcelo Sá Malbouisson3
,
Talita Rojas Sanches1
and Lúcia Andrade1,4*
Source
https://doi.org/10.1186/s12245-024-00676-4
Date
2024
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
João Isuk Suh1
, Daiane Leite da Roza2
, Filipe Matheus Cadamuro3
, Luiz Marcelo Sá Malbouisson3
,
Talita Rojas Sanches1
and Lúcia Andrade1,4*, “Catecholamine concentration as a predictor of mortality in emergency surgical patients,” Repository Horizon University Indonesia, accessed April 25, 2026, https://repository.horizon.ac.id/items/show/12396.