Safety and Health at Work Vol. 10 Issue 1 2019
Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene (Original Article)
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Title
Safety and Health at Work Vol. 10 Issue 1 2019
Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene (Original Article)
Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene (Original Article)
Subject
Biological exposure indices, Correlation, Styrene, Urinary mandelic acid, Urinary phenylglyoxylic acid
Description
Background: This study was designed to provide logical backgrounds for the revision of biological
exposure indices (BEIs) for styrene exposure in Korea. In order to investigate the correlation between airborne styrene and biological exposure indices, we measured urinary mandelic acid (MA) and phenylglyoxylic acid (PGA) in workers exposed to styrene occupationally, as well as airborne styrene at workplaces.
Methods: Surveys were conducted for 56 subjects. The concentrations of airborne styrene and urinary
metabolites of styrene were measured in 36 workers who were occupationally exposed to styrene, and in 20 controls. Air samples were collected using personal air samplers and analyzed by gas chromatography. Urine samples were collected at the end of the shift and analyzed by high performance liquid chromatography.
Results: The geometric mean concentration of airborne styrene was 9.6 ppm. The concentrations of urinary MA, PGA, and MAþPGA in the exposure group were 267.7, 143.3, and 416.8 mg/g creatinine,
respectively. The correlation coefficients for correlation between airborne styrene and MA, PGA, and MAþPGA were 0.714, 0.604, and 0.769, respectively. The sum of urinary MA and PGA corresponding to an exposure of 20 ppm styrene was 603 mg/g creatinine.
Conclusion: The correlation of the sum of urinary MA and PGA with airborne styrene was better than the correlation of each individual urinary determinant. It is considered appropriate to amend the concentration of urinary MAþPGA to 600 mg/g creatinine as a BEI, which corresponds to an airborne styrene concentration of 20 ppm in Korea.
exposure indices (BEIs) for styrene exposure in Korea. In order to investigate the correlation between airborne styrene and biological exposure indices, we measured urinary mandelic acid (MA) and phenylglyoxylic acid (PGA) in workers exposed to styrene occupationally, as well as airborne styrene at workplaces.
Methods: Surveys were conducted for 56 subjects. The concentrations of airborne styrene and urinary
metabolites of styrene were measured in 36 workers who were occupationally exposed to styrene, and in 20 controls. Air samples were collected using personal air samplers and analyzed by gas chromatography. Urine samples were collected at the end of the shift and analyzed by high performance liquid chromatography.
Results: The geometric mean concentration of airborne styrene was 9.6 ppm. The concentrations of urinary MA, PGA, and MAþPGA in the exposure group were 267.7, 143.3, and 416.8 mg/g creatinine,
respectively. The correlation coefficients for correlation between airborne styrene and MA, PGA, and MAþPGA were 0.714, 0.604, and 0.769, respectively. The sum of urinary MA and PGA corresponding to an exposure of 20 ppm styrene was 603 mg/g creatinine.
Conclusion: The correlation of the sum of urinary MA and PGA with airborne styrene was better than the correlation of each individual urinary determinant. It is considered appropriate to amend the concentration of urinary MAþPGA to 600 mg/g creatinine as a BEI, which corresponds to an airborne styrene concentration of 20 ppm in Korea.
Creator
Ah-rum Choi, Sung-guk Im, Mi-young Lee, Se-Hoon Lee
Publisher
Elsevier Korea LLC
Date
March 2019
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 10 Issue 1 2019
Files
Citation
Ah-rum Choi, Sung-guk Im, Mi-young Lee, Se-Hoon Lee, “Safety and Health at Work Vol. 10 Issue 1 2019
Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene (Original Article),” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1879.
Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene (Original Article),” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1879.