Jurnal Internasional Afrika vol.10 issue.3 2020
African Journal of Emergency Medicine
Colchicine overdose: A South African experience, a case report
Dublin Core
Title
Jurnal Internasional Afrika vol.10 issue.3 2020
African Journal of Emergency Medicine
Colchicine overdose: A South African experience, a case report
African Journal of Emergency Medicine
Colchicine overdose: A South African experience, a case report
Subject
Overdose
Colchicine
Multi-organ failure
Colchicine
Multi-organ failure
Description
Introduction: Colchicine overdose is uncommon but is associated with a high mortality rate. It has a narrow
therapeutic index and has been described to have a 100% mortality with ingestion of > 0.8 mg/kg (Finkelstein
et al., 2010; Herran-Monge et al., 2013; Aghabiklooei et al., 2014; Erden et al., 2013).
Case report: This is a case report of a 19-year-old male who ingested 0.4 mg/kg of colchicine in a suicide attempt.
He developed multiorgan dysfunction. He was managed supportively, and the dysfunction resolved.
Discussion: The clinical presentation and management should be familiar to all those who work in acute care in
order to be able to identify and treat it timeously thus preventing morbidity and mortality. Treatment is largely
supportive. To the best of our knowledge this is the first case of colchicine overdose described in Sub-Saharan
Africa.
therapeutic index and has been described to have a 100% mortality with ingestion of > 0.8 mg/kg (Finkelstein
et al., 2010; Herran-Monge et al., 2013; Aghabiklooei et al., 2014; Erden et al., 2013).
Case report: This is a case report of a 19-year-old male who ingested 0.4 mg/kg of colchicine in a suicide attempt.
He developed multiorgan dysfunction. He was managed supportively, and the dysfunction resolved.
Discussion: The clinical presentation and management should be familiar to all those who work in acute care in
order to be able to identify and treat it timeously thus preventing morbidity and mortality. Treatment is largely
supportive. To the best of our knowledge this is the first case of colchicine overdose described in Sub-Saharan
Africa.
Creator
Jenna Essam, Saul Grossberg, Adam Mahomed
Source
https://doi.org/10.1016/j.afjem.2019.12.005
Date
31 December 2019
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Jenna Essam, Saul Grossberg, Adam Mahomed, “Jurnal Internasional Afrika vol.10 issue.3 2020
African Journal of Emergency Medicine
Colchicine overdose: A South African experience, a case report,” Repository Horizon University Indonesia, accessed February 4, 2025, https://repository.horizon.ac.id/items/show/1815.
African Journal of Emergency Medicine
Colchicine overdose: A South African experience, a case report,” Repository Horizon University Indonesia, accessed February 4, 2025, https://repository.horizon.ac.id/items/show/1815.