Jurnal Internasional Afrika vol.9 issue 3 2019
African Journal of Emergency Medicine
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial
Dublin Core
Title
Jurnal Internasional Afrika vol.9 issue 3 2019
African Journal of Emergency Medicine
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial
African Journal of Emergency Medicine
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial
Subject
Pain management
Bone fractures
Sedation
Fentanyl
Ketamine
Bone fractures
Sedation
Fentanyl
Ketamine
Description
Introduction: Fentanyl is a lipid soluble, highly potent opioid. The lipid solubility of fentanyl makes it an ideal
opioid to be administrated by inhalation. The current study compared ketamine infusion and nebulized fentanyl
in bone fracture pain relief.
Methods: In this double-blind, randomized clinical trial, patients aged 18 to 55 years who were admitted to the
emergency department (ED) with limb fracture were recruited. A total of 127 patients were included in the
study, 51.1% (65) of whom were male and 48.9% (62) of whom were female. The patients were divided equally
into two groups: Group I received 100 cm3 IV infusion of normal saline and 4 μg/kg of 50 μg/ml nebulized
fentanyl; Group II received 0.4 mg/kg ketamine in 10 min and 5 cm3 nebulized normal saline. Pain was assessed
using a visual analog scale just before treatment and 5, 10, 15, 30, and 60 min post-treatment.
Results: Before intervention, the pain scores of both groups showed no significant difference. However, log linear
analysis in both groups showed a significantly decrement during the follow up (60 min) (p < 0.0001). Multiple
comparison analysis showed that pain scores were significantly higher in the patients of Group I. Moreover,
patients in Group I required additional treatment.
Conclusion: Ketamine can be used as an alternative non-invasive treatment to successfully relieve pain in patients
with limb fractures
opioid to be administrated by inhalation. The current study compared ketamine infusion and nebulized fentanyl
in bone fracture pain relief.
Methods: In this double-blind, randomized clinical trial, patients aged 18 to 55 years who were admitted to the
emergency department (ED) with limb fracture were recruited. A total of 127 patients were included in the
study, 51.1% (65) of whom were male and 48.9% (62) of whom were female. The patients were divided equally
into two groups: Group I received 100 cm3 IV infusion of normal saline and 4 μg/kg of 50 μg/ml nebulized
fentanyl; Group II received 0.4 mg/kg ketamine in 10 min and 5 cm3 nebulized normal saline. Pain was assessed
using a visual analog scale just before treatment and 5, 10, 15, 30, and 60 min post-treatment.
Results: Before intervention, the pain scores of both groups showed no significant difference. However, log linear
analysis in both groups showed a significantly decrement during the follow up (60 min) (p < 0.0001). Multiple
comparison analysis showed that pain scores were significantly higher in the patients of Group I. Moreover,
patients in Group I required additional treatment.
Conclusion: Ketamine can be used as an alternative non-invasive treatment to successfully relieve pain in patients
with limb fractures
Creator
Mohammadreza Maleki Verki, Javad Mozafari, Fateme Tirandaz, Hassan Motamed, Afsane Khazaeli
Source
https://doi.org/10.1016/j.afjem.2019.02.003
Date
4 February 2019
Contributor
peri irawan
Format
pdf
Language
ENGLISH
Type
text
Files
Citation
Mohammadreza Maleki Verki, Javad Mozafari, Fateme Tirandaz, Hassan Motamed, Afsane Khazaeli , “Jurnal Internasional Afrika vol.9 issue 3 2019
African Journal of Emergency Medicine
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1774.
African Journal of Emergency Medicine
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1774.