Case report : pyridaben poisoning induced acute respiratory and circulating failure
Dublin Core
Title
Case report : pyridaben poisoning induced acute respiratory and circulating failure
Subject
Pyridaben, Acute respiratory, Circulating failure, Hemoperfusion, CRRT
Description
Abstract
Background Pyridaben, a commonly employed pyridazinone insecticide, is extensively utilized in safeguarding crops
against insects and mites. Pyridaben is known to impede mitochondrial complex I activity, inducing mitochondrial
impairment, which subsequently culminates in cellular hypoxia, cessation of glycolysis, swift lactic acid buildup, and
the onset of lactic acidosis. Prolonged exposure to pyridaben has been demonstrated to elicit deleterious effects
on neuronal cells. Furthermore, pyridaben has been associated with the manifestation of cardiotoxicity, leading to
abnormal cardiac function.
Case presentation A 55-year-old Male was expeditiously transported to our medical facility thirty minutes
subsequent to ingesting 10 mL of pyridaben. Upon admission, the patient exhibited symptoms of vomiting and
coma. Within the next half-hour, he progressed to hypotonic hypoxemia and hypotension as a result of pyridaben
intoxication. With the implementation of prompt gastric lavage, oral administration of activated charcoal, respiratory
and circulatory support, as well as continuous renal replacement therapy (CRRT), the patient was ultimately
discharged successfully without any lingering sequelae.
Conclusion This case report delineates a rare occurrence of acute human poisoning stemming from contact
with novel synthetic pesticides. The document elucidates the clinical manifestations observed and the efficacious
administration of supportive therapeutic interventions.
Keywords Pyridaben, Acute respiratory, Circulating failure, Hemoperfusion, CRRT
Background Pyridaben, a commonly employed pyridazinone insecticide, is extensively utilized in safeguarding crops
against insects and mites. Pyridaben is known to impede mitochondrial complex I activity, inducing mitochondrial
impairment, which subsequently culminates in cellular hypoxia, cessation of glycolysis, swift lactic acid buildup, and
the onset of lactic acidosis. Prolonged exposure to pyridaben has been demonstrated to elicit deleterious effects
on neuronal cells. Furthermore, pyridaben has been associated with the manifestation of cardiotoxicity, leading to
abnormal cardiac function.
Case presentation A 55-year-old Male was expeditiously transported to our medical facility thirty minutes
subsequent to ingesting 10 mL of pyridaben. Upon admission, the patient exhibited symptoms of vomiting and
coma. Within the next half-hour, he progressed to hypotonic hypoxemia and hypotension as a result of pyridaben
intoxication. With the implementation of prompt gastric lavage, oral administration of activated charcoal, respiratory
and circulatory support, as well as continuous renal replacement therapy (CRRT), the patient was ultimately
discharged successfully without any lingering sequelae.
Conclusion This case report delineates a rare occurrence of acute human poisoning stemming from contact
with novel synthetic pesticides. The document elucidates the clinical manifestations observed and the efficacious
administration of supportive therapeutic interventions.
Keywords Pyridaben, Acute respiratory, Circulating failure, Hemoperfusion, CRRT
Creator
Dan Zhang1
, Juan Wang1* and WeiYi Zhang1
, Juan Wang1* and WeiYi Zhang1
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Dan Zhang1
, Juan Wang1* and WeiYi Zhang1, “Case report : pyridaben poisoning induced acute respiratory and circulating failure,” Repository Horizon University Indonesia, accessed April 22, 2026, https://repository.horizon.ac.id/items/show/13242.