Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study
Dublin Core
Title
Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study
Subject
Ulcer, Stomach, Liver, Lung, Peptic, Mortality, SEER
Description
Abstract
Introduction Non-cancer deaths are now becoming a significant threat to the health of cancer patients. Death from
stomach and duodenal ulcer is linked to cancer due to the side effects of treatment and its pathogenesis. However,
guidelines for identifying cancer patients at the highest risk of death from stomach and duodenal ulcer remain
unclear.
Methods Data of all patients diagnosed with cancer between 2000 and 2021 were obtained from the Surveillance,
Epidemiology, and End Results (SEER) database. Data regarding the causes of death and clinicopathological
features such as sex, age, race, marital status, SEER stage, and treatment procedures were extracted. We calculated
standardized mortality ratios (SMRs) using the SEER*Stat software V8.4.3.
Results Of the 6,891,191 cancer patients, 2,318 died of stomach and duodenal ulcer, a rate higher than that in the
general population (SMR=1.58, 95% CI [1.52–1.65]). Stomach and duodenal ulcer-related deaths decreased over
time from 870 deaths between 2000 and 2004 to 294 deaths between 2015 and 2019. Among the 2,318 stomach
and duodenal ulcer deaths, the highest numbers were observed in patients with prostate cancer (n=389, 16.8%),
and lung and bronchus cancer (n=255, 11%). Patients with liver and intrahepatic bile duct cancers (SMR=10.53, 95%
CI [8.3-13.18]), and pancreatic cancer (SMR=6.84, 95% CI [5.11–8.97]) had a significantly higher rate of death from
stomach and duodenal ulcer than the general population.
Conclusion Our study revealed a significantly higher risk of stomach and duodenal ulcer mortality among patients
with cancer in the United States, underscoring the critical need for integrated care strategies that address both
cancer and ulcer-related complications. To reduce ulcer-related mortality, we recommend the implementation of
targeted prevention protocols, including routine gastrointestinal screenings for high-risk cancer patients, proactive
management of ulcer risk factors, and collaboration between oncology, gastroenterology, and surgical teams.
Introduction Non-cancer deaths are now becoming a significant threat to the health of cancer patients. Death from
stomach and duodenal ulcer is linked to cancer due to the side effects of treatment and its pathogenesis. However,
guidelines for identifying cancer patients at the highest risk of death from stomach and duodenal ulcer remain
unclear.
Methods Data of all patients diagnosed with cancer between 2000 and 2021 were obtained from the Surveillance,
Epidemiology, and End Results (SEER) database. Data regarding the causes of death and clinicopathological
features such as sex, age, race, marital status, SEER stage, and treatment procedures were extracted. We calculated
standardized mortality ratios (SMRs) using the SEER*Stat software V8.4.3.
Results Of the 6,891,191 cancer patients, 2,318 died of stomach and duodenal ulcer, a rate higher than that in the
general population (SMR=1.58, 95% CI [1.52–1.65]). Stomach and duodenal ulcer-related deaths decreased over
time from 870 deaths between 2000 and 2004 to 294 deaths between 2015 and 2019. Among the 2,318 stomach
and duodenal ulcer deaths, the highest numbers were observed in patients with prostate cancer (n=389, 16.8%),
and lung and bronchus cancer (n=255, 11%). Patients with liver and intrahepatic bile duct cancers (SMR=10.53, 95%
CI [8.3-13.18]), and pancreatic cancer (SMR=6.84, 95% CI [5.11–8.97]) had a significantly higher rate of death from
stomach and duodenal ulcer than the general population.
Conclusion Our study revealed a significantly higher risk of stomach and duodenal ulcer mortality among patients
with cancer in the United States, underscoring the critical need for integrated care strategies that address both
cancer and ulcer-related complications. To reduce ulcer-related mortality, we recommend the implementation of
targeted prevention protocols, including routine gastrointestinal screenings for high-risk cancer patients, proactive
management of ulcer risk factors, and collaboration between oncology, gastroenterology, and surgical teams.
Creator
Ramez M. Odat1 , Muhammad Idrees2 , Mohammed Dheyaa Marsool Marsool3 , Shahed Mamoun Oglat1 ,
Salma Omar Tbayshat1 , Zaid Ibrahim Adnan1 , Yousef Adeeb Alkhateeb1 , Ali O. Aldamen4 , Hritvik Jain5 ,
Dang Nguyen6 and Hamdah Hanifa7*
Salma Omar Tbayshat1 , Zaid Ibrahim Adnan1 , Yousef Adeeb Alkhateeb1 , Ali O. Aldamen4 , Hritvik Jain5 ,
Dang Nguyen6 and Hamdah Hanifa7*
Source
https://doi.org/10.1186/s12245-024-00795-y
Date
2024
Contributor
Peri Irawan
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Collection
Citation
Ramez M. Odat1 , Muhammad Idrees2 , Mohammed Dheyaa Marsool Marsool3 , Shahed Mamoun Oglat1 ,
Salma Omar Tbayshat1 , Zaid Ibrahim Adnan1 , Yousef Adeeb Alkhateeb1 , Ali O. Aldamen4 , Hritvik Jain5 ,
Dang Nguyen6 and Hamdah Hanifa7*, “Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study,” Repository Horizon University Indonesia, accessed April 13, 2026, https://repository.horizon.ac.id/items/show/12553.