Anaphylactic reaction to tranexamic acid infusion in a six‐year‐old child: a case report
Dublin Core
Title
Anaphylactic reaction to tranexamic acid infusion in a six‐year‐old child: a case report
Subject
Allergy, Anaphylaxis, Case report, Critical care, Pediatrics, Tranexamic acid
Description
Abstract
Background Tranexamic acid (TXA) is commonly considered a safe drug to mitigate bleeding during and after vari-
ous surgical settings among adults and children. In recent decades, anaphylaxis induced by TXA has been increasingly
reported in adults. However, among pediatrics, there are fewer reported cases.
Case presentation We report a case of a 6-year-old female who experienced anaphylaxis after receiving intravenous
TXA following unilateral cleft lip and palate repair surgery. She exhibited clinical symptoms involving the cardio-
vascular system, respiratory system, and skin. Following the administration of epinephrine, corticosteroid, and anti-
histamine, the patient’s symptoms were relieved. A few months after discharge, an intradermal test, yielded a positive
result, confirming TXA as the culprit drug.
Conclusion Our report emphasizes the importance of considering anaphylaxis as a potential adverse reaction to TXA
in pediatric patients, showing the criticality of rapid diagnosis and appropriate management for a successful outcome.
Keywords Allergy, Anaphylaxis, Case report, Critical care, Pediatrics, Tranexamic acid
Background Tranexamic acid (TXA) is commonly considered a safe drug to mitigate bleeding during and after vari-
ous surgical settings among adults and children. In recent decades, anaphylaxis induced by TXA has been increasingly
reported in adults. However, among pediatrics, there are fewer reported cases.
Case presentation We report a case of a 6-year-old female who experienced anaphylaxis after receiving intravenous
TXA following unilateral cleft lip and palate repair surgery. She exhibited clinical symptoms involving the cardio-
vascular system, respiratory system, and skin. Following the administration of epinephrine, corticosteroid, and anti-
histamine, the patient’s symptoms were relieved. A few months after discharge, an intradermal test, yielded a positive
result, confirming TXA as the culprit drug.
Conclusion Our report emphasizes the importance of considering anaphylaxis as a potential adverse reaction to TXA
in pediatric patients, showing the criticality of rapid diagnosis and appropriate management for a successful outcome.
Keywords Allergy, Anaphylaxis, Case report, Critical care, Pediatrics, Tranexamic acid
Creator
Nazanin Zibanejad1,2†, Nikta Nouri3† and Sharareh Babaie1,2*
Source
https://doi.org/10.1186/s12245-024-00718-x
Date
2024
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Nazanin Zibanejad1,2†, Nikta Nouri3† and Sharareh Babaie1,2*, “Anaphylactic reaction to tranexamic acid infusion in a six‐year‐old child: a case report,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12443.