Prevalence of anemia and its association
with poor outcomes in acute heart failure
patients in northeastern Thailand
Dublin Core
Title
Prevalence of anemia and its association
with poor outcomes in acute heart failure
patients in northeastern Thailand
with poor outcomes in acute heart failure
patients in northeastern Thailand
Subject
Anemia is a common comorbidity among patients with acute heart failure (AHF)
Description
Abstract
Background Anemia is a common comorbidity among patients with acute heart failure (AHF) and is associated with
worse clinical outcomes. However, there is limited data on the effects of anemia in AHF patients in Asian populations.
Moreover, the impact of anemia at varying severity levels in patients presenting to the emergency department (ED) is
still not well understood.
Objectives This study aimed to evaluate the prevalence and severity of anemia, together with its association with
clinical outcomes in adult patients with AHF.
Methods A retrospective analysis was conducted on 890 adult AHF patients extracted from 100,420 ED visits at
Srinagarind Hospital between October 2021 and March 2023. Anemia was classified into three categories: mild
(hemoglobin 11.0 g/dl to normal), moderate (hemoglobin 8.0–10.9 g/dl), and severe (hemoglobin<8.0 g/dl). Patient
characteristics, laboratory markers, and outcomes were compared among groups.
Results Of the 890 patients, 71% were anemic, with 25% having mild, 51% moderate, and 24% severe anemia.
Anemic patients, particularly those with moderate and severe anemia, were older (median age 74 and 71.5 years vs.
64 years for non-anemic, p-value<0.001) and had higher rates of comorbidities, including chronic kidney disease and
diabetes. Severe anemia was associated with worse kidney function (median eGFR 28.9 vs. 62.9 mL/min/1.73 m2 for
non-anemic, p-value<0.001) and higher initial cardiac troponin T levels (85.8 vs. 39.1 ng/dL, p-value<0.001). Hospital
admission rates increased with anemia severity, with 93% of severely anemic patients being admitted compared to
81% of non-anemic patients. In-hospital mortality was highest in the severe anemia group (8.6%), though this was not
statistically significant (p-value=0.238).
Conclusion Anemia is common in patients with AHF, with many exhibiting moderate or severe levels of anemia.
Greater severity of anemia correlates with older age, more comorbidities, and higher hospital admission rates, along
with a trend toward higher mortality.
Clinical trial number Not applicable.
Keywords Emergency department, Comorbidities, Cardiac biomarkers, Renal function, Hospital admission, Mortality
Background Anemia is a common comorbidity among patients with acute heart failure (AHF) and is associated with
worse clinical outcomes. However, there is limited data on the effects of anemia in AHF patients in Asian populations.
Moreover, the impact of anemia at varying severity levels in patients presenting to the emergency department (ED) is
still not well understood.
Objectives This study aimed to evaluate the prevalence and severity of anemia, together with its association with
clinical outcomes in adult patients with AHF.
Methods A retrospective analysis was conducted on 890 adult AHF patients extracted from 100,420 ED visits at
Srinagarind Hospital between October 2021 and March 2023. Anemia was classified into three categories: mild
(hemoglobin 11.0 g/dl to normal), moderate (hemoglobin 8.0–10.9 g/dl), and severe (hemoglobin<8.0 g/dl). Patient
characteristics, laboratory markers, and outcomes were compared among groups.
Results Of the 890 patients, 71% were anemic, with 25% having mild, 51% moderate, and 24% severe anemia.
Anemic patients, particularly those with moderate and severe anemia, were older (median age 74 and 71.5 years vs.
64 years for non-anemic, p-value<0.001) and had higher rates of comorbidities, including chronic kidney disease and
diabetes. Severe anemia was associated with worse kidney function (median eGFR 28.9 vs. 62.9 mL/min/1.73 m2 for
non-anemic, p-value<0.001) and higher initial cardiac troponin T levels (85.8 vs. 39.1 ng/dL, p-value<0.001). Hospital
admission rates increased with anemia severity, with 93% of severely anemic patients being admitted compared to
81% of non-anemic patients. In-hospital mortality was highest in the severe anemia group (8.6%), though this was not
statistically significant (p-value=0.238).
Conclusion Anemia is common in patients with AHF, with many exhibiting moderate or severe levels of anemia.
Greater severity of anemia correlates with older age, more comorbidities, and higher hospital admission rates, along
with a trend toward higher mortality.
Clinical trial number Not applicable.
Keywords Emergency department, Comorbidities, Cardiac biomarkers, Renal function, Hospital admission, Mortality
Creator
Praew Kotruchin1
, Pannita Duangprasat1
, Thanat Tangpaisarn1*, Pariwat Phungoen1
, Thapanawong Mitsungnern1
,
Marturod Buranasakda1
and Vichai Senthong2
, Pannita Duangprasat1
, Thanat Tangpaisarn1*, Pariwat Phungoen1
, Thapanawong Mitsungnern1
,
Marturod Buranasakda1
and Vichai Senthong2
Source
https://doi.org/10.1186/s12245-025-01051-7
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Praew Kotruchin1
, Pannita Duangprasat1
, Thanat Tangpaisarn1*, Pariwat Phungoen1
, Thapanawong Mitsungnern1
,
Marturod Buranasakda1
and Vichai Senthong2, “Prevalence of anemia and its association
with poor outcomes in acute heart failure
patients in northeastern Thailand,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12888.
with poor outcomes in acute heart failure
patients in northeastern Thailand,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12888.