A Guillain Barre Syndrome (GBS): a case report
Dublin Core
Title
A Guillain Barre Syndrome (GBS): a case report
Subject
Guillain-Barré Syndrome (GBS), Acute motor axonal neuropathy (AMAN), Respiratory failure, Intravenous
immunoglobulin (IVIG), Infusion reaction, Prolonged mechanical ventilation
immunoglobulin (IVIG), Infusion reaction, Prolonged mechanical ventilation
Description
Abstract
Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy, with several clinical variants
including the acute motor axonal neuropathy (AMAN) subtype. AMAN often presents with rapid motor weakness,
respiratory compromise, and may follow antecedent infections. We report a rare and severe case of AMAN in a
25-year-old female presenting with rapidly progressive quadriplegia and type II respiratory failure. She required
prolonged mechanical ventilation, developed multiple hospital-acquired infections, and experienced infusion-
related adverse reactions to intravenous immunoglobulin (IVIg). Despite these complications, gradual improvement
was achieved through multidisciplinary care. This case underscores the potential severity of AMAN, especially
when complicated by immunotherapy intolerance and secondary infections. It highlights the importance of early
diagnosis, vigilant respiratory support, and individualised treatment strategies in improving outcomes in severe GBS
variants.
Keywords Guillain-Barré Syndrome (GBS), Acute motor axonal neuropathy (AMAN), Respiratory failure, Intravenous
immunoglobulin (IVIG), Infusion reaction, Prolonged mechanical ventilation
Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy, with several clinical variants
including the acute motor axonal neuropathy (AMAN) subtype. AMAN often presents with rapid motor weakness,
respiratory compromise, and may follow antecedent infections. We report a rare and severe case of AMAN in a
25-year-old female presenting with rapidly progressive quadriplegia and type II respiratory failure. She required
prolonged mechanical ventilation, developed multiple hospital-acquired infections, and experienced infusion-
related adverse reactions to intravenous immunoglobulin (IVIg). Despite these complications, gradual improvement
was achieved through multidisciplinary care. This case underscores the potential severity of AMAN, especially
when complicated by immunotherapy intolerance and secondary infections. It highlights the importance of early
diagnosis, vigilant respiratory support, and individualised treatment strategies in improving outcomes in severe GBS
variants.
Keywords Guillain-Barré Syndrome (GBS), Acute motor axonal neuropathy (AMAN), Respiratory failure, Intravenous
immunoglobulin (IVIG), Infusion reaction, Prolonged mechanical ventilation
Creator
Sara Timerga1* and Aynalem Befkadu1
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Sara Timerga1* and Aynalem Befkadu1, “A Guillain Barre Syndrome (GBS): a case report,” Repository Horizon University Indonesia, accessed April 15, 2026, https://repository.horizon.ac.id/items/show/13234.