Sepsis in patients with severe TBI: a retrospective CT scoring study
Dublin Core
Title
Sepsis in patients with severe TBI: a retrospective CT scoring study
Subject
Multiple organ failure (MOF)
Description
Abstract
Background Multiple organ failure (MOF) is a severe complication associated with high mortality in sepsis after
severe TBI (sTBI).
Objective To investigate the usefulness of a rapid computed tomography (CT) screening score for predicting of
mortality and outcomes of sepsis after sTBI.
Methods We retrospectively analyzed those data of patients who were admitted to the ICU. All sTBI patients with
or without sepsis underwent rapid CT screening before ICU admission and were admitted to the ICU for >24 h were
included in this study. The main outcome was sepsis-related the mortality after sTBI. The secondary outcome was the
GOSE score during the first 60 days.
Results Among a random sample of 412 adult patients with sTBI, we found 249 sepsis after sTBI (60.4%) and 163
(39.6%) non- sepsis after sTBI events. The main organ failure was early brain (94.8%) and lung injury(91.2%) caused by
community-acquired pnumonia (CPA). The CT score was higher in the sTBI with sepsis group than in the sTBI without
sepsis group(wean 3.5 score vs. 0.9 score, p<0.001).The SOFA score was also higher in the sTBI with sepsis group than
in the sTBI without sepsis group(wean 5.9 score vs. 3.6 score, p<0.001). The risk of death for sepsis after sTBI was an
elevated CT score (hazard ratio[HR], 4.6; 95% confidence interval[CI], 3.373–10.49; p<0.001) and an elevated SOFA
score (HR,3.0; 95% CI, 2.054–4.826; p<0.001).The area under the ROC curve for mortality was significantly larger for the
elevated CT score (0.90, 95%CI 0.86–0.97 ) than for the elevated score (0.85, 95%CI 0.81–0.89 ) (P<0.001). The elevated
CT score in the area under the ROC curve for mortality was with 97.0% of sensitivity and 100.0% of specificity. At 60
days follow-up, the risk of death for sepsis after sTBI was higher than those non- sepsis after sTBI (p<0.001).
Conclusions Elevated CT score is a well indicator of high incidence and mortality for sepsis after sTBI in the ICU,
which suggests that this very current and practical event is involved to a global health care problem. But it could still
need further verification in future investigation.
Background Multiple organ failure (MOF) is a severe complication associated with high mortality in sepsis after
severe TBI (sTBI).
Objective To investigate the usefulness of a rapid computed tomography (CT) screening score for predicting of
mortality and outcomes of sepsis after sTBI.
Methods We retrospectively analyzed those data of patients who were admitted to the ICU. All sTBI patients with
or without sepsis underwent rapid CT screening before ICU admission and were admitted to the ICU for >24 h were
included in this study. The main outcome was sepsis-related the mortality after sTBI. The secondary outcome was the
GOSE score during the first 60 days.
Results Among a random sample of 412 adult patients with sTBI, we found 249 sepsis after sTBI (60.4%) and 163
(39.6%) non- sepsis after sTBI events. The main organ failure was early brain (94.8%) and lung injury(91.2%) caused by
community-acquired pnumonia (CPA). The CT score was higher in the sTBI with sepsis group than in the sTBI without
sepsis group(wean 3.5 score vs. 0.9 score, p<0.001).The SOFA score was also higher in the sTBI with sepsis group than
in the sTBI without sepsis group(wean 5.9 score vs. 3.6 score, p<0.001). The risk of death for sepsis after sTBI was an
elevated CT score (hazard ratio[HR], 4.6; 95% confidence interval[CI], 3.373–10.49; p<0.001) and an elevated SOFA
score (HR,3.0; 95% CI, 2.054–4.826; p<0.001).The area under the ROC curve for mortality was significantly larger for the
elevated CT score (0.90, 95%CI 0.86–0.97 ) than for the elevated score (0.85, 95%CI 0.81–0.89 ) (P<0.001). The elevated
CT score in the area under the ROC curve for mortality was with 97.0% of sensitivity and 100.0% of specificity. At 60
days follow-up, the risk of death for sepsis after sTBI was higher than those non- sepsis after sTBI (p<0.001).
Conclusions Elevated CT score is a well indicator of high incidence and mortality for sepsis after sTBI in the ICU,
which suggests that this very current and practical event is involved to a global health care problem. But it could still
need further verification in future investigation.
Creator
Guang-Sheng Wang1
, Da-Zhi Zhou2
, Shao-Dan Wang3
, Ye-Ting Zhou4
and Dao-Ming Tong5*
, Da-Zhi Zhou2
, Shao-Dan Wang3
, Ye-Ting Zhou4
and Dao-Ming Tong5*
Source
https://doi.org/10.1186/s12245-025-00911-6
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Guang-Sheng Wang1
, Da-Zhi Zhou2
, Shao-Dan Wang3
, Ye-Ting Zhou4
and Dao-Ming Tong5*, “Sepsis in patients with severe TBI: a retrospective CT scoring study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12820.