Characteristics and risk factors of opioid poisoning in opioid-dependent individuals using their primary opioid of dependence: a registry-based study
Dublin Core
Title
Characteristics and risk factors of opioid poisoning in opioid-dependent individuals using their primary opioid of dependence: a registry-based study
Subject
Opioids, Substance related disorders, Poisoning, Iran, Public health
Description
Abstract
Background Opioid addiction and poisoning are prevalent health issues in Iran, where various types of opioids are
easily accessible. Despite being dependent on a specific type of opioid, some opioid-dependents abuse different
types opioids which can prone them to some consequences. This study aimed to assess the characteristics and risk
factors of opioid poisoning among opioid-dependent individuals poisoned by their own or opioid.
Methods This cross-sectional study analyzed data from the MTR-MUMS-Iran (May 2021-January 2022), including
opioid-dependent adults poisoned by their regularly used opioid. Opioid dependency was categorized as
synthetic opioid or opiate. Data extracted included demographics, opioid type, manner of poisoning, and clinical
manifestations. Also, a comparison was conducted between poisoning prevalence with 2011 Iranian Mental Health
Survey (IMHS) opioid dependency data.
Results Among 3064 registered cases, 116 patients with a mean age of 40.27 years were included, with a mortality
rate of 1.7% (n=2). The frequency of synthetic opioid and opiate overdose was similar (50.9% vs. 49.1%). Opium and
methadone were the most common opioids involved. The most common clinical presentation was decreased level
of consciousness (72.4%). Excessive use (50.9%), suicide (24.1%), were the main scenarios leading to poisoning. The
manner of poisoning among elderly and opiate-dependent patients was excessive use, while younger synthetic
opioid-dependent patients tended to attempt suicide. Furthermore, opiate-dependent individuals were more likely
to co-ingest therapeutic medications and have underlying renal disease. The average hospital stay was 2.31 days, with
age being a significant predictor of length of stay.
Background Opioid addiction and poisoning are prevalent health issues in Iran, where various types of opioids are
easily accessible. Despite being dependent on a specific type of opioid, some opioid-dependents abuse different
types opioids which can prone them to some consequences. This study aimed to assess the characteristics and risk
factors of opioid poisoning among opioid-dependent individuals poisoned by their own or opioid.
Methods This cross-sectional study analyzed data from the MTR-MUMS-Iran (May 2021-January 2022), including
opioid-dependent adults poisoned by their regularly used opioid. Opioid dependency was categorized as
synthetic opioid or opiate. Data extracted included demographics, opioid type, manner of poisoning, and clinical
manifestations. Also, a comparison was conducted between poisoning prevalence with 2011 Iranian Mental Health
Survey (IMHS) opioid dependency data.
Results Among 3064 registered cases, 116 patients with a mean age of 40.27 years were included, with a mortality
rate of 1.7% (n=2). The frequency of synthetic opioid and opiate overdose was similar (50.9% vs. 49.1%). Opium and
methadone were the most common opioids involved. The most common clinical presentation was decreased level
of consciousness (72.4%). Excessive use (50.9%), suicide (24.1%), were the main scenarios leading to poisoning. The
manner of poisoning among elderly and opiate-dependent patients was excessive use, while younger synthetic
opioid-dependent patients tended to attempt suicide. Furthermore, opiate-dependent individuals were more likely
to co-ingest therapeutic medications and have underlying renal disease. The average hospital stay was 2.31 days, with
age being a significant predictor of length of stay.
Creator
Ahmad Nemati1
, Leila Etemad2,3, Bita Dadpour4,5, Anselm Wong6,7, Mobin Gholami1
, Seyed Reza Mousavi4,5,
Anahita Alizadeh Ghomsari4,5, Seyed Hadi Mousavi4,5, Alireza Ghassemi Toussi4,5, Khalil Kimiafar8
, Zahra Ataee9
,
Maryam Vahabzadeh4,5, Mohammad Amin Talebpour10, Amir Mohammad Arasteh Nodeh1
, Fatemeh Abavisani10 and
Mohammad Moshiri4,5*
, Leila Etemad2,3, Bita Dadpour4,5, Anselm Wong6,7, Mobin Gholami1
, Seyed Reza Mousavi4,5,
Anahita Alizadeh Ghomsari4,5, Seyed Hadi Mousavi4,5, Alireza Ghassemi Toussi4,5, Khalil Kimiafar8
, Zahra Ataee9
,
Maryam Vahabzadeh4,5, Mohammad Amin Talebpour10, Amir Mohammad Arasteh Nodeh1
, Fatemeh Abavisani10 and
Mohammad Moshiri4,5*
Source
https://doi.org/10.1186/s12245-025-01045-5
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Ahmad Nemati1
, Leila Etemad2,3, Bita Dadpour4,5, Anselm Wong6,7, Mobin Gholami1
, Seyed Reza Mousavi4,5,
Anahita Alizadeh Ghomsari4,5, Seyed Hadi Mousavi4,5, Alireza Ghassemi Toussi4,5, Khalil Kimiafar8
, Zahra Ataee9
,
Maryam Vahabzadeh4,5, Mohammad Amin Talebpour10, Amir Mohammad Arasteh Nodeh1
, Fatemeh Abavisani10 and
Mohammad Moshiri4,5*, “Characteristics and risk factors of opioid poisoning in opioid-dependent individuals using their primary opioid of dependence: a registry-based study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12882.