The effect of time to neurosurgical or neuroradiological intervention therapy on outcomes and quality of care after traumatic brain injury, a registry-based observational study
Dublin Core
Title
The effect of time to neurosurgical or neuroradiological intervention therapy on outcomes and quality of care after traumatic brain injury, a registry-based observational study
Subject
Traumatic brain injury, Intervention, Mortality, Disability
Description
Abstract
Background Evidence regarding the effect of time to neurosurgical and neuroradiological intervention on outcomes
in traumatic brain injury (TBI) across Asia-Pacific region is limited. This study evaluates the quality of care and
outcomes for TBI patients undergoing neurosurgical and neuroradiological procedures at different timings.
Methods Adult TBI patients who received any neurosurgical or neuroradiological interventions during the year
2015–2022 in the Pan-Asian Trauma Outcome Study database were analyzed. The time to intervention, as the main
exposure, was classified into three groups (Early, Intermediate, and Delayed) using Restricted Cubic Spline (RCS)
analysis. The outcomes were in-hospital mortality and unfavorable neurological outcomes. W score was utilized to
compare the quality of care among exposure groups. Multivariable logistic regression analysis and interaction analysis
were performed to identify the association between the exposure groups and outcomes, reported as adjusted odds
ratios (AOR) with 95% confidence intervals (CI).
Results A total of 1,780 patients were included. From the RCS analysis, patients were classified into three groups
according to time to intervention: Early (<1.9 h), Intermediate (1.9–4.1 h), and Delayed (>4.1 h). According to the time
to intervention, W score was −8.6 in the early group, -1.1 in the intermediate group, and +0.4 in the delayed group.
Patients receiving intermediate and delayed intervention showed significantly lower mortality (AOR 0.64, 95% CI
0.47–0.86 and AOR 0.66, 95%CI 0.48–0.90, respectively).
Conclusion Early neurosurgical and neuroradiological interventions in TBI patients in the Asia-Pacific region were
associated with lower quality of care and higher mortality. The quality of care should be focused and improved during
the early hours of TBI.
Background Evidence regarding the effect of time to neurosurgical and neuroradiological intervention on outcomes
in traumatic brain injury (TBI) across Asia-Pacific region is limited. This study evaluates the quality of care and
outcomes for TBI patients undergoing neurosurgical and neuroradiological procedures at different timings.
Methods Adult TBI patients who received any neurosurgical or neuroradiological interventions during the year
2015–2022 in the Pan-Asian Trauma Outcome Study database were analyzed. The time to intervention, as the main
exposure, was classified into three groups (Early, Intermediate, and Delayed) using Restricted Cubic Spline (RCS)
analysis. The outcomes were in-hospital mortality and unfavorable neurological outcomes. W score was utilized to
compare the quality of care among exposure groups. Multivariable logistic regression analysis and interaction analysis
were performed to identify the association between the exposure groups and outcomes, reported as adjusted odds
ratios (AOR) with 95% confidence intervals (CI).
Results A total of 1,780 patients were included. From the RCS analysis, patients were classified into three groups
according to time to intervention: Early (<1.9 h), Intermediate (1.9–4.1 h), and Delayed (>4.1 h). According to the time
to intervention, W score was −8.6 in the early group, -1.1 in the intermediate group, and +0.4 in the delayed group.
Patients receiving intermediate and delayed intervention showed significantly lower mortality (AOR 0.64, 95% CI
0.47–0.86 and AOR 0.66, 95%CI 0.48–0.90, respectively).
Conclusion Early neurosurgical and neuroradiological interventions in TBI patients in the Asia-Pacific region were
associated with lower quality of care and higher mortality. The quality of care should be focused and improved during
the early hours of TBI.
Creator
Wasin Pansiritanachot1
, Sattha Riyapan1*, Sang Do Shin2
, Jirayu Chantanakomes1
, Netiporn Thirawattanasoot1
,
Wichayada Rangabpai1
, Bongkot Somboonkul3
, Joo Jeong4,5, Kyoung Jun Song5,6, Wen-Chiu Chiang7
, Sabariah
Faizah Jamaluddin8
and Kentaro Kajino9
, Sattha Riyapan1*, Sang Do Shin2
, Jirayu Chantanakomes1
, Netiporn Thirawattanasoot1
,
Wichayada Rangabpai1
, Bongkot Somboonkul3
, Joo Jeong4,5, Kyoung Jun Song5,6, Wen-Chiu Chiang7
, Sabariah
Faizah Jamaluddin8
and Kentaro Kajino9
Source
https://doi.org/10.1186/s12245-024-00787-y
Date
2024
Contributor
Peri Irawan
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Wasin Pansiritanachot1
, Sattha Riyapan1*, Sang Do Shin2
, Jirayu Chantanakomes1
, Netiporn Thirawattanasoot1
,
Wichayada Rangabpai1
, Bongkot Somboonkul3
, Joo Jeong4,5, Kyoung Jun Song5,6, Wen-Chiu Chiang7
, Sabariah
Faizah Jamaluddin8
and Kentaro Kajino9, “The effect of time to neurosurgical or neuroradiological intervention therapy on outcomes and quality of care after traumatic brain injury, a registry-based observational study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12547.