Jurnal internasional Afrika vol.11 issue 4 2021
African Journal of Emergency Medicine
Demographics and clinical characteristics of hospitalised patients under investigation for COVID-19 with an initial negative SARS-CoV-2 PCR test result
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Title
Jurnal internasional Afrika vol.11 issue 4 2021
African Journal of Emergency Medicine
Demographics and clinical characteristics of hospitalised patients under investigation for COVID-19 with an initial negative SARS-CoV-2 PCR test result
African Journal of Emergency Medicine
Demographics and clinical characteristics of hospitalised patients under investigation for COVID-19 with an initial negative SARS-CoV-2 PCR test result
Subject
COVID-19
South Africa
Emergency
District
Negative
South Africa
Emergency
District
Negative
Description
Background: The COVID-19 pandemic is placing abnormally high and ongoing demands on healthcare systems.
Little is known about the full effect of the COVID-19 pandemic on diseases other than COVID-19 in the South
African setting.
Objective: To describe a cohort of hospitalised patients under investigation for SARS-CoV-2 that initially tested
negative.
Methods: Consecutive patients hospitalised at Khayelitsha Hospital from April to June 2020, whose initial po-
lymerase chain reaction test for SARS-CoV-2 was negative were included. Patient demographics, clinical char-
acteristics, ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th
Revision) diagnosis, referral to tertiary level facilities and ICU, and all-cause in-hospital mortality were collected.
The 90-day re-test rate was determined and comparisons were made using the χ2
-test and the independent
samples median test.
Results: Overall, 261 patients were included: median age 39.8 years, 55.6% female (n = 145). Frequent
comorbidities included HIV (41.4%), hypertension (26.4%), and previous or current tuberculosis (24.1%). Nine
(3.7%) patients were admitted to ICU and 38 (15.6%) patients died. Ninety-three patients (35.6%) were re-tested
and 21 (22.6%) were positive for SARS-CoV-2. The top primary diagnoses related to respiratory diseases (n = 82,
33.6%), and infectious and parasitic diseases (n = 62, 25.4%). Thirty-five (14.3%) had a COVID-19 diagnostic
code assigned (26 without microbiological confirmation) and 43 (16.5%) had tuberculosis. Older age (p =
0.001), chronic renal impairment (p = 0.03) and referral to higher level of care (all p < 0.001; ICU p = 0.03)
were more frequent in those that died.
Conclusion: Patients with tuberculosis and other diseases are still presenting to emergency centres with symptoms
that may be attributable to SARS-CoV-2 and requiring admission. Extreme vigilance will be necessary to diag-
nosis and treat tuberculosis and other diseases as we emerge from the COVID-19 pandemic.
Little is known about the full effect of the COVID-19 pandemic on diseases other than COVID-19 in the South
African setting.
Objective: To describe a cohort of hospitalised patients under investigation for SARS-CoV-2 that initially tested
negative.
Methods: Consecutive patients hospitalised at Khayelitsha Hospital from April to June 2020, whose initial po-
lymerase chain reaction test for SARS-CoV-2 was negative were included. Patient demographics, clinical char-
acteristics, ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th
Revision) diagnosis, referral to tertiary level facilities and ICU, and all-cause in-hospital mortality were collected.
The 90-day re-test rate was determined and comparisons were made using the χ2
-test and the independent
samples median test.
Results: Overall, 261 patients were included: median age 39.8 years, 55.6% female (n = 145). Frequent
comorbidities included HIV (41.4%), hypertension (26.4%), and previous or current tuberculosis (24.1%). Nine
(3.7%) patients were admitted to ICU and 38 (15.6%) patients died. Ninety-three patients (35.6%) were re-tested
and 21 (22.6%) were positive for SARS-CoV-2. The top primary diagnoses related to respiratory diseases (n = 82,
33.6%), and infectious and parasitic diseases (n = 62, 25.4%). Thirty-five (14.3%) had a COVID-19 diagnostic
code assigned (26 without microbiological confirmation) and 43 (16.5%) had tuberculosis. Older age (p =
0.001), chronic renal impairment (p = 0.03) and referral to higher level of care (all p < 0.001; ICU p = 0.03)
were more frequent in those that died.
Conclusion: Patients with tuberculosis and other diseases are still presenting to emergency centres with symptoms
that may be attributable to SARS-CoV-2 and requiring admission. Extreme vigilance will be necessary to diag-
nosis and treat tuberculosis and other diseases as we emerge from the COVID-19 pandemic.
Creator
D.J. van Hoving , N. Hattingh , S.K. Pillay , T. Lockey , D.J. McAlpine , K. Nieuwenhuys , E. Erasmus
Source
https://doi.org/10.1016/j.afjem.2021.09.002
Date
16 September 2021
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
D.J. van Hoving , N. Hattingh , S.K. Pillay , T. Lockey , D.J. McAlpine , K. Nieuwenhuys , E. Erasmus , “Jurnal internasional Afrika vol.11 issue 4 2021
African Journal of Emergency Medicine
Demographics and clinical characteristics of hospitalised patients under investigation for COVID-19 with an initial negative SARS-CoV-2 PCR test result,” Repository Horizon University Indonesia, accessed April 26, 2025, https://repository.horizon.ac.id/items/show/1852.
African Journal of Emergency Medicine
Demographics and clinical characteristics of hospitalised patients under investigation for COVID-19 with an initial negative SARS-CoV-2 PCR test result,” Repository Horizon University Indonesia, accessed April 26, 2025, https://repository.horizon.ac.id/items/show/1852.